{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T15:11:56Z","timestamp":1775920316572,"version":"3.50.1"},"reference-count":16,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T00:00:00Z","timestamp":1662768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health","award":["NCI 2P30 CA118100"],"award-info":[{"award-number":["NCI 2P30 CA118100"]}]},{"name":"National Institute of Health","award":["2019-20-002"],"award-info":[{"award-number":["2019-20-002"]}]},{"name":"UNM Brain &amp; Behavioral Health Institute","award":["NCI 2P30 CA118100"],"award-info":[{"award-number":["NCI 2P30 CA118100"]}]},{"name":"UNM Brain &amp; Behavioral Health Institute","award":["2019-20-002"],"award-info":[{"award-number":["2019-20-002"]}]},{"name":"UNM Faculty Start-up funding","award":["NCI 2P30 CA118100"],"award-info":[{"award-number":["NCI 2P30 CA118100"]}]},{"name":"UNM Faculty Start-up funding","award":["2019-20-002"],"award-info":[{"award-number":["2019-20-002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Current imaging approaches used to monitor tumor progression can lack the ability to distinguish true progression from pseudoprogression. Simultaneous metabolic 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) and magnetic resonance imaging (MRI) offers new opportunities to overcome this challenge by refining tumor identification and monitoring therapeutic responses to cancer immunotherapy. In the current work, spatial and quantitative analysis of tumor burden were performed using simultaneous [18F]FDG-PET\/MRI to monitor therapeutic responses to a novel silicified cancer cell immunotherapy in a mouse model of disseminated serous epithelial ovarian cancer. Tumor progression was validated by bioluminescence imaging of luciferase expressing tumor cells, flow cytometric analysis of immune cells in the tumor microenvironment, and histopathology. While PET demonstrated the presence of metabolically active cancer cells through [18F]FDG uptake, MRI confirmed cancer-related accumulation of ascites and tissue anatomy. This approach provides complementary information on disease status without a confounding signal from treatment-induced inflammation. This work provides a possible roadmap to facilitate accurate monitoring of therapeutic responses to cancer immunotherapies.<\/jats:p>","DOI":"10.3390\/ijms231810525","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T22:53:46Z","timestamp":1663023226000},"page":"10525","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Monitoring Therapeutic Responses to Silicified Cancer Cell Immunotherapy Using PET\/MRI in a Mouse Model of Disseminated Ovarian Cancer"],"prefix":"10.3390","volume":"23","author":[{"given":"Erik N.","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Radiology, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin M.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2470-8199","authenticated-orcid":false,"given":"Stefan","family":"Franco","sequence":"additional","affiliation":[{"name":"Internal Medicine, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2687-1173","authenticated-orcid":false,"given":"Henning","family":"De May","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lor\u00e9l Y.","family":"Medina","sequence":"additional","affiliation":[{"name":"Internal Medicine, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yirong","family":"Yang","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1018-1883","authenticated-orcid":false,"given":"Erica B.","family":"Flores","sequence":"additional","affiliation":[{"name":"Internal Medicine, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Bartee","sequence":"additional","affiliation":[{"name":"Internal Medicine, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reed G.","family":"Selwyn","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4640-6332","authenticated-orcid":false,"given":"Rita E.","family":"Serda","sequence":"additional","affiliation":[{"name":"Internal Medicine, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2217\/imt.11.20","article-title":"Immunity and immune suppression in human ovarian cancer","volume":"3","author":"Preston","year":"2011","journal-title":"Immunotherapy"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1080\/15384047.2015.1040960","article-title":"Tumor infiltrating lymphocytes in ovarian cancer","volume":"16","author":"Santoiemma","year":"2015","journal-title":"Cancer Biol. 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