{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T22:07:33Z","timestamp":1768687653181,"version":"3.49.0"},"reference-count":149,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T00:00:00Z","timestamp":1665187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ESTEVE Pharmaceuticals","award":["066\/13 23\/01\/2017"],"award-info":[{"award-number":["066\/13 23\/01\/2017"]}]},{"name":"ESTEVE Pharmaceuticals","award":["MPCUdG2016\/087"],"award-info":[{"award-number":["MPCUdG2016\/087"]}]},{"DOI":"10.13039\/100008722","name":"Vice-Chancellorship of Research of the University of Girona","doi-asserted-by":"publisher","award":["066\/13 23\/01\/2017"],"award-info":[{"award-number":["066\/13 23\/01\/2017"]}],"id":[{"id":"10.13039\/100008722","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008722","name":"Vice-Chancellorship of Research of the University of Girona","doi-asserted-by":"publisher","award":["MPCUdG2016\/087"],"award-info":[{"award-number":["MPCUdG2016\/087"]}],"id":[{"id":"10.13039\/100008722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sigma-1 receptor (\u03c31R) ligands have been shown to be effective at relieving neuropathic and inflammatory pain, but have not yet been tested in experimental models of fibromyalgia. The objective of this study was to evaluate the effect of a \u03c31R antagonist (BD1063) compared to pregabalin. ICR-CD1 female mice were subjected to either six repeated injections of reserpine, to cause reserpine-induced myalgia (RIM6), or acidified saline intramuscular injections (ASI). In these two models, we evaluated the effect of BD1063 and pregabalin on thermal hypersensitivity, anxiety-like and depression-like behaviors, and on spinal cord gliosis. BD1063 exerted an antinociceptive effect on both reflexive (thermal hyperalgesia) and nonreflexive (anxiety- and depression-like) pain behaviors, and reduced spinal astroglial and microglial reactivity, following repeated treatment for 2 weeks. Interestingly, the effects of BD1063 were long-term, lasting several weeks after treatment discontinuation in both fibromyalgia-like models. Similar results were obtained with pregabalin, but the effects on pain behaviors lasted for a shorter length of time, and pregabalin did not significantly modulate spinal glial reactivity. The inhibitory and long-lasting effect of pharmacological blockade of \u03c31Rs on both sensory and affective dimensions of nociplastic-like pain and spinal cord gliosis in two experimental models of fibromyalgia support the application of this therapeutic strategy to treat fibromyalgia.<\/jats:p>","DOI":"10.3390\/ijms231911933","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T23:39:31Z","timestamp":1665272371000},"page":"11933","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Long-Lasting Nociplastic Pain Modulation by Repeated Administration of Sigma-1 Receptor Antagonist BD1063 in Fibromyalgia-like Mouse Models"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8033-3136","authenticated-orcid":false,"given":"Beltr\u00e1n","family":"\u00c1lvarez-P\u00e9rez","sequence":"first","affiliation":[{"name":"Research Group of Clinical Anatomy, Embryology and Neuroscience (NEOMA), Department of Medical Sciences, University of Girona, E-17003 Girona, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Bag\u00f3-Mas","sequence":"additional","affiliation":[{"name":"Research Group of Clinical Anatomy, Embryology and Neuroscience (NEOMA), Department of Medical Sciences, University of Girona, E-17003 Girona, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meritxell","family":"Deulofeu","sequence":"additional","affiliation":[{"name":"Research Group of Clinical Anatomy, Embryology and Neuroscience (NEOMA), Department of Medical Sciences, University of Girona, E-17003 Girona, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Miguel","family":"Vela","sequence":"additional","affiliation":[{"name":"WeLab Barcelona, Parc Cient\u00edfic de Barcelona, E-08028 Barcelona, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Merlos","sequence":"additional","affiliation":[{"name":"WeLab Barcelona, Parc Cient\u00edfic de Barcelona, E-08028 Barcelona, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Verd\u00fa","sequence":"additional","affiliation":[{"name":"Research Group of Clinical Anatomy, Embryology and Neuroscience (NEOMA), Department of Medical Sciences, University of Girona, E-17003 Girona, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8497-1207","authenticated-orcid":false,"given":"Pere","family":"Boadas-Vaello","sequence":"additional","affiliation":[{"name":"Research Group of Clinical Anatomy, Embryology and Neuroscience (NEOMA), Department of Medical Sciences, University of Girona, E-17003 Girona, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s12016-015-8509-4","article-title":"Fibromyalgia: A critical and comprehensive review","volume":"49","author":"Borchers","year":"2015","journal-title":"Clin. 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