{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:18:14Z","timestamp":1790309894254,"version":"4.1.0"},"reference-count":47,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["31660744"],"award-info":[{"award-number":["31660744"]}]},{"name":"National Natural Science Foundation of China","award":["32060835"],"award-info":[{"award-number":["32060835"]}]},{"name":"National Natural Science Foundation of China","award":["32260927"],"award-info":[{"award-number":["32260927"]}]},{"name":"National Natural Science Foundation of China","award":["2020YFD0901104"],"award-info":[{"award-number":["2020YFD0901104"]}]},{"name":"National Natural Science Foundation of China","award":["HHCL201813"],"award-info":[{"award-number":["HHCL201813"]}]},{"name":"National Natural Science Foundation of China","award":["HHCL201802"],"award-info":[{"award-number":["HHCL201802"]}]},{"name":"National Key Research and Development Plan","award":["31660744"],"award-info":[{"award-number":["31660744"]}]},{"name":"National Key Research and Development Plan","award":["32060835"],"award-info":[{"award-number":["32060835"]}]},{"name":"National Key Research and Development Plan","award":["32260927"],"award-info":[{"award-number":["32260927"]}]},{"name":"National Key Research and Development Plan","award":["2020YFD0901104"],"award-info":[{"award-number":["2020YFD0901104"]}]},{"name":"National Key Research and Development Plan","award":["HHCL201813"],"award-info":[{"award-number":["HHCL201813"]}]},{"name":"National Key Research and Development Plan","award":["HHCL201802"],"award-info":[{"award-number":["HHCL201802"]}]},{"name":"National \u201c13th Five-Year Plan\u201d Marine Economic Innovation Development Demonstration City Project","award":["31660744"],"award-info":[{"award-number":["31660744"]}]},{"name":"National \u201c13th Five-Year Plan\u201d Marine Economic Innovation Development Demonstration City Project","award":["32060835"],"award-info":[{"award-number":["32060835"]}]},{"name":"National \u201c13th Five-Year Plan\u201d Marine Economic Innovation Development Demonstration City Project","award":["32260927"],"award-info":[{"award-number":["32260927"]}]},{"name":"National \u201c13th Five-Year Plan\u201d Marine Economic Innovation Development Demonstration City Project","award":["2020YFD0901104"],"award-info":[{"award-number":["2020YFD0901104"]}]},{"name":"National \u201c13th Five-Year Plan\u201d Marine Economic Innovation Development Demonstration City Project","award":["HHCL201813"],"award-info":[{"award-number":["HHCL201813"]}]},{"name":"National \u201c13th Five-Year Plan\u201d Marine Economic Innovation Development Demonstration City Project","award":["HHCL201802"],"award-info":[{"award-number":["HHCL201802"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Vibrio harveyi is one of the most serious bacterial pathogens to aquatic animals worldwide. Evidence is mounting that coinfections caused by multiple pathogens are common in nature and can alter the severity of diseases in marine animals. However, bacterial coinfections involving V. harveyi have received little attention in mariculture. In this study, the results of pathogen isolation indicated that bacterial coinfection was a common and overlooked risk for hybrid groupers (\u2640 Epinephelus polyphekadion \u00d7 \u2642 E. fuscoguttatus) reared in an industrialized flow-through pattern in Hainan Province. The artificial infection in hybrid groupers revealed that coinfections with V. harveyi strain GDH11385 (a serious lethal causative agent to groupers) and other isolated pathogens resulted in higher mortality (46.67%) than infection with strain GDH11385 alone (33.33%), whereas no mortality was observed in single infection with other pathogens. Furthermore, the intestine, liver and spleen of hybrid groupers are target organs for bacterial coinfections involving V. harveyi. Based on the infection patterns found in this study, we propose that V. harveyi may have a specific spatiotemporal expression pattern of virulence genes when infecting the host. Taken together, bacterial coinfection with V. harveyi is a neglected high-risk lethal causative agent to hybrid groupers in the industrialized flow-through aquaculture systems in Hainan Province.<\/jats:p>","DOI":"10.3390\/ijms231911628","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T22:19:27Z","timestamp":1665267567000},"page":"11628","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence of Bacterial Coinfections with Vibrio harveyi in the Industrialized Flow-through Aquaculture Systems in Hainan Province: A Neglected High-Risk Lethal Causative Agent to Hybrid Grouper"],"prefix":"10.3390","volume":"23","author":[{"given":"He","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Marine Resource Utilization in the South China Sea, Hainan University, Haikou 570228, China"},{"name":"Laboratory of Development and Utilization of Marine 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