{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:57:47Z","timestamp":1789657067120,"version":"4.0.1"},"reference-count":153,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Lottery Grants Board"},{"name":"Nutricia Research Foundation"},{"name":"Otago Doctoral Scholarships (University of Otago, New Zealand)"},{"name":"Graham Langridge Scholarship (Gillies McIndoe Research Institute, NZ)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Fructose consumption is now recognised as a major risk factor in the development of metabolic diseases, such as hyperlipidaemia, diabetes, non-alcoholic fatty liver disease and obesity. In addition to environmental, social, and genetic factors, an unfavourable intrauterine environment is now also recognised as an important factor in the progression of, or susceptibility to, metabolic disease during adulthood. Developmental trajectory in the short term, in response to nutrient restriction or excessive nutrient availability, may promote adaptation that serves to maintain organ functionality necessary for immediate survival and foetal development. Consequently, this may lead to decreased function of organ systems when presented with an unfavourable neonatal, adolescent and\/or adult nutritional environment. These early events may exacerbate susceptibility to later-life disease since sub-optimal maternal nutrition increases the risk of non-communicable diseases (NCDs) in future generations. Earlier dietary interventions, implemented in pregnant mothers or those considering pregnancy, may have added benefit. Although, the mechanisms by which maternal diets high in fructose and the vertical transmission of maternal metabolic phenotype may lead to the predisposition to adult disease are poorly understood. In this review, we will discuss the potential contribution of excessive fructose intake during pregnancy and how this may lead to developmental reprogramming of mitochondrial function and predisposition to metabolic disease in offspring.<\/jats:p>","DOI":"10.3390\/ijms232012215","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T22:21:11Z","timestamp":1665699671000},"page":"12215","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Maternal Fructose Intake, Programmed Mitochondrial Function and Predisposition to Adult Disease"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0477-0569","authenticated-orcid":false,"given":"Erin Vanessa LaRae","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Child Health, University of Otago, Wellington 6021, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2319-6897","authenticated-orcid":false,"given":"Rebecca Maree","family":"Dyson","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, University of Otago, Wellington 6021, New Zealand"},{"name":"Centre for Translational Research, University of Otago, Wellington 6021, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freya Rebecca","family":"Weth","sequence":"additional","affiliation":[{"name":"Gillies McIndoe Research Institute, 7 Hospital Road, Newtown, Wellington 6021, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9798-6790","authenticated-orcid":false,"given":"Mary Judith","family":"Berry","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, University of Otago, Wellington 6021, New Zealand"},{"name":"Centre for Translational Research, University of Otago, Wellington 6021, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clint","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, University of Otago, Wellington 6021, New Zealand"},{"name":"Centre for Translational Research, University of Otago, Wellington 6021, New Zealand"},{"name":"Gillies McIndoe Research Institute, 7 Hospital Road, Newtown, Wellington 6021, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ouellette, R.J., and Rawn, J.D. 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