{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T02:21:52Z","timestamp":1769826112045,"version":"3.49.0"},"reference-count":26,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Grants-in-Aid for Scientific Research (C)","award":["19K09999"],"award-info":[{"award-number":["19K09999"]}]},{"name":"Grants-in-Aid for Scientific Research (C)","award":["21K09682"],"award-info":[{"award-number":["21K09682"]}]},{"name":"Ministry of Education, Culture, Sports, Science and Technology, Japan","award":["19K09999"],"award-info":[{"award-number":["19K09999"]}]},{"name":"Ministry of Education, Culture, Sports, Science and Technology, Japan","award":["21K09682"],"award-info":[{"award-number":["21K09682"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>\u201cIdiopathic\u201d is the most common category of uveitis, representing cases in which a specific diagnosis has not been established despite work-up. Sarcoidosis is a systemic granulomatous disorder affecting multiple organs including the lungs, skin, kidneys, and eyes. We used microRNA (miRNA) microarrays to investigate serum miRNA profiles of patients with ocular sarcoidosis as diagnosed by specific criteria (diagnosed ocular sarcoidosis), and patients with idiopathic uveitis characterized by ocular manifestations of sarcoidosis (suspected ocular sarcoidosis). Principal component analysis (PCA) and hierarchical clustering showed that serum miRNA profiles of diagnosed ocular sarcoidosis and suspected ocular sarcoidosis were both clearly distinguishable from healthy controls. Furthermore, comparative analysis of the miRNA profiles showed highly similar patterns between diagnosed ocular sarcoidosis and suspected ocular sarcoidosis. Pathway analysis revealed common pathways were involved in the two groups, including those of WNT signaling and TGF-beta signaling. Our study demonstrated a high overlap of differentially expressed serum miRNAs in patients with diagnosed ocular sarcoidosis and suspected ocular sarcoidosis, suggesting that these groups share a similar underlying pathology and may represent possible variants of the disease. Characterization of serum miRNA profiles may provide an opportunity for earlier diagnosis and treatment, and may inform more accurate clinical prognosis in patients with an ocular sarcoidosis phenotype.<\/jats:p>","DOI":"10.3390\/ijms231810749","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T22:11:10Z","timestamp":1663279870000},"page":"10749","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparative Analysis of Serum microRNA in Diagnosed Ocular Sarcoidosis versus Idiopathic Uveitis with Ocular Manifestations of Sarcoidosis"],"prefix":"10.3390","volume":"23","author":[{"given":"Shoko","family":"Saito","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Tokyo 181-8611, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Keino","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Tokyo 181-8611, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6083-1119","authenticated-orcid":false,"given":"Ichiro","family":"Takasaki","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Graduate School of Science and Engineering for Research, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Kohno","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Jikei University School of Medicine, 3-25-8 Nishishinbashi, Tokyo 105-8461, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kousuke","family":"Ichihara","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Jikei University School of Medicine, 3-25-8 Nishishinbashi, Tokyo 105-8461, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isami","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Tokyo 181-8611, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makiko","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Tokyo 181-8611, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Tsuboshita","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, Faculty of Health Sciences, Kyorin University, 5-4-1 Shimorenjyaku, Tokyo 181-8611, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sawako","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Tokyo 181-8611, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Tokyo 181-8611, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annabelle A.","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Tokyo 181-8611, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ajo.2005.03.057","article-title":"Standardization of uveitis nomenclature for reporting clinical data. 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