{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:43:05Z","timestamp":1790811785622,"version":"4.1.0"},"reference-count":204,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["21593"],"award-info":[{"award-number":["21593"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["20164"],"award-info":[{"award-number":["20164"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["BRC773\/III\/CC\/101350"],"award-info":[{"award-number":["BRC773\/III\/CC\/101350"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIHR UCLH Biomedical Research Centre","award":["21593"],"award-info":[{"award-number":["21593"]}]},{"name":"NIHR UCLH Biomedical Research Centre","award":["20164"],"award-info":[{"award-number":["20164"]}]},{"name":"NIHR UCLH Biomedical Research Centre","award":["BRC773\/III\/CC\/101350"],"award-info":[{"award-number":["BRC773\/III\/CC\/101350"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>CD8+ T cells are cytotoxic lymphocytes that destroy pathogen infected and malignant cells through release of cytolytic molecules and proinflammatory cytokines. Although the role of CD8+ T cells in connective tissue diseases (CTDs) has not been explored as thoroughly as that of other immune cells, research focusing on this key component of the immune system has recently gained momentum. Aberrations in cytotoxic cell function may have implications in triggering autoimmunity and may promote tissue damage leading to exacerbation of disease. In this comprehensive review of current literature, we examine the role of CD8+ T cells in systemic lupus erythematosus, Sj\u00f6gren\u2019s syndrome, systemic sclerosis, polymyositis, and dermatomyositis with specific focus on comparing what is known about CD8+ T cell peripheral blood phenotypes, CD8+ T cell function, and CD8+ T cell organ-specific profiles in adult and juvenile forms of these disorders. Although, the precise role of CD8+ T cells in the initiation of autoimmunity and disease progression remains to be elucidated, increasing evidence indicates that CD8+ T cells are emerging as an attractive target for therapy in CTDs.<\/jats:p>","DOI":"10.3390\/ijms231911431","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T22:53:19Z","timestamp":1664405599000},"page":"11431","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["CD8+ T Cell Phenotype and Function in Childhood and Adult-Onset Connective Tissue Disease"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3885-3477","authenticated-orcid":false,"given":"Anna","family":"Radziszewska","sequence":"first","affiliation":[{"name":"Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH), Great Ormond Street Hospital (GOSH), London WC1E 6JF, UK"},{"name":"Centre for Rheumatology Research, Division of Medicine, University College London, London WC1E 6JF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4006-6587","authenticated-orcid":false,"given":"Zachary","family":"Moulder","sequence":"additional","affiliation":[{"name":"University College London Medical School, University College London, London WC1E 6DE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2389-3396","authenticated-orcid":false,"given":"Elizabeth C.","family":"Jury","sequence":"additional","affiliation":[{"name":"Centre for Rheumatology Research, Division of Medicine, University College London, London WC1E 6JF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8911-4113","authenticated-orcid":false,"given":"Coziana","family":"Ciurtin","sequence":"additional","affiliation":[{"name":"Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH), Great Ormond Street Hospital (GOSH), London WC1E 6JF, UK"},{"name":"Centre for Rheumatology Research, Division of Medicine, University College London, London WC1E 6JF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1172\/JCI78088","article-title":"Mechanisms of human autoimmunity","volume":"125","author":"Rosenblum","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.coi.2005.09.014","article-title":"CD8+ T cells in autoimmunity","volume":"17","author":"Walter","year":"2005","journal-title":"Curr. Opin. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/ni889","article-title":"Lineage relationship and protective immunity of memory CD8 T cell subsets","volume":"4","author":"Wherry","year":"2003","journal-title":"Nat. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1002\/eji.201343751","article-title":"The who\u2019s who of T-cell differentiation: Human memory T-cell subsets","volume":"43","author":"Mahnke","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/sj.jid.5700001","article-title":"Cytotoxic T cells","volume":"126","author":"Andersen","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.tcb.2020.06.003","article-title":"The Roles of CD8+ T Cell Subsets in Antitumor Immunity","volume":"30","author":"Ohashi","year":"2020","journal-title":"Trends Cell Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nri3307","article-title":"Transcriptional control of effector and memory CD8+ T cell differentiation","volume":"12","author":"Kaech","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1365-2567.2005.02168.x","article-title":"The phenotype of type 1 and type 2 CD8+ T cells activated in vitro is affected by culture conditions and correlates with effector activity","volume":"115","author":"Kemp","year":"2005","journal-title":"Immunology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/j.jaci.2011.12.976","article-title":"Antigen-specific effector CD8 T cells regulate allergic responses via IFN-\u03b3 and dendritic cell function","volume":"129","author":"Tang","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S1074-7613(03)00210-3","article-title":"CD8 T cell-specific downregulation of histone hyperacetylation and gene activation of the IL-4 gene locus by ROG, repressor of GATA","volume":"19","author":"Omori","year":"2003","journal-title":"Immunity"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/eji.201242825","article-title":"Tc9 cells, a new subset of CD8(+) T cells, support Th2-mediated airway inflammation","volume":"43","author":"Visekruna","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1073\/pnas.1317431111","article-title":"Tumor-specific IL-9-producing CD8+ Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers","volume":"111","author":"Lu","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.4049\/jimmunol.0801814","article-title":"Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge","volume":"182","author":"Hamada","year":"2009","journal-title":"J. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1002\/eji.200939412","article-title":"A Th17-like developmental process leads to CD8+ Tc17 cells with reduced cytotoxic activity","volume":"39","author":"Huber","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Nanjappa, S.G., Heninger, E., W\u00fcthrich, M., Gasper, D.J., and Klein, B.S. (2012). Tc17 cells mediate vaccine immunity against lethal fungal pneumonia in immune deficient hosts lacking CD4+ T cells. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002771"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/eji.202048614","article-title":"CD8+ Tregs revisited: A heterogeneous population with different phenotypes and properties","volume":"51","author":"Niederlova","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"ref_17","first-page":"8187","article-title":"Recent advances in CD8(+) regulatory T cell research","volume":"15","author":"Yu","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5898","DOI":"10.1182\/blood-2011-12-396119","article-title":"Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation","volume":"119","author":"Robb","year":"2012","journal-title":"Blood"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/jmcb\/mjt026","article-title":"Phenotypic and functional characteristic of a newly identified CD8+ Foxp3- CD103+ regulatory T cells","volume":"6","author":"Liu","year":"2014","journal-title":"J. Mol. Cell. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1126\/science.1202947","article-title":"Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4","volume":"332","author":"Qureshi","year":"2011","journal-title":"Science"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/ni760","article-title":"Tolerization of dendritic cells by TS cells: The crucial role of inhibitory receptors ILT3 and ILT4","volume":"3","author":"Chang","year":"2002","journal-title":"Nat. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nature09370","article-title":"Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance","volume":"467","author":"Kim","year":"2010","journal-title":"Nature"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev-immunol-032712-095954","article-title":"Memory T Cell Subsets, Migration Patterns, and Tissue Residence","volume":"31","author":"Mueller","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/ni.1718","article-title":"Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus","volume":"10","author":"Gebhardt","year":"2009","journal-title":"Nat. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"17872","DOI":"10.1073\/pnas.1010201107","article-title":"Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence","volume":"107","author":"Wakim","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1056\/NEJMra1100359","article-title":"Systemic lupus erythematosus","volume":"365","author":"Tsokos","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1177\/0961203307087875","article-title":"Adolescent onset of lupus results in more aggressive disease and worse outcomes: Results of a nested matched case-control study within LUMINA, a multiethnic US cohort (LUMINA LVII)","volume":"17","author":"Tucker","year":"2008","journal-title":"Lupus"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.semarthrit.2012.05.001","article-title":"Differences in autoantibody profiles and disease activity and damage scores between childhood- and adult-onset systemic lupus erythematosus: A meta-analysis","volume":"42","author":"Livingston","year":"2012","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/art.40038","article-title":"Signaling Lymphocytic Activation Molecule Family Member 7 Engagement Restores Defective Effector CD8+ T Cell Function in Systemic Lupus Erythematosus","volume":"69","author":"Comte","year":"2017","journal-title":"Arthritis Rheumatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/art.20745","article-title":"Increase in activated CD8+ T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus","volume":"52","author":"Blanco","year":"2005","journal-title":"Arthritis Rheum."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1097\/BOR.0000000000000815","article-title":"The role of CD8+ T-cell systemic lupus erythematosus pathogenesis: An update","volume":"33","author":"Chen","year":"2021","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"16047","DOI":"10.1038\/nrdp.2016.47","article-title":"Sjogren syndrome","volume":"2","author":"Baldini","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1001\/archinte.164.12.1275","article-title":"Clinical manifestations and early diagnosis of Sjogren syndrome","volume":"164","author":"Kassan","year":"2004","journal-title":"Arch. Intern. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1093\/rheumatology\/keab579","article-title":"Treatment strategies for Sjogren\u2019s syndrome with childhood onset: A systematic review of the literature","volume":"61","author":"Doolan","year":"2022","journal-title":"Rheumatology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1007\/s10067-017-3745-z","article-title":"A systematic review of primary Sjogren\u2019s syndrome in male and paediatric populations","volume":"36","author":"Virdee","year":"2017","journal-title":"Clin. Rheumatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"602823","DOI":"10.3389\/fimmu.2020.602823","article-title":"CD8+ T Lymphocytes: Crucial Players in Sj\u00f6gren\u2019s Syndrome","volume":"11","author":"Zhou","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"15002","DOI":"10.1038\/nrdp.2015.2","article-title":"Systemic sclerosis","volume":"1","author":"Allanore","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.rdc.2021.07.014","article-title":"Juvenile Localized Scleroderma: Updates and Differences from Adult-Onset Disease","volume":"47","author":"Li","year":"2021","journal-title":"Rheum. Dis. Clin. N. Am."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1002\/art.22207","article-title":"Systemic sclerosis in childhood: Clinical and immunologic features of 153 patients in an international database","volume":"54","author":"Martini","year":"2006","journal-title":"Arthritis Rheum."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.imlet.2017.10.002","article-title":"Current perspectives on the role of CD8+ T cells in systemic sclerosis","volume":"195","author":"Fuschiotti","year":"2018","journal-title":"Immunol. Lett."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0140-6736(03)14368-1","article-title":"Polymyositis and dermatomyositis","volume":"362","author":"Dalakas","year":"2003","journal-title":"Lancet"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/MD.0b013e31827f264d","article-title":"The clinical phenotypes of the juvenile idiopathic inflammatory myopathies","volume":"92","author":"Shah","year":"2013","journal-title":"Medicine"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/s41590-021-00949-7","article-title":"Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity","volume":"22","author":"Collier","year":"2021","journal-title":"Nat. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1074-7613(02)00338-2","article-title":"Autoreactive CD8 T Cells in Organ-Specific Autoimmunity: Emerging Targets for Therapeutic Intervention","volume":"17","author":"Liblau","year":"2002","journal-title":"Immunity"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3389\/fimmu.2019.00856","article-title":"The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review","volume":"10","author":"Deng","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.autrev.2010.03.006","article-title":"CD8+ Tregs in lupus, autoimmunity, and beyond","volume":"9","author":"Dinesh","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Ceeraz, S., Thompson, C.R., Beatson, R., and Choy, E.H. (2021). Harnessing CD8+CD28\u2212 Regulatory T Cells as a Tool to Treat Autoimmune Disease. Cells, 10.","DOI":"10.3390\/cells10112973"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"616949","DOI":"10.3389\/fimmu.2020.616949","article-title":"The Complex Role of Regulatory T Cells in Immunity and Aging","volume":"11","author":"Melzer","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/cei.13577","article-title":"Exhausted T cells in systemic lupus erythematosus patients in long-standing remission","volume":"204","author":"Lima","year":"2021","journal-title":"Clin. Exp. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1177\/0961203308089400","article-title":"CD8+CD28-, suppressive T cells in systemic lupus erythematosus","volume":"17","author":"Tulunay","year":"2008","journal-title":"Lupus"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.cellimm.2005.08.031","article-title":"The abnormal apoptosis of T cell subsets and possible involvement of IL-10 in systemic lupus erythematosus","volume":"235","author":"Wang","year":"2005","journal-title":"Cell. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.0007-0963.2004.05883.x","article-title":"The circulating lymphocyte profiles in patients with discoid lupus erythematosus and systemic lupus erythematosus suggest a pathogenetic relationship","volume":"150","author":"Wouters","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e8131","DOI":"10.1590\/1414-431x20198131","article-title":"Altered peripheral lymphocyte subsets in untreated systemic lupus erythematosus patients with infections","volume":"52","author":"Lu","year":"2019","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_54","first-page":"229","article-title":"Evaluation of PBMC Distribution and TLR9 Expression in Patients with Systemic Lupus Erythematosus","volume":"15","author":"Mortezagholi","year":"2016","journal-title":"Iran. J. Allergy Asthma Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.4049\/jimmunol.1101602","article-title":"Enhanced Phosphoinositide 3-Kinase \u03b4 Activity Is a Frequent Event in Systemic Lupus Erythematosus That Confers Resistance to Activation-Induced T Cell Death","volume":"187","author":"Barber","year":"2011","journal-title":"J. Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.molimm.2005.05.002","article-title":"Increased association of CD38 with lipid rafts in T cells from patients with systemic lupus erythematosus and in activated normal T cells","volume":"43","author":"Navarro","year":"2006","journal-title":"Mol. Immunol."},{"key":"ref_57","first-page":"108","article-title":"Immunophenotyping of lymphocyte T and B in the peripheral blood of systemic lupus erythematosus","volume":"21","author":"Hu","year":"2001","journal-title":"J. Tongji Med. Univ."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3109\/10715762.2011.555765","article-title":"Association between T lymphocyte sub-sets apoptosis and peripheral blood mononuclear cells oxidative stress in systemic lupus erythematosus","volume":"45","author":"Shah","year":"2011","journal-title":"Free Radic. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1177\/0961203317726378","article-title":"Preliminary study on the changes of ovarian reserve, menstruation, and lymphocyte subpopulation in systemic lupus erythematosus (SLE) patients of childbearing age","volume":"27","author":"Gao","year":"2018","journal-title":"Lupus"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.biopha.2005.06.007","article-title":"Quantification of absolute peripheral white blood cells and their subsets in patients with lupus erythematosus: Comparison with other inflammatory diseases with and without autoimmune background","volume":"60","year":"2006","journal-title":"Biomed. Pharmacother."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/S0140-6736(18)30485-9","article-title":"Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: A single-arm, open-label, phase 1\/2 trial","volume":"391","author":"Lai","year":"2018","journal-title":"Lancet"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1136\/ard.2009.124636","article-title":"Urinary T cells in active lupus nephritis show an effector memory phenotype","volume":"69","author":"Dolff","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"124","DOI":"10.4049\/immunohorizons.1700028","article-title":"A Systemic Lupus Erythematosus Endophenotype Characterized by Increased CD8 Cytotoxic Signature Associates with Renal Involvement","volume":"1","author":"Menard","year":"2017","journal-title":"ImmunoHorizons"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/nm.2130","article-title":"A CD8+ T cell transcription signature predicts prognosis in autoimmune disease","volume":"16","author":"McKinney","year":"2010","journal-title":"Nat. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1002\/art.40180","article-title":"Peripheral Immunophenotyping Identifies Three Subgroups Based on T Cell Heterogeneity in Lupus Patients","volume":"69","author":"Kubo","year":"2017","journal-title":"Arthritis Rheumatol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1007\/s10067-020-05480-y","article-title":"Lymphocyte subset clustering analysis in treatment-naive patients with systemic lupus erythematosus","volume":"40","author":"Lu","year":"2021","journal-title":"Clin. Rheumatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1046\/j.1365-2249.2001.01623.x","article-title":"HLA-DR expression on lymphocyte subsets as a marker of disease activity in patients with systemic lupus erythematosus","volume":"125","author":"Viallard","year":"2001","journal-title":"Clin. Exp. Immunol."},{"key":"ref_68","first-page":"1058165","article-title":"CD3(+)CD8(+)CD28(-) T Lymphocytes in Patients with Lupus Nephritis","volume":"2016","author":"Krajewska","year":"2016","journal-title":"J. Immunol. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1177\/0961203319867130","article-title":"Imbalance between CD8+CD28+ and CD8+CD28\u2212 T-cell subsets and its clinical significance in patients with systemic lupus erythematosus","volume":"28","author":"Minning","year":"2019","journal-title":"Lupus"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cellimm.2011.03.004","article-title":"Soluble granzyme B and cytotoxic T lymphocyte activity in the pathogenesis of systemic lupus erythematosus","volume":"269","author":"Shah","year":"2011","journal-title":"Cell. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1093\/rheumatology\/kes100","article-title":"IL-7R\u03b1low memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus","volume":"51","author":"Kim","year":"2012","journal-title":"Rheumatology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"556776","DOI":"10.3389\/fmed.2021.556776","article-title":"CD107a+ (LAMP-1) Cytotoxic CD8+ T-Cells in Lupus Nephritis Patients","volume":"8","author":"Wiechmann","year":"2021","journal-title":"Front. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1002\/art.41708","article-title":"Stratification of Patients With Sj\u00f6gren\u2019s Syndrome and Patients With Systemic Lupus Erythematosus According to Two Shared Immune Cell Signatures, With Potential Therapeutic Implications","volume":"73","author":"Peng","year":"2021","journal-title":"Arthritis Rheumatol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cellimm.2016.08.013","article-title":"Are cytotoxic effector cells changes in peripheral blood of patients with Sjogren\u2019s syndrome related to persistent virus infection: Suggestions and conundrums","volume":"310","author":"Narkeviciute","year":"2016","journal-title":"Cell Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"854706","DOI":"10.1155\/2015\/854706","article-title":"Distribution of Peripheral Lymphocyte Populations in Primary Sj\u00f6gren\u2019s Syndrome Patients","volume":"2015","author":"Sudzius","year":"2015","journal-title":"J. Immunol. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/j.jaci.2016.01.024","article-title":"Cytometry by time-of-flight immunophenotyping identifies a blood Sjogren\u2019s signature correlating with disease activity and glandular inflammation","volume":"137","author":"Mingueneau","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1080\/03009740802378832","article-title":"Brain-derived neurotrophic factor and nerve growth factor correlate with T-cell activation in primary Sjogren\u2019s syndrome","volume":"38","author":"Fauchais","year":"2009","journal-title":"Scand. J. Rheumatol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1136\/annrheumdis-2016-210788","article-title":"Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sj\u00f6gren\u2019s syndrome","volume":"76","author":"Tasaki","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cellimm.2012.08.001","article-title":"Increased percentage of CD8+CD28- T cells correlates with clinical activity in primary Sjogren\u2019s syndrome","volume":"278","author":"Smolenska","year":"2012","journal-title":"Cell Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cyto.2018.04.015","article-title":"Increased frequency of CCR7(+)CD4(+) T cells from patients with primary Sjogren\u2019s syndrome: An indicator of disease activity rather than of damage severity","volume":"110","author":"Wu","year":"2018","journal-title":"Cytokine"},{"key":"ref_81","first-page":"1252","article-title":"Increased frequency of interleukin 4 producing CD4+ and CD8+ cells in peripheral blood from patients with systemic sclerosis","volume":"28","author":"Nakazawa","year":"2001","journal-title":"J. Rheumatol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1365-2249.2004.02647.x","article-title":"T cell repertoire in patients with stable scleroderma","volume":"139","author":"Tiev","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1136\/jcp.2004.019224","article-title":"Alterations of mononuclear inflammatory cells, CD4\/CD8+ T cells, interleukin 1beta, and tumour necrosis factor alpha in the bronchoalveolar lavage fluid, peripheral blood, and skin of patients with systemic sclerosis","volume":"58","author":"Hussein","year":"2005","journal-title":"J. Clin. Pathol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/2047-783X-15-1-44","article-title":"Absolute count of T and B lymphocyte subsets is decreased in systemic sclerosis","volume":"15","author":"Gambichler","year":"2010","journal-title":"Eur. J. Med. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/art.24432","article-title":"Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosis","volume":"60","author":"Fuschiotti","year":"2009","journal-title":"Arthritis Rheum."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.jid.2016.11.037","article-title":"Skin-Resident Effector Memory CD8(+)CD28(\u2212) T Cells Exhibit a Profibrotic Phenotype in Patients with Systemic Sclerosis","volume":"137","author":"Li","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1007\/s10067-012-2075-4","article-title":"Clinical significance of peripheral blood lymphocyte subsets in patients with polymyositis and dermatomyositis","volume":"31","author":"Wang","year":"2012","journal-title":"Clin. Rheumatol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"4792","DOI":"10.4049\/jimmunol.0803688","article-title":"T cell infiltrates in the muscles of patients with dermatomyositis and polymyositis are dominated by CD28null T cells","volume":"183","author":"Fasth","year":"2009","journal-title":"J. Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1136\/ard.2003.017715","article-title":"Altered cytokine expression of peripheral blood lymphocytes in polymyositis and dermatomyositis","volume":"64","author":"Aleksza","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"ref_90","first-page":"194","article-title":"Using peripheral blood immune signatures to stratify patients with adult and juvenile inflammatory myopathies","volume":"59","author":"Wilkinson","year":"2020","journal-title":"Rheumatology"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.4049\/jimmunol.167.6.3521","article-title":"Severe perturbations of the blood T cell repertoire in polymyositis, but not dermatomyositis patients","volume":"167","author":"Benveniste","year":"2001","journal-title":"J. Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Lerkvaleekul, B., Apiwattanakul, N., Tangnararatchakit, K., Jirapattananon, N., Srisala, S., and Vilaiyuk, S. (2022). Associations of lymphocyte subpopulations with clinical phenotypes and long-term outcomes in juvenile-onset systemic lupus erythematosus. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0263536"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e485","DOI":"10.1016\/S2665-9913(20)30168-5","article-title":"Disease-associated and patient-specific immune cell signatures in juvenile-onset systemic lupus erythematosus: Patient stratification using a machine-learning approach","volume":"2","author":"Robinson","year":"2020","journal-title":"Lancet Rheumatol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"32963","DOI":"10.3402\/fnr.v60.32963","article-title":"Effects of royal jelly supplementation on regulatory T cells in children with SLE","volume":"60","author":"Zahran","year":"2016","journal-title":"Food Nutr. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1177\/0961203310397409","article-title":"Vaccine antibodies and T- and B-cell interaction in juvenile systemic lupus erythematosus","volume":"20","author":"Miyamoto","year":"2011","journal-title":"Lupus"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/s41590-020-0743-0","article-title":"Mapping systemic lupus erythematosus heterogeneity at the single-cell level","volume":"21","author":"Hong","year":"2020","journal-title":"Nat. Immunol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1128\/CDLI.7.4.693-697.2000","article-title":"Decreased levels of CD54 (ICAM-1)-positive lymphocytes in the peripheral blood in untreated patients with active juvenile dermatomyositis","volume":"7","author":"Bianchi","year":"2000","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0022-510X(90)90156-H","article-title":"Nature of the mononuclear infiltrate and the mechanism of muscle damage in juvenile dermatomyositis and Duchenne muscular dystrophy","volume":"99","author":"McDouall","year":"1990","journal-title":"J. Neurol. Sci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3389\/fimmu.2018.00172","article-title":"Establishment of the Reference Intervals of Lymphocyte Function in Healthy Adults Based on IFN-\u03b3 Secretion Assay upon Phorbol-12-Myristate-13-Acetate\/Ionomycin Stimulation","volume":"9","author":"Hou","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.4049\/jimmunol.181.3.2211","article-title":"Excessive production of IFN-gamma in patients with systemic lupus erythematosus and its contribution to induction of B lymphocyte stimulator\/B cell-activating factor\/TNF ligand superfamily-13B","volume":"181","author":"Harigai","year":"2008","journal-title":"J. Immunol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"892","DOI":"10.4049\/jimmunol.1403046","article-title":"Increased CD226 Expression on CD8+ T Cells Is Associated with Upregulated Cytokine Production and Endothelial Cell Injury in Patients with Systemic Sclerosis","volume":"195","author":"Ayano","year":"2015","journal-title":"J. Immunol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.celrep.2019.12.014","article-title":"The CD38\/NAD\/SIRTUIN1\/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections","volume":"30","author":"Katsuyama","year":"2020","journal-title":"Cell Rep."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/art.39410","article-title":"Selective Loss of Signaling Lymphocytic Activation Molecule Family Member 4-Positive CD8+ T Cells Contributes to the Decreased Cytotoxic Cell Activity in Systemic Lupus Erythematosus","volume":"68","author":"Comte","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/jaut.2001.0525","article-title":"Quantitative and Qualitative Analysis of the Balance Between Type 1 and Type 2 Cytokine-producing CD8\u2212and CD8+T Cells in Systemic Lupus Erythematosus","volume":"17","author":"Huggins","year":"2001","journal-title":"J. Autoimmun."},{"key":"ref_105","first-page":"877","article-title":"The relationship between Th1\/Th2-type cells and disease activity in patients with systemic lupus erythematosus","volume":"113","author":"Chen","year":"2000","journal-title":"Chin. Med. J."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/art.1780380408","article-title":"Impaired polyclonal T cell cytolytic activity. A possible risk factor for systemic lupus erythematosus","volume":"38","author":"Stohl","year":"1995","journal-title":"Arthritis Rheum."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1002\/art.1780400618","article-title":"Impaired nonrestricted cytolytic activity in systemic lupus erythematosus: Involvement of a pathway independent of Fas, tumor necrosis factor, and extracellular ATP that is associated with little detectable perforin","volume":"40","author":"Stohl","year":"1997","journal-title":"Arthritis Rheum."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1191\/096120399678847768","article-title":"Impaired cytotoxic T lymphocyte activity in systemic lupus erythematosus following in vitro polyclonal T cell stimulation: A contributory role for non-T cells","volume":"8","author":"Stohl","year":"1999","journal-title":"Lupus"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Larsen, M., Sauce, D., Deback, C., Arnaud, L., Mathian, A., Miyara, M., Boutolleau, D., Parizot, C., Dorgham, K., and Papagno, L. (2011). Exhausted cytotoxic control of Epstein-Barr virus in human lupus. PLoS Pathog., 7.","DOI":"10.1371\/journal.ppat.1002328"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cellimm.2005.06.010","article-title":"Phenotypic and functional analysis of EBV-specific memory CD8 cells in SLE","volume":"235","author":"Berner","year":"2005","journal-title":"Cell. Immunol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.4049\/jimmunol.172.2.1287","article-title":"Defective Control of Latent Epstein-Barr Virus Infection in Systemic Lupus Erythematosus","volume":"172","author":"Kang","year":"2004","journal-title":"J. Immunol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1038\/s41598-020-60563-9","article-title":"Using the circulating proteome to assess type I interferon activity in systemic lupus erythematosus","volume":"10","author":"Smith","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/nature14468","article-title":"T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection","volume":"523","author":"McKinney","year":"2015","journal-title":"Nature"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1038\/s41467-021-22312-y","article-title":"Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus","volume":"12","author":"Buang","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1080\/03009740802409496","article-title":"Enhanced propensity of T lymphocytes in patients with systemic lupus erythematosus to apoptosis in the presence of tumour necrosis factor alpha","volume":"38","author":"Habib","year":"2009","journal-title":"Scand. J. Rheumatol."},{"key":"ref_116","first-page":"283","article-title":"Increased Fas and Bcl-2 expression on peripheral blood T and B lymphocytes from juvenile-onset systemic lupus erythematosus, but not from juvenile rheumatoid arthritis and juvenile dermatomyositis","volume":"13","author":"Liphaus","year":"2006","journal-title":"Clin. Dev. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3109\/08916934.2010.530627","article-title":"SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells","volume":"44","author":"Chatterjee","year":"2011","journal-title":"Autoimmunity"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1046\/j.1365-3083.1998.00366.x","article-title":"Participation of the CD69 antigen in the T-cell activation process of patients with systemic lupus erythematosus","volume":"48","author":"Crispin","year":"1998","journal-title":"Scand. J. Immunol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1172\/JCI118643","article-title":"Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production","volume":"97","author":"Lu","year":"1996","journal-title":"J. Clin. Investig."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1023\/A:1020566618980","article-title":"Expression of CD80 and CD86 on Peripheral Blood T Lymphocytes in Patients with Systemic Lupus Erythematosus","volume":"19","author":"Abe","year":"1999","journal-title":"J. Clin. Immunol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1023\/B:JOCI.0000018060.36183.bb","article-title":"Increased CD8+ T cell apoptosis in scleroderma is associated with low levels of NF-kappa B","volume":"24","author":"Kessel","year":"2004","journal-title":"J. Clin. Immunol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jaci.2017.10.029","article-title":"14-3-3z sequesters cytosolic T-bet, upregulating IL-13 levels in TC2 and CD8(+) lymphocytes from patients with scleroderma","volume":"142","author":"Cascio","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1002\/art.30489","article-title":"GATA-3 up-regulation in CD8+ T cells as a biomarker of immune dysfunction in systemic sclerosis, resulting in excessive interleukin-13 production","volume":"63","author":"Medsger","year":"2011","journal-title":"Arthritis Rheum."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1365-2567.2004.01862.x","article-title":"Aberration of CCR7 CD8 memory T cells from patients with systemic lupus erythematosus: An inducer of T helper type 2 bias of CD4 T cells","volume":"112","author":"Sen","year":"2004","journal-title":"Immunology"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1002\/1529-0131(199906)42:6<1168::AID-ANR13>3.0.CO;2-L","article-title":"Production of type 2 cytokines by CD8+ lung cells is associated with greater decline in pulmonary function in patients with systemic sclerosis","volume":"42","author":"Atamas","year":"1999","journal-title":"Arthritis Rheumatol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1080\/08916934.2016.1217997","article-title":"Contribution of CD8+ T cells to inflammatory cytokine production in systemic sclerosis (SSc)","volume":"49","author":"Klein","year":"2016","journal-title":"Autoimmunity"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1002\/art.11080","article-title":"Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T cells from scleroderma patients","volume":"48","author":"Luzina","year":"2003","journal-title":"Arthritis Rheum."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1136\/ard.2009.108043","article-title":"Novel expression signatures identified by transcriptional analysis of separated leucocyte subsets in systemic lupus erythematosus and vasculitis","volume":"69","author":"Lyons","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.jid.2017.12.003","article-title":"Genome-Wide DNA Methylation Analysis in Systemic Sclerosis Reveals Hypomethylation of IFN-Associated Genes in CD4(+) and CD8(+) T Cells","volume":"138","author":"Ding","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s13075-018-1688-7","article-title":"T-cell transcriptomics from peripheral blood highlights differences between polymyositis and dermatomyositis patients","volume":"20","author":"Houtman","year":"2018","journal-title":"Arthritis Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nrrheum.2018.31","article-title":"Type I interferon in rheumatic diseases","volume":"14","author":"Muskardin","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1016\/S2665-9913(21)00254-X","article-title":"The interferon gene signature as a clinically relevant biomarker in autoimmune rheumatic disease","volume":"4","author":"Cooles","year":"2022","journal-title":"Lancet Rheumatol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/s41590-019-0398-x","article-title":"The immune cell landscape in kidneys of patients with lupus nephritis","volume":"20","author":"Arazi","year":"2019","journal-title":"Nat. Immunol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"102424","DOI":"10.1016\/j.jaut.2020.102424","article-title":"JAK\/STAT signaling controls the fate of CD8(+)CD103(+) tissue-resident memory T cell in lupus nephritis","volume":"109","author":"Zhou","year":"2020","journal-title":"J. Autoimmun."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"R36","DOI":"10.1186\/ar4189","article-title":"Urinary CD8+ T-cell counts discriminate between active and inactive lupus nephritis","volume":"15","author":"Dolff","year":"2013","journal-title":"Arthritis Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1002\/art.22654","article-title":"Predominance of CD8+ T lymphocytes among periglomerular infiltrating cells and link to the prognosis of class III and class IV lupus nephritis","volume":"56","author":"Couzi","year":"2007","journal-title":"Arthritis Rheum."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"107877","DOI":"10.1016\/j.intimp.2021.107877","article-title":"Association between tubulointerstitial CD8+T cells and renal prognosis in lupus nephritis","volume":"99","author":"Zhang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13075-015-0600-y","article-title":"The cellular signature of urinary immune cells in Lupus nephritis: New insights into potential biomarkers","volume":"17","author":"Kopetschke","year":"2015","journal-title":"Arthritis Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.clim.2016.04.005","article-title":"Immune cells and type 1 IFN in urine of SLE patients correlate with immunopathology in the kidney","volume":"168","author":"Scott","year":"2016","journal-title":"Clin. Immunol."},{"key":"ref_140","first-page":"834291","article-title":"Cutaneous Manifestations of Systemic Lupus Erythematosus","volume":"2012","author":"Uva","year":"2012","journal-title":"Autoimmune Dis."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/j.1600-0560.2009.01443.x","article-title":"The phenotypic profile of dermatomyositis and lupus erythematosus: A comparative analysis","volume":"37","author":"Magro","year":"2010","journal-title":"J. Cutan. Pathol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1111\/j.1365-2230.2009.03297.x","article-title":"Identification of granzyme B-expressing CD-8-positive T cells in lymphocytic inflammatory infiltrate in cutaneous lupus erythematosus and in dermatomyositis","volume":"34","author":"Grassi","year":"2009","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000246922","article-title":"Susceptibility to UVB light in cultured keratinocytes of cutaneous lupus erythematosus","volume":"189","author":"Furukawa","year":"1994","journal-title":"Dermatology"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1600-0560.2006.00652.x","article-title":"Lupus erythematosus: Clinical and histopathological study of oral manifestations and immunohistochemical profile of the inflammatory infiltrate","volume":"34","author":"Boggio","year":"2007","journal-title":"J. Cutan. Pathol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1365-2249.1993.tb05989.x","article-title":"Bronchoalveolar lavage cell analysis and lung function impairment in patients with systemic lupus erythematosus (SLE)","volume":"94","author":"Groen","year":"1993","journal-title":"Clin. Exp. Immunol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1136\/ard.2010.140012","article-title":"Expansion of myelin autoreactive CD8+ T lymphocytes in patients with neuropsychiatric systemic lupus erythematosus","volume":"70","author":"Lazaro","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.4049\/jimmunol.163.4.2226","article-title":"Preferential localization of CD8+ alpha E beta 7+ T cells around acinar epithelial cells with apoptosis in patients with Sjogren\u2019s syndrome","volume":"163","author":"Fujihara","year":"1999","journal-title":"J. Immunol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/art.1780400113","article-title":"Fas and Fas ligand expression in the salivary glands of patients with primary Sj\u00f6gren\u2019s syndrome","volume":"40","author":"Kong","year":"1997","journal-title":"Arthritis Rheum."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/labinvest.3780215","article-title":"Fas-induced apoptosis is a rare event in Sjogren\u2019s syndrome","volume":"81","author":"Ohlsson","year":"2001","journal-title":"Lab. Investig."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00296-006-0229-x","article-title":"Activation of MKK4 (SEK1), JNK, and c-Jun in labial salivary infiltrating T cells in patients with Sjogren\u2019s syndrome","volume":"27","author":"Soejima","year":"2007","journal-title":"Rheumatol. Int."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/path.1533","article-title":"Expression of BAFF (BLyS) in T cells infiltrating labial salivary glands from patients with Sjogren\u2019s syndrome","volume":"202","author":"Lavie","year":"2004","journal-title":"J. Pathol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/ana.410160206","article-title":"Monoclonal antibody analysis of mononuclear cells in myopathies. I: Quantitation of subsets according to diagnosis and sites of accumulation and demonstration and counts of muscle fibers invaded by T cells","volume":"16","author":"Arahata","year":"1984","journal-title":"Ann. Neurol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/art.37706","article-title":"Interleukin-13-producing CD8+ T cells mediate dermal fibrosis in patients with systemic sclerosis","volume":"65","author":"Fuschiotti","year":"2013","journal-title":"Arthritis Rheum."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1365-2249.2006.03180.x","article-title":"Interleukin-18 overexpression as a hallmark of the activity of autoimmune inflammatory myopathies","volume":"146","author":"Tucci","year":"2006","journal-title":"Clin. Exp. Immunol."},{"key":"ref_155","first-page":"1178","article-title":"Immunocytochemical study of CD45 T cell isoforms in inflammatory myopathies","volume":"146","author":"Engel","year":"1995","journal-title":"Am. J. Pathol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1136\/jcp.39.3.271","article-title":"Immunohistochemical analysis of mononuclear cell subsets in inflammatory and non-inflammatory myopathies","volume":"39","author":"Lemoine","year":"1986","journal-title":"J. Clin. Pathol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jns.2006.06.021","article-title":"Expression of CCR7 and its ligands CCL19\/CCL21 in muscles of polymyositis","volume":"249","author":"Tateyama","year":"2006","journal-title":"J. Neurol. Sci."},{"key":"ref_158","first-page":"1135","article-title":"Mechanisms of lysis by activated cytotoxic cells expressing perforin and granzyme-B genes and the protein TIA-1 in muscle biopsies of myositis","volume":"23","author":"Cherin","year":"1996","journal-title":"J. Rheumatol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0960-8966(94)90022-1","article-title":"Immunohistochemical analysis of perforin and granzyme A in inflammatory myopathies","volume":"4","author":"Orimo","year":"1994","journal-title":"Neuromuscul. Disord."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Danielsson, O., Haggqvist, B., Grontoft, L., Ollinger, K., and Ernerudh, J. (2020). Apoptosis in idiopathic inflammatory myopathies with partial invasion; a role for CD8+ cytotoxic T cells?. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0239176"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1002\/art.39650","article-title":"CD4+ and CD8+ CD28(null) T Cells Are Cytotoxic to Autologous Muscle Cells in Patients With Polymyositis","volume":"68","author":"Pandya","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1172\/JCI118749","article-title":"Differential expression of perforin in muscle-infiltrating T cells in polymyositis and dermatomyositis","volume":"97","author":"Goebels","year":"1996","journal-title":"J. Clin. Investig."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s42358-018-0037-5","article-title":"Comparison between treatment naive juvenile and adult dermatomyositis muscle biopsies: Difference of inflammatory cells phenotyping","volume":"58","author":"Shinjo","year":"2018","journal-title":"Adv. Rheumatol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00296-001-0146-y","article-title":"Lymphocyte subsets in lung tissues of interstitial pneumonia associated with untreated polymyositis\/dermatomyositis","volume":"21","author":"Yamadori","year":"2001","journal-title":"Rheumatol. Int."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0065-2776(08)60801-9","article-title":"The Human la System","volume":"Volume 28","author":"Dixon","year":"1980","journal-title":"Advances in Immunology"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jim.2004.07.006","article-title":"Comparative analysis of lymphocyte activation marker expression and cytokine secretion profile in stimulated human peripheral blood mononuclear cell cultures: An in vitro model to monitor cellular immune function","volume":"293","author":"Reddy","year":"2004","journal-title":"J. Immunol. Methods"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.0105-2896.2005.00256.x","article-title":"CD28 extinction in human T cells: Altered functions and the program of T-cell senescence","volume":"205","author":"Vallejo","year":"2005","journal-title":"Immunol. Rev."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.autrev.2018.05.005","article-title":"Clinical and immunological parameters of Sj\u00f6gren\u2019s syndrome","volume":"17","author":"Psianou","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1046\/j.1365-2567.1996.d01-689.x","article-title":"Expansion of cytotoxic CD8+ CD28- T cells in healthy ageing people, including centenarians","volume":"88","author":"Fagnoni","year":"1996","journal-title":"Immunology"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/nm1295-1279","article-title":"Genetic control of the CD4\/CD8 T-cell ratio in humans","volume":"1","author":"Amadori","year":"1995","journal-title":"Nat. Med."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12979-019-0165-8","article-title":"Age related human T cell subset evolution and senescence","volume":"16","author":"Li","year":"2019","journal-title":"Immun. Ageing"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/cyto.a.22855","article-title":"Age and gender leucocytes variances and references values generated using the standardized ONE-Study protocol","volume":"89","author":"Kverneland","year":"2016","journal-title":"Cytom. Part A"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"720694","DOI":"10.3389\/fphar.2021.720694","article-title":"Machine Learning Techniques for Personalised Medicine Approaches in Immune-Mediated Chronic Inflammatory Diseases: Applications and Challenges","volume":"12","author":"Peng","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"103243","DOI":"10.1016\/j.ebiom.2021.103243","article-title":"Increased apolipoprotein-B:A1 ratio predicts cardiometabolic risk in patients with juvenile onset SLE","volume":"65","author":"Robinson","year":"2021","journal-title":"EBioMedicine"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.cell.2016.03.008","article-title":"Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients","volume":"165","author":"Banchereau","year":"2016","journal-title":"Cell"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1038\/s41467-021-23472-7","article-title":"A new molecular classification to drive precision treatment strategies in primary Sj\u00f6gren\u2019s syndrome","volume":"12","author":"Soret","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"911977","DOI":"10.3389\/fmed.2022.911977","article-title":"Toward Molecular Stratification and Precision Medicine in Systemic Sclerosis","volume":"9","author":"Noviani","year":"2022","journal-title":"Front. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"107612","DOI":"10.1016\/j.intimp.2021.107612","article-title":"A review on applications of abatacept in systemic rheumatic diseases","volume":"96","author":"Liu","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1136\/annrheumdis-2013-204653","article-title":"Abatacept treatment reduces disease activity in early primary Sj\u00f6gren\u2019s syndrome (open-label proof of concept ASAP study)","volume":"73","author":"Meiners","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"891","DOI":"10.3109\/14397595.2016.1158773","article-title":"Effectiveness of abatacept for patients with Sj\u00f6gren\u2019s syndrome associated with rheumatoid arthritis. An open label, multicenter, one-year, prospective study: ROSE (Rheumatoid Arthritis with Orencia Trial toward Sj\u00f6gren\u2019s syndrome Endocrinopathy) trial","volume":"26","author":"Tsuboi","year":"2016","journal-title":"Mod. Rheumatol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1016\/S2665-9913(19)30160-2","article-title":"Abatacept treatment for patients with early active primary Sj\u00f6gren\u2019s syndrome: A single-centre, randomised, double-blind, placebo-controlled, phase 3 trial (ASAP-III study)","volume":"2","author":"Mossel","year":"2020","journal-title":"Lancet Rheumatol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/annrheumdis-2020-218599","article-title":"Efficacy and safety of abatacept in active primary Sj\u00f6gren\u2019s syndrome: Results of a phase III, randomised, placebo-controlled trial","volume":"80","author":"Baer","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.semarthrit.2019.12.004","article-title":"Safety and effectiveness of abatacept in systemic sclerosis: The EUSTAR experience","volume":"50","author":"Elhai","year":"2020","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/art.41055","article-title":"Abatacept in Early Diffuse Cutaneous Systemic Sclerosis: Results of a Phase II Investigator-Initiated, Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial","volume":"72","author":"Khanna","year":"2020","journal-title":"Arthritis Rheumatol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1136\/annrheumdis-2017-211751","article-title":"Abatacept in the treatment of adult dermatomyositis and polymyositis: A randomised, phase IIb treatment delayed-start trial","volume":"77","author":"Tang","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"e12732","DOI":"10.1111\/sji.12732","article-title":"Effect of CTLA4-Ig (abatacept) treatment on T cells and B cells in peripheral blood of patients with polymyositis and dermatomyositis","volume":"89","author":"Tang","year":"2019","journal-title":"Scand. J. Immunol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1517\/13543784.2016.1154943","article-title":"Abatacept for the treatment of systemic lupus erythematosus","volume":"25","year":"2016","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1002\/art.27601","article-title":"The efficacy and safety of abatacept in patients with non-life-threatening manifestations of systemic lupus erythematosus: Results of a twelve-month, multicenter, exploratory, phase IIb, randomized, double-blind, placebo-controlled trial","volume":"62","author":"Merrill","year":"2010","journal-title":"Arthritis Rheum."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/art.38260","article-title":"Efficacy and Safety of Abatacept in Lupus Nephritis: A Twelve-Month, Randomized, Double-Blind Study","volume":"66","author":"Furie","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1002\/art.39248","article-title":"Blockade of Interferon-\u03b3 Normalizes Interferon-Regulated Gene Expression and Serum CXCL10 Levels in Patients With Systemic Lupus Erythematosus","volume":"67","author":"Welcher","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"e000226","DOI":"10.1136\/lupus-2017-000226","article-title":"Safety, pharmacokinetics and pharmacodynamics of AMG 811, an anti-interferon-\u03b3 monoclonal antibody, in SLE subjects without or with lupus nephritis","volume":"4","author":"Boedigheimer","year":"2017","journal-title":"Lupus Sci. Med."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12974-015-0376-7","article-title":"Granzyme B-inhibitor serpina3n induces neuroprotection in vitro and in vivo","volume":"12","author":"Haile","year":"2015","journal-title":"J. Neuroinflamm."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/s41467-020-20604-3","article-title":"Granzyme B inhibition reduces disease severity in autoimmune blistering diseases","volume":"12","author":"Hiroyasu","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/s13075-018-1760-3","article-title":"The risks of cancer development in systemic lupus erythematosus (SLE) patients: A systematic review and meta-analysis","volume":"20","author":"Song","year":"2018","journal-title":"Arthritis Res."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13045-017-0464-5","article-title":"Characterization and risk estimate of cancer in patients with primary Sj\u00f6gren syndrome","volume":"10","author":"Kostov","year":"2017","journal-title":"J. Hematol. Oncol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1002\/art.37969","article-title":"Cancer Incidence in Systemic Sclerosis: Meta-Analysis of Population-Based Cohort Studies","volume":"65","author":"Onishi","year":"2013","journal-title":"Arthritis Rheum."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1093\/rheumatology\/keab166","article-title":"A systematic review and meta-analysis to inform cancer screening guidelines in idiopathic inflammatory myopathies","volume":"60","author":"Oldroyd","year":"2021","journal-title":"Rheumatology"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1126\/science.1246886","article-title":"Association of the autoimmune disease scleroderma with an immunologic response to cancer","volume":"343","author":"Joseph","year":"2014","journal-title":"Science"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.semcancer.2019.06.012","article-title":"Autoimmunity, checkpoint inhibitor therapy and immune-related adverse events: A review","volume":"64","author":"Khan","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41416-020-01048-4","article-title":"Cytotoxic CD8+ T cells in cancer and cancer immunotherapy","volume":"124","author":"Raskov","year":"2021","journal-title":"Br. J. Cancer"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1001\/jamaoncol.2015.4368","article-title":"Ipilimumab Therapy in Patients With Advanced Melanoma and Preexisting Autoimmune Disorders","volume":"2","author":"Johnson","year":"2016","journal-title":"JAMA Oncol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1517\/14712590903020759","article-title":"Treating autoimmune disease by targeting CD8(+) T suppressor cells","volume":"9","author":"Konya","year":"2009","journal-title":"Expert Opin. Biol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/imr.12812","article-title":"Future prospects for CD8(+) regulatory T cells in immune tolerance","volume":"292","author":"Flippe","year":"2019","journal-title":"Immunol. Rev."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"50098","DOI":"10.18632\/oncotarget.15100","article-title":"Predictable biomarkers of developing lymphoma in patients with Sj\u00f6gren syndrome: A nationwide population-based cohort study","volume":"8","author":"Chiu","year":"2017","journal-title":"Oncotarget"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/19\/11431\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:40:55Z","timestamp":1760143255000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/19\/11431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,28]]},"references-count":204,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["ijms231911431"],"URL":"https:\/\/doi.org\/10.3390\/ijms231911431","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,28]]}}}