{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:06:45Z","timestamp":1788952005026,"version":"build-2803163510"},"reference-count":42,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 108-2113-M-400-005"],"award-info":[{"award-number":["MOST 108-2113-M-400-005"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["109-2113-M-400-006"],"award-info":[{"award-number":["109-2113-M-400-006"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["109-2622-B-400-001"],"award-info":[{"award-number":["109-2622-B-400-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["110-2113-M-400-001"],"award-info":[{"award-number":["110-2113-M-400-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Hearth Research Institutes, Taiwan","award":["MOST 108-2113-M-400-005"],"award-info":[{"award-number":["MOST 108-2113-M-400-005"]}]},{"name":"National Hearth Research Institutes, Taiwan","award":["109-2113-M-400-006"],"award-info":[{"award-number":["109-2113-M-400-006"]}]},{"name":"National Hearth Research Institutes, Taiwan","award":["109-2622-B-400-001"],"award-info":[{"award-number":["109-2622-B-400-001"]}]},{"name":"National Hearth Research Institutes, Taiwan","award":["110-2113-M-400-001"],"award-info":[{"award-number":["110-2113-M-400-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>CXCR4 antagonists have been claimed to reduce mortality after myocardial infarction in myocardial infarction (MI) animals, presumably due to suppressing inflammatory responses caused by myocardial ischemia-reperfusion injury, thus, subsequently facilitating tissue repair and cardiac function recovery. This study aims to determine whether a newly designed CXCR4 antagonist DBPR807 could exert better vascular-protective effects than other clinical counterparts (e.g., AMD3100) to alleviate cardiac damage further exacerbated by reperfusion. Consequently, we find that instead of traditional continuous treatment or multiple-dose treatment at different intervals of time, a single-dose treatment of DBPR807 before reperfusion in MI animals could attenuate inflammation via protecting oxidative stress damage and preserve vascular\/capillary density and integrity via mobilizing endothelial progenitor cells, leading to a desirable fibrosis reduction and recovery of cardiac function, as evaluated with the LVEF (left ventricular ejection fraction) in infarcted hearts in rats and mini-pigs, respectively. Thus, it is highly suggested that CXCR4 antagonists should be given at a single high dose prior to reperfusion to provide the maximal cardiac functional improvement. Based on its favorable efficacy and safety profiles indicated in tested animals, DBPR807 has a great potential to serve as an adjunctive medicine for percutaneous coronary intervention (PCI) therapies in acute MI patients.<\/jats:p>","DOI":"10.3390\/ijms231911730","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T23:39:31Z","timestamp":1665272371000},"page":"11730","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Protective Effect of CXCR4 Antagonist DBPR807 against Ischemia-Reperfusion Injury in a Rat and Porcine Model of Myocardial Infarction: Potential Adjunctive Therapy for Percutaneous Coronary Intervention"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9101-1562","authenticated-orcid":false,"given":"Kai-Chia","family":"Yeh","sequence":"first","affiliation":[{"name":"Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Jui","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen-Shin","family":"Song","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Huang","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng-Kuang","family":"Yeh","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szu-Huei","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Chin","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Ting","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan-Yi","family":"Tseng","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Lung","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiung-Tong","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiing-Jyh","family":"Jan","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Chen","family":"Chou","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kak-Shan","family":"Shia","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0376-9862","authenticated-orcid":false,"given":"Kuang-Hsing","family":"Chiang","sequence":"additional","affiliation":[{"name":"Taipei Heart Institute, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Department of Cardiology, Taipei Medical University Hospital, Taipei 11031, Taiwan"},{"name":"Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 106319, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1093\/eurheartj\/ehab892","article-title":"European Society of Cardiology: Cardiovascular Disease Statistics 2021","volume":"43","author":"Timmis","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7018393","DOI":"10.1155\/2017\/7018393","article-title":"Ischemia\/Reperfusion Injury following Acute Myocardial Infarction: A Critical Issue for Clinicians and Forensic Pathologists","volume":"2017","author":"Neri","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1159\/000489241","article-title":"Current Mechanistic Concepts in Ischemia and Reperfusion Injury","volume":"46","author":"Wu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.jacc.2015.02.032","article-title":"Evolving Therapies for Myocardial Ischemia\/Reperfusion Injury","volume":"65","author":"Ibanez","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial Ischemia-Reperfusion Injury: A Neglected Therapeutic Target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0928-4680(03)00025-7","article-title":"Clinical Implications of Ischaemia-Reperfusion Injury","volume":"9","author":"Abela","year":"2003","journal-title":"Pathophysiology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial Reperfusion Injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_8","first-page":"761","article-title":"Pathogenesis of Myocardial Ischemia-Reperfusion Injury and Rationale for Therapy","volume":"37","author":"Turer","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1160\/TH07-01-0022","article-title":"Chemokines in Ischemia and Reperfusion","volume":"97","author":"Frangogiannis","year":"2007","journal-title":"Thromb. Haemost."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1161\/CIRCULATIONAHA.118.036053","article-title":"C-X-C Motif Chemokine Receptor 4 Blockade Promotes Tissue Repair after Myocardial Infarction by Enhancing Regulatory T Cell Mobilization and Immune-Regulatory Function","volume":"139","author":"Wang","year":"2019","journal-title":"Circulation"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Yu, S.J., Wu, K.J., Wang, Y.S., Song, J.S., Wu, C.H., Jan, J.J., Bae, E., Chen, H., Shia, K.S., and Wang, Y. (2020). Protective Effect of CXCR4 Antagonist CX807 in a Rat Model of Hemorrhagic Stroke. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197085"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3727\/096368916X693563","article-title":"A Novel CXCR4 Antagonist CX549 Induces Neuroprotection in Stroke Brain","volume":"26","author":"Wu","year":"2017","journal-title":"Cell Transplant."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1161\/hc2301.092122","article-title":"Mobilization of Endothelial Progenitor Cells in Patients with Acute Myocardial Infarction","volume":"103","author":"Shintani","year":"2001","journal-title":"Circulation"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.atherosclerosis.2011.02.014","article-title":"Are Endothelial Progenitor Cells Mobilized by Myocardial Ischemia or Myocardial Necrosis? A Cardiac Magnetic Resonance Study","volume":"216","author":"Porto","year":"2011","journal-title":"Atherosclerosis"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1182\/blood-2004-05-1831","article-title":"Increased Circulating Hematopoietic and Endothelial Progenitor Cells in the Early Phase of Acute Myocardial Infarction","volume":"105","author":"Massa","year":"2005","journal-title":"Blood"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.yjmcc.2015.01.005","article-title":"Mobilization of Endothelial Progenitor Cells in Acute Cardiovascular Events in the PROCELL Study: Time-Course after Acute Myocardial Infarction and Stroke","volume":"80","author":"Regueiro","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1161\/CIRCULATIONAHA.107.694992","article-title":"Stromal Cell-Derived Factor-1alpha is Cardioprotective after Myocardial Infarction","volume":"117","author":"Saxena","year":"2008","journal-title":"Circulation"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1161\/01.CIR.0000143161.01901.BD","article-title":"Cytokine-Induced Mobilization of Circulating Endothelial Progenitor Cells Enhances Repair of Injured Arteries","volume":"110","author":"Kong","year":"2004","journal-title":"Circulation"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1073\/pnas.97.7.3422","article-title":"Transplantation of ex vivo Expanded Endothelial Progenitor Cells for Therapeutic Neovascularization","volume":"97","author":"Kalka","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0301-472X(02)00867-6","article-title":"Determination of Bone Marrow-Derived Endothelial Progenitor Cell Significance in Angiogenic Growth Factor-Induced Neovascularization in vivo","volume":"30","author":"Murayama","year":"2002","journal-title":"Exp. Hematol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.3389\/fphys.2018.01940","article-title":"Velvet Antler Mobilizes Endothelial Progenitor Cells to Promote Angiogenesis and Repair Vascular Endothelial Injury in Rats Following Myocardial Infarction","volume":"9","author":"Li","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_22","first-page":"1091","article-title":"Increased Expression of Sonic Hedgehog Restores Diabetic Endothelial Progenitor Cells and Improves Cardiac Repair after Acute Myocardial Infarction in Diabetic Mice","volume":"44","author":"Xiao","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"11008","DOI":"10.1073\/pnas.0914248107","article-title":"CXCR4 Blockade Augments Bone Marrow Progenitor Cell Recruitment to the Neovasculature and Reduces Mortality after Myocardial Infarction","volume":"107","author":"Jujo","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.3727\/096368914X681739","article-title":"CXCR4 Antagonist TG-0054 Mobilizes Mesenchymal Stem Cells, Attenuates Inflammation, and Preserves Cardiac Systolic Function in a Porcine Model of Myocardial Infarction","volume":"24","author":"Hsu","year":"2015","journal-title":"Cell Transplant."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1161\/CIRCULATIONAHA.112.099242","article-title":"CXC-Chemokine Receptor 4 Antagonist AMD3100 Promotes Cardiac Functional Recovery after Ischemia\/Reperfusion Injury via Endothelial Nitric Oxide Synthase-Dependent Mechanism","volume":"127","author":"Jujo","year":"2013","journal-title":"Circulation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e2015433118","DOI":"10.1073\/pnas.2015433118","article-title":"A Highly Selective and Potent CXCR4 Antagonist for Hepatocellular Carcinoma Treatment","volume":"118","author":"Song","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Grdovi\u0107, N., Dini\u0107, S., Mihailovi\u0107, M., Uskokovi\u0107, A., Jovanovi\u0107, J.A., Poznanovi\u0107, G., Wagner, L., and Vidakovi\u0107, M. (2014). CXC Chemokine Ligand 12 Protects Pancreatic \u03b2-cells from Necrosis through Akt Kinase-Mediated Modulation of Poly(ADP-Ribose) Polymerase-1 Activity. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0101172"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s12307-013-0136-0","article-title":"Cysteine (C)-X-C Receptor 4 Regulates NADPH Oxidase-2 During Oxidative Stress in Prostate Cancer Cells","volume":"6","author":"Jones","year":"2013","journal-title":"Cancer Microenviron."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00109-013-1002-8","article-title":"Endothelial Progenitor Cell: A Blood Cell by Many Other Names May Serve Similar Functions","volume":"91","author":"Yoder","year":"2013","journal-title":"J. Mol. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1159\/000335285","article-title":"Granulocyte Colony-Stimulating Factor Reduces Hyperoxia-Induced Alveolarization Inhibition by Increasing Angiogenic Factors","volume":"101","author":"Lee","year":"2012","journal-title":"Neonatology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jvs.2008.08.077","article-title":"Limb Ischemia After Iliac Ligation in Aged Mice Stimulates Angiogenesis without Arteriogenesis","volume":"49","author":"Westvik","year":"2009","journal-title":"J. Vasc. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e88","DOI":"10.1161\/CIRCRESAHA.113.301162","article-title":"Visualizing Regional Myocardial Blood Flow in the Mouse","volume":"112","author":"Krueger","year":"2013","journal-title":"Circ. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"103990","DOI":"10.1016\/j.mvr.2020.103990","article-title":"Three-Dimensional Visualization of Coronary Microvasculature in Rats with Myocardial Infarction","volume":"130","author":"Liu","year":"2020","journal-title":"Microvasc. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1161\/CIRCHEARTFAILURE.108.814459","article-title":"Large Animal Models of Heart Failure: A Critical Link in the Translation of Basic Science to Clinical Practice","volume":"2","author":"Dixon","year":"2009","journal-title":"Circ. Heart Fail."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.pharmthera.2013.10.007","article-title":"Small and Large Animal Models in Cardiac Contraction Research: Advantages and Disadvantages","volume":"141","author":"Janssen","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1007\/s12350-015-0078-7","article-title":"Large Animal Models of Ischemic Cardiomyopathy: Are They Enough to Bridge the Translational Gap?","volume":"22","author":"Nguyen","year":"2015","journal-title":"J. Nucl. Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1874120701007010001","article-title":"Role of Endothelial Cells in Myocardial Ischemia-Reperfusion Injury","volume":"7","author":"Singhal","year":"2010","journal-title":"Vasc. Dis. Prev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.carpath.2005.03.006","article-title":"Myocardial Ischemia and Reperfusion Injury","volume":"14","author":"Buja","year":"2005","journal-title":"Cardiovasc. Pathol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1002\/med.21464","article-title":"Harnessing CXCR4 Antagonists in Stem Cell Mobilization, HIV infection, Ischemic Diseases and Oncology","volume":"38","author":"Tsou","year":"2018","journal-title":"Med. Res. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1021\/acs.jmedchem.7b01322","article-title":"Development of Stem Cell Mobilizing Agents Targeting CXCR4 Receptors for Peripheral Blood Stem Cell Transplantation and Beyond","volume":"61","author":"Wu","year":"2018","journal-title":"J. Med. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1021\/jm501769r","article-title":"Stem Cell Mobilizers Targeting Chemokine Receptor CXCR4: Renoprotective Application in Acute Kidney Injury","volume":"58","author":"Wu","year":"2015","journal-title":"J. Med. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s12276-021-00720-w","article-title":"Cu06-1004 Enhances Vascular Integrity and Improves Cardiac Remodeling by Suppressing Edema and Inflammation in Myocardial Ischemia\u2013Reperfusion Injury","volume":"54","author":"Zhang","year":"2022","journal-title":"Exp. Mol. Med."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/19\/11730\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:46:01Z","timestamp":1760143561000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/19\/11730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,3]]},"references-count":42,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["ijms231911730"],"URL":"https:\/\/doi.org\/10.3390\/ijms231911730","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,3]]}}}