{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T06:43:54Z","timestamp":1785825834192,"version":"3.56.0"},"reference-count":35,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Gobierno de Aragon","award":["B14-7R"],"award-info":[{"award-number":["B14-7R"]}]},{"name":"Gobierno de Aragon","award":["PI18\/01777"],"award-info":[{"award-number":["PI18\/01777"]}]},{"name":"Gobierno de Aragon","award":["PI19\/0694"],"award-info":[{"award-number":["PI19\/0694"]}]},{"name":"Gobierno de Aragon","award":["CIBERCV"],"award-info":[{"award-number":["CIBERCV"]}]},{"name":"Spanish Ministry of Economy and competitiveness","award":["B14-7R"],"award-info":[{"award-number":["B14-7R"]}]},{"name":"Spanish Ministry of Economy and competitiveness","award":["PI18\/01777"],"award-info":[{"award-number":["PI18\/01777"]}]},{"name":"Spanish Ministry of Economy and competitiveness","award":["PI19\/0694"],"award-info":[{"award-number":["PI19\/0694"]}]},{"name":"Spanish Ministry of Economy and competitiveness","award":["CIBERCV"],"award-info":[{"award-number":["CIBERCV"]}]},{"name":"Instituto de Salud Carlos III","award":["B14-7R"],"award-info":[{"award-number":["B14-7R"]}]},{"name":"Instituto de Salud Carlos III","award":["PI18\/01777"],"award-info":[{"award-number":["PI18\/01777"]}]},{"name":"Instituto de Salud Carlos III","award":["PI19\/0694"],"award-info":[{"award-number":["PI19\/0694"]}]},{"name":"Instituto de Salud Carlos III","award":["CIBERCV"],"award-info":[{"award-number":["CIBERCV"]}]},{"name":"European Regional Development Fund (ERDF) of the European Union","award":["B14-7R"],"award-info":[{"award-number":["B14-7R"]}]},{"name":"European Regional Development Fund (ERDF) of the European Union","award":["PI18\/01777"],"award-info":[{"award-number":["PI18\/01777"]}]},{"name":"European Regional Development Fund (ERDF) of the European Union","award":["PI19\/0694"],"award-info":[{"award-number":["PI19\/0694"]}]},{"name":"European Regional Development Fund (ERDF) of the European Union","award":["CIBERCV"],"award-info":[{"award-number":["CIBERCV"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The association between APOE genotypes and cardiovascular disease (CVD) is partially mediated by LDL-cholesterol concentration but persists after adjusting for lipid levels and other cardiovascular risk factors. Data from the Aragon Workers Health Study (AWHS) (n = 4159) and the Lipid Unit at the Hospital Universitario Miguel Servet (HUMS) (n = 3705) were used to investigate the relationship between C-reactive protein (CRP) levels and APOE genotype. Lipoprotein particle and GlycA concentrations were analyzed in a subsample from AWHS. APOE genotyping was carried out by the Sanger method in both cohorts. APOE4 carriers had significantly lower levels of CRP than APOE3 carriers. Furthermore, APOE4 carriers had cholesterol-enriched LDL particles compared to APOE2 carriers. APOE4 carriers also had higher concentrations of small, medium, and large LDL particles. CRP levels were not associated with lipoprotein particle number, size, or composition. GlycA levels were not associated with APOE genotypes. However, GlycA levels were significantly associated with the size and the amount of cholesterol contained in HDL, VLDL, and LDL particles. APOE genotype influences CRP concentration regardless of lipid profile. APOE2 carriers showed the highest CRP levels, followed by APOE3 and APOE4. A more atherogenic lipid profile, but not inflammatory markers could partly explain the higher CVD risk observed in APOE4 carriers.<\/jats:p>","DOI":"10.3390\/ijms232112947","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T07:17:48Z","timestamp":1666768668000},"page":"12947","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["APOE Genotypes Modulate Inflammation Independently of Their Effect on Lipid Metabolism"],"prefix":"10.3390","volume":"23","author":[{"given":"Mar\u00eda","family":"Civeira-Mar\u00edn","sequence":"first","affiliation":[{"name":"Lipid Unit, Hospital Universitario Miguel Servet, Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Arag\u00f3n), Centro de Investigaci\u00f3n Biom\u00e9dicas en Red Enfermedades Cardiovacsulares (CIBERCV), 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Cenarro","sequence":"additional","affiliation":[{"name":"Lipid Unit, Hospital Universitario Miguel Servet, Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Arag\u00f3n), Centro de Investigaci\u00f3n Biom\u00e9dicas en Red Enfermedades Cardiovacsulares (CIBERCV), 50009 Zaragoza, Spain"},{"name":"Instituto Aragon\u00e9s de Ciencias de la Salud (IACS), 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Marco-Bened\u00ed","sequence":"additional","affiliation":[{"name":"Lipid Unit, Hospital Universitario Miguel Servet, Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Arag\u00f3n), Centro de Investigaci\u00f3n Biom\u00e9dicas en Red Enfermedades Cardiovacsulares (CIBERCV), 50009 Zaragoza, Spain"},{"name":"Departamento de Medicina, Psiquiatr\u00eda y Dermatolog\u00eda, Facultad de Medicina, Universidad de Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Bea","sequence":"additional","affiliation":[{"name":"Lipid Unit, Hospital Universitario Miguel Servet, Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Arag\u00f3n), Centro de Investigaci\u00f3n Biom\u00e9dicas en Red Enfermedades Cardiovacsulares (CIBERCV), 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Mateo-Gallego","sequence":"additional","affiliation":[{"name":"Lipid Unit, Hospital Universitario Miguel Servet, Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Arag\u00f3n), Centro de Investigaci\u00f3n Biom\u00e9dicas en Red Enfermedades Cardiovacsulares (CIBERCV), 50009 Zaragoza, Spain"},{"name":"Departamento de Fisiatr\u00eda y Enfermer\u00eda, Facultad de Ciencias de la Salud y del Deporte, Universidad de Zaragoza, 22001 Huesca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Moreno-Franco","sequence":"additional","affiliation":[{"name":"Lipid Unit, Hospital Universitario Miguel Servet, Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Arag\u00f3n), Centro de Investigaci\u00f3n Biom\u00e9dicas en Red Enfermedades Cardiovacsulares (CIBERCV), 50009 Zaragoza, Spain"},{"name":"Departamento de Medicina, Microbiolog\u00eda, Pediatr\u00eda, Radiolog\u00eda y Salud P\u00fablica, Facultad de Medicina, Universidad de Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Ordov\u00e1s","sequence":"additional","affiliation":[{"name":"Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA"},{"name":"Precision Nutrition and Obesity Program, IMDEA Alimentaci\u00f3n, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn","family":"Laclaustra","sequence":"additional","affiliation":[{"name":"Lipid Unit, Hospital Universitario Miguel Servet, Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Arag\u00f3n), Centro de Investigaci\u00f3n Biom\u00e9dicas en Red Enfermedades Cardiovacsulares (CIBERCV), 50009 Zaragoza, Spain"},{"name":"Departamento de Medicina, Psiquiatr\u00eda y Dermatolog\u00eda, Facultad de Medicina, Universidad de Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7043-0952","authenticated-orcid":false,"given":"Fernando","family":"Civeira","sequence":"additional","affiliation":[{"name":"Lipid Unit, Hospital Universitario Miguel Servet, Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Arag\u00f3n), Centro de Investigaci\u00f3n Biom\u00e9dicas en Red Enfermedades Cardiovacsulares (CIBERCV), 50009 Zaragoza, Spain"},{"name":"Departamento de Medicina, Psiquiatr\u00eda y Dermatolog\u00eda, Facultad de Medicina, Universidad de Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itziar","family":"Lamiquiz-Moneo","sequence":"additional","affiliation":[{"name":"Lipid Unit, Hospital Universitario Miguel Servet, Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Arag\u00f3n), Centro de Investigaci\u00f3n Biom\u00e9dicas en Red Enfermedades Cardiovacsulares (CIBERCV), 50009 Zaragoza, Spain"},{"name":"Departamento de Anatom\u00eda e Histolog\u00eda Humanas, Facultad de Medicina, Universidad de Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.csbj.2017.05.003","article-title":"Apolipoprotein E\u2014A Multifunctional Protein with Implications in Various 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