{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:21:39Z","timestamp":1784784099692,"version":"3.55.0"},"reference-count":41,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007801","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["iscIII PI19\/00188"],"award-info":[{"award-number":["iscIII PI19\/00188"]}],"id":[{"id":"10.13039\/100007801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007801","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["BIO2017-84702-R"],"award-info":[{"award-number":["BIO2017-84702-R"]}],"id":[{"id":"10.13039\/100007801","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondos Europeos de Desarrollo Regional","award":["iscIII PI19\/00188"],"award-info":[{"award-number":["iscIII PI19\/00188"]}]},{"name":"Fondos Europeos de Desarrollo Regional","award":["BIO2017-84702-R"],"award-info":[{"award-number":["BIO2017-84702-R"]}]},{"name":"Fundaci\u00f3n Ram\u00f3n Areces","award":["iscIII PI19\/00188"],"award-info":[{"award-number":["iscIII PI19\/00188"]}]},{"name":"Fundaci\u00f3n Ram\u00f3n Areces","award":["BIO2017-84702-R"],"award-info":[{"award-number":["BIO2017-84702-R"]}]},{"name":"University Catholic of Murcia","award":["iscIII PI19\/00188"],"award-info":[{"award-number":["iscIII PI19\/00188"]}]},{"name":"University Catholic of Murcia","award":["BIO2017-84702-R"],"award-info":[{"award-number":["BIO2017-84702-R"]}]},{"name":"Cancer Research Institute and Fibrolamellar Cancer Foundation and Consejer\u00eda de Sanidad de la Region de Murcia","award":["iscIII PI19\/00188"],"award-info":[{"award-number":["iscIII PI19\/00188"]}]},{"name":"Cancer Research Institute and Fibrolamellar Cancer Foundation and Consejer\u00eda de Sanidad de la Region de Murcia","award":["BIO2017-84702-R"],"award-info":[{"award-number":["BIO2017-84702-R"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Telomere shortening is the main molecular mechanism of aging, but not the only one. The adaptive immune system also ages, and older organisms tend to develop a chronic pro-inflammatory status with low-grade inflammation characterized by chronic activation of the innate immune system, called inflammaging. One of the main stimuli that fuels inflammaging is a high nutrient intake, triggering a metabolic inflammation process called metainflammation. In this study, we report the anti-inflammatory activity of several senolytic drugs in the context of chronic inflammation, by using two different zebrafish models: (i) a chronic skin inflammation model with a hypomorphic mutation in spint1a, the gene encoding the serine protease inhibitor, kunitz-type, 1a (also known as hai1a) and (ii) a non-alcoholic fatty liver disease\/non-alcoholic steatohepatitis (NAFLD\/NASH) model with inflammation induced by a high-fat diet. Our results show that, although these models do not manifest premature aging, the senolytic drugs dasatinib, navitoclax, and venetoclax have an anti-inflammatory effect that results in the amelioration of chronic inflammation.<\/jats:p>","DOI":"10.3390\/ijms231810468","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T22:53:46Z","timestamp":1663023226000},"page":"10468","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Senescence-Independent Anti-Inflammatory Activity of the Senolytic Drugs Dasatinib, Navitoclax, and Venetoclax in Zebrafish Models of Chronic Inflammation"],"prefix":"10.3390","volume":"23","author":[{"given":"David","family":"Hern\u00e1ndez-Silva","sequence":"first","affiliation":[{"name":"Telomerase Cancer and Aging Group (TCAG), Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain"},{"name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria-Arrixaca (IMIB-Arrixaca), 30120 Murcia, Spain"},{"name":"Structural Bioinformatics and High-Performance Computing Research Group (BIO-HPC), Computer Engineering Department, Universidad Cat\u00f3lica de Murcia (UCAM), Guadalupe, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Cant\u00f3n-Sandoval","sequence":"additional","affiliation":[{"name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria-Arrixaca (IMIB-Arrixaca), 30120 Murcia, Spain"},{"name":"Departamento de Biolog\u00eda Celular e Histolog\u00eda, Facultad de Biolog\u00eda, Universidad de Murcia, 30100 Murcia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER), ISCIII, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2093-0040","authenticated-orcid":false,"given":"Francisco Juan","family":"Mart\u00ednez-Navarro","sequence":"additional","affiliation":[{"name":"Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA"},{"name":"Department of Medicine (Hepatology), Albert Einstein College of Medicine, Bronx, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4468-7898","authenticated-orcid":false,"given":"Horacio","family":"P\u00e9rez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Structural Bioinformatics and High-Performance Computing Research Group (BIO-HPC), Computer Engineering Department, Universidad Cat\u00f3lica de Murcia (UCAM), Guadalupe, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA"},{"name":"Department of Medicine (Hepatology), Albert Einstein College of Medicine, Bronx, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9527-0211","authenticated-orcid":false,"given":"Victoriano","family":"Mulero","sequence":"additional","affiliation":[{"name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria-Arrixaca (IMIB-Arrixaca), 30120 Murcia, Spain"},{"name":"Departamento de Biolog\u00eda Celular e Histolog\u00eda, Facultad de Biolog\u00eda, Universidad de Murcia, 30100 Murcia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER), ISCIII, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1802-4943","authenticated-orcid":false,"given":"Francisca","family":"Alcaraz-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Telomerase Cancer and Aging Group (TCAG), Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain"},{"name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria-Arrixaca (IMIB-Arrixaca), 30120 Murcia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER), ISCIII, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2021-9822","authenticated-orcid":false,"given":"Mar\u00eda Luisa","family":"Cayuela","sequence":"additional","affiliation":[{"name":"Telomerase Cancer and Aging Group (TCAG), Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain"},{"name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria-Arrixaca (IMIB-Arrixaca), 30120 Murcia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER), ISCIII, 30100 Murcia, 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