{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T13:29:09Z","timestamp":1767965349484,"version":"3.49.0"},"reference-count":29,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"GlaxoSmithKline","award":["3200B0-105993"],"award-info":[{"award-number":["3200B0-105993"]}]},{"name":"GlaxoSmithKline","award":["3200B0-118308"],"award-info":[{"award-number":["3200B0-118308"]}]},{"name":"GlaxoSmithKline","award":["33CSCO-122661"],"award-info":[{"award-number":["33CSCO-122661"]}]},{"name":"GlaxoSmithKline","award":["33CS30-139468"],"award-info":[{"award-number":["33CS30-139468"]}]},{"name":"GlaxoSmithKline","award":["33CS30-148401"],"award-info":[{"award-number":["33CS30-148401"]}]},{"name":"GlaxoSmithKline","award":["33CS30_177535\/1"],"award-info":[{"award-number":["33CS30_177535\/1"]}]},{"name":"the Faculty of Biology and Medicine of Lausanne","award":["3200B0-105993"],"award-info":[{"award-number":["3200B0-105993"]}]},{"name":"the Faculty of Biology and Medicine of Lausanne","award":["3200B0-118308"],"award-info":[{"award-number":["3200B0-118308"]}]},{"name":"the Faculty of Biology and Medicine of Lausanne","award":["33CSCO-122661"],"award-info":[{"award-number":["33CSCO-122661"]}]},{"name":"the Faculty of Biology and Medicine of Lausanne","award":["33CS30-139468"],"award-info":[{"award-number":["33CS30-139468"]}]},{"name":"the Faculty of Biology and Medicine of Lausanne","award":["33CS30-148401"],"award-info":[{"award-number":["33CS30-148401"]}]},{"name":"the Faculty of Biology and Medicine of Lausanne","award":["33CS30_177535\/1"],"award-info":[{"award-number":["33CS30_177535\/1"]}]},{"name":"the Swiss National Science Foundation","award":["3200B0-105993"],"award-info":[{"award-number":["3200B0-105993"]}]},{"name":"the Swiss National Science Foundation","award":["3200B0-118308"],"award-info":[{"award-number":["3200B0-118308"]}]},{"name":"the Swiss National Science Foundation","award":["33CSCO-122661"],"award-info":[{"award-number":["33CSCO-122661"]}]},{"name":"the Swiss National Science Foundation","award":["33CS30-139468"],"award-info":[{"award-number":["33CS30-139468"]}]},{"name":"the Swiss National Science Foundation","award":["33CS30-148401"],"award-info":[{"award-number":["33CS30-148401"]}]},{"name":"the Swiss National Science Foundation","award":["33CS30_177535\/1"],"award-info":[{"award-number":["33CS30_177535\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The association between 25-hydroxyvitamin D and 5-, 10-, or 15-year weight change were assessed in a population-based, prospective study conducted in Lausanne, Switzerland. Data from the first (2009\u20132012, N = 3527, 51.3% women), second (2014\u20132017, N = 3237, 53.8% women), and third (2018\u20132021, N = 2567, 54.2% women) follow-ups were used. A weighted genetic risk score (GRS) of 115 SNPs associated with vitamin D levels was constructed. At baseline, the GRS correlated positively with 25-hydroxyvitamin D levels based on a Spearman rank correlation and 95% confidence interval: 0.198 (0.166; 0.231), p &lt; 0.001; and with body mass index: 0.036 (0.004; 0.068), p = 0.028. No association was found between quartiles of GRS and weight changes at 5, 10, or 15 years: multivariate-adjusted weight changes \u00b1 SEM at 5-years follow-up were 1.39 \u00b1 0.17, 1.13 \u00b1 0.17, 1.24 \u00b1 0.17, and 1.00 \u00b1 0.17 kg for the first to the fourth quartile of the GRS, respectively (p = 0.401). Two-step linear regression showed a significant but clinically meaningless association between GRS-derived vitamin D and weight change at 5- and 15-years: slope and 95% confidence interval for a 5 nmol\/L increase in GRS-derived 25-hydroxyvitamin D levels: 0.082 (0.013; 0.150) and 0.130 (0.018; 0.243) kg, respectively. We conclude that there is little association between genetically determined 25-hydroxyvitamin D levels and weight gain.<\/jats:p>","DOI":"10.3390\/ijms231911100","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T01:47:06Z","timestamp":1663811226000},"page":"11100","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Vitamin D and Weight Change: A Mendelian Randomization, Prospective Study"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0853-1458","authenticated-orcid":false,"given":"Pollyanna","family":"Patriota","sequence":"first","affiliation":[{"name":"Swiss Nutrition and Health Foundation, 1066 Epalinges, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Rezzi","sequence":"additional","affiliation":[{"name":"Swiss Nutrition and Health Foundation, 1066 Epalinges, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idris","family":"Guessous","sequence":"additional","affiliation":[{"name":"Division of Primary Care Medicine, Department of Primary Care Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4548-8500","authenticated-orcid":false,"given":"Pedro","family":"Marques-Vidal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, 46 rue du Bugnon, 1011 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s13679-021-00433-1","article-title":"Vitamin D and Obesity: Current Evidence and Controversies","volume":"10","author":"Karampela","year":"2021","journal-title":"Curr. 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