{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:55:10Z","timestamp":1784804110066,"version":"3.55.0"},"reference-count":124,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T00:00:00Z","timestamp":1662768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto Nacional de Pediatr\u00eda","award":["063\/2018"],"award-info":[{"award-number":["063\/2018"]}]},{"name":"Instituto Nacional de Pediatr\u00eda","award":["637704"],"award-info":[{"award-number":["637704"]}]},{"name":"CONACyT for the scholarship awarded to the student Fabiola Garc\u00eda Andrade","award":["063\/2018"],"award-info":[{"award-number":["063\/2018"]}]},{"name":"CONACyT for the scholarship awarded to the student Fabiola Garc\u00eda Andrade","award":["637704"],"award-info":[{"award-number":["637704"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Some pediatric patients with cryptorchidism preserve cells with gonocyte characteristics beyond their differentiation period, which could support the theory of the gonocyte as a target for malignancy in the development of testicular neoplasia. One of the key molecules in gonocyte malignancy is represented by microRNAs (miRNAs). The goal of this review is to give an overview of miRNAs, a class of small non-coding RNAs that participate in the regulation of gene expression. We also aim to review the crucial role of several miRNAs that have been further described in the regulation of gonocyte differentiation to spermatogonia, which, when transformed, could give rise to germ cell neoplasia in situ, a precursor lesion to testicular germ cell tumors. Finally, the potential use of miRNAs as diagnostic and prognostic biomarkers in testicular neoplasia is addressed, due to their specificity and sensitivity compared to conventional markers, as well as their applications in therapeutics.<\/jats:p>","DOI":"10.3390\/ijms231810526","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T22:53:46Z","timestamp":1663023226000},"page":"10526","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Role of microRNAs in the Gonocyte Theory as Target of Malignancy: Looking for Potential Diagnostic Biomarkers"],"prefix":"10.3390","volume":"23","author":[{"given":"Fabiola","family":"Garc\u00eda-Andrade","sequence":"first","affiliation":[{"name":"Laboratorio de Biolog\u00eda de la Reproducci\u00f3n, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico 04530, Mexico"},{"name":"Posgrado en Biolog\u00eda Experimental, Universidad Aut\u00f3noma Metropolitana Unidad Iztapalapa, Ciudad de M\u00e9xico 09310, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0187-1994","authenticated-orcid":false,"given":"Rosa Mar\u00eda","family":"Vigueras-Villase\u00f1or","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda de la Reproducci\u00f3n, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico 04530, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita Dolores","family":"Ch\u00e1vez-Salda\u00f1a","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda de la Reproducci\u00f3n, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico 04530, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7988-2231","authenticated-orcid":false,"given":"Julio C\u00e9sar","family":"Rojas-Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda de la Reproducci\u00f3n, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico 04530, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1361-3573","authenticated-orcid":false,"given":"Iv\u00e1n Uriel","family":"Bahena-Ocampo","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias de la Salud, Universidad Aut\u00f3noma Metropolitana Unidad Iztapalapa, Ciudad de M\u00e9xico 09310, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0787-5593","authenticated-orcid":false,"given":"Elena","family":"Ar\u00e9chaga-Ocampo","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Naturales, Universidad Aut\u00f3noma Metropolitana Unidad Cuajimalpa, Ciudad de M\u00e9xico 05348, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9583-3790","authenticated-orcid":false,"given":"Jos\u00e9","family":"D\u00edaz-Ch\u00e1vez","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Cancerolog\u00eda, Ciudad de M\u00e9xico 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9226-7412","authenticated-orcid":false,"given":"Daniel Adrian","family":"Landero-Huerta","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda de la Reproducci\u00f3n, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico 04530, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Palazzo, A.F., and Gregory, T.R. 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