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Translational studies have reported that pelvic floor muscle disorders are due to a GDM-induced-myopathy (GDiM) of the pelvic floor muscle and rectus abdominis muscle (RAM). We now describe the transcriptome profiling of the RAM obtained by Cesarean section from GDM and non-GDM women with and without pregnancy-specific urinary incontinence (PSUI). We identified 650 genes in total, and the differentially expressed genes were defined by comparing three control groups to the GDM with PSUI group (GDiM). Enrichment analysis showed that GDM with PSUI was associated with decreased gene expression related to muscle structure and muscle protein synthesis, the reduced ability of muscle fibers to ameliorate muscle damage, and the altered the maintenance and generation of energy through glycogenesis. Potential genetic muscle biomarkers were validated by RT-PCR, and their relationship to the pathophysiology of the disease was verified. These findings help elucidate the molecular mechanisms of GDiM and will promote the development of innovative interventions to prevent and treat complications such as post-GDM urinary incontinence.<\/jats:p>","DOI":"10.3390\/ijms232112864","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T22:00:27Z","timestamp":1666735227000},"page":"12864","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Transcriptomic Profiling of Rectus Abdominis Muscle in Women with Gestational Diabetes-Induced Myopathy: Characterization of Pathophysiology and Potential Muscle Biomarkers of Pregnancy-Specific Urinary Incontinence"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4640-5332","authenticated-orcid":false,"given":"Fernanda Cristina Bergamo","family":"Alves","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Botucatu Medical 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India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3504-6936","authenticated-orcid":false,"given":"Edson Assun\u00e7\u00e3o","family":"Mareco","sequence":"additional","affiliation":[{"name":"Environment and Regional Development Graduate Program, University of Western S\u00e3o Paulo (UNOESTE), Presidente Prudente 19050-680, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7269-9197","authenticated-orcid":false,"given":"Maeli","family":"Dal-Pai-Silva","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology, Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Botucatu 18618-689, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer Luiz Marques","family":"Pay\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Genetics, Faculdade de Medicina de Mar\u00edlia (FAMEMA), Mar\u00edlia 17519-030, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima Pereira de","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Physics, UNESP-IBILCE, S\u00e3o Jos\u00e9 do Rio Preto 15054-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven S.","family":"Witkin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA"},{"name":"Laboratory of Virology, Institute of Tropical Medicine, University of Sao Paulo Faculty of Medicine, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5802-2243","authenticated-orcid":false,"given":"Luis","family":"Sobrevia","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Botucatu Medical School (FMB), S\u00e3o Paulo State University (UNESP), Botucatu 18618-687, 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