{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:53:00Z","timestamp":1791287580602,"version":"4.1.0"},"reference-count":141,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Chongqing","award":["2021ycjh-bgzxm0169"],"award-info":[{"award-number":["2021ycjh-bgzxm0169"]}]},{"name":"Natural Science Foundation of Chongqing","award":["cstc2021jcyj-cxttX0002cstc"],"award-info":[{"award-number":["cstc2021jcyj-cxttX0002cstc"]}]},{"name":"Natural Science Foundation of Chongqing","award":["2021LZXNYD-D08"],"award-info":[{"award-number":["2021LZXNYD-D08"]}]},{"name":"Natural Science Foundation of Chongqing","award":["2021ZKZD011"],"award-info":[{"award-number":["2021ZKZD011"]}]},{"name":"The Joint foundation of Luzhou Government and Southwest Medical University","award":["2021ycjh-bgzxm0169"],"award-info":[{"award-number":["2021ycjh-bgzxm0169"]}]},{"name":"The Joint foundation of Luzhou Government and Southwest Medical University","award":["cstc2021jcyj-cxttX0002cstc"],"award-info":[{"award-number":["cstc2021jcyj-cxttX0002cstc"]}]},{"name":"The Joint foundation of Luzhou Government and Southwest Medical University","award":["2021LZXNYD-D08"],"award-info":[{"award-number":["2021LZXNYD-D08"]}]},{"name":"The Joint foundation of Luzhou Government and Southwest Medical University","award":["2021ZKZD011"],"award-info":[{"award-number":["2021ZKZD011"]}]},{"name":"Scientific Research Foundation of Southwest Medical University","award":["2021ycjh-bgzxm0169"],"award-info":[{"award-number":["2021ycjh-bgzxm0169"]}]},{"name":"Scientific Research Foundation of Southwest Medical University","award":["cstc2021jcyj-cxttX0002cstc"],"award-info":[{"award-number":["cstc2021jcyj-cxttX0002cstc"]}]},{"name":"Scientific Research Foundation of Southwest Medical University","award":["2021LZXNYD-D08"],"award-info":[{"award-number":["2021LZXNYD-D08"]}]},{"name":"Scientific Research Foundation of Southwest Medical University","award":["2021ZKZD011"],"award-info":[{"award-number":["2021ZKZD011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The advancement in high-throughput sequencing analysis and the evaluation of chromatin state maps have revealed that eukaryotic cells produce many non-coding transcripts\/RNAs. Further, a strong association was observed between some non-coding RNAs and cancer development. The mitogen-activated protein kinases (MAPK) belong to the serine\u2013threonine kinase family and are the primary signaling pathways involved in cell proliferation from the cell surface to the nucleus. They play an important role in various human diseases. A few non-coding RNAs associated with the MAPK signaling pathway play a significant role in the development of several malignancies, including liver cancer. In this review, we summarize the molecular mechanisms and interactions of microRNA, lncRNA, and other non-coding RNAs in the development of liver cancer that are associated with the MAPK signaling pathway. Further, we briefly discuss the therapeutic strategies for liver cancer related to ncRNA and the MAPK signaling pathway.<\/jats:p>","DOI":"10.3390\/ijms231911908","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T23:39:31Z","timestamp":1665272371000},"page":"11908","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer"],"prefix":"10.3390","volume":"23","author":[{"given":"Qiuxia","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5830-3317","authenticated-orcid":false,"given":"Jianguo","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China"},{"name":"Laboratory of Anesthesiology, Southwest Medical University, Luzhou 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6640-0857","authenticated-orcid":false,"given":"Liling","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s41590-018-0044-z","article-title":"The immunology of hepatocellular carcinoma","volume":"19","author":"Ringelhan","year":"2018","journal-title":"Nat. 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