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\u201cFrancesco Tonni\u201d","award":["21510"],"award-info":[{"award-number":["21510"]}]},{"name":"AIRC fellowship for Italy \u201cFrancesco Tonni\u201d","award":["20174TB8KW"],"award-info":[{"award-number":["20174TB8KW"]}]},{"name":"AIRC fellowship for Italy \u201cFrancesco Tonni\u201d","award":["813834"],"award-info":[{"award-number":["813834"]}]},{"name":"AIRC fellowship for Italy \u201cFrancesco Tonni\u201d","award":["24020"],"award-info":[{"award-number":["24020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>hERG1 potassium channels are widely expressed in human cancers of different origins, where they affect several key aspects of cellular behaviour. The present study was designed to evaluate the expression and clinical relevance of hERG1 protein in cancer tissues from patients suffering from neuroendocrine tumours (NETs) of ileal (iNETs) and pancreatic (pNETs) origin, with available clinicopathological history and follow-up. The study was carried out by immunohistochemistry with an anti-hERG1 monoclonal antibody. In a subset of samples, a different antibody directed against the hERG1\/\u03b21 integrin complex was also used. The analysis showed for the first time that hERG1 is expressed in human NETs originating from either the ileum or the pancreas. hERG1 turned out to have a prognostic value in NETs, showing (i) a statistically significant positive impact on OS of patients affected by ileal NETs, regardless the TNM stage; (ii) a statistically significant positive impact on OS of patients affected by aggressive (TNM stage IV) disease, either ileal or pancreatic; (iii) a trend to a negative impact on OS of patients affected by less aggressive (TNM stage I-III) disease, either ileal or pancreatic. Moreover, in order to evaluate whether ERG1 was functionally expressed in a cellular model of pNET, the INS1E rat insulinoma cell line was used, and it emerged that blocking ERG1 with a specific inhibitor of the channel (E4031) turned out in a significant reduction in cell proliferation.<\/jats:p>","DOI":"10.3390\/ijms231810623","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T21:06:52Z","timestamp":1663103212000},"page":"10623","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prognostic role of hERG1 Potassium Channels in Neuroendocrine Tumours of the Ileum and Pancreas"],"prefix":"10.3390","volume":"23","author":[{"given":"Jessica","family":"Iorio","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, 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Res. Clin. Endocrinol. Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S1590-8658(02)80212-2","article-title":"Molecular insights into gastrointestinal neuroendocrine tumours: Importance and recent advances","volume":"34","author":"Corleto","year":"2002","journal-title":"Dig. Liver Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1053\/j.gastro.2008.05.047","article-title":"Gastrointestinal neuroendocrine tumors: Pancreatic endocrine tumors","volume":"135","author":"Metz","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1038\/modpathol.2010.166","article-title":"The origin of neuroendocrine tumors and the neural crest saga","volume":"24","author":"Rosai","year":"2011","journal-title":"Mod. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/aja.1001410407","article-title":"Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types","volume":"141","author":"Cheng","year":"1974","journal-title":"Am. J. Anat."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1159\/000333035","article-title":"The Novel WHO 2010 Classification for Gastrointestinal Neuroendocrine Tumours Correlates Well with the Metastatic Potential of Rectal Neuroendocrine Tumours","volume":"95","author":"Jernman","year":"2012","journal-title":"Neuroendocrinology"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Sansone, A., Lauretta, R., Vottari, S., Chiefari, A., Barnabei, A., Romanelli, F., and Appetecchia, M. (2019). Specific and Non-Specific Biomarkers in Neuroendocrine Gastroenteropancreatic Tumors. Cancers, 11.","DOI":"10.3390\/cancers11081113"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.neo.2017.09.002","article-title":"Nothing But NET: A Review of Neuroendocrine Tumors and Carcinomas","volume":"19","author":"Oronsky","year":"2017","journal-title":"Neoplasia"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.bpg.2012.12.006","article-title":"Biochemical markers for gastroenteropancreatic neuroendocrine tumours (GEP-NETs)","volume":"26","author":"Kanakis","year":"2012","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/s41574-018-0082-5","article-title":"Role of biomarker tests for diagnosis of neuroendocrine tumours","volume":"14","author":"Hofland","year":"2018","journal-title":"Nat. Rev. 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Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1158\/0008-5472.CAN-03-2360","article-title":"herg1 Gene and HERG1 Protein Are Overexpressed in Colorectal Cancers and Regulate Cell Invasion of Tumor Cells","volume":"64","author":"Lastraioli","year":"2004","journal-title":"Cancer Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4161\/cbt.7.1.5126","article-title":"Expression and significance of HERG protein in gastric cancer","volume":"7","author":"Shao","year":"2008","journal-title":"Cancer Biol. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/sj.bjc.6602775","article-title":"hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines","volume":"93","author":"Masi","year":"2005","journal-title":"Br. J. Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12935-018-0592-1","article-title":"hERG1 channel expression associates with molecular subtypes and prognosis in breast cancer","volume":"18","author":"Iorio","year":"2018","journal-title":"Cancer Cell Int."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1054\/bjoc.2000.1497","article-title":"HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium","volume":"83","author":"Cherubini","year":"2000","journal-title":"Br. J. Cancer"},{"key":"ref_19","first-page":"815","article-title":"herg Encodes a K+ Current Highly Conserved in Tumors of Different Histogenesis: A Selective Advantage for Cancer Cells?","volume":"58","author":"Bianchi","year":"1998","journal-title":"Cancer Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ejso.2019.10.031","article-title":"hERG1 and CA IX expression are associated with disease recurrence in surgically resected clear cell renal carcinoma","volume":"46","author":"Lastraioli","year":"2019","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/bjc.2015.28","article-title":"HERG1 channels drive tumour malignancy and may serve as prognostic factor in pancreatic ductal adenocarcinoma","volume":"112","author":"Lastraioli","year":"2015","journal-title":"Br. J. Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0092-8674(95)90340-2","article-title":"A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel","volume":"81","author":"Sanguinetti","year":"1995","journal-title":"Cell"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1113\/JP275477","article-title":"Ether-\u00e0-go-go K + channels: Effective modulators of neuronal excitability","volume":"596","author":"Bauer","year":"2018","journal-title":"J. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"R895","DOI":"10.1152\/ajpregu.00521.2007","article-title":"Erg K+ channels modulate contractile activity in the bovine epididymal duct","volume":"294","author":"Mewe","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0303-7207(98)00241-X","article-title":"A functional role of the erg-like inward-rectifying K+ current in prolactin secretion from rat lactotrophs","volume":"148","author":"Bauer","year":"1999","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1096\/fj.02-0200fje","article-title":"ERG K+ channel blockade enhances firing and epinephrine secretion in rat chromaffin cells: The missing link to LQT2-related sudden death?","volume":"17","author":"Gullo","year":"2003","journal-title":"FASEB J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0022-5193(86)80209-0","article-title":"Membrane potentials and sodium channels: Hypotheses for growth regulation and cancer formation based on changes in sodium channels and gap junctions","volume":"123","author":"Binggeli","year":"1986","journal-title":"J. Theor. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"C1138","DOI":"10.1152\/ajpcell.00107.2022","article-title":"Dynamics and physiological meaning of complexes between ion channels and integrin receptors: The case of Kv11.1","volume":"322","author":"Becchetti","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"eaaf3236","DOI":"10.1126\/scisignal.aaf3236","article-title":"The conformational state of hERG1 channels determines integrin association, downstream signaling, and cancer progression","volume":"10","author":"Becchetti","year":"2017","journal-title":"Sci. Signal."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/jso.20891","article-title":"Overexpression of hERG1 in resected esophageal squamous cell carcinomas: A marker for poor prognosis","volume":"97","author":"Ding","year":"2008","journal-title":"J. Surg. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"100740","DOI":"10.1016\/j.tranon.2020.01.001","article-title":"hERG1 and HIF-2\u03b1 Behave as Biomarkers of Positive Response to Bevacizumab in Metastatic Colorectal Cancer Patients","volume":"13","author":"Iorio","year":"2020","journal-title":"Transl. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5732","DOI":"10.3748\/wjg.v25.i38.5732","article-title":"Role of ion channels in gastrointestinal cancer","volume":"25","author":"Anderson","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1158\/1535-7163.MCT-20-1111","article-title":"Harnessing the hERG1\/\u03b21 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers","volume":"20","author":"Duranti","year":"2021","journal-title":"Mol. Cancer Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.beem.2016.01.002","article-title":"Neuroendocrine tumor biomarkers: From monoanalytes to transcripts and algorithms","volume":"30","author":"Modlin","year":"2016","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"831","DOI":"10.3389\/fonc.2020.00831","article-title":"Biomarkers for Pancreatic Neuroendocrine Neoplasms (PanNENs) Management-An Updated Review","volume":"10","author":"Bocchini","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000501397","article-title":"Ca2+ Channel Toolkit in Neuroendocrine Tumors","volume":"110","author":"Gkika","year":"2020","journal-title":"Neuroendocrinology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.bbrc.2020.02.176","article-title":"Involvement of the \u03b31 subunit of the large-conductance Ca2+-activated K+ channel in the proliferation of human somatostatinoma cells","volume":"525","author":"Noda","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/CMR.0b013e32835fc6c9","article-title":"High hERG1 expression in advanced melanoma","volume":"23","author":"Arcangeli","year":"2013","journal-title":"Melanoma Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"59535","DOI":"10.18632\/oncotarget.11149","article-title":"hERG1 behaves as biomarker of progression to adenocarcinoma in Barrett\u2019s esophagus and can be exploited for a novel endoscopic surveillance","volume":"7","author":"Lastraioli","year":"2016","journal-title":"Oncotarget"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1007\/s10620-009-0834-0","article-title":"Prognostic significance of hERG1 expression in gastric cancer","volume":"55","author":"Ding","year":"2010","journal-title":"Dig. Dis. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1158\/1078-0432.CCR-15-3169","article-title":"Administration of Non-Torsadogenic human Ether-\u00e0-go-go-Related Gene Inhibitors Is Associated with Better Survival for High hERG-Expressing Glioblastoma Patients","volume":"23","author":"Pointer","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"6325","DOI":"10.2147\/OTT.S114090","article-title":"HERG1 positivity and Glut-1 negativity identifies high-risk TNM stage I and II colorectal cancer patients, regardless of adjuvant chemotherapy","volume":"9","author":"Muratori","year":"2016","journal-title":"Onco. Targets. Ther."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1002\/hed.24493","article-title":"HERG1 potassium channel expression in potentially malignant disorders of the oral mucosa and prognostic relevance in oral squamous cell carcinoma","volume":"38","author":"Rodrigo","year":"2016","journal-title":"Head Neck"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1593\/tlo.11250","article-title":"hERG1 channels and Glut-1 as independent prognostic indicators of worse outcome in stage I and II colorectal cancer: A pilot study","volume":"5","author":"Lastraioli","year":"2012","journal-title":"Transl. Oncol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1096\/fj.00-0077com","article-title":"Glucose- and arginine-induced insulin secretion by human pancreatic beta-cells: The role of HERG K(+) channels in firing and release","volume":"14","author":"Rosati","year":"2000","journal-title":"FASEB J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1158\/1078-0432.CCR-13-2633","article-title":"HERG1 channels regulate VEGF-A secretion in human gastric cancer: Clinicopathological correlations and therapeutical implications","volume":"20","author":"Crociani","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S1567-133X(03)00124-8","article-title":"Developmentally regulated expression of the mouse homologues of the potassium channel encoding genes m-erg1, m-erg2 and m-erg3","volume":"3","author":"Polvani","year":"2003","journal-title":"Gene Expr. Patterns"},{"key":"ref_48","first-page":"304","article-title":"Protein distribution of Kcnq1, Kcnh2, and Kcne3 potassium channel subunits during mouse embryonic development","volume":"288","author":"Franco","year":"2006","journal-title":"Anat. Rec. Part A Discov. Mol. Cell. Evol. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1111\/j.1460-9568.1997.tb01689.x","article-title":"HERG- and IRK-like inward rectifier currents are sequentially expressed during neuronal development of neural crest cells and their derivatives","volume":"9","author":"Arcangeli","year":"1997","journal-title":"Eur. J. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1083\/jcb.122.5.1131","article-title":"Integrin-mediated neurite outgrowth in neuroblastoma cells depends on the activation of potassium channels","volume":"122","author":"Arcangeli","year":"1993","journal-title":"J. Cell Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1113\/jphysiol.1995.sp021065","article-title":"A novel inward-rectifying K+ current with a cell-cycle dependence governs the resting potential of mammalian neuroblastoma cells","volume":"489","author":"Arcangeli","year":"1995","journal-title":"J. Physiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"105879","DOI":"10.1016\/j.pep.2021.105879","article-title":"Expression and purification of a novel single-chain diabody (scDb-hERG1\/\u03b21) from Pichia pastoris transformants","volume":"184","author":"Duranti","year":"2021","journal-title":"Protein Expr. Purif."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1182\/blood-2006-02-003772","article-title":"VEGFR-1 (FLT-1), beta1 integrin, and hERG K+ channel for a macromolecular signaling complex in acute myeloid leukemia: Role in cell migration and clinical outcome","volume":"110","author":"Pillozzi","year":"2007","journal-title":"Blood"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"8847","DOI":"10.1038\/s41598-021-87492-5","article-title":"Transgenic mice overexpressing the LH receptor in the female reproductive system spontaneously develop endometrial tumour masses","volume":"11","author":"Lottini","year":"2021","journal-title":"Sci. Rep."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/18\/10623\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:30:31Z","timestamp":1760142631000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/18\/10623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,13]]},"references-count":54,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["ijms231810623"],"URL":"https:\/\/doi.org\/10.3390\/ijms231810623","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,13]]}}}