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Recent research has found that infection of these astroviruses usually cause visceral gout in chicken, duckling and gosling. However, the underlying mechanism remains unknown. In the current article, we review recent discoveries of genetic diversity and variation of these astroviruses, as well as pathogenesis after astrovirus infection. In addition, we discuss the relation between avian astrovirus infection and visceral gout in poultry. 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Dis."},{"key":"ref_5","first-page":"1529","article-title":"Duck hepatitis: Vaccination against two serological types","volume":"77","author":"Asplin","year":"1965","journal-title":"Vet. Rec."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/03079457.2011.587792","article-title":"Detection of astrovirus infection in pigeons (Columbia livia) during an outbreak of diarrhoea","volume":"40","author":"Zhao","year":"2011","journal-title":"Avian Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"728","DOI":"10.2307\/1590577","article-title":"Astrovirus: A cause of an enteric disease in turkey poults","volume":"30","author":"Reynolds","year":"1986","journal-title":"Avian Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2307\/1589732","article-title":"Characterization of a picornavirus isolated from broiler chicks","volume":"23","author":"Yamaguchi","year":"1979","journal-title":"Avian Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1080\/03079457.2012.733340","article-title":"Circulation and phylogenetic relationship of chicken and turkey-origin astroviruses detected in domestic ducks (Anas platyrhynchos domesticus)","volume":"41","author":"Bidin","year":"2012","journal-title":"Avian Pathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/tbed.13410","article-title":"Characterization and genomic analysis of emerging astroviruses causing fatal gout in goslings","volume":"67","author":"Chen","year":"2020","journal-title":"Transbound. 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Virol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.psj.2020.11.003","article-title":"Isolation and evolutionary analyses of gout-associated goose astrovirus causing disease in experimentally infected chickens","volume":"100","author":"Li","year":"2021","journal-title":"Poult. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s13337-019-00554-1","article-title":"Molecular characterization of chicken astroviruses in gout-affected commercial broiler chickens in Haryana, India","volume":"30","author":"Panigrahi","year":"2019","journal-title":"Virusdisease"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1080\/03079457.2013.828194","article-title":"Role of chicken astrovirus as a causative agent of gout in commercial broilers in India","volume":"42","author":"Bulbule","year":"2013","journal-title":"Avian Pathol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Raji, A.A., and Omar, A.R. (2022). An Insight into the Molecular Characteristics and Associated Pathology of Chicken Astroviruses. Viruses, 14.","DOI":"10.3390\/v14040722"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1136\/vr.106.26.561","article-title":"Detection of astroviruses in turkey faeces by direct electron microscopy","volume":"106","author":"McNulty","year":"1980","journal-title":"Vet. Rec."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"8487","DOI":"10.1128\/JVI.74.18.8487-8493.2000","article-title":"Avian nephritis virus (ANV) as a new member of the family Astroviridae and construction of infectious ANV cDNA","volume":"74","author":"Imada","year":"2000","journal-title":"J. Virol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/03079450220136521","article-title":"Avian astroviruses","volume":"31","author":"Koci","year":"2002","journal-title":"Avian Pathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1136\/vr.114.11.279-a","article-title":"Astrovirus-like particles associated with hepatitis in ducklings","volume":"114","author":"Gough","year":"1984","journal-title":"Vet. Rec."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.vetmic.2014.01.026","article-title":"Molecular characterization of a duck hepatitis virus 3-like astrovirus","volume":"170","author":"Liu","year":"2014","journal-title":"Vet. Microbiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.meegid.2015.02.025","article-title":"Genetic characterization of a novel astrovirus in Pekin ducks","volume":"32","author":"Liao","year":"2015","journal-title":"Infect. Genet. Evol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1136\/vr.114.9.216-a","article-title":"Isolation of an enterovirus-like agent from the meconium of dead-in-shell chicken embryos","volume":"114","author":"Spackman","year":"1984","journal-title":"Vet. Rec."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1128\/JVI.01993-07","article-title":"Genomic analysis of closely related astroviruses","volume":"82","author":"Strain","year":"2008","journal-title":"J. Virol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/tbed.13418","article-title":"First report of a novel goose astrovirus outbreak in Cherry Valley ducklings in China","volume":"67","author":"Chen","year":"2020","journal-title":"Transbound. Emerg. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41426-018-0153-7","article-title":"An emerging novel goose astrovirus associated with gosling gout disease, China","volume":"7","author":"Zhang","year":"2018","journal-title":"Emerg. Microbes. Infect."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41426-018-0074-5","article-title":"Isolation and characterization of an astrovirus causing fatal visceral gout in domestic goslings","volume":"7","author":"Zhang","year":"2018","journal-title":"Emerg. Microbes. Infect."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"101432","DOI":"10.1016\/j.psj.2021.101432","article-title":"Isolation and characterization of a goose astrovirus 1 strain causing fatal gout in goslings, China","volume":"100","author":"Wang","year":"2021","journal-title":"Poult. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1111\/tbed.14060","article-title":"Identification and genomic characterization of emerging goose astrovirus in central China, 2020","volume":"69","author":"Zhang","year":"2022","journal-title":"Transbound. Emerg. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1080\/00071668.2020.1723790","article-title":"Metabolomic profiling of goslings with visceral gout reveals a distinct metabolic signature","volume":"61","author":"Xi","year":"2020","journal-title":"Br. Poult. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/jmv.1890030308","article-title":"Astrovirus infection in volunteers","volume":"3","author":"Kurtz","year":"1979","journal-title":"J. Med. Virol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Arias, C.F., and DuBois, R.M. (2017). The Astrovirus Capsid: A Review. Viruses, 9.","DOI":"10.3390\/v9010015"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Lan, J., Zhang, R., Li, P., Chen, J., Xie, Z., and Jiang, S. (2019). Identification of a Type-Specific Epitope in the ORF2 Protein of Duck Astrovirus Type 1. Animals, 9.","DOI":"10.3390\/ani9121069"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1080\/03079457.2010.516387","article-title":"Development and evaluation of real-time TaqMan(R) RT-PCR assays for the detection of avian nephritis virus and chicken astrovirus in chickens","volume":"39","author":"Smyth","year":"2010","journal-title":"Avian Pathol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/03079457.2011.652938","article-title":"Capsid protein sequence diversity of chicken astrovirus","volume":"41","author":"Smyth","year":"2012","journal-title":"Avian Pathol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/03079457.2011.553583","article-title":"Capsid protein sequence diversity of avian nephritis virus","volume":"40","author":"Todd","year":"2011","journal-title":"Avian Pathol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"8666","DOI":"10.1128\/jvi.71.11.8666-8671.1997","article-title":"Characterization of human serotype 1 astrovirus-neutralizing epitopes","volume":"71","author":"Bass","year":"1997","journal-title":"J. Virol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1089\/vim.2005.18.17","article-title":"Identification of structural domains involved in astrovirus capsid biology","volume":"18","author":"Krishna","year":"2005","journal-title":"Viral Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s00705-011-0931-1","article-title":"Comparison of capsid gene sequences of turkey astrovirus-2 from poult-enteritis-syndrome-affected and apparently healthy turkeys","volume":"156","author":"Jindal","year":"2011","journal-title":"Arch. Virol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/03079457.2011.632402","article-title":"Investigation into the aetiology of runting and stunting syndrome in chickens","volume":"41","author":"Kang","year":"2012","journal-title":"Avian Pathol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1637\/11802-012018-Case.1","article-title":"White Chick Syndrome Associated with Chicken Astrovirus in Ontario, Canada","volume":"62","author":"Long","year":"2018","journal-title":"Avian Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2307\/1591515","article-title":"Pathologically and serologically different avian nephritis virus isolates implicated in etiology of baby chick nephropathy","volume":"36","author":"Shirai","year":"1992","journal-title":"Avian Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1637\/11229-070515-Review.1","article-title":"Hepatitis Virus Infections in Poultry","volume":"60","author":"Yugo","year":"2016","journal-title":"Avian Dis."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Janowski, A.B. (2021). Beyond the Gastrointestinal Tract: The Emerging and Diverse Tissue Tropisms of Astroviruses. Viruses, 13.","DOI":"10.3390\/v13050732"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1007\/s00705-011-1034-8","article-title":"Complete sequence and genetic characterization of pigeon avian nephritis virus, a member of the family Astroviridae","volume":"156","author":"Zhao","year":"2011","journal-title":"Arch. Virol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2307\/1591176","article-title":"Differences in the induction of urate deposition of specific-pathogen-free chicks inoculated with avian nephritis virus passaged by five different methods","volume":"35","author":"Shirai","year":"1991","journal-title":"Avian Dis."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Zhang, F., Li, Y., Jiang, W., Yu, X., Zhuang, Q., Wang, S., Yuan, L., Wang, K., Sun, S., and Liu, H. (2022). Surveillance and genetic diversity analysis of avian astrovirus in China. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0264308"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Yin, D., Tian, J., Yang, J., Tang, Y., and Diao, Y. (2021). Pathogenicity of novel goose-origin astrovirus causing gout in goslings. BMC Vet. Res., 17.","DOI":"10.1186\/s12917-020-02739-z"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"114263","DOI":"10.1016\/j.jviromet.2021.114263","article-title":"Development of immunochromatographic strip assay for rapid detection of novel goose astrovirus","volume":"297","author":"Yang","year":"2021","journal-title":"J. Virol. Methods"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Ding, R., Huang, H., Wang, H., Yi, Z., Qiu, S., Lv, Y., and Bao, E. (2021). Goose Nephritic Astrovirus Infection of Goslings Induces Lymphocyte Apoptosis, Reticular Fiber Destruction, and CD8 T-Cell Depletion in Spleen Tissue. Viruses, 13.","DOI":"10.3390\/v13061108"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"109244","DOI":"10.1016\/j.vetmic.2021.109244","article-title":"Goose nephritic astrovirus infection increases autophagy, destroys intercellular junctions in renal tubular epithelial cells, and damages podocytes in the kidneys of infected goslings","volume":"263","author":"Huang","year":"2021","journal-title":"Vet. Microbiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"101407","DOI":"10.1016\/j.psj.2021.101407","article-title":"First report of a novel goose astrovirus outbreak in Muscovy ducklings in China","volume":"100","author":"Chen","year":"2021","journal-title":"Poult. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1111\/tbed.12928","article-title":"Isolation and genomic characterization of gosling gout caused by a novel goose astrovirus","volume":"65","author":"Yang","year":"2018","journal-title":"Transbound. Emerg. Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"101800","DOI":"10.1016\/j.psj.2022.101800","article-title":"Isolation and phylogenetic analysis of goose astrovirus type 1 from goslings with gout in Jiangxi province, China","volume":"101","author":"Zhang","year":"2022","journal-title":"Poult. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/03079457.2021.2000939","article-title":"Molecular characterization and pathogenicity of novel Malaysian chicken astrovirus isolates","volume":"51","author":"Raji","year":"2022","journal-title":"Avian Pathol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"17448069211047863","DOI":"10.1177\/17448069211047863","article-title":"Selective inhibition of adenylyl cyclase subtype 1 reduces inflammatory pain in chicken of gouty arthritis","volume":"17","author":"Liu","year":"2021","journal-title":"Mol. Pain"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1016\/j.psj.2019.11.064","article-title":"Goose astrovirus infection affects uric acid production and excretion in goslings","volume":"99","author":"Wu","year":"2020","journal-title":"Poult. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/S0140-6736(21)00569-9","article-title":"Gout","volume":"397","author":"Dalbeth","year":"2021","journal-title":"Lancet"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijcard.2015.08.109","article-title":"Regulation of uric acid metabolism and excretion","volume":"213","author":"Maiuolo","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"11937","DOI":"10.1128\/JVI.00942-07","article-title":"Astrovirus increases epithelial barrier permeability independently of viral replication","volume":"81","author":"Moser","year":"2007","journal-title":"J. Virol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000484281","article-title":"Gout: A Disease of Kings","volume":"192","author":"Tang","year":"2018","journal-title":"Contrib. Nephrol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"873062","DOI":"10.3389\/fvets.2022.873062","article-title":"First Identification and Genetic Characterization of a Novel Duck Astrovirus in Ducklings in China","volume":"9","author":"Zhang","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1128\/JCM.43.2.916-918.2005","article-title":"Emergence of a nephropathogenic avian infectious bronchitis virus with a novel genotype in India","volume":"43","author":"Bayry","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1637\/aviandiseases-D-19-00110","article-title":"Clinical and Histologic Characterization of Co-infection with Astrovirus and Goose Parvovirus in Goslings","volume":"63","author":"Liu","year":"2019","journal-title":"Avian Dis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1111\/tbed.13652","article-title":"Coinfection of parvovirus and astrovirus in gout-affected goslings","volume":"67","author":"Liu","year":"2020","journal-title":"Transbound. Emerg. Dis."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Xu, P., Liu, P., Zhou, C., Shi, Y., Wu, Q., Yang, Y., Li, G., Hu, G., and Guo, X. (2019). A Multi-Omics Study of Chicken Infected by Nephropathogenic Infectious Bronchitis Virus. Viruses, 11.","DOI":"10.3390\/v11111070"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"101780","DOI":"10.1016\/j.psj.2022.101780","article-title":"The effects of dietary protein and fiber levels on growth performance, gout occurrence, intestinal microbial communities, and immunoregulation in the gut-kidney axis of goslings","volume":"101","author":"Xi","year":"2022","journal-title":"Poult. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/00071660500302661","article-title":"Clinicopathology of gout in growing layers induced by high calcium and high protein diets","volume":"46","author":"Guo","year":"2005","journal-title":"Br. Poult. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1007\/s00705-018-3932-5","article-title":"Genetic characterization of a new astrovirus in goslings suffering from gout","volume":"163","author":"Jin","year":"2018","journal-title":"Arch. Virol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Xi, Y., Huang, Y., Li, Y., Yan, J., and Shi, Z. (2020). Fermented Feed Supplement Relieves Caecal Microbiota Dysbiosis and Kidney Injury Caused by High-Protein Diet in the Development of Gosling Gout. Animals, 10.","DOI":"10.3390\/ani10112139"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Palomino-Tapia, V., Mitevski, D., Inglis, T., van der Meer, F., Martin, E., Brash, M., Provost, C., Gagnon, C.A., and Abdul-Careem, M.F. (2020). Chicken Astrovirus (CAstV) Molecular Studies Reveal Evidence of Multiple Past Recombination Events in Sequences Originated from Clinical Samples of White Chick Syndrome (WCS) in Western Canada. Viruses, 12.","DOI":"10.3390\/v12101096"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/18\/10429\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:28:03Z","timestamp":1760142483000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/18\/10429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,9]]},"references-count":72,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["ijms231810429"],"URL":"https:\/\/doi.org\/10.3390\/ijms231810429","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,9]]}}}