{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T04:55:07Z","timestamp":1784177707074,"version":"3.55.0"},"reference-count":119,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["455614"],"award-info":[{"award-number":["455614"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Female gynecological organ dysfunction can cause infertility and psychological distress, decreasing the quality of life of affected women. Incidence is constantly increasing due to growing rates of cancer and increase of childbearing age in the developed world. Current treatments are often unable to restore organ function, and occasionally are the cause of female infertility. Alternative treatment options are currently being developed in order to face the inadequacy of current practices. In this review, pathologies and current treatments of gynecological organs (ovaries, uterus, and vagina) are described. State-of-the-art of tissue engineering alternatives to common practices are evaluated with a focus on in vivo models. Tissue engineering is an ever-expanding field, integrating various domains of modern science to create sophisticated tissue substitutes in the hope of repairing or replacing dysfunctional organs using autologous cells. Its application to gynecology has the potential of restoring female fertility and sexual wellbeing.<\/jats:p>","DOI":"10.3390\/ijms232012319","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T02:29:46Z","timestamp":1665973786000},"page":"12319","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Tissue Engineering in Gynecology"],"prefix":"10.3390","volume":"23","author":[{"given":"David","family":"Brownell","sequence":"first","affiliation":[{"name":"Centre de Recherche en Organog\u00e9ne\u00e8se Exp\u00e9rimentale\/LOEX, Regenerative Medicine Division, CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center, Qu\u00e9bec, QC G1J 1Z4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0389-667X","authenticated-orcid":false,"given":"St\u00e9phane","family":"Chabaud","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Organog\u00e9ne\u00e8se Exp\u00e9rimentale\/LOEX, Regenerative Medicine Division, CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center, Qu\u00e9bec, QC G1J 1Z4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6680-5563","authenticated-orcid":false,"given":"St\u00e9phane","family":"Bolduc","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Organog\u00e9ne\u00e8se Exp\u00e9rimentale\/LOEX, Regenerative Medicine Division, CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center, Qu\u00e9bec, QC G1J 1Z4, Canada"},{"name":"Division of Urology, Department of Surgery, CHU de Qu\u00e9bec-Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 4G2, Canada"},{"name":"Department of Surgery, Faculty of Medicine, Laval University, Qu\u00e9bec, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"ref_1","first-page":"556","article-title":"Female Infertility","volume":"Volume 8","author":"Barbier","year":"2017","journal-title":"Yen & Jaffe\u2019s Reproductive Endocrinology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.fertnstert.2014.12.121","article-title":"Cumulative incidence of infertility in a New Zealand birth cohort to age 38 by sex and the relationship with family formation","volume":"103","author":"Dickson","year":"2015","journal-title":"Fertil. 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