{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T03:00:48Z","timestamp":1780801248767,"version":"3.54.1"},"reference-count":41,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T00:00:00Z","timestamp":1665187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["21867004"],"award-info":[{"award-number":["21867004"]}]},{"name":"National Natural Science Foundation of China","award":["22007022"],"award-info":[{"award-number":["22007022"]}]},{"name":"National Natural Science Foundation of China","award":["ZZK [2021]034"],"award-info":[{"award-number":["ZZK [2021]034"]}]},{"name":"National Natural Science Foundation of China","award":["Qjh KY Zi [2021] No. 041"],"award-info":[{"award-number":["Qjh KY Zi [2021] No. 041"]}]},{"name":"Guizhou Provincial Natural Science Foundation","award":["21867004"],"award-info":[{"award-number":["21867004"]}]},{"name":"Guizhou Provincial Natural Science Foundation","award":["22007022"],"award-info":[{"award-number":["22007022"]}]},{"name":"Guizhou Provincial Natural Science Foundation","award":["ZZK [2021]034"],"award-info":[{"award-number":["ZZK [2021]034"]}]},{"name":"Guizhou Provincial Natural Science Foundation","award":["Qjh KY Zi [2021] No. 041"],"award-info":[{"award-number":["Qjh KY Zi [2021] No. 041"]}]},{"DOI":"10.13039\/501100010828","name":"Guizhou Provincial Department of Education","doi-asserted-by":"publisher","award":["21867004"],"award-info":[{"award-number":["21867004"]}],"id":[{"id":"10.13039\/501100010828","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010828","name":"Guizhou Provincial Department of Education","doi-asserted-by":"publisher","award":["22007022"],"award-info":[{"award-number":["22007022"]}],"id":[{"id":"10.13039\/501100010828","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010828","name":"Guizhou Provincial Department of Education","doi-asserted-by":"publisher","award":["ZZK [2021]034"],"award-info":[{"award-number":["ZZK [2021]034"]}],"id":[{"id":"10.13039\/501100010828","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010828","name":"Guizhou Provincial Department of Education","doi-asserted-by":"publisher","award":["Qjh KY Zi [2021] No. 041"],"award-info":[{"award-number":["Qjh KY Zi [2021] No. 041"]}],"id":[{"id":"10.13039\/501100010828","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Xanthomonas axonopodis pv. citri (Xac) belongs to the Gram-negative species, causing citrus canker that seriously affects the fruit yield and quality of many rutaceae plants. Herein, we found that compound 2-(butyldisulfanyl) quinazolin-4(3H)-one exhibited remarkable anti-Xac activity in vitro with a half effective concentration (EC50) of 2.6 \u03bcg\/mL, while the positive controls thiodiazole-copper with 57 \u03bcg\/mL and bismerthiazol with 68 \u03bcg\/mL and this compound showed great anti-citrus canker activity in vivo. This active compound also was confirmed to reduce biofilm formation, increase the level of reactive oxygen species, damage the morphological structure of the bacteria, and cause bacterial death. Proteomics and RT-qPCR analysis results indicated that this compound down-regulated the expression of enzymes in the MEP (2-methyl-D-erythritol 4-phosphate) pathway and might achieve destructive ability of Xac. Overall, this study indicates that such derivatives could be a promising scaffold to develop novel bactericides to control citrus canker.<\/jats:p>","DOI":"10.3390\/ijms231911947","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T23:39:31Z","timestamp":1665272371000},"page":"11947","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Antibacterial Activity of Allicin-Inspired Disulfide Derivatives against Xanthomonas\u00a0axonopodis pv. citri"],"prefix":"10.3390","volume":"23","author":[{"given":"Mei","family":"Zhu","sequence":"first","affiliation":[{"name":"Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1670-8623","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesha","family":"Long","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congyu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiping","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, China"},{"name":"School of Pharmacy, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9560-7627","authenticated-orcid":false,"given":"Zhenchao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1046\/j.1364-3703.2003.00163.x","article-title":"Xanthomonas citri: Breaking the surface","volume":"4","author":"Brunings","year":"2003","journal-title":"Mol. 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