{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:12:26Z","timestamp":1772799146182,"version":"3.50.1"},"reference-count":58,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T00:00:00Z","timestamp":1666483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"MIUR","doi-asserted-by":"publisher","award":["PON01_02093"],"award-info":[{"award-number":["PON01_02093"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University Campus Bio-Medico of Rome","award":["PON01_02093"],"award-info":[{"award-number":["PON01_02093"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sumac, Rhus coriaria L., is a Mediterranean plant showing several useful properties, such as antioxidant and neuroprotective effects. Currently, there is no evidence about its possible neuroprotective action in Parkinson\u2019s disease (PD). We hypothesized that sumac could modulate mitochondrial functionality in fibroblasts of familial early-onset PD patients showing PARK2 mutations. Sumac extract volatile profile, polyphenolic content and antioxidant activity have been previously characterized. We evaluated ROS and ATP levels on sumac-treated patients\u2019 and healthy control fibroblasts. In PD fibroblasts, all treatments were effective in reducing H2O2 levels, while patients\u2019 ATP content was modulated differently, probably due to the varying mutations in the PARK2 gene found in individual patients which are also involved in different mitochondrial phenotypes. We also investigated the effect of sumac extract on THP-1-differentiated macrophages, which show different embryogenic origin with respect to fibroblasts. In THP-1 macrophages, sumac treatment determined a reduction in H2O2 levels and an increase in the mitochondrial ATP content in M1, assuming that sumac could polarize the M1 to M2 phenotype, as demonstrated with other food-derived compounds rich in polyphenols. In conclusion, Rhus coriaria L. extracts could represent a potential nutraceutical approach to PD.<\/jats:p>","DOI":"10.3390\/ijms232112774","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T04:40:36Z","timestamp":1666586436000},"page":"12774","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Rhus Coriaria L. Extract: Antioxidant Effect and Modulation of Bioenergetic Capacity in Fibroblasts from Parkinson\u2019s Disease Patients and THP-1 Macrophages"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9981-4121","authenticated-orcid":false,"given":"Camilla","family":"Isgr\u00f2","sequence":"first","affiliation":[{"name":"Department of Translational Biomedicine Neuroscience \u2018DiBraiN\u2019, University of Bari \u201cAldo Moro\u201d, Piazza G. Cesare 11, 70124 Bari, Italy"},{"name":"Department of Medicine, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9565-5362","authenticated-orcid":false,"given":"Ludovica","family":"Spagnuolo","sequence":"additional","affiliation":[{"name":"Department of Science and Technology for Humans and the Environment, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Pannucci","sequence":"additional","affiliation":[{"name":"Department of Science and Technology for Humans and the Environment, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8890-675X","authenticated-orcid":false,"given":"Luigi","family":"Mondello","sequence":"additional","affiliation":[{"name":"Department of Science and Technology for Humans and the Environment, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128 Roma, Italy"},{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy"},{"name":"Chromaleont s.r.l., c\/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Santi","sequence":"additional","affiliation":[{"name":"Department of Agriculture and Forest Sciences, University of Tuscia, Via San Camillo de Lellis snc, 01100 Viterbo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5527-0364","authenticated-orcid":false,"given":"Laura","family":"Dugo","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8535-7601","authenticated-orcid":false,"given":"Anna Maria","family":"Sardanelli","sequence":"additional","affiliation":[{"name":"Department of Translational Biomedicine Neuroscience \u2018DiBraiN\u2019, University of Bari \u201cAldo Moro\u201d, Piazza G. Cesare 11, 70124 Bari, Italy"},{"name":"Department of Medicine, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s11940-012-0175-8","article-title":"Considerations Regarding the Etiology and Future Treatment of Autosomal Recessive versus Idiopathic Parkinson Disease","volume":"14","author":"Kitada","year":"2012","journal-title":"Curr. Treat. Options Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"a008888","DOI":"10.1101\/cshperspect.a008888","article-title":"Genetics of Parkinson\u2019s Disease","volume":"2","author":"Klein","year":"2012","journal-title":"Cold Spring Harb. Perspect. 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