{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T16:47:18Z","timestamp":1780764438367,"version":"3.54.1"},"reference-count":102,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Russian Ministry of Science and High Education","award":["075-15-2020-801"],"award-info":[{"award-number":["075-15-2020-801"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The search for strategies for strengthening the synaptic efficiency in A\u03b225-35-treated slices is a challenge for the compensation of amyloidosis-related pathologies. Here, we used the recording of field excitatory postsynaptic potentials (fEPSPs), nitric oxide (NO) imaging, measurements of serine\/threonine protein phosphatase (STPP) activity, and the detection of the functional mitochondrial parameters in suspension of brain mitochondria to study the A\u03b225-35-associated signaling in the hippocampus. A\u03b225-35 aggregates shifted the kinase\u2013phosphatase balance during the long-term potentiation (LTP) induction in the enhancement of STPP activity. The PP1\/PP2A inhibitor, okadaic acid, but not the PP2B blocker, cyclosporin A, prevented A\u03b225-35-dependent LTP suppression for both simultaneous and delayed enzyme blockade protocols. STPP activity in the A\u03b225-35-treated slices was upregulated, which is reverted relative to the control values in the presence of PP1\/PP2A but not in the presence of the PP2B blocker. A selective inhibitor of stress-induced PP1\u03b1, sephin1, but not of the PP2A blocker, cantharidin, is crucial for A\u03b225-35-mediated LTP suppression prevention. A mitochondrial Na+\/Ca2+ exchanger (mNCX) blocker, CGP37157, also attenuated the A\u03b225-35-induced LTP decline. A\u03b225-35 aggregates did not change the mitochondrial transmembrane potential or reactive oxygen species (ROS) production but affected the ion transport and Ca2+-dependent swelling of organelles. The staining of hippocampal slices with NO-sensitive fluorescence dye, DAF-FM, showed stimulation of the NO production in the A\u03b225-35-pretreated slices at the dendrite-containing regions of CA1 and CA3, in the dentate gyrus (DG), and in the CA1\/DG somata. NO scavenger, PTIO, or nNOS blockade by selective inhibitor 3Br-7NI partly restored the A\u03b225-35-induced LTP decline. Thus, hippocampal NO production could be another marker for the impairment of synaptic plasticity in amyloidosis-related states, and kinase\u2013phosphatase balance management could be a promising strategy for the compensation of A\u03b225-35-driven deteriorations.<\/jats:p>","DOI":"10.3390\/ijms231911848","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T23:39:31Z","timestamp":1665272371000},"page":"11848","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Amyloid A\u03b225-35 Aggregates Say \u2018NO\u2019 to Long-Term Potentiation in the Hippocampus through Activation of Stress-Induced Phosphatase 1 and Mitochondrial Na+\/Ca2+ Exchanger"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2836-336X","authenticated-orcid":false,"given":"Alexander V.","family":"Maltsev","sequence":"first","affiliation":[{"name":"Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Butlerova 5A, 117485 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4095-6560","authenticated-orcid":false,"given":"Anna B.","family":"Nikiforova","sequence":"additional","affiliation":[{"name":"Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, Pushchino, 142290 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5894-9548","authenticated-orcid":false,"given":"Natalia V.","family":"Bal","sequence":"additional","affiliation":[{"name":"Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Butlerova 5A, 117485 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9248-8207","authenticated-orcid":false,"given":"Pavel M.","family":"Balaban","sequence":"additional","affiliation":[{"name":"Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Butlerova 5A, 117485 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. 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