{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:38:56Z","timestamp":1790912336532,"version":"4.1.0"},"reference-count":116,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea","award":["NRF-2021R1C1C1013875"],"award-info":[{"award-number":["NRF-2021R1C1C1013875"]}]},{"name":"National Research Foundation of Korea","award":["001072"],"award-info":[{"award-number":["001072"]}]},{"name":"National Research Foundation of Korea","award":["001329"],"award-info":[{"award-number":["001329"]}]},{"name":"University of Suwon","award":["NRF-2021R1C1C1013875"],"award-info":[{"award-number":["NRF-2021R1C1C1013875"]}]},{"name":"University of Suwon","award":["001072"],"award-info":[{"award-number":["001072"]}]},{"name":"University of Suwon","award":["001329"],"award-info":[{"award-number":["001329"]}]},{"name":"Kangnam University Research Fund","award":["NRF-2021R1C1C1013875"],"award-info":[{"award-number":["NRF-2021R1C1C1013875"]}]},{"name":"Kangnam University Research Fund","award":["001072"],"award-info":[{"award-number":["001072"]}]},{"name":"Kangnam University Research Fund","award":["001329"],"award-info":[{"award-number":["001329"]}]},{"name":"Small and Medium Business Technology Development","award":["NRF-2021R1C1C1013875"],"award-info":[{"award-number":["NRF-2021R1C1C1013875"]}]},{"name":"Small and Medium Business Technology Development","award":["001072"],"award-info":[{"award-number":["001072"]}]},{"name":"Small and Medium Business Technology Development","award":["001329"],"award-info":[{"award-number":["001329"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Nanotechnology has been developed to deliver cargos effectively to the vascular system. Nanomedicine is a novel and effective approach for targeted vascular disease treatment including atherosclerosis, coronary artery disease, strokes, peripheral arterial disease, and cancer. It has been well known for some time that vascular disease patients have a higher cancer risk than the general population. During atherogenesis, the endothelial cells are activated to increase the expression of adhesion molecules such as Intercellular Adhesion Molecule 1 (ICAM-1), Vascular cell adhesion protein 1 (VCAM-1), E-selectin, and P-selectin. This biological activation of endothelial cells gives a targetability clue for nanoparticle strategies. Nanoparticle formation has a passive targeting pathway due to the increased adhesion molecule expression on the cell surface as well as increased cell activation. In addition, the VCAM-1-targeting peptide has been widely used to target the inflamed endothelial cells. Biomimetic nanoparticles using platelet and leukocyte membrane fragment strategies have been promising techniques for targeted vascular disease treatment. Cyclodextrin, a natural oligosaccharide with a hydrophobic cavity, increase the solubility of cholesterol crystals at the atherosclerotic plaque site and has been used to deliver the hydrophobic drug statin as a therapeutic in a targeted manner. In summary, nanoparticles decorated with various targeting molecules will be an effective and promising strategy for targeted vascular disease treatment.<\/jats:p>","DOI":"10.3390\/ijms232012397","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T05:08:02Z","timestamp":1665983282000},"page":"12397","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Current Nanomedicine for Targeted Vascular Disease Treatment: Trends and Perspectives"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6768-828X","authenticated-orcid":false,"given":"Kyung-A","family":"Choi","sequence":"first","affiliation":[{"name":"National Institute of Medical Welfare, Kangnam University, Yongin 16979, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2305-0567","authenticated-orcid":false,"given":"June Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, The University of Suwon, Suwon 18323, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kitae","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, The University of Suwon, Suwon 18323, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8671-6779","authenticated-orcid":false,"given":"Neha","family":"Kaushik","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, The University of Suwon, Suwon 18323, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1161\/01.ATV.0000051384.43104.FC","article-title":"Endothelial dysfunction: A marker of atherosclerotic risk","volume":"23","author":"Bonetti","year":"2003","journal-title":"Arterioscler. 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