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Myocardial infarction increases the burden of atrial fibrillation and ventricular tachycardia by structural and electrical remodeling of the heart. The current management of new-onset atrial fibrillation includes electric cardioversion with very high conversion rates and pharmacologic cardioversion, with less a than 50% conversion rate. If atrial fibrillation cannot be converted, the focus becomes the control of the symptoms ensuring a constant rhythm and rate control, without considering other contributory factors such as autonomic imbalance. Recently, a huge success was obtained by developing ablation techniques or addressing the vagal nerve stimulation. On the other hand, ventricular tachycardia is more sensitive to drug therapies. However, in cases of non-responsiveness to drugs, the usual therapeutic choice is represented by stereotactic ablative therapy or catheter ablation. This review focuses on these newly developed strategies for treatment of arrhythmias in clinical practice, specifically on vernakalant and low-level tragus stimulation for atrial fibrillation and stereotactic ablative therapy for drug-refractory ventricular tachycardia. These therapies are important for the significant improvement of the management of atrial fibrillation and ventricular tachycardia, providing: (1) a safer profile than current therapies, (2) higher success rate than current solutions, (3) low cost of delivery.<\/jats:p>","DOI":"10.3390\/ijms232012612","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T22:49:46Z","timestamp":1666306186000},"page":"12612","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Promising Therapies for Atrial Fibrillation and Ventricular Tachycardia"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6581-4449","authenticated-orcid":false,"given":"Andrei Alexandru","family":"Mircea","sequence":"first","affiliation":[{"name":"Victor Babes National Institute of Pathology, 050096 Bucharest, Romania"},{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Rusu","sequence":"additional","affiliation":[{"name":"Department for Cardiology, Angiology and Internal Intensive Care, Medical Faculty, RWTH Aachen University, 5207 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa Anamaria","family":"Liehn","sequence":"additional","affiliation":[{"name":"Victor Babes National Institute of Pathology, 050096 Bucharest, Romania"},{"name":"Institute for Molecular Medicine, University of Southern Denmark, DK-5230 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8501-588X","authenticated-orcid":false,"given":"Octavian","family":"Bucur","sequence":"additional","affiliation":[{"name":"Victor Babes National Institute of Pathology, 050096 Bucharest, Romania"},{"name":"Viron Molecular Medicine Institute, Boston, MA 02108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.15420\/aer.2018:15:2","article-title":"Sudden Cardiac Death and Arrhythmias","volume":"7","author":"Srinivasan","year":"2018","journal-title":"Arrhythmia Electrophysiol. 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