{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:45:44Z","timestamp":1778661944162,"version":"3.51.4"},"reference-count":59,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Background: Studies have demonstrated a higher risk of nonmelanoma skin cancers (NMSC) and a modestly increased melanoma risk in patients with psoriasis. To date, no biomarkers predictive of evolution have been identified yet. Methods: The aim of this prospective case-control study was to investigate the potential role of neutrophil gelatinase-associated lipocalin (NGAL) as a predictive biomarker of skin cancers in psoriatic patients. Patients with a diagnosis of psoriasis were enrolled, as well as healthy subjects and patients with skin cancers as controls. Plasma protein expression of NGAL, metalloproteinases (MMP)-2, and MMP-9 was performed by an enzyme-linked immunosorbent assay (ELISA). In all the patients who developed skin cancer at follow-up, NGAL, MMP-2, and MMP-9 serum levels were dosed again. Results: Plasma NGAL levels were significantly higher in psoriatic patients with NMSC than without (182.3 \u00b1 36.6 ng\/mL vs. 139.9 \u00b1 39.3 ng\/mL) (p &lt; 0.001). Plasma NGAL levels were significantly higher (p &lt; 0.00001) in patients with psoriasis and NMSC than in patients with skin tumors without psoriasis (182.3 vs. 122.9). Patients with psoriasis who developed NMSC at follow-up showed increased plasma MMP-9 levels. Conclusion: NGAL seems to play a role in the pathogenesis of NMSC but not melanoma in patients with psoriasis.<\/jats:p>","DOI":"10.3390\/ijms232012291","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T02:29:46Z","timestamp":1665973786000},"page":"12291","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Neutrophil Gelatinase-Associated Lipocalin as Potential Predictive Biomarker of Melanoma and Non-Melanoma Skin Cancers in Psoriatic Patients: A Pilot Study"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1982-888X","authenticated-orcid":false,"given":"Alice","family":"Verdelli","sequence":"first","affiliation":[{"name":"Department of Health Sciences, Section of Dermatology, Rare Dermatological Unit, Azienda USL Toscana Centro, University of Florence, 50125 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzia","family":"Caproni","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Section of Dermatology, Rare Dermatological Unit, Azienda USL Toscana Centro, University of Florence, 50125 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-3144","authenticated-orcid":false,"given":"Alessio","family":"Coi","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology of Rare Diseases and Congenital Anomalies, Institute of Clinical Physiology, National Research Council, 56127 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0903-4998","authenticated-orcid":false,"given":"Alberto","family":"Corr\u00e0","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Section of Dermatology, University of Florence, 50125 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3342-5537","authenticated-orcid":false,"given":"Donatella","family":"Degl\u2019Innocenti","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4241-3992","authenticated-orcid":false,"given":"Marzia","family":"Vasarri","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lavinia","family":"Quintarelli","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Section of Dermatology, Rare Dermatological Unit, Azienda USL Toscana Centro, University of Florence, 50125 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valter","family":"Volpi","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Section of Dermatology, Rare Dermatological Unit, Azienda USL Toscana Centro, University of Florence, 50125 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele Maria","family":"Cipollini","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Section of Dermatology, Rare Dermatological Unit, Azienda USL Toscana Centro, University of Florence, 50125 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7493-1498","authenticated-orcid":false,"given":"Emanuela","family":"Barletta","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fmolb.2015.00019","article-title":"Multifaceted role of matrix metalloproteinases (MMPs)","volume":"2","author":"Singh","year":"2015","journal-title":"Front. Mol. Biosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bbcan.2012.03.008","article-title":"The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer","volume":"1826","author":"Chakraborty","year":"2012","journal-title":"Biochim. Biophys. Acta BBA Rev. Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"22565","DOI":"10.1074\/jbc.270.38.22565","article-title":"Identification of a New Acute Phase Protein","volume":"270","author":"Liu","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nature03104","article-title":"Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron","volume":"432","author":"Flo","year":"2004","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-nutr-071816-064559","article-title":"Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation","volume":"37","author":"Xiao","year":"2017","journal-title":"Annu. Rev. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.2174\/1389203717666160909125004","article-title":"The Update of NGAL in Acute Kidney Injury","volume":"18","author":"Shang","year":"2017","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_7","first-page":"55","article-title":"Neutrophil Gelatinase-Associated Lipocalin as an Early Biomarker of Acute Kidney Injury in Newborns","volume":"59","author":"Cekovska","year":"2020","journal-title":"Acta Clin. Croat."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2215\/CJN.02780319","article-title":"Urine Markers of Kidney Tubule Cell Injury and Kidney Function Decline in SPRINT Trial Participants with CKD","volume":"15","author":"Malhotra","year":"2020","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e011028","DOI":"10.1161\/JAHA.118.011028","article-title":"Association Between Plasma Neutrophil Gelatinase-Associated Lipocalin and Cardiac Disease Hospitalizations and Deaths in Older Women","volume":"8","author":"Chong","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"450","DOI":"10.5152\/akd.2014.5513","article-title":"Serum neutrophil gelatinase-associated lipocalin levels are correlated with the complexity and the severity of atherosclerosis in acute coronary syndrome","volume":"15","author":"Soylu","year":"2015","journal-title":"Anatol. J. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"568800","DOI":"10.3389\/fphys.2020.568800","article-title":"Newly Discovered Adipokines: Pathophysiological Link between Obesity and Cardiometabolic Disorders","volume":"11","author":"Kim","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/ecco-jcc\/jjaa124","article-title":"Fecal biomarkers in inflammatory bowel diseases: Calprotectin versus lipocalin-2\u2014A comparative study","volume":"15","author":"Zollner","year":"2020","journal-title":"J. Crohns Colitis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nrrheum.2011.107","article-title":"What\u2019s new in our understanding of the role of adipokines in rheumatic diseases?","volume":"7","author":"Conde","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1002\/art.23789","article-title":"Proteomic characterization of mouse cartilage degradation in vitro","volume":"58","author":"Wilson","year":"2008","journal-title":"Arthritis Care Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1177\/0961203314530484","article-title":"Serum anti-lipocalin 2 IgG is a novel biomarker in the diagnosis of systemic lupus erythematosus","volume":"23","author":"Li","year":"2014","journal-title":"Lupus"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2021.07.001","article-title":"Serum and cerebrospinal fluid Neutrophil gelatinase-associated lipocalin (NGAL) levels as biomarkers for the conversion from mild cognitive impairment to Alzheimer\u2019s disease dementia","volume":"107","author":"Ramakers","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.1212\/NXI.0000000000000191","article-title":"Lipocalin-2 is increased in progressive multiple sclerosis and inhibits remyelination","volume":"3","author":"Elliott","year":"2016","journal-title":"Neurol.-Neuroimmunol. Neuroinflammation"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Santiago-S\u00e1nchez, G.S., Pita-Grisanti, V., Qui\u00f1ones-D\u00edaz, B., Gumpper, K., Cruz-Monserrate, Z., and Vivas-Mej\u00eda, P.E. (2020). Biological Functions and Therapeutic Potential of Lipocalin 2 in Cancer. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124365"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1007\/s11033-020-05261-5","article-title":"Implication and role of neutrophil gelatinase-associated lipocalin in cancer: Lipocalin-2 as a potential novel emerging comprehensive therapeutic target for a variety of cancer types","volume":"47","author":"Rahimi","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1073\/pnas.0810617106","article-title":"Lipocalin 2 promotes breast cancer progression","volume":"106","author":"Yang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1111\/cas.13389","article-title":"Lipocalin 2 negatively regulates cell proliferation and epithelial to mesenchymal transition through changing metabolic gene expression in colorectal cancer","volume":"108","author":"Kim","year":"2017","journal-title":"Cancer Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"796","DOI":"10.3390\/cancers6020796","article-title":"Neutrophil Gelatinase-Associated Lipocalin (NGAL), Pro-Matrix Metalloproteinase-9 (pro-MMP-9) and Their Complex Pro-MMP-9\/NGAL in Leukaemias","volume":"6","author":"Bouchet","year":"2014","journal-title":"Cancers"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.bbamcr.2015.08.010","article-title":"Roles of NGAL and MMP-9 in the tumor microenvironment and sensitivity to targeted therapy","volume":"1863","author":"Candido","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/j.jid.2016.03.002","article-title":"Increased Lipocalin-2 Contributes to the Pathogenesis of Psoriasis by Modulating Neutrophil Chemotaxis and Cytokine Secretion","volume":"136","author":"Shao","year":"2016","journal-title":"J. Invest. Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1034\/j.1600-0625.2002.110611.x","article-title":"Neutrophil gelatinase-associated lipocalin is a marker for dysregulated keratinocyte differentiation in human skin","volume":"11","author":"Mallbris","year":"2002","journal-title":"Exp. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3346\/jkms.2008.23.2.302","article-title":"Expression of Neutrophil Gelatinase-Associated Lipocalin in Calcium-Induced Keratinocyte Differentiation","volume":"23","author":"Lee","year":"2008","journal-title":"J. Korean Med Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1111\/bjd.15424","article-title":"Lipocalin-2 is expressed by activated granulocytes and keratinocytes in affected skin and reflects disease activity in acne inversa\/hidradenitis suppurativa","volume":"177","author":"Wolk","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/bjd.15961","article-title":"New insights into hidradenitis suppurativa: Is lipocalin-2 acting as an amplifier?","volume":"177","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.18632\/oncotarget.22260","article-title":"Serum levels of adipokines and cytokines in psoriasis patients: A systematic review and meta-analysis","volume":"9","author":"Bai","year":"2017","journal-title":"Oncotarget"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1365-2230.2011.04265.x","article-title":"Serum lipocalin-2 levels are increased in patients with psoriasis","volume":"37","author":"Kamata","year":"2012","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00403-013-1414-x","article-title":"Estimation of tissue and serum lipocalin-2 in psoriasis vulgaris and its relation to metabolic syndrome","volume":"306","author":"Samir","year":"2014","journal-title":"Arch. Dermatol. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jdermsci.2017.12.018","article-title":"Increased levels of lipocalin 2 in palmoplantar pustular psoriasis","volume":"90","author":"Wolk","year":"2018","journal-title":"J. Dermatol. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jdermsci.2017.03.014","article-title":"Serum peptides as putative modulators of inflammation in psoriasis","volume":"87","author":"Matsuura","year":"2017","journal-title":"J. Dermatol. Sci."},{"key":"ref_34","first-page":"541709","article-title":"Assessment of Lipocalin 2, Clusterin, Soluble Tumor Necrosis Factor Receptor-1, Interleukin-6, Homocysteine, and Uric Acid Levels in Patients with Psoriasis","volume":"2014","author":"Ataseven","year":"2014","journal-title":"Dis. Mark."},{"key":"ref_35","first-page":"7361826","article-title":"Association of Serum Lipocalin-2 Concentrations with Psoriasis and Psoriatic Arthritis: An Updated Meta-Analysis","volume":"2019","author":"Wang","year":"2019","journal-title":"Dis. Mark."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/1346-8138.13227","article-title":"Lipocalin-2 exacerbates psoriasiform skin inflammation by augmenting T-helper 17 response","volume":"43","author":"Hau","year":"2015","journal-title":"J. Dermatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"14088","DOI":"10.1074\/jbc.M109.017129","article-title":"Induction of neutrophil gelatinase-associated lipocalin expression by co-stimulation with interleukin-17 and tumor necrosis factor-alpha is controlled by IkappaB-zeta but neither by C\/EBP-beta nor C\/EBP-delta","volume":"285","author":"Karlsen","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00403-012-1306-5","article-title":"Circulating levels of lipocalin-2 and retinol-binding protein-4 are increased in psoriatic patients and correlated with baseline PASI","volume":"305","author":"Carrascosa","year":"2013","journal-title":"Arch. Dermatol. Res."},{"key":"ref_39","first-page":"1","article-title":"Tissue lipocalin-2 in psoriasis: Is it a marker of metabolic disturbance or a possible marker of therapeutic efficacy after narrow band ultraviolet","volume":"17","author":"Samir","year":"2019","journal-title":"Br. J. Dermatolog. Treat."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.18632\/oncotarget.1738","article-title":"Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer","volume":"5","author":"Candido","year":"2014","journal-title":"Oncotarget"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1001\/jamadermatol.2015.4847","article-title":"The Risk of Cancer in Patients with Psoriasis: A Population-Based Cohort Study in the Health Improvement Network","volume":"152","author":"Fuxench","year":"2016","journal-title":"JAMA Dermatol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/jdv.12165","article-title":"Risk of cancer in psoriasis: A systematic review and meta-analysis of epidemiological studies","volume":"27","author":"Pouplard","year":"2013","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1111\/jdv.13619","article-title":"Skin cancer in patients with psoriasis","volume":"30","author":"Egeberg","year":"2016","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1080\/1744666X.2020.1754194","article-title":"Cancer risk in patients with psoriasis: Should we be paying more attention?","volume":"16","author":"Loft","year":"2020","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_45","first-page":"1059","article-title":"Non-Melanoma Skin Cancer Risk Among Patients in the Psoriasis Longitudinal Assessment and Registry (PSOLAR)","volume":"18","author":"Krishnasamy","year":"2019","journal-title":"J. Drugs Dermatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.7150\/jca.37015","article-title":"Risk of non-melanoma skin cancer in patients with psoriasis: An updated evidence from systematic review with meta-analysis","volume":"11","author":"Wang","year":"2020","journal-title":"J. Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1001\/jamadermatol.2019.3056","article-title":"Association of Psoriasis With the Risk of Developing or Dying of Cancer: A Systematic Review and Meta-analysis","volume":"155","author":"Trafford","year":"2019","journal-title":"JAMA Dermatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"16028","DOI":"10.1038\/cddiscovery.2016.28","article-title":"Transcription factor 7-like 1 dysregulates keratinocyte differentiation through upregulating lipocalin 2","volume":"2","author":"Xu","year":"2016","journal-title":"Cell Death Discov."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/nyas.13008","article-title":"Iron and cancer: Recent insights","volume":"1368","author":"Manz","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Didona, D., Paolino, G., Bottoni, U., and Cantisani, C. (2018). Non Melanoma Skin Cancer Pathogenesis Overview. Biomedicines, 6.","DOI":"10.3390\/biomedicines6010006"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev.cb.09.110193.002545","article-title":"Tumor Cell Interactions with the Extracellular Matrix during Invasion and Metastasis","volume":"9","author":"Aznavoorian","year":"1993","journal-title":"Annu. Rev. Cell Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"613","DOI":"10.4103\/0973-1482.126456","article-title":"Role of cyclooxygenase-2, ezrin and matrix metalloproteinase-9 as predictive markers for recurrence of basal cell carcinoma","volume":"9","year":"2013","journal-title":"J. Cancer Res. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/920595","article-title":"Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma","volume":"2013","author":"Vilen","year":"2013","journal-title":"Sci. World J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2188\/jea.JE20100128","article-title":"High-Sensitivity C-Reactive Protein and Cancer","volume":"21","author":"Lee","year":"2011","journal-title":"J. Epidemiology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/CEJ.0000000000000334","article-title":"Vitamin D status and risk for malignant cutaneous melanoma: Recent advances","volume":"26","author":"Ombra","year":"2017","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"13151","DOI":"10.1038\/s41598-020-70078-y","article-title":"25-Hydroxyvitamin D status, vitamin D intake, and skin cancer risk: A systematic review and dose-response meta-analysis of prospective studies","volume":"10","author":"Aune","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1016\/j.ejca.2014.06.024","article-title":"Vitamin D and melanoma and non-melanoma skin cancer risk and prognosis: A comprehensive review and meta-analysis","volume":"50","author":"Caini","year":"2014","journal-title":"Eur. J. Cancer"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s40257-017-0337-2","article-title":"Malignancy Risk and Recurrence with Psoriasis and its Treatments: A Concise Update","volume":"19","author":"Geller","year":"2018","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1080\/01635581.2011.539314","article-title":"Inverse Association between Dietary Vitamin D and Risk of Cutaneous Melanoma in a Northern Italy Population","volume":"63","author":"Vinceti","year":"2011","journal-title":"Nutr. Cancer"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/20\/12291\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:54:09Z","timestamp":1760144049000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/20\/12291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,14]]},"references-count":59,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["ijms232012291"],"URL":"https:\/\/doi.org\/10.3390\/ijms232012291","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,14]]}}}