{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:38:08Z","timestamp":1793036288693,"version":"4.5.0"},"reference-count":226,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007757","name":"Agencia Canaria de Investigaci\u00f3n, Innovaci\u00f3n y Sociedad de la Informaci\u00f3n (ACIISI) del Gobierno de Canarias","doi-asserted-by":"publisher","award":["ProID2020010134"],"award-info":[{"award-number":["ProID2020010134"]}],"id":[{"id":"10.13039\/501100007757","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007757","name":"Agencia Canaria de Investigaci\u00f3n, Innovaci\u00f3n y Sociedad de la Informaci\u00f3n (ACIISI) del Gobierno de Canarias","doi-asserted-by":"publisher","award":["PID2019-105838RB-C31"],"award-info":[{"award-number":["PID2019-105838RB-C31"]}],"id":[{"id":"10.13039\/501100007757","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish Ministry of Economy and Competitiveness","award":["ProID2020010134"],"award-info":[{"award-number":["ProID2020010134"]}]},{"name":"Spanish Ministry of Economy and Competitiveness","award":["PID2019-105838RB-C31"],"award-info":[{"award-number":["PID2019-105838RB-C31"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This review discusses the formation of hypochlorous acid HOCl and the role of reactive chlorinated species (RCS), which are catalysed by the enzyme myeloperoxidase MPO, mainly located in leukocytes and which in turn contribute to cellular oxidative stress. The reactions of RCS with various organic molecules such as amines, amino acids, proteins, lipids, carbohydrates, nucleic acids, and DNA are described, and an attempt is made to explain the chemical mechanisms of the formation of the various chlorinated derivatives and the data available so far on the effects of MPO, RCS and halogenative stress. Their presence in numerous pathologies such as atherosclerosis, arthritis, neurological and renal diseases, diabetes, and obesity is reviewed and were found to be a feature of debilitating diseases.<\/jats:p>","DOI":"10.3390\/ijms231810735","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T23:16:36Z","timestamp":1663197396000},"page":"10735","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":165,"title":["Hypochlorous Acid Chemistry in Mammalian Cells\u2014Influence on Infection and Role in Various Pathologies"],"prefix":"10.3390","volume":"23","author":[{"given":"Celia Mar\u00eda Curieses","family":"Andr\u00e9s","sequence":"first","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valladolid, Avenida de Ram\u00f3n y Cajal, 3, 47003 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4663-5565","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"P\u00e9rez de la Lastra","sequence":"additional","affiliation":[{"name":"Institute of Natural Products and Agrobiology, IPNA-CSIC-Spanish Research Council, Avda. Astrof\u00edsico Fco. S\u00e1nchez, 38206 San Crist\u00f3bal de La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia Andr\u00e9s","family":"Juan","sequence":"additional","affiliation":[{"name":"Cinquima Institute and Department of Organic Chemistry, Faculty of Sciences, Valladolid University, Paseo de Bel\u00e9n, 7, 47011 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0831-893X","authenticated-orcid":false,"given":"Francisco J.","family":"Plou","sequence":"additional","affiliation":[{"name":"Institute of Catalysis and Petrochemistry, CSIC-Spanish Research Council, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"P\u00e9rez-Lebe\u00f1a","sequence":"additional","affiliation":[{"name":"Sistemas de Biotecnolog\u00eda y Recursos Naturales, 47625 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"da Cruz Nizer, W.S., Inkovskiy, V., and Overhage, J. 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