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In this study, the correlation between mitophagy and HCC prognosis was evaluated using data from The Cancer Genome Atlas (TCGA). Clinical and transcriptomic data of HCC patients were downloaded from TCGA dataset, and mitophagy-related gene (MRG) datasets were obtained from the Molecular Signature Database. Then, a consensus clustering analysis was performed to classify the patients into two clusters. Furthermore, tumor prognosis, clinicopathological features, functional analysis, immune infiltration, immune checkpoint (IC)-related gene expression level, tumor stem cells, ferroptosis status, and N6-methyladenosine analysis were compared between the two clusters. Finally, a mitophagy-related signature was developed. Two clusters (C1 and C2) were identified using the consensus clustering analysis based on the MRG signature. Patients with the C1 subtype exhibited upregulated pathways with better liver function, downregulated cancer-related pathways, lower cancer stem cell scores, lower Tumor Immune Dysfunction and Exclusion scores (TIDE), different ferroptosis status, and better prognosis compared with the patients with the C2 subtype. The C2 subtype was characterized by the increased grade of HCC, as well as the increased number of immune-related pathways and m6A-related genes. Higher immune scores were also observed for the C2 subtype. A signature containing four MRGs (PGAM5, SQSTM1, ATG9A, and GABARAPL1) which can accurately predict the prognosis of HCC patients was then identified. This four-gene signature exhibited a predictive effect in five other cancer types, namely glioma, uveal melanoma, acute myeloid leukemia, adrenocortical carcinoma, and mesothelioma. The mitophagy-associated subtypes of HCC were closely related to the immune microenvironment, immune checkpoint-related gene expression, cancer stem cells, ferroptosis status, m6A, prognosis, and HCC progression. The established MRG signature could predict prognosis in patients with HCC.<\/jats:p>","DOI":"10.3390\/ijms232012123","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T05:31:18Z","timestamp":1665552678000},"page":"12123","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["A Mitophagy-Related Gene Signature for Subtype Identification and Prognosis Prediction of Hepatocellular Carcinoma"],"prefix":"10.3390","volume":"23","author":[{"given":"Chang","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Geriatric Cardiovascular Disease, Chengdu Medical College, Chengdu 610083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0125-6724","authenticated-orcid":false,"given":"Zhen","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Fudan University, Shanghai 200437, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Geriatric Cardiovascular Disease, Chengdu Medical College, Chengdu 610083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Geriatric Cardiovascular Disease, Chengdu Medical College, Chengdu 610083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, Department of Pathophysiology, Institute of Cardiovascular Disease, Hengyang Medical School, University of South China, Hengyang 421009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4848-7842","authenticated-orcid":false,"given":"Jichang","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Geriatric Cardiovascular Disease, Chengdu Medical College, Chengdu 610083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,12]]},"reference":[{"key":"ref_1","unstructured":"(2021). Hepatocellular Carcinoma. Nat. Rev. Dis. Primers, 7, 7."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1056\/NEJMra1713263","article-title":"Hepatocellular Carcinoma","volume":"380","author":"Villanueva","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_3","first-page":"54","article-title":"Progress and Prospects of Biomarkers in Primary Liver Cancer (Review)","volume":"57","author":"Gao","year":"2020","journal-title":"Int. J. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global Cancer Statistics 2018: Globocan Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"300","DOI":"10.4254\/wjh.v9.i6.300","article-title":"Clinical Features, Histology, and Histogenesis of Combined Hepatocellular-Cholangiocarcinoma","volume":"9","author":"Gera","year":"2017","journal-title":"World J. Hepatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"188314","DOI":"10.1016\/j.bbcan.2019.188314","article-title":"Challenges in Liver Cancer and Possible Treatment Approaches","volume":"1873","author":"Anwanwan","year":"2020","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.32074\/1591-951X-295","article-title":"Hepatocellular Carcinoma: A Clinical and Pathological Overview","volume":"113","author":"Renne","year":"2021","journal-title":"Pathologica"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/bjs\/znaa167","article-title":"Prognostication in Hepatocellular Carcinoma: Is It a Burden or a Ticket?","volume":"108","author":"Tsilimigras","year":"2021","journal-title":"Br. J. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.cld.2020.07.010","article-title":"Hepatocellular Carcinoma: Role of Pathology in the Era of Precision Medicine","volume":"24","author":"Vyas","year":"2020","journal-title":"Clin. Liver Dis."},{"key":"ref_10","first-page":"e926760","article-title":"Connection between Cdc20 Expression and Hepatocellular Carcinoma Prognosis","volume":"27","author":"Zhang","year":"2021","journal-title":"Med. Sci. Monit."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1053\/j.semdp.2016.12.011","article-title":"The Diagnosis and Treatment of Hepatocellular Carcinoma","volume":"34","author":"Hartke","year":"2017","journal-title":"Semin. Diagn. Pathol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Pinero, F., Dirchwolf, M., and Pessoa, M.G. (2020). Biomarkers in Hepatocellular Carcinoma: Diagnosis, Prognosis and Treatment Response Assessment. Cells, 9.","DOI":"10.3390\/cells9061370"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e104705","DOI":"10.15252\/embj.2020104705","article-title":"Molecular Mechanisms and Physiological Functions of Mitophagy","volume":"40","author":"Onishi","year":"2021","journal-title":"EMBO J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1007\/s00018-021-03774-1","article-title":"Mitophagy in Tumorigenesis and Metastasis","volume":"78","author":"Poole","year":"2021","journal-title":"Cell Mol. Life Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.semcancer.2019.07.015","article-title":"The Emerging, Multifaceted Role of Mitophagy in Cancer and Cancer Therapeutics","volume":"66","author":"Panigrahi","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ma, X., McKeen, T., Zhang, J., and Ding, W.X. (2020). Role and Mechanisms of Mitophagy in Liver Diseases. Cells, 9.","DOI":"10.3390\/cells9040837"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/15548627.2019.1607686","article-title":"Mitigation of Cocaine-Mediated Mitochondrial Damage, Defective Mitophagy and Microglial Activation by Superoxide Dismutase Mimetics","volume":"16","author":"Thangaraj","year":"2020","journal-title":"Autophagy"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1080\/15548627.2020.1810919","article-title":"Mitophagy Coordination with Retrograde Transport Ensures the Integrity of Synaptic Mitochondria","volume":"16","author":"Han","year":"2020","journal-title":"Autophagy"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1080\/15548627.2020.1720427","article-title":"Autophagy Regulates Functional Differentiation of Mammary Epithelial Cells","volume":"17","author":"Elswood","year":"2021","journal-title":"Autophagy"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molmed.2019.07.002","article-title":"Mitophagy and Neuroprotection","volume":"26","author":"Lou","year":"2020","journal-title":"Trends Mol. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.canlet.2020.10.036","article-title":"Mitochondrial Rewiring through Mitophagy and Mitochondrial Biogenesis in Cancer Stem Cells: A Potential Target for Anti-Csc Cancer Therapy","volume":"498","author":"Praharaj","year":"2021","journal-title":"Cancer Lett."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3390\/cells8050493","article-title":"Mitophagy in Cancer: A Tale of Adaptation","volume":"8","author":"Agostinis","year":"2019","journal-title":"Cells"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.bbrc.2016.10.088","article-title":"Mitophagy: Link to Cancer Development and Therapy","volume":"482","author":"Kulikov","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e1600200","DOI":"10.1126\/sciadv.1600200","article-title":"Fundamentals of Cancer Metabolism","volume":"2","author":"DeBerardinis","year":"2016","journal-title":"Sci. Adv."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/onc.2016.302","article-title":"Parkin and Mitophagy in Cancer","volume":"36","author":"Bernardini","year":"2017","journal-title":"Oncogene"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/ng.491","article-title":"Somatic Mutations of the Parkinson\u2019s Disease-Associated Gene Park2 in Glioblastoma and Other Human Malignancies","volume":"42","author":"Veeriah","year":"2010","journal-title":"Nat. Genet."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s12943-018-0900-3","article-title":"Role of the Nlrp3 Inflammasome in Cancer","volume":"17","author":"Moossavi","year":"2018","journal-title":"Mol. Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.immuni.2015.07.012","article-title":"Bnip3- and Bnip3l-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory","volume":"43","author":"Johnson","year":"2015","journal-title":"Immunity"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"601240","DOI":"10.3389\/fonc.2020.601240","article-title":"Immune Checkpoint Inhibitors in the Treatment of Hcc","volume":"10","author":"Donisi","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_30","first-page":"51","article-title":"The Regulation of Iron Absorption and Homeostasis","volume":"37","author":"Wallace","year":"2016","journal-title":"Clin. Biochem. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.devcel.2018.07.012","article-title":"Pink1 and Park2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism","volume":"46","author":"Li","year":"2018","journal-title":"Dev. Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1002\/hep.29683","article-title":"Rna N6-Methyladenosine Methyltransferase-Like 3 Promotes Liver Cancer Progression through Ythdf2-Dependent Posttranscriptional Silencing of Socs2","volume":"67","author":"Chen","year":"2018","journal-title":"Hepatology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/hep.28885","article-title":"Mettl14 Suppresses the Metastatic Potential of Hepatocellular Carcinoma by Modulating N(6) -Methyladenosine-Dependent Primary Microrna Processing","volume":"65","author":"Ma","year":"2017","journal-title":"Hepatology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"108613","DOI":"10.1016\/j.biopha.2019.108613","article-title":"The Role of M6a Rna Methylation in Cancer","volume":"112","author":"Sun","year":"2019","journal-title":"BioMed. Pharm."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5035","DOI":"10.3892\/mmr.2015.4029","article-title":"Promotion of Mitochondrial Energy Metabolism During Hepatocyte Apoptosis in a Rat Model of Acute Liver Failure","volume":"12","author":"Chen","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/ni.1980","article-title":"Autophagy Proteins Regulate Innate Immune Responses by Inhibiting the Release of Mitochondrial DNA Mediated by the Nalp3 Inflammasome","volume":"12","author":"Nakahira","year":"2011","journal-title":"Nat. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"832","DOI":"10.3389\/fimmu.2018.00832","article-title":"Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases","volume":"9","author":"Grazioli","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"45728","DOI":"10.1038\/srep45728","article-title":"Sesamol Induces Human Hepatocellular Carcinoma Cells Apoptosis by Impairing Mitochondrial Function and Suppressing Autophagy","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s12192-018-0937-7","article-title":"Matrine Promotes Liver Cancer Cell Apoptosis by Inhibiting Mitophagy and Pink1\/Parkin Pathways","volume":"23","author":"Wei","year":"2018","journal-title":"Cell Stress Chaperones"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1080\/21691401.2019.1593854","article-title":"Alantolactone Induces Apoptosis through Ros-Mediated Akt Pathway and Inhibition of Pink1-Mediated Mitophagy in Human Hepg2 Cells","volume":"47","author":"Kang","year":"2019","journal-title":"Artif. Cells NanoMed. Biotechnol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"Swiss-Model: Homology Modelling of Protein Structures and Complexes","volume":"46","author":"Waterhouse","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.semcdb.2019.05.029","article-title":"Autophagy and Mitophagy in Cancer Metabolic Remodelling","volume":"98","author":"Ferro","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1080\/15548627.2016.1162359","article-title":"Atg7 Regulates Energy Metabolism, Differentiation and Survival of Philadelphia-Chromosome-Positive Cells","volume":"12","author":"Karvela","year":"2016","journal-title":"Autophagy"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1101\/gad.2051011","article-title":"Suppression of Autophagy by Fip200 Deletion Inhibits Mammary Tumorigenesis","volume":"25","author":"Wei","year":"2011","journal-title":"Genes Dev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"814735","DOI":"10.3389\/fcell.2022.814735","article-title":"Integrated Analysis of Energy Metabolism Signature-Identified Distinct Subtypes of Bladder Urothelial Carcinoma","volume":"10","author":"Zhang","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1093\/jmcb\/mjaa040","article-title":"Gain-of-Function Mutant P53 in Cancer Progression and Therapy","volume":"12","author":"Zhang","year":"2020","journal-title":"J. Mol. Cell Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bj.2015.10.002","article-title":"Metabolic, Autophagic, and Mitophagic Activities in Cancer Initiation and Progression","volume":"39","author":"Hjelmeland","year":"2016","journal-title":"BioMed. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.molcel.2017.09.022","article-title":"Mitophagy Controls the Activities of Tumor Suppressor P53 to Regulate Hepatic Cancer Stem Cells","volume":"68","author":"Liu","year":"2017","journal-title":"Mol. Cell"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Chen, Y.Y., Wang, W.H., Che, L., Lan, Y., Zhang, L.Y., Zhan, D.L., Huang, Z.-Y., Lin, Z.-N., and Lin, Y.-C. (2020). Bnip3l-Dependent Mitophagy Promotes Hbx-Induced Cancer Stemness of Hepatocellular Carcinoma Cells Via Glycolysis Metabolism Reprogramming. Cancers, 12.","DOI":"10.3390\/cancers12030655"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cell.2018.05.028","article-title":"Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity During Tumorigenesis","volume":"174","author":"Ziegler","year":"2018","journal-title":"Cell"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/s41556-021-00706-w","article-title":"Atg9a Protects the Plasma Membrane from Programmed and Incidental Permeabilization","volume":"23","author":"Jia","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"107837","DOI":"10.1016\/j.celrep.2020.107837","article-title":"Structure of Human Atg9a, the Only Transmembrane Protein of the Core Autophagy Machinery","volume":"31","author":"Guardia","year":"2020","journal-title":"Cell Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/s41594-020-00520-2","article-title":"Structure, Lipid Scrambling Activity and Role in Autophagosome Formation of Atg9a","volume":"27","author":"Maeda","year":"2020","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"151144","DOI":"10.1016\/j.ejcb.2020.151144","article-title":"Pgam5: A Crucial Role in Mitochondrial Dynamics and Programmed Cell Death","volume":"100","author":"Cheng","year":"2021","journal-title":"Eur. J. Cell Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1038\/s41467-020-16312-7","article-title":"Mitochondrial Phosphatase Pgam5 Modulates Cellular Senescence by Regulating Mitochondrial Dynamics","volume":"11","author":"Yu","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"730604","DOI":"10.3389\/fnmol.2021.730604","article-title":"Mitochondrial Protein Pgam5 Emerges as a New Regulator in Neurological Diseases","volume":"14","author":"Liang","year":"2021","journal-title":"Front. Mol. NeuroSci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.biopha.2018.12.128","article-title":"Pgam5-Cypd Pathway Is Involved in Bromocriptine-Induced Rip3\/Mlkl-Dependent Necroptosis of Prolactinoma Cells","volume":"111","author":"Zhang","year":"2019","journal-title":"BioMed. Pharm."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1042\/EBC20170035","article-title":"Regulation of Selective Autophagy: The P62\/Sqstm1 Paradigm","volume":"61","author":"Lamark","year":"2017","journal-title":"Essays Biochem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.semcancer.2017.04.008","article-title":"Expanding Perspectives on the Significance of Mitophagy in Cancer","volume":"47","author":"Drake","year":"2017","journal-title":"Semin. Cancer Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.cell.2016.09.030","article-title":"P62 in Cancer: Signaling Adaptor Beyond Autophagy","volume":"167","author":"Moscat","year":"2016","journal-title":"Cell"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1182\/blood-2018-02-833475","article-title":"Loss of the Selective Autophagy Receptor P62 Impairs Murine Myeloid Leukemia Progression and Mitophagy","volume":"133","author":"Nguyen","year":"2019","journal-title":"Blood"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1096\/fj.201600698R","article-title":"Lc3\/Gabarap Family Proteins: Autophagy-(Un)Related Functions","volume":"30","author":"Schaaf","year":"2016","journal-title":"FASEB J."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/sj.bjc.6605568","article-title":"High Expression of Gabarapl1 Is Associated with a Better Outcome for Patients with Lymph Node-Positive Breast Cancer","volume":"102","author":"Berthier","year":"2010","journal-title":"Br. J. Cancer"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.3892\/or.2014.3096","article-title":"Low Expression of Gabarapl1 Is Associated with a Poor Outcome for Patients with Hepatocellular Carcinoma","volume":"31","author":"Liu","year":"2014","journal-title":"Oncol. Rep."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"917584","DOI":"10.3389\/fgene.2022.917584","article-title":"The prognostic value and clinical significance of mitophagy-related genes in hepatocellular carcinoma","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Genet."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"5070099","DOI":"10.1155\/2021\/5070099","article-title":"Development and Validation of a Novel Mitophagy-Related Gene Prognostic Signature for Hepatocellular Carcinoma Based on Immunoscore Classification of Tumor","volume":"2021","author":"Chen","year":"2021","journal-title":"J. Oncol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"799507","DOI":"10.3389\/fcell.2021.799507","article-title":"Identification of HCC Subtypes With Different Prognosis and Metabolic Patterns Based on Mitophagy","volume":"9","author":"Wang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"857968","DOI":"10.3389\/fonc.2022.857968","article-title":"Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5","volume":"12","author":"Liang","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/14737140.2018.1432357","article-title":"Nivolumab for the Treatment of Urothelial Cancers","volume":"18","author":"Teo","year":"2018","journal-title":"Expert Rev. Anticancer."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1734847","DOI":"10.1155\/2022\/1734847","article-title":"Identification of Potential Immune Checkpoint Inhibitor Targets in Gliomas via Bioinformatic Analyses","volume":"2022","author":"Ding","year":"2022","journal-title":"BioMed. Res. Int."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"101302","DOI":"10.1016\/j.isci.2020.101302","article-title":"Systematic Analysis of the Aberrances and Functional Implications of Ferroptosis in Cancer","volume":"23","author":"Liu","year":"2020","journal-title":"iScience"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12943-019-1066-3","article-title":"Molecular Characterization and Clinical Relevance of M(6)a Regulators across 33 Cancer Types","volume":"18","author":"Li","year":"2019","journal-title":"Mol. 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