{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:36:46Z","timestamp":1790177806629,"version":"4.1.0"},"reference-count":69,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chung-Ang University industry Academic Cooperation Foundation","award":["202110956"],"award-info":[{"award-number":["202110956"]}]},{"name":"Ju Yeong NS Co., Ltd. (Korea, Seoul)","award":["202110956"],"award-info":[{"award-number":["202110956"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Fish-derived collagen has recently emerged as an alternative collagen source with bioactive properties, including the enhancement of hair and skin health. It is also cost-effective and has high bioavailability, in addition to having fewer side-effects compared to collagen from porcine skin or bovine skin. Collagen peptides (CPs) extracted from the scales of Mozambique tilapia (Oreochromis mossambicus) reportedly promote hair and skin health. This study sought to evaluate the effects of CPs on hair growth using in vitro and in vivo models. CP significantly enhanced hair regrowth and the proliferation of human dermal papilla cells (hDPCs) in vitro. CP was orally administered to C57BL\/6 mice for 6 weeks to confirm the hair-growth-promoting effects. The mice were divided into four groups: negative control (distilled water), positive control (1 mg\/kg of finasteride), CP500 (500 mg\/kg of CP), and CP1000 (1000 mg\/kg of CP). CP treatment significantly enhanced the proliferation of hDPCs compared to 0.2 \u03bcM finasteride, in addition to enhancing hair regrowth. Particularly, CP1000 treatment achieved a hair-growth index similar to that of the PC. In H&amp;E staining, the CP groups exhibited a high A\/T ratio. Furthermore, CP increased the expression of hair growth factors (IGF-1, VEGF, krt27, Gprc5d, and Ki67) and decreased the growth inhibitory factor (TGF-\u03b21). Furthermore, CP significantly upregulated the Wnt\/\u03b2-catenin pathways and downregulated the BMP pathways. Therefore, these results indicate that CP could be used as food supplements and nutraceuticals for hair loss prevention as well as hair regrowth during alopecia.<\/jats:p>","DOI":"10.3390\/ijms231911904","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T23:39:31Z","timestamp":1665272371000},"page":"11904","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Hair-Growth-Promoting Effects of the Fish Collagen Peptide in Human Dermal Papilla Cells and C57BL\/6 Mice Modulating Wnt\/\u03b2-Catenin and BMP Signaling Pathways"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7266-3530","authenticated-orcid":false,"given":"Su Bin","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition, Chung-Ang University, Anseong 17546, Gyeonggi, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5698-6775","authenticated-orcid":false,"given":"Hyeon Ju","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Chung-Ang University, Anseong 17546, Gyeonggi, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5021-5881","authenticated-orcid":false,"given":"Bog-Hieu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Chung-Ang University, Anseong 17546, Gyeonggi, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Park, S., and Lee, J. (2021). Modulation of Hair Growth Promoting Effect by Natural Products. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13122163"},{"key":"ref_2","first-page":"94","article-title":"Hair loss: A review of the role of food bioactive compounds","volume":"2","author":"Wei","year":"2019","journal-title":"Bioact. Compd. Health Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1152\/physrev.2001.81.1.449","article-title":"Controls of hair follicle cycling","volume":"81","author":"Stenn","year":"2001","journal-title":"Physiol. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1432-0436.2004.07209004.x","article-title":"In search of the \u201chair cycle clock\u201d: A guided tour","volume":"72","author":"Paus","year":"2004","journal-title":"Differentiation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.14405\/kjvr.2016.56.2.97","article-title":"Hair growth promoting effects of emodin in telogenic C57BL\/6 mice","volume":"56","author":"Yon","year":"2016","journal-title":"Korean J. Vet. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"593","DOI":"10.4155\/tde-2018-0025","article-title":"Nanotechnology advances for hair loss","volume":"9","author":"Pereira","year":"2018","journal-title":"Ther. Deliv."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/jocd.12051","article-title":"Hair loss and herbs for treatment","volume":"12","author":"Lourith","year":"2013","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11934-018-0814-z","article-title":"The Impact of 5\u03b1-Reductase inhibitor use for male pattern hair loss on men\u2019s health","volume":"19","author":"Said","year":"2018","journal-title":"Curr. Urol. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e13059","DOI":"10.1111\/dth.13059","article-title":"Physiopathology and current treatments of androgenetic alopecia: Going beyond androgens and anti-androgens","volume":"32","author":"Katzer","year":"2019","journal-title":"Dermatol. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1159\/000369830","article-title":"Effects of food-derived collagen peptides on the expression of keratin and keratin-associated protein genes in the Mouse Skin","volume":"28","author":"Takatori","year":"2015","journal-title":"Ski. Pharmacol. Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-017-1624-4","article-title":"Hair growth-promoting effect of Geranium sibiricum extract in human dermal papilla cells and C57BL\/6 mice","volume":"17","author":"Boisvert","year":"2017","journal-title":"BMC Complementary Altern. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"111793","DOI":"10.1016\/j.biopha.2021.111793","article-title":"Liposomal honokiol promotes hair growth via activating Wnt3a\/\u03b2-catenin signaling pathway and down regulating TGF-\u03b21 in C57BL\/6N mice","volume":"141","author":"Li","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1046\/j.1523-1747.2003.12174.x","article-title":"Identification of androgen-inducible TGF-\u03b21 derived from dermal papilla cells as a key mediator in androgenetic alopecia","volume":"8","author":"Inui","year":"2003","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3906\/vet-1310-35","article-title":"Expression of the GPRC5D gene in Liaoning Cashmere goats","volume":"38","author":"Jin","year":"2014","journal-title":"Turk. J. Vet. Anim. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Ahn, S., Lee, J.Y., Choi, S.M., Shin, Y., and Park, S. (2020). A Mixture of Tocopherol Acetate and L-Menthol Synergistically Promotes Hair Growth in C57BL\/6 Mice. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12121234"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4103\/0974-7753.96908","article-title":"The germinative epithelium of sheep vibrissae and wool follicles has extensive proliferative potential but is dependent on the dermal papilla","volume":"4","author":"Rufaut","year":"2012","journal-title":"Int. J. Trichology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.2174\/1381612824666180911114810","article-title":"Medicinal plants for the treatment of hair loss and the suggested mechanisms","volume":"24","author":"Shen","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Choi, B.Y. (2018). Hair-growth potential of ginseng and its major metabolites: A review on its molecular mechanisms. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092703"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1365-2230.2011.04019.x","article-title":"Wnt10b promotes growth of hair follicles via a canonical Wnt signalling pathway","volume":"36","author":"Li","year":"2011","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1038\/jid.2012.24","article-title":"Dickkopf 1 promotes regression of hair follicles","volume":"132","author":"Kwack","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/jid.2012.235","article-title":"Adenovirus-mediated Wnt10b overexpression induces hair follicle regeneration","volume":"133","author":"Li","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"ref_22","first-page":"1","article-title":"Wnt10b promotes hair follicles growth and dermal papilla cells proliferation via Wnt\/\u03b2-Catenin signaling pathway in Rex rabbits","volume":"40","author":"Wu","year":"2020","journal-title":"Biosci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1432-0436.2004.07209005.x","article-title":"BMP signaling in the control of skin development and hair follicle growth","volume":"72","author":"Botchkarev","year":"2004","journal-title":"Differentiation"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12964-019-0330-x","article-title":"The balance of Bmp6 and Wnt10b regulates the telogen-anagen transition of hair follicles","volume":"17","author":"Wu","year":"2019","journal-title":"Cell Commun. Signal."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Abe, Y., and Tanaka, N. (2017). Roles of the hedgehog signaling pathway in epidermal and hair follicle development, homeostasis, and cancer. J. Dev. Biol., 5.","DOI":"10.3390\/jdb5040012"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/jid.2012.38","article-title":"New activators and inhibitors in the hair cycle clock: Targeting stem cells\u2019 state of competence","volume":"132","author":"Plikus","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1159\/000351376","article-title":"Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: A double-blind, placebo-controlled study","volume":"27","author":"Proksch","year":"2014","journal-title":"Ski. Pharmacol. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Aguirre-Cruz, G., Le\u00f3n-L\u00f3pez, A., Cruz-G\u00f3mez, V., Jim\u00e9nez-Alvarado, R., and Aguirre-\u00c1lvarez, G. (2020). Collagen hydrolysates for skin protection: Oral administration and topical formulation. Antioxidants, 9.","DOI":"10.3390\/antiox9020181"},{"key":"ref_29","first-page":"134","article-title":"The oral intake of specific Bioactive Collagen Peptides has a positive effect on hair thickness","volume":"1","author":"Oesser","year":"2020","journal-title":"Int. J. Nutraceuticals Funct. Foods Nov. Foods"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.jff.2018.08.006","article-title":"Effects of oral administration of peptides with low molecular weight from Alaska Pollock (Theragra chalcogramma) on cutaneous wound healing","volume":"48","author":"Yang","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1271\/bbb.80649","article-title":"Effects of collagen peptide ingestion on UV-B-induced skin damage","volume":"73","author":"Tanaka","year":"2009","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_32","first-page":"611","article-title":"The effect of collagen peptide intake on UVB-induced skin damage in hairless mice","volume":"17","author":"Shin","year":"2016","journal-title":"J. Korea Acad.-Ind. Coop. Soc."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Kang, M.C., Yumnam, S., and Kim, S.Y. (2018). Oral intake of collagen peptide attenuates ultraviolet B irradiation-induced skin dehydration in vivo by regulating hyaluronic acid synthesis. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113551"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/j.foodhyd.2011.02.007","article-title":"Functional and bioactive properties of collagen and gelatin from alternative sources: A review","volume":"25","author":"Montero","year":"2011","journal-title":"Food Hydrocoll."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Rahman, A., and Silva, T.H. (2022). Collagens from marine organisms towards biomedical applications. Mar. Drugs, 20.","DOI":"10.3390\/md20030170"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.jaad.2020.06.1009","article-title":"Oral minoxidil treatment for hair loss: A review of efficacy and safety","volume":"84","author":"Randolph","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1021\/jf802785h","article-title":"Effect of prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin","volume":"57","author":"Shigemura","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1016\/j.lfs.2005.03.016","article-title":"Investigation of jumbo squid (Dosidicus gigas) skin gelatin peptides for their in vitro antioxidant effects","volume":"77","author":"Mendis","year":"2005","journal-title":"Life Sci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Hu, Z., Yang, P., Zhou, C., Li, S., and Hong, P. (2017). Marine collagen peptides from the skin of Nile Tilapia (Oreochromis niloticus): Characterization and wound healing evaluation. Mar. Drugs, 15.","DOI":"10.3390\/md15040102"},{"key":"ref_40","first-page":"002","article-title":"A nutritional supplement formulated with peptides, lipids, collagen and hyaluronic acid optimizes key aspects of physical appearance in nails, hair and skin","volume":"5","author":"Yagoda","year":"2014","journal-title":"J. Nutr Food Sci. S"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1177\/0963689717741139","article-title":"Effect of Cinnamomum osmophloeum Kanehira leaf aqueous extract on dermal papilla cell proliferation and hair growth","volume":"27","author":"Wen","year":"2018","journal-title":"Cell Transplant."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40543-019-0178-0","article-title":"The effect of Lactobacillus plantarum hydrolysates promoting VEGF production on vascular growth and hair growth of C57BL\/6 mice","volume":"10","author":"Woo","year":"2019","journal-title":"J. Anal. Sci. Technol."},{"key":"ref_43","first-page":"9","article-title":"Ethanol extract of medicinal herbal mixture accelerates hair growth and melanogenesis in vivo and in vitro","volume":"33","author":"Kim","year":"2018","journal-title":"Korea J. Herbol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e4297","DOI":"10.1097\/MD.0000000000004297","article-title":"An investigation of crosstalk between Wnt\/\u03b2-catenin and transforming growth factor-\u03b2 signaling in androgenetic alopecia","volume":"95","author":"Lu","year":"2016","journal-title":"Medicine"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1046\/j.0022-202x.2001.01670.x","article-title":"Molecular mechanisms regulating hair follicle development","volume":"118","author":"Millar","year":"2002","journal-title":"J. Investig. Dermatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/9054514","article-title":"Promotion of hair growth by conditioned medium from extracellular matrix\/stromal vascular fraction gel in C57BL\/6 Mice","volume":"2020","author":"Xiao","year":"2020","journal-title":"Stem Cells Int."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s11655-017-2755-7","article-title":"Effect of Miscanthus sinensis var. purpurascens flower extract on proliferation and molecular regulation in human dermal papilla cells and stressed C57BL\/6 mice","volume":"24","author":"Jeong","year":"2018","journal-title":"Chin. J. Integr. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.jep.2011.12.010","article-title":"5\u03b1-reductase inhibition and hair growth promotion of some Thai plants traditionally used for hair treatment","volume":"139","author":"Kumar","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.0022-202x.2001.01377.x","article-title":"A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages","volume":"117","author":"Foitzik","year":"2001","journal-title":"J. Investig. Dermatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.biopha.2017.02.036","article-title":"Hair growth promoting effect of white wax and policosanol from white wax on the mouse model of testosterone-induced hair loss","volume":"89","author":"Feng","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/sj.jid.5700999","article-title":"Dihydrotestosterone-inducible dickkopf 1 from balding dermal papilla cells causes apoptosis in follicular keratinocytes","volume":"128","author":"Kwack","year":"2008","journal-title":"J. Investig. Dermatol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/exd.12024","article-title":"Androgen actions on the human hair follicle: Perspectives","volume":"22","author":"Inui","year":"2013","journal-title":"Exp. Dermatol."},{"key":"ref_53","first-page":"1","article-title":"Hair Growth Promotion Effect of Nelumbinis Semen Extract with High Antioxidant Activity","volume":"2021","author":"Park","year":"2021","journal-title":"Evid.-Based Complementary Altern. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1346-8138.2010.00827.x","article-title":"Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts","volume":"37","author":"Ohara","year":"2010","journal-title":"J. Dermatol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Kim, D.-U., Chung, H.-C., Choi, J., Sakai, Y., and Lee, B.-Y. (2018). Oral intake of low-molecular-weight collagen peptide improves hydration, elasticity, and wrinkling in human skin: A randomized, double-blind, placebo-controlled study. Nutrients, 10.","DOI":"10.3390\/nu10070826"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Ito, N., Seki, S., and Ueda, F. (2018). Effects of composite supplement containing collagen peptide and ornithine on skin conditions and plasma IGF-1 levels\u2014A randomized, double-blind, placebo-controlled trial. Mar. Drugs, 16.","DOI":"10.3390\/md16120482"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1046\/j.0022-202X.2004.12628.x","article-title":"The RAIG family member, GPRC5D, is associated with hard-keratinized structures","volume":"122","author":"Inoue","year":"2004","journal-title":"J. Investig. Dermatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1038\/sj.jid.5700494","article-title":"K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle","volume":"126","author":"Langbein","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1016\/j.yexcr.2007.02.032","article-title":"Hair follicle-specific keratins and their diseases","volume":"313","author":"Schweizer","year":"2007","journal-title":"Exp. Cell Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"144968","DOI":"10.1016\/j.gene.2020.144968","article-title":"Comparative investigation of coarse and fine wool sheep skin indicates the early regulators for skin and wool diversity","volume":"758","author":"Li","year":"2020","journal-title":"Gene"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1080\/13880209.2020.1759654","article-title":"Hair growth potential of Salvia plebeia extract and its associated mechanisms","volume":"58","author":"Jin","year":"2020","journal-title":"Pharm. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.3389\/fphar.2019.01528","article-title":"Dihydrotestosterone regulates hair growth through the Wnt\/\u03b2-catenin pathway in C57BL\/6 mice and in vitro organ culture","volume":"10","author":"Chen","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/11078","article-title":"Noggin is a mesenchymally derived stimulator of hair-follicle induction","volume":"1","author":"Botchkarev","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7181\/acfs.2013.14.1.1","article-title":"Effect of seaweed extract on hair growth promotion in experimental study of C57BL\/6 mice","volume":"14","author":"Ha","year":"2013","journal-title":"Arch. Craniofacial Surg."},{"key":"ref_65","first-page":"138","article-title":"Effect of Yikgeebohyul-tang (Yiqib\u01d4xu\u00e8-tang) on Hair Regrowth and Cytokine Changes on Hair-Removed C57BL\/6 Mice","volume":"31","author":"Hong","year":"2010","journal-title":"J. Korean Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.fct.2010.02.036","article-title":"Hair growth promoting effect of Zizyphus jujuba essential oil","volume":"48","author":"Yoon","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/ptr.5324","article-title":"The androgenic alopecia protective effects of forsythiaside-A and the molecular regulation in a mouse model","volume":"29","author":"Shin","year":"2015","journal-title":"Phytother. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1002\/ptr.4870","article-title":"Hair growth activity of Crataegus pinnatifida on C57BL\/6 mouse model","volume":"27","author":"Shin","year":"2013","journal-title":"Phytother. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ejphar.2014.02.024","article-title":"The inductive effect of ginsenoside F2 on hair growth by altering the WNT signal pathway in telogen mouse skin","volume":"730","author":"Shin","year":"2014","journal-title":"Eur. J. Pharmacol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/19\/11904\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:47:42Z","timestamp":1760143662000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/19\/11904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,7]]},"references-count":69,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["ijms231911904"],"URL":"https:\/\/doi.org\/10.3390\/ijms231911904","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,7]]}}}