{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:21:02Z","timestamp":1793740862812,"version":"4.6.1"},"reference-count":53,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beyond Borders","award":["D.R. 1347\/2019"],"award-info":[{"award-number":["D.R. 1347\/2019"]}]},{"name":"Beyond Borders","award":["E89C20000800005"],"award-info":[{"award-number":["E89C20000800005"]}]},{"name":"Beyond Borders","award":["B79J21038330001"],"award-info":[{"award-number":["B79J21038330001"]}]},{"name":"Beyond Borders","award":["PRJ-0991"],"award-info":[{"award-number":["PRJ-0991"]}]},{"name":"Eurostart_PSEBPEHRD","award":["D.R. 1347\/2019"],"award-info":[{"award-number":["D.R. 1347\/2019"]}]},{"name":"Eurostart_PSEBPEHRD","award":["E89C20000800005"],"award-info":[{"award-number":["E89C20000800005"]}]},{"name":"Eurostart_PSEBPEHRD","award":["B79J21038330001"],"award-info":[{"award-number":["B79J21038330001"]}]},{"name":"Eurostart_PSEBPEHRD","award":["PRJ-0991"],"award-info":[{"award-number":["PRJ-0991"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The pathobiology of ascending aorta aneurysms (AAA) onset and progression is not well understood and only partially characterized. AAA are also complicated in case of bicuspid aorta valve (BAV) anatomy. There is emerging evidence about the crucial role of endothelium-related pathways, which show in AAA an altered expression and function. Here, we examined the involvement of ERG-related pathways in the differential progression of disease in aortic tissues from patients having a BAV or tricuspid aorta valve (TAV) with or without AAA. Our findings identified ERG as a novel endothelial-specific regulator of TGF-\u03b2-SMAD, Notch, and NO pathways, by modulating a differential fibrotic or calcified AAA progression in BAV and TAV aortas. We provided evidence that calcification is correlated to different ERG expression (as gene and protein), which appears to be under control of Notch signaling. The latter, when increased, associated with an early calcification in aortas with BAV valve and aneurysmatic, was demonstrated to favor the progression versus severe complications, i.e., dissection or rupture. In TAV aneurysmatic aortas, ERG appeared to modulate fibrosis. Therefore, we proposed that ERG may represent a sensitive tissue biomarker to monitor AAA progression and a target to develop therapeutic strategies and influence surgical procedures.<\/jats:p>","DOI":"10.3390\/ijms231810848","type":"journal-article","created":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T23:39:22Z","timestamp":1663544362000},"page":"10848","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Endothelial Transcription Factor ERG Mediates a Differential Role in the Aneurysmatic Ascending Aorta with Bicuspid or Tricuspid Aorta Valve: A Preliminary Study"],"prefix":"10.3390","volume":"23","author":[{"given":"Calogera","family":"Pisano","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Tor Vergata University Polyclinic, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Terriaca","sequence":"additional","affiliation":[{"name":"Pathological Anatomy, Department of Biomedicine and Prevention, Tor Vergata University, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giovanna","family":"Scioli","sequence":"additional","affiliation":[{"name":"Pathological Anatomy, Department of Biomedicine and Prevention, Tor Vergata University, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Nardi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Tor Vergata University Polyclinic, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Altieri","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Tor Vergata University Polyclinic, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7202-5854","authenticated-orcid":false,"given":"Augusto","family":"Orlandi","sequence":"additional","affiliation":[{"name":"Pathological Anatomy, Department of Biomedicine and Prevention, Tor Vergata University, 00133 Rome, Italy"},{"name":"Department of Biomedical Sciences, Catholic University of Our Lady of Good Counsel, 1001 Tirana, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Ruvolo","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Tor Vergata University Polyclinic, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5393-1007","authenticated-orcid":false,"given":"Carmela Rita","family":"Balistreri","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Laboratory, Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, 90134 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.amjmed.2013.01.029","article-title":"Aortopathies: Etiologies, Genetics, Differential Diagnosis, Prognosis and Management","volume":"126","author":"Paterick","year":"2013","journal-title":"Am. 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