{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T08:44:33Z","timestamp":1769849073282,"version":"3.49.0"},"reference-count":61,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T00:00:00Z","timestamp":1663459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MH CZ\u2013DRO, Institute of Endocrinology E\u00da","award":["00023761"],"award-info":[{"award-number":["00023761"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The fast-track process to approve vaccines against COVID-19 has raised questions about their safety, especially in relation to fertility. Over the last 2 years, studies have appeared monitoring female fertility, especially from assisted reproduction centers or in animal experiments. However, studies monitoring healthy populations are still limited. The aim of our study was to monitor the relevant parameters of female fertility (sex and other steroids, LH, FSH, SHBG, Antim\u00fcllerian hormone and antral follicle count) before and then 2\u20134 months after the third dose of vaccination against COVID-19 in a group of 25 healthy fertile woman. In addition, anti-SARS-CoV-2 and anti-SARS-CoV-2S antibodies were determined. We did not observe significant changes in the measured parameters before and after the third dose of vaccination. By comparing levels of the analytes with antibodies indicating a prior COVID-19 infection, we found that women who had experienced the disease had statistically lower levels of estrone, estradiol, SHBG and 5\u03b1-dihydroprogesterone, and conversely, higher levels of androgen active dehydroepiandrosterone and dihydrotestosterone. Our results confirm that vaccination does not affect female fertility, and that what fertile women should be worried about is not vaccination, but rather COVID-19 infection itself.<\/jats:p>","DOI":"10.3390\/ijms231810909","type":"journal-article","created":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T23:39:22Z","timestamp":1663544362000},"page":"10909","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["COVID-19, Vaccination, and Female Fertility in the Czech Republic"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8206-4598","authenticated-orcid":false,"given":"Lucie","family":"Kolatorova","sequence":"first","affiliation":[{"name":"Department of Steroids and Proteofactors, Institute of Endocrinology, Narodni 8, 116 94 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Adamcova","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, General University Hospital, 1st Faculty of Medicine, Charles University in Prague, Apolinarska 18, 128 51 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0805-7602","authenticated-orcid":false,"given":"Jana","family":"Vitku","sequence":"additional","affiliation":[{"name":"Department of Steroids and Proteofactors, Institute of Endocrinology, Narodni 8, 116 94 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lenka","family":"Horackova","sequence":"additional","affiliation":[{"name":"Department of Steroids and Proteofactors, Institute of Endocrinology, Narodni 8, 116 94 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0417-9867","authenticated-orcid":false,"given":"Marketa","family":"Simkova","sequence":"additional","affiliation":[{"name":"Department of Steroids and Proteofactors, Institute of Endocrinology, Narodni 8, 116 94 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marketa","family":"Hornova","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, General University Hospital, 1st Faculty of Medicine, Charles University in Prague, Apolinarska 18, 128 51 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michala","family":"Vosatkova","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Institute of Endocrinology, Narodni 8, 116 94 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Vaisova","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, General University Hospital, 1st Faculty of Medicine, Charles University in Prague, Apolinarska 18, 128 51 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonin","family":"Parizek","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, General University Hospital, 1st Faculty of Medicine, Charles University in Prague, Apolinarska 18, 128 51 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Duskova","sequence":"additional","affiliation":[{"name":"Department of Steroids and Proteofactors, Institute of Endocrinology, Narodni 8, 116 94 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,18]]},"reference":[{"key":"ref_1","first-page":"20","article-title":"COVID-19 vaccination hesitancy among health care workers, communication, and policy-making","volume":"50","author":"Swirsky","year":"2021","journal-title":"Am. 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