{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:33:15Z","timestamp":1787736795256,"version":"build-2784847793"},"reference-count":31,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T00:00:00Z","timestamp":1666396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PRIN 2017 from University of Viterbo"},{"name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca (MIUR), Rome, Italy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The placenta is a crucial interface between the fetus and the maternal environment. It allows for nutrient absorption, thermal regulation, waste elimination, and gas exchange through the mother\u2019s blood supply. Furthermore, the placenta determines important adjustments and epigenetic modifications that can change the phenotypic expression of the individual even long after birth. Polyethylene glycol (PEG) is a polyether compound derived from petroleum with many applications, from medicine to industrial manufacturing. In this study, for the first time, an integration of ultra-high-performance liquid chromatography (UHPLC) coupled with mass spectrometry (MS) was used to detect suites of PEG compounds in human placenta samples, collected from 12 placentas, originating from physiological pregnancy. In 10 placentas, we identified fragments of PEG in both chorioamniotic membranes and placental cotyledons, for a total of 36 samples.<\/jats:p>","DOI":"10.3390\/ijms232112743","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T04:40:36Z","timestamp":1666586436000},"page":"12743","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Plastic and Placenta: Identification of Polyethylene Glycol (PEG) Compounds in the Human Placenta by HPLC-MS\/MS System"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2579-1027","authenticated-orcid":false,"given":"Antonio","family":"Ragusa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Universit\u00e0 Campus Bio Medico di Roma, Via \u00c1lvaro del Portillo, 21, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Lelli","sequence":"additional","affiliation":[{"name":"Department of Ecological and Biological Sciences, Universit\u00e0 degli Studi della Tuscia, 01100 Viterbo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8423-065X","authenticated-orcid":false,"given":"Giuseppina","family":"Fanelli","sequence":"additional","affiliation":[{"name":"Department of Ecological and Biological Sciences, Universit\u00e0 degli Studi della Tuscia, 01100 Viterbo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4713-9539","authenticated-orcid":false,"given":"Alessandro","family":"Svelato","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Universit\u00e0 Campus Bio Medico di Roma, Via \u00c1lvaro del Portillo, 21, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"D\u2019Avino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Universit\u00e0 Campus Bio Medico di Roma, Via \u00c1lvaro del Portillo, 21, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6208-8130","authenticated-orcid":false,"given":"Federica","family":"Gevi","sequence":"additional","affiliation":[{"name":"Department of Ecological and Biological Sciences, Universit\u00e0 degli Studi della Tuscia, 01100 Viterbo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Criselda","family":"Santacroce","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy, San Giovanni Calibita Fatebenefratelli Hospital, Isola Tiberina, Via di Ponte Quattro Capi, 39, 00186 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piera","family":"Catalano","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy, San Giovanni Calibita Fatebenefratelli Hospital, Isola Tiberina, Via di Ponte Quattro Capi, 39, 00186 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Ciro Antonio","family":"Rongioletti","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy, San Giovanni Calibita Fatebenefratelli Hospital, Isola Tiberina, Via di Ponte Quattro Capi, 39, 00186 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"De Luca","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Universit\u00e0 Campus Bio Medico di Roma, Via \u00c1lvaro del Portillo, 21, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Gulotta","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Universit\u00e0 Degli Studi di Sassari, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Rinalducci","sequence":"additional","affiliation":[{"name":"Department of Ecological and Biological Sciences, Universit\u00e0 degli Studi della Tuscia, 01100 Viterbo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8457-042X","authenticated-orcid":false,"given":"Anna Maria","family":"Timperio","sequence":"additional","affiliation":[{"name":"Department of Ecological and Biological Sciences, Universit\u00e0 degli Studi della Tuscia, 01100 Viterbo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7185\/geochemlet.1829","article-title":"Microplastics contaminate the deepest part of the world\u2019s ocean","volume":"9","author":"Peng","year":"2018","journal-title":"Geochem. 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