{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T23:28:13Z","timestamp":1770334093755,"version":"3.49.0"},"reference-count":53,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005758","name":"Fondi di Ateneo UNIVPM 2021","doi-asserted-by":"publisher","award":["FA 2021"],"award-info":[{"award-number":["FA 2021"]}],"id":[{"id":"10.13039\/501100005758","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Preeclampsia is a human pregnancy-specific disease characterized by abnormal placentation that usually presents with maternal hypertension and proteinuria. The main hallmark of preeclampsia, impaired trophoblast migration, and the subsequent disruption of uterine arteries remodeling lead to several molecular alterations in the placental compartments with those occurring in the chorionic villi being of the utmost importance. Given the essential role of the endocannabinoid system during preimplantation and trophoblast migration, we have combined the histological and hyperspectral imaging analyses to shed light on the involvement of two cannabinoid receptors in the macromolecular alterations related to preeclampsia. The results obtained by immunohistochemistry showed a significant increase in the protein levels of cannabinoid receptor 1 (CB1) in the preeclamptic chorionic villi. However, no changes were reported regarding transient receptor potential vanilloid 1 (TRPV-1) levels either in the bulk placental samples or chorionic villi when comparing control and preeclamptic patients. Histological analysis and Fourier-transform infrared spectroscopy (FTIRI) showed an increase in collagen deposition together with higher levels of lipid peroxidation and phosphorylated compounds in the pathological villi. Since CB1 enhancement has been described as promoting fibrosis and oxidative stress in several tissues, we proposed that the higher receptor abundance in preeclampsia could be triggering similar molecular effects in preeclamptic term placentas.<\/jats:p>","DOI":"10.3390\/ijms232112931","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T07:17:48Z","timestamp":1666768668000},"page":"12931","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Preeclampsia Correlates with an Increase in Cannabinoid Receptor 1 Levels Leading to Macromolecular Alterations in Chorionic Villi of Term Placenta"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2042-798X","authenticated-orcid":false,"given":"Marta","family":"Lomb\u00f3","sequence":"first","affiliation":[{"name":"Department of Life and Environmental Sciences, Universit\u00e0 Politecnica delle Marche, 60131 Ancona, Italy"},{"name":"Department of Molecular Biology, Faculty of Biology and Environmental Sciences, Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8451-2569","authenticated-orcid":false,"given":"Christian","family":"Giommi","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, Universit\u00e0 Politecnica delle Marche, 60131 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Paolucci","sequence":"additional","affiliation":[{"name":"Department of Odontostomatological and Specialized Clinical Sciences, Universit\u00e0 Politecnica delle Marche, 60020 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4651-6235","authenticated-orcid":false,"given":"Valentina","family":"Notarstefano","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, Universit\u00e0 Politecnica delle Marche, 60131 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Montik","sequence":"additional","affiliation":[{"name":"Department of Odontostomatological and Specialized Clinical Sciences, Universit\u00e0 Politecnica delle Marche, 60020 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Delli Carpini","sequence":"additional","affiliation":[{"name":"Department of Odontostomatological and Specialized Clinical Sciences, Universit\u00e0 Politecnica delle Marche, 60020 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ciavattini","sequence":"additional","affiliation":[{"name":"Department of Odontostomatological and Specialized Clinical Sciences, Universit\u00e0 Politecnica delle Marche, 60020 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2579-1027","authenticated-orcid":false,"given":"Antonio","family":"Ragusa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Universit\u00e0 Campus Bio Medico di Roma, 00128 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6677-1017","authenticated-orcid":false,"given":"Francesca","family":"Maradonna","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, Universit\u00e0 Politecnica delle Marche, 60131 Ancona, Italy"},{"name":"INBB\u2014Consorzio Interuniversitario di Biosistemi e Biostrutture, 00136 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0503-5870","authenticated-orcid":false,"given":"Elisabetta","family":"Giorgini","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, Universit\u00e0 Politecnica delle Marche, 60131 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5994-0572","authenticated-orcid":false,"given":"Oliana","family":"Carnevali","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, Universit\u00e0 Politecnica delle Marche, 60131 Ancona, Italy"},{"name":"INBB\u2014Consorzio Interuniversitario di Biosistemi e Biostrutture, 00136 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1053\/j.semperi.2011.09.011","article-title":"Maternal Mortality from Preeclampsia\/Eclampsia","volume":"36","author":"Ghulmiyyah","year":"2012","journal-title":"Semin. 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