{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:44:05Z","timestamp":1762069445545,"version":"build-2065373602"},"reference-count":103,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T00:00:00Z","timestamp":1664928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Institutes of Health","award":["R35 ES030443\u221201","P42 ES004699","R01MH106781"],"award-info":[{"award-number":["R35 ES030443\u221201","P42 ES004699","R01MH106781"]}]},{"name":"the National Institute of Environmental Health Sciences (NIEHS)","award":["R35 ES030443\u221201","P42 ES004699","R01MH106781"],"award-info":[{"award-number":["R35 ES030443\u221201","P42 ES004699","R01MH106781"]}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health (NIMH)","doi-asserted-by":"publisher","award":["R35 ES030443\u221201","P42 ES004699","R01MH106781"],"award-info":[{"award-number":["R35 ES030443\u221201","P42 ES004699","R01MH106781"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The metabolism of bioactive oxylipins by soluble epoxide hydrolase (sEH) plays an important role in inflammation, and sEH may be a risk modifier in various human diseases and disorders. The relationships that sEH has with the risk factors of these diseases remain elusive. Herein, sEH protein expression and activity in white blood cells were characterized before and after a high-fat meal in healthy women (HW) and women with anorexia nervosa (AN). sEH expression and sEH activity were significantly correlated and increased in both groups two hours after consumption of the study meal. Fasting sEH expression and activity were positively associated with body mass index (BMI) in both groups, while an inverse association with age was found in AN only (p value &lt; 0.05). sEH was not associated with anxiety or depression in either group at the fasting timepoint. While the anxiety score decreased after eating in both groups, a higher fasting sEH was associated with a lower postprandial anxiety decrease in HW (p value &lt; 0.05). sEH characterization using direct measurements verified the relationship between the protein expression and in vivo activity of this important oxylipin modulator, while a well-controlled food challenge study design using HW and a clinical control group of women with disordered eating elucidated sEH\u2019s role in the health of adult women.<\/jats:p>","DOI":"10.3390\/ijms231911798","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T23:39:31Z","timestamp":1665272371000},"page":"11798","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Soluble Epoxide Hydrolase Is Associated with Postprandial Anxiety Decrease in Healthy Adult Women"],"prefix":"10.3390","volume":"23","author":[{"given":"Nhien","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of California San Diego, San Diego, CA 92037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5672-6631","authenticated-orcid":false,"given":"Christophe","family":"Morisseau","sequence":"additional","affiliation":[{"name":"Department of Entomology and Nematology and Comprehensive Cancer Center, University of California, Davis, CA 95616, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Entomology and Nematology and Comprehensive Cancer Center, University of California, Davis, CA 95616, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8126-1728","authenticated-orcid":false,"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Entomology and Nematology and Comprehensive Cancer Center, University of California, Davis, CA 95616, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Lam","sequence":"additional","affiliation":[{"name":"Centre for Mental Health, University Health Network, Toronto, ON M5G 2C4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Blake","family":"Woodside","sequence":"additional","affiliation":[{"name":"Centre for Mental Health, University Health Network, Toronto, ON M5G 2C4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1408-8317","authenticated-orcid":false,"given":"Bruce D.","family":"Hammock","sequence":"additional","affiliation":[{"name":"Department of Entomology and Nematology and Comprehensive Cancer Center, University of California, Davis, CA 95616, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-an Betty","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of California San Diego, San Diego, CA 92037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.bbalip.2014.07.020","article-title":"Cytochrome P450 epoxygenase pathway of polyunsaturated fatty acid metabolism","volume":"1851","author":"Spector","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1126\/science.285.5431.1276","article-title":"Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids","volume":"285","author":"Node","year":"1999","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.plipres.2013.11.003","article-title":"Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer","volume":"53","author":"Zhang","year":"2014","journal-title":"Prog. Lipid Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"6402","DOI":"10.1016\/S0021-9258(18)53266-X","article-title":"Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase","volume":"268","author":"Zeldin","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1161\/01.RES.87.11.992","article-title":"Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids","volume":"87","author":"Yu","year":"2000","journal-title":"Circ. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fphar.2019.00036","article-title":"Role of Soluble Epoxide Hydrolase in Metabolism of PUFAs in Psychiatric and Neurological Disorders","volume":"10","author":"Hashimoto","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plipres.2004.10.001","article-title":"Epoxide hydrolases: Their roles and interactions with lipid metabolism","volume":"44","author":"Newman","year":"2005","journal-title":"Prog. Lipid Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1369\/jhc.5A6808.2005","article-title":"Cell-specific subcellular localization of soluble epoxide hydrolase in human tissues","volume":"54","author":"Enayetallah","year":"2006","journal-title":"J. Histochem. Cytochem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/oby.2009.227","article-title":"Expression and regulation of soluble epoxide hydrolase in adipose tissue","volume":"18","author":"Morisseau","year":"2010","journal-title":"Obesity"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"F720","DOI":"10.1152\/ajprenal.00165.2003","article-title":"Vascular localization of soluble epoxide hydrolase in the human kidney","volume":"286","author":"Yu","year":"2004","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/BF00332483","article-title":"Cytosolic epoxide hydrolase in humans: Development and tissue distribution","volume":"62","author":"Pacifici","year":"1988","journal-title":"Arch. Toxicol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0006-2952(80)90518-3","article-title":"Distribution and properties of a mammalian soluble epoxide hydrase","volume":"29","author":"Gill","year":"1980","journal-title":"Biochem. Pharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1177\/002215540405200403","article-title":"Distribution of soluble epoxide hydrolase and of cytochrome P450 2C8, 2C9, and 2J2 in human tissues","volume":"52","author":"Enayetallah","year":"2004","journal-title":"J. Histochem. Cytochem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1152\/physrev.00021.2011","article-title":"Epoxides and soluble epoxide hydrolase in cardiovascular physiology","volume":"92","author":"Imig","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_15","unstructured":"(2022, April 25). EPHX2 epoxide hydrolase 2 [Homo sapiens (human)], Available online: https:\/\/www.ncbi.nlm.nih.gov\/gene\/2053."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jnutbio.2017.07.006","article-title":"Postprandial effect to decrease soluble epoxide hydrolase activity: Roles of insulin and gut microbiota","volume":"49","author":"Yang","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1017\/jns.2019.11","article-title":"Addition of milk fat globule membrane-enriched supplement to a high-fat meal attenuates insulin secretion and induction of soluble epoxide hydrolase gene expression in the postprandial state in overweight and obese subjects","volume":"8","author":"Beals","year":"2019","journal-title":"J. Nutr. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.freeradbiomed.2021.05.029","article-title":"Genetic deficiency or pharmacological inhibition of soluble epoxide hydrolase ameliorates high fat diet-induced pancreatic \u03b2-cell dysfunction and loss","volume":"172","author":"Koike","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"778470","DOI":"10.3389\/fphar.2021.778470","article-title":"Soluble Epoxide Hydrolase Deletion Limits High-Fat Diet-Induced Inflammation","volume":"12","author":"Wagner","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"14189","DOI":"10.1074\/jbc.M113.458414","article-title":"Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue","volume":"288","author":"Bettaieb","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.3389\/fimmu.2018.02649","article-title":"Inflammatory Links Between High Fat Diets and Diseases","volume":"9","author":"Duan","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.immuni.2019.09.020","article-title":"Western Diet and the Immune System: An Inflammatory Connection","volume":"51","author":"Christ","year":"2019","journal-title":"Immunity"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/s12974-019-1635-9","article-title":"Genetic deletion of soluble epoxide hydrolase delays the progression of Alzheimer\u2019s disease","volume":"16","author":"Lee","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"E5815","DOI":"10.1073\/pnas.1802179115","article-title":"Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson\u2019s disease","volume":"115","author":"Ren","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1146\/annurev-pharmtox-011112-140244","article-title":"Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health","volume":"53","author":"Morisseau","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.pharmthera.2017.06.006","article-title":"Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases","volume":"180","author":"Wagner","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.mehy.2017.07.033","article-title":"The role of soluble epoxide hydrolase in preeclampsia","volume":"108","author":"Santos","year":"2017","journal-title":"Med. Hypotheses"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1002\/oby.23175","article-title":"Cardiovascular Disease Risk Factors by BMI and Age in United States Firefighters","volume":"29","author":"Bode","year":"2021","journal-title":"Obesity"},{"key":"ref_29","first-page":"389","article-title":"Managing cardiometabolic risk in primary care: Summary of the 2011 consensus statement","volume":"58","author":"Chatterjee","year":"2012","journal-title":"Can. Fam. Physician"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"R741","DOI":"10.1016\/j.cub.2012.07.024","article-title":"Ageing as a risk factor for disease","volume":"22","author":"Niccoli","year":"2012","journal-title":"Curr. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1177\/003335490712200412","article-title":"Age and race impact the association between BMI and CVD mortality in women","volume":"122","author":"Abell","year":"2007","journal-title":"Public Health Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"ref_33","unstructured":"National Cancer Institute (2022, May 01). Age and Cancer Risk, Available online: https:\/\/www.cancer.gov\/about-cancer\/causes-prevention\/risk\/age#:~:text=Age%20and%20Cancer%20Risk&text=The%20incidence%20rates%20for%20cancer,groups%2060%20years%20and%20older."},{"key":"ref_34","first-page":"291546","article-title":"Obesity as a major risk factor for cancer","volume":"2013","author":"Silvestris","year":"2013","journal-title":"J. Obes."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"9517","DOI":"10.1038\/s41598-019-46011-3","article-title":"Incidence and risk factors for Preeclampsia in a cohort of healthy nulliparous pregnant women: A nested case-control study","volume":"9","author":"Mayrink","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"182","DOI":"10.4103\/jpgm.JPGM_712_16","article-title":"Psychiatric disorders and obesity: A review of association studies","volume":"63","author":"Rajan","year":"2017","journal-title":"J. Postgrad. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/wps.20894","article-title":"Risk and protective factors for mental disorders beyond genetics: An evidence-based atlas","volume":"20","author":"Arango","year":"2021","journal-title":"World Psychiatry"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/wps.20193","article-title":"Prevalence of psychiatric disorders in U.S. older adults: Findings from a nationally representative survey","volume":"14","author":"Reynolds","year":"2015","journal-title":"World Psychiatry"},{"key":"ref_39","unstructured":"(2018). Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet, 392, 1923\u20131994."},{"key":"ref_40","first-page":"S13","article-title":"Obesity increases risk for diabetes","volume":"16","author":"Bray","year":"1992","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Hancock, A.M., Witonsky, D.B., Gordon, A.S., Eshel, G., Pritchard, J.K., Coop, G., and Di Rienzo, A. (2008). Adaptations to climate in candidate genes for common metabolic disorders. PLoS Genet., 4.","DOI":"10.1371\/journal.pgen.0040032"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5283","DOI":"10.1073\/pnas.1721711115","article-title":"Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation","volume":"115","author":"Wang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Khadir, A., Kavalakatt, S., Madhu, D., Cherian, P., Al-Mulla, F., Abubaker, J., and Tiss, A. (2020). Soluble Epoxide Hydrolase 2 Expression Is Elevated in Obese Humans and Decreased by Physical Activity. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21062056"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1073\/pnas.1422590112","article-title":"Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides","volume":"112","author":"Rius","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.yjmcc.2020.12.013","article-title":"Soluble epoxide hydrolase deficiency attenuates lipotoxic cardiomyopathy via upregulation of AMPK-mTORC mediated autophagy","volume":"154","author":"Wang","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"8431","DOI":"10.1073\/pnas.1916189117","article-title":"Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation","volume":"117","author":"Wang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Overby, H., Yang, Y., Xu, X., Graham, K., Hildreth, K., Choi, S., Wan, D., Morisseau, C., Zeldin, D.C., and Hammock, B.D. (2020). Soluble Epoxide Hydrolase Inhibition by t-TUCB Promotes Brown Adipogenesis and Reduces Serum Triglycerides in Diet-Induced Obesity. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197039"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Liu, Y., Dang, H., Li, D., Pang, W., Hammock, B.D., and Zhu, Y. (2012). Inhibition of soluble epoxide hydrolase attenuates high-fat-diet-induced hepatic steatosis by reduced systemic inflammatory status in mice. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0039165"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1194\/jlr.M053199","article-title":"Functional characterization of cytochrome P450-derived epoxyeicosatrienoic acids in adipogenesis and obesity","volume":"55","author":"Zha","year":"2014","journal-title":"J. Lipid Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.prostaglandins.2017.01.001","article-title":"Genetic deletion of soluble epoxide hydrolase provides cardioprotective responses following myocardial infarction in aged mice","volume":"132","author":"Jamieson","year":"2017","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.prostaglandins.2012.08.001","article-title":"Differential effects of soluble epoxide hydrolase inhibition and CYP2J2 overexpression on postischemic cardiac function in aged mice","volume":"104\u2013105","author":"Chaudhary","year":"2013","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_52","first-page":"290","article-title":"Soluble epoxide hydrolase gene deletion improves blood flow and reduces infarct size after cerebral ischemia in reproductively senescent female mice","volume":"5","author":"Zuloaga","year":"2014","journal-title":"Front. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1176\/appi.ajp.2009.09060881","article-title":"Association of Western and traditional diets with depression and anxiety in women","volume":"167","author":"Jacka","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ebiom.2017.02.020","article-title":"Nutritional Psychiatry: Where to Next?","volume":"17","author":"Jacka","year":"2017","journal-title":"EBioMedicine"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3389\/fnins.2019.00265","article-title":"Diet-Derived Fatty Acids, Brain Inflammation, and Mental Health","volume":"13","author":"Melo","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3109\/00048670903571598","article-title":"Associations between diet quality and depressed mood in adolescents: Results from the Australian Healthy Neighbourhoods Study","volume":"44","author":"Jacka","year":"2010","journal-title":"Aust. New Zealand J. Psychiatry"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1017\/S1368980011003077","article-title":"Is there any relationship between dietary patterns and depression and anxiety in Chinese adolescents?","volume":"15","author":"Weng","year":"2012","journal-title":"Public Health Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jad.2020.03.070","article-title":"Increased expression of soluble epoxide hydrolase in the brain and liver from patients with major psychiatric disorders: A role of brain\u2014Liver axis","volume":"270","author":"Zhang","year":"2020","journal-title":"J. Affect. Disord."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1016\/j.celrep.2019.11.006","article-title":"Liver Soluble Epoxide Hydrolase Regulates Behavioral and Cellular Effects of Chronic Stress","volume":"29","author":"Qin","year":"2019","journal-title":"Cell Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.1523\/JNEUROSCI.3069-18.2019","article-title":"Astrocytic Epoxyeicosatrienoic Acid Signaling in the Medial Prefrontal Cortex Modulates Depressive-like Behaviors","volume":"39","author":"Xiong","year":"2019","journal-title":"J. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1002\/jnr.24080","article-title":"The effects of sEH inhibitor on depression-like behavior and neurogenesis in male mice","volume":"95","author":"Wu","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1007\/s12035-018-1261-z","article-title":"Genetic Deletion of Soluble Epoxide Hydroxylase Causes Anxiety-Like Behaviors in Mice","volume":"56","author":"Lee","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"E375","DOI":"10.1152\/ajpendo.00131.2009","article-title":"Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase","volume":"297","author":"Luria","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"E1944","DOI":"10.1073\/pnas.1601532113","article-title":"Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress","volume":"113","author":"Ren","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1194\/jlr.R800038-JLR200","article-title":"Arachidonic acid cytochrome P450 epoxygenase pathway","volume":"50","author":"Spector","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.plefa.2016.05.004","article-title":"Regulation of rat plasma and cerebral cortex oxylipin concentrations with increasing levels of dietary linoleic acid","volume":"138","author":"Taha","year":"2018","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1194\/jlr.M300463-JLR200","article-title":"Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides","volume":"45","author":"Potin","year":"2004","journal-title":"J. Lipid Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.biochi.2019.01.020","article-title":"Role of epoxy-fatty acids and epoxide hydrolases in the pathology of neuro-inflammation","volume":"159","author":"Kodani","year":"2019","journal-title":"Biochimie"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-3-030-50621-6_5","article-title":"Epoxy Fatty Acids Are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation","volume":"1274","author":"McReynolds","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"105149","DOI":"10.1016\/j.psyneuen.2021.105149","article-title":"Serum soluble epoxide hydrolase related oxylipins and major depression in patients with type 2 diabetes","volume":"126","author":"Anita","year":"2021","journal-title":"Psychoneuroendocrinology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1177\/0004867411432071","article-title":"The comorbidity between eating disorders and anxiety disorders: Prevalence in an eating disorder sample and anxiety disorder sample","volume":"46","author":"Swinbourne","year":"2012","journal-title":"Aust. New Zealand J. Psychiatry"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1176\/appi.ajp.161.12.2215","article-title":"Comorbidity of anxiety disorders with anorexia and bulimia nervosa","volume":"161","author":"Kaye","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0924-9338(00)00212-1","article-title":"Anxiety disorders in anorexia nervosa and bulimia nervosa: Co-morbidity and chronology of appearance","volume":"15","author":"Godart","year":"2000","journal-title":"Eur. Psychiatry"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1600-0447.1997.tb09913.x","article-title":"Eating disorders and antecedent anxiety disorders: A controlled study","volume":"96","author":"Bulik","year":"1997","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1097\/NMD.0000000000000194","article-title":"The impact of comorbid depressive and anxiety disorders on severity of anorexia nervosa in adolescent girls","volume":"202","author":"Leor","year":"2014","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.jpsychires.2013.02.011","article-title":"Factors associated with recovery from anorexia nervosa","volume":"47","author":"Zerwas","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1097\/00004583-199209000-00006","article-title":"Psychiatric comorbidity in treatment-seeking anorexics and bulimics","volume":"31","author":"Herzog","year":"1992","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1001\/archpsyc.1991.01810320036006","article-title":"Comorbidity of psychiatric diagnoses in anorexia nervosa","volume":"48","author":"Halmi","year":"1991","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"13281","DOI":"10.1074\/jbc.272.20.13281","article-title":"Intracellular location of thymidylate synthase and its state of phosphorylation","volume":"272","author":"Samsonoff","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"8977","DOI":"10.1073\/pnas.88.20.8977","article-title":"Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase","volume":"88","author":"Chu","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/oby.21692","article-title":"Lipidomic profiling of high-fat diet-induced obesity in mice: Importance of cytochrome P450-derived fatty acid epoxides","volume":"25","author":"Wang","year":"2017","journal-title":"Obesity"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.prostaglandins.2016.11.003","article-title":"Effects of high-fat diet on plasma profiles of eicosanoid metabolites in mice","volume":"127","author":"Wang","year":"2016","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_83","unstructured":"Yang, J., Hammock, B.D., Halmi, K., Woodside, B., German, B., Schork, N., Bailer, U.F., Kaye, W., Morisseau, C., and Shih, P.-A.B. (2015). Substrate-Dependent Postprandial Oxylipin Responses Revealed Evidence of Nutrient-Gene Interaction in Anorexia Nervosa. Neuropsychopharmacology, Nature Publishing Group. Nature Publishing Group Macmillan Building, 4 CRINAN ST."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Micali, N., Martini, M.G., Thomas, J.J., Eddy, K.T., Kothari, R., Russell, E., Bulik, C.M., and Treasure, J. (2017). Lifetime and 12-month prevalence of eating disorders amongst women in mid-life: A population-based study of diagnoses and risk factors. BMC Med., 15.","DOI":"10.1186\/s12916-016-0766-4"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jadohealth.2019.08.032","article-title":"What Are the Effects of Restrictive Eating Disorders on Growth and Puberty and Are Effects Permanent? A Systematic Review and Meta-Analysis","volume":"66","author":"Neale","year":"2020","journal-title":"J. Adolesc. Health"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nrendo.2016.175","article-title":"The endocrine manifestations of anorexia nervosa: Mechanisms and management","volume":"13","author":"Schorr","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1210\/er.2018-00063","article-title":"Effects of Anorexia Nervosa on Bone Metabolism","volume":"39","author":"Fazeli","year":"2018","journal-title":"Endocr. Rev."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.3389\/fphar.2018.01222","article-title":"Sexually Dimorphic Regulation of EET Synthesis and Metabolism: Roles of Estrogen","volume":"9","author":"Huang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1073\/pnas.1716016115","article-title":"Estrogen-dependent epigenetic regulation of soluble epoxide hydrolase via DNA methylation","volume":"115","author":"Yang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.2741\/2889","article-title":"Soluble epoxide hydrolase: Regulation by estrogen and role in the inflammatory response to cerebral ischemia","volume":"13","author":"Koerner","year":"2008","journal-title":"Front. Biosci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/mp.2013.91","article-title":"Evidence for the role of EPHX2 gene variants in anorexia nervosa","volume":"19","author":"Bloss","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"ref_92","unstructured":"Terlizzi EP, S.J. (2021). Estimates of Mental Health Symptomatology, by Month of Interview: United States, 2019, National Center for Health Statistics."},{"key":"ref_93","unstructured":"U.S. Census Bureau (2021). Household Pulse Survey, 2020\u20132021, National Center for Health Statistics."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3389\/fpsyt.2018.00444","article-title":"Interoceptive Anxiety and Body Representation in Anorexia Nervosa","volume":"9","author":"Khalsa","year":"2018","journal-title":"Front. Psychiatry"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1600-0447.2007.00966.x","article-title":"Epidemiology of subtypes of depression","volume":"115","author":"Kessing","year":"2007","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.4238\/2015.April.15.11","article-title":"Relationship between EPHX2 gene polymorphisms and essential hypertension in Uygur, Kazakh, and Han","volume":"14","author":"Zhu","year":"2015","journal-title":"Genet. Mol. Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1161\/CIRCGENETICS.113.000303","article-title":"Cytochrome p450 gene variants, race, and mortality among clopidogrel-treated patients after acute myocardial infarction","volume":"7","author":"Cresci","year":"2014","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1093\/hmg\/ddl085","article-title":"Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study","volume":"15","author":"Lee","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1369\/jhc.2008.950659","article-title":"Distribution and expression of soluble epoxide hydrolase in human brain","volume":"56","author":"Sura","year":"2008","journal-title":"J. Histochem. Cytochem."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Lee, A.R., Pechenino, A.S., Dong, H., Hammock, B.D., and Knowlton, A.A. (2013). Aging, estrogen loss and epoxyeicosatrienoic acids (EETs). PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0070719"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0006-2952(95)00167-X","article-title":"Differential regulation of soluble epoxide hydrolase by clofibrate and sexual hormones in the liver and kidneys of mice","volume":"50","author":"Pinot","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"6248","DOI":"10.1021\/acs.analchem.7b01247","article-title":"Nanobody Based Immunoassay for Human Soluble Epoxide Hydrolase Detection Using Polymeric Horseradish Peroxidase (PolyHRP) for Signal Enhancement: The Rediscovery of PolyHRP?","volume":"89","author":"Li","year":"2017","journal-title":"Anal. Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1006\/abio.1995.1520","article-title":"Improved radiolabeled substrates for soluble epoxide hydrolase","volume":"231","author":"Borhan","year":"1995","journal-title":"Anal. Biochem."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/19\/11798\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:46:35Z","timestamp":1760143595000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/19\/11798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,5]]},"references-count":103,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["ijms231911798"],"URL":"https:\/\/doi.org\/10.3390\/ijms231911798","relation":{},"ISSN":["1422-0067"],"issn-type":[{"type":"electronic","value":"1422-0067"}],"subject":[],"published":{"date-parts":[[2022,10,5]]}}}