{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:11:41Z","timestamp":1790745101913,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Flexible spine tethering is a relatively novel fusionless surgical technique that aims to correct scoliosis based on growth modulation due to the pressure exerted on the vertebral body epiphyseal growth plate. The correction occurs in two phases: immediate intraoperative and postoperative with growth. The aim of this study was to evaluate the reactivation of vertebral growth plate function after applying corrective forces. The rat tail model was used. Asymmetric compression and distraction of caudal growth plates were performed using a modified external fixation apparatus. Radiological and histopathological data were analysed. After three weeks of correction, the activity of the structures increased across the entire growth plate width, and the plate was thickened. The height of the hypertrophic layer and chondrocytes on the concave side doubled in height. The height of chondrocytes and the cartilage thickness on the concave and central sides after the correction did not differ statistically significantly from the control group. Initiation of the correction of scoliosis in the growing spine, with relief of the pressure on the growth plate, allows the return of the physiological activity of the growth cartilage and restoration of the deformed vertebral body.<\/jats:p>","DOI":"10.3390\/ijms231911596","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T22:19:27Z","timestamp":1665267567000},"page":"11596","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reactivation of Vertebral Growth Plate Function in Vertebral Body Tethering in an Animal Model"],"prefix":"10.3390","volume":"23","author":[{"given":"Micha\u0142","family":"Latalski","sequence":"first","affiliation":[{"name":"Childrens\u2019 Orthopedic Department, Medical University of Lublin, G\u0119bali 6, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Szponder","sequence":"additional","affiliation":[{"name":"Department and Clinic of Animal Surgery, Faculty of Veterinary Medicine, University of Life Sciences, G\u0142\u0119boka 30, 20-612 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6043-1473","authenticated-orcid":false,"given":"Grzegorz","family":"Starobrat","sequence":"additional","affiliation":[{"name":"Childrens\u2019 Orthopedic Department, Medical University of Lublin, G\u0119bali 6, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Warda","sequence":"additional","affiliation":[{"name":"Orthopedics and Traumatology Department, University Hospital, Jaczewskiego 8, 20-954 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0466-1343","authenticated-orcid":false,"given":"Magdalena","family":"W\u00f3jciak","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4413-3748","authenticated-orcid":false,"given":"S\u0142awomir","family":"Dresler","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland"},{"name":"Department of Plant Physiology and Biophysics, Institute of Biological Science, Maria Curie-Sk\u0142odowska University, 19 Akademicka Str., 20-033 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Danielewicz","sequence":"additional","affiliation":[{"name":"Childrens\u2019 Orthopedic Department, Medical University of Lublin, G\u0119bali 6, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5945-1047","authenticated-orcid":false,"given":"Jan","family":"Sawicki","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9346-6325","authenticated-orcid":false,"given":"Ireneusz","family":"Sowa","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s43390-020-00131-3","article-title":"Efficacy of Bracing in Skeletally Immature Patients with Moderate-Severe Idiopathic Scoliosis Curves between 40\u00b0 and 60\u00b0","volume":"8","author":"Verhofste","year":"2020","journal-title":"Spine Deform."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/BPO.0000000000000073","article-title":"A Classification of Growth Friendly Spine Implants","volume":"34","author":"Skaggs","year":"2014","journal-title":"J. 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