{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:44:02Z","timestamp":1792086242541,"version":"4.4.0"},"reference-count":49,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["21-75-30009"],"award-info":[{"award-number":["21-75-30009"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>We investigated the nephroprotective effect of D-panthenol in rhabdomyolysis-induced acute kidney injury (AKI). Adult male Wistar rats were injected with 50% glycerol solution to induce rhabdomyolysis. Animals with rhabdomyolysis were injected with D-panthenol (200 mg\/kg) for 7 days. On day 8, we examined AKI markers, renal histology, antioxidant capacity, and protein glutathionylation in kidneys to uncover mechanisms of D-panthenol effects. Rhabdomyolysis kidneys were shown to have pathomorphological alterations (mononuclear infiltration, dilatation of tubules, and hyaline casts in Henle\u2019s loops and collecting ducts). Activities of skeletal muscle damage markers (creatine kinase and lactate dehydrogenase) increased, myoglobinuria was observed, and creatinine, BUN, and pantetheinase activity in serum and urine rose. Signs of oxidative stress in the kidney tissue of rhabdomyolysis rats, increased levels of lipid peroxidation products, and activities of antioxidant enzymes (SOD, catalase, and glutathione peroxidase) were all alleviated by administration of D-panthenol. Its application improved kidney morphology and decreased AKI markers. Mechanisms of D-panthenol\u2019s beneficial effects were associated with an increase in total coenzyme A levels, activity of Krebs cycle enzymes, and attenuation of protein glutathionylation. D-Panthenol protects kidneys from rhabdomyolysis-induced AKI through antioxidant effects, normalization of mitochondrial metabolism, and modulation of glutathione-dependent signaling.<\/jats:p>","DOI":"10.3390\/ijms232012273","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T02:29:46Z","timestamp":1665973786000},"page":"12273","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Protective Effect of D-Panthenol in Rhabdomyolysis-Induced Acute Kidney Injury"],"prefix":"10.3390","volume":"23","author":[{"given":"Dmitry S.","family":"Semenovich","sequence":"first","affiliation":[{"name":"A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, 119992 Moscow, Russia"},{"name":"Institute of Biochemistry of Biologically Active Substances, NAS of Belarus, 230030 Grodno, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2838-3704","authenticated-orcid":false,"given":"Egor Y.","family":"Plotnikov","sequence":"additional","affiliation":[{"name":"A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, 119992 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena P.","family":"Lukiyenko","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry of Biologically Active Substances, NAS of Belarus, 230030 Grodno, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander A.","family":"Astrowski","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry of Biologically Active Substances, NAS of Belarus, 230030 Grodno, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina P.","family":"Kanunnikova","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry of Biologically Active Substances, NAS of Belarus, 230030 Grodno, Belarus"},{"name":"Faculty of Biology and Ecology, Yanka Kupala State University of Grodno, 230023 Grodno, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"ref_1","unstructured":"Stanley, M., Chippa, V., Aeddula, N.R., Quintanilla Rodriguez, B.S., and Adigun, R. 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