{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:55:10Z","timestamp":1787702110210,"version":"build-2784847793"},"reference-count":211,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T00:00:00Z","timestamp":1663372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sistema Nacional de Investigadores","award":["84949"],"award-info":[{"award-number":["84949"]}]},{"name":"Sistema Nacional de Investigadores","award":["171055"],"award-info":[{"award-number":["171055"]}]},{"name":"Sistema Nacional de Investigadores","award":["76397"],"award-info":[{"award-number":["76397"]}]},{"name":"Sistema Nacional de Investigadores","award":["32753"],"award-info":[{"award-number":["32753"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Depressive disorders are among the most disabling diseases experienced around the world, and their incidence has significantly increased over the last few decades due to multiple environmental, social, and biological factors. The search for new pharmacological alternatives to treat depression is a global priority. In preclinical research, molecules obtained from plants, such as flavonoids, have shown promising antidepressant-like properties through several mechanisms of action that have not been fully elucidated, including crossing of the blood brain barrier (BBB). This review will focus on discussing the main findings related to the participation of the serotonergic system and brain-derived neurotrophic factor (BDNF) on the antidepressant-like effect of some flavonoids reported by behavioral, neurochemical, and molecular studies. In this sense, evidence shows that depressive individuals have low levels of serotonin and BDNF, while flavonoids can reverse it. Finally, the elucidation of the mechanism used by flavonoids to modulate serotonin and BDNF will contribute to our understanding of the neurobiological bases underlying the antidepressant-like effects produced by these natural compounds.<\/jats:p>","DOI":"10.3390\/ijms231810896","type":"journal-article","created":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T23:39:22Z","timestamp":1663544362000},"page":"10896","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Participation of the Serotonergic System and Brain-Derived Neurotrophic Factor in the Antidepressant-like Effect of Flavonoids"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9185-2900","authenticated-orcid":false,"given":"Le\u00f3n Jes\u00fas","family":"German-Ponciano","sequence":"first","affiliation":[{"name":"Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Xalapa 91190, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0753-0069","authenticated-orcid":false,"given":"Gilberto Uriel","family":"Rosas-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Xalapa 91190, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Cueto-Escobedo","sequence":"additional","affiliation":[{"name":"Departamento de Investigaci\u00f3n Cl\u00ednica y Traslacional Instituto de Ciencias de la Salud, Universidad Veracruzana, Xalapa 91190, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Fern\u00e1ndez-Demeneghi","sequence":"additional","affiliation":[{"name":"Facultad de Nutrici\u00f3n, Universidad Veracruzana, Xalapa 91017, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4428-4706","authenticated-orcid":false,"given":"Gabriel","family":"Guill\u00e9n-Ruiz","sequence":"additional","affiliation":[{"name":"Programa de Investigadoras e Investigadores por M\u00e9xico CONACyT-Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Xalapa 91190, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7829-6222","authenticated-orcid":false,"given":"C\u00e9sar","family":"Soria-Fregozo","sequence":"additional","affiliation":[{"name":"Centro Universitario de Los Lagos, Universidad de Guadalajara, Lagos de Moreno 47460, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma Virginia","family":"Herrera-Huerta","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Qu\u00edmicas, Universidad Veracruzana, Orizaba 94340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5837-103X","authenticated-orcid":false,"given":"Juan Francisco","family":"Rodr\u00edguez-Landa","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda, Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Xalapa 91190, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"102006","DOI":"10.1016\/j.cpr.2021.102006","article-title":"Addressing the mental health impact of COVID-19 through population health","volume":"85","author":"Boden","year":"2021","journal-title":"Clin. 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