{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:31:31Z","timestamp":1790404291061,"version":"4.1.0"},"reference-count":29,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015800","name":"Jilin Provincial Development and Reform Commission","doi-asserted-by":"publisher","award":["2021C019"],"award-info":[{"award-number":["2021C019"]}],"id":[{"id":"10.13039\/100015800","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015800","name":"Jilin Provincial Development and Reform Commission","doi-asserted-by":"publisher","award":["2019C049-4"],"award-info":[{"award-number":["2019C049-4"]}],"id":[{"id":"10.13039\/100015800","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015800","name":"Jilin Provincial Development and Reform Commission","doi-asserted-by":"publisher","award":["81570253"],"award-info":[{"award-number":["81570253"]}],"id":[{"id":"10.13039\/100015800","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015800","name":"Jilin Provincial Development and Reform Commission","doi-asserted-by":"publisher","award":["2022B23"],"award-info":[{"award-number":["2022B23"]}],"id":[{"id":"10.13039\/100015800","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Natural Science Foundation of China","award":["2021C019"],"award-info":[{"award-number":["2021C019"]}]},{"name":"National Natural Science Foundation of China","award":["2019C049-4"],"award-info":[{"award-number":["2019C049-4"]}]},{"name":"National Natural Science Foundation of China","award":["81570253"],"award-info":[{"award-number":["81570253"]}]},{"name":"National Natural Science Foundation of China","award":["2022B23"],"award-info":[{"award-number":["2022B23"]}]},{"name":"Norman Bethune Program of Jilin University","award":["2021C019"],"award-info":[{"award-number":["2021C019"]}]},{"name":"Norman Bethune Program of Jilin University","award":["2019C049-4"],"award-info":[{"award-number":["2019C049-4"]}]},{"name":"Norman Bethune Program of Jilin University","award":["81570253"],"award-info":[{"award-number":["81570253"]}]},{"name":"Norman Bethune Program of Jilin University","award":["2022B23"],"award-info":[{"award-number":["2022B23"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cell senescence is one of the most important forms of injury induced by cardiovascular and other ischemic diseases. Fibroblasts are important participants in tissue repair after ischemic injury and the main source of IL11 secretion. However, the roles of oxygen\u2013glucose deprivation (OGD) and IL11 in promoting fibroblast senescence and their regulatory mechanisms remain unclear. This study selected the NIH3T3 and L929 fibroblast cell lines as research objects. We found that OGD could induce the expression of p53, P16, p21, and collagen in fibroblasts. In the condition of OGD, when IL11 intervened, fibroblasts\u2019 senescence and collagen expression were changed. Some studies have found that changes in kynurenine (KYN) metabolism are related to aging diseases, and indoleamine 2,3-dioxygenase 1 (IDO1) is a key rate-limiting enzyme in the KYN metabolic pathway. We found that KYN secretion decreased after OGD increased fibroblast senescence, and inhibition of IL11 promoted IDO1 and increased KYN secretion. These results suggest that OGD may promote fibroblast senescence and collagen expression via IL11 inhibition of the IDO1\/KYN metabolic pathway. Therefore, the revealed mechanism of OGD-promoted fibroblast senescence could provide an effective theoretical basis for the clinical treatment of aging-related ischemic diseases.<\/jats:p>","DOI":"10.3390\/ijms232012090","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T22:18:13Z","timestamp":1665526693000},"page":"12090","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Oxygen\u2013Glucose Deprivation Promoted Fibroblast Senescence and Collagen Expression via IL11"],"prefix":"10.3390","volume":"23","author":[{"given":"Tongtong","family":"Song","sequence":"first","affiliation":[{"name":"Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.cell.2017.05.015","article-title":"Senescence in Health and Disease","volume":"169","author":"He","year":"2017","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1093\/cvr\/cvab161","article-title":"Senescence mechanisms and targets in the heart","volume":"118","author":"Chen","year":"2022","journal-title":"Cardiovasc. 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