{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:36:43Z","timestamp":1762069003059,"version":"build-2065373602"},"reference-count":75,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cellular memory is a controversial concept representing the ability of cells to \u201cwrite and memorize\u201d stressful experiences via epigenetic operators. The progressive course of chronic, non-communicable diseases such as type 2 diabetes mellitus, cancer, and arteriosclerosis, is likely driven through an abnormal epigenetic reprogramming, fostering the hypothesis of a cellular pathologic memory. Accordingly, cultured diabetic and cancer patient-derived cells recall behavioral traits as when in the donor\u2019s organism irrespective to culture time and conditions. Here, we analyze the data of studies conducted by our group and led by a cascade of hypothesis, in which we aimed to validate the hypothetical existence and transmissibility of a cellular pathologic memory in diabetes, arteriosclerotic peripheral arterial disease, and cancer. These experiments were based on the administration to otherwise healthy animals of cell-free filtrates prepared from human pathologic tissue samples representative of each disease condition. The administration of each pathologic tissue homogenate consistently induced the faithful recapitulation of: (1) Diabetic archetypical changes in cutaneous arterioles and nerves. (2) Non-thrombotic arteriosclerotic thickening, collagenous arterial encroachment, aberrant angiogenesis, and vascular remodeling. (3) Pre-malignant and malignant epithelial and mesenchymal tumors in different organs; all evocative of the donor\u2019s tissue histopathology and with no barriers for interspecies transmission. We hypothesize that homogenates contain pathologic tissue memory codes represented in soluble drivers that \u201cinfiltrate\u201d host\u2019s animal cells, and ultimately impose their phenotypic signatures. The identification and validation of the actors in behind may pave the way for future therapies.<\/jats:p>","DOI":"10.3390\/ijms231911575","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T22:19:27Z","timestamp":1665267567000},"page":"11575","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cell-Free Filtrates (CFF) as Vectors of a Transmissible Pathologic Tissue Memory Code: A Hypothetical and Narrative Review"],"prefix":"10.3390","volume":"23","author":[{"given":"Jorge","family":"Berlanga-Acosta","sequence":"first","affiliation":[{"name":"Tissue Repair, Wound Healing and Cytoprotection Research Group, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 S\/N. e\/ 158 and 190, Cubanac\u00e1n, Playa, Havana 10600, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maday","family":"Fernandez-Mayola","sequence":"additional","affiliation":[{"name":"Tissue Repair, Wound Healing and Cytoprotection Research Group, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 S\/N. e\/ 158 and 190, Cubanac\u00e1n, Playa, Havana 10600, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2788-0701","authenticated-orcid":false,"given":"Yssel","family":"Mendoza-Mari","sequence":"additional","affiliation":[{"name":"Tissue Repair, Wound Healing and Cytoprotection Research Group, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 S\/N. e\/ 158 and 190, Cubanac\u00e1n, Playa, Havana 10600, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariana","family":"Garcia-Ojalvo","sequence":"additional","affiliation":[{"name":"Tissue Repair, Wound Healing and Cytoprotection Research Group, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 S\/N. e\/ 158 and 190, Cubanac\u00e1n, Playa, Havana 10600, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indira","family":"Martinez-Jimenez","sequence":"additional","affiliation":[{"name":"Tissue Repair, Wound Healing and Cytoprotection Research Group, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 S\/N. e\/ 158 and 190, Cubanac\u00e1n, Playa, Havana 10600, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Rodriguez-Rodriguez","sequence":"additional","affiliation":[{"name":"Tissue Repair, Wound Healing and Cytoprotection Research Group, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 S\/N. e\/ 158 and 190, Cubanac\u00e1n, Playa, Havana 10600, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Garcia del Barco Herrera","sequence":"additional","affiliation":[{"name":"Tissue Repair, Wound Healing and Cytoprotection Research Group, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 S\/N. e\/ 158 and 190, Cubanac\u00e1n, Playa, Havana 10600, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3098-0970","authenticated-orcid":false,"given":"Gerardo","family":"Guill\u00e9n-Nieto","sequence":"additional","affiliation":[{"name":"Tissue Repair, Wound Healing and Cytoprotection Research Group, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 S\/N. e\/ 158 and 190, Cubanac\u00e1n, Playa, Havana 10600, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3758\/BF03328256","article-title":"Retention of a position discrimination after regeneration in planarians","volume":"5","author":"Corning","year":"1966","journal-title":"Psychon. 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