{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:03:55Z","timestamp":1788314635267,"version":"build-2803163510"},"reference-count":108,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"Research Career Scientist Award","doi-asserted-by":"publisher","award":["IK6BX004212"],"award-info":[{"award-number":["IK6BX004212"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"Research Career Scientist Award","doi-asserted-by":"publisher","award":["IK6BX006032"],"award-info":[{"award-number":["IK6BX006032"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"Research Career Scientist Award","doi-asserted-by":"publisher","award":["BX003413"],"award-info":[{"award-number":["BX003413"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Veterans Affairs Merit Review","award":["IK6BX004212"],"award-info":[{"award-number":["IK6BX004212"]}]},{"name":"Veterans Affairs Merit Review","award":["IK6BX006032"],"award-info":[{"award-number":["IK6BX006032"]}]},{"name":"Veterans Affairs Merit Review","award":["BX003413"],"award-info":[{"award-number":["BX003413"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>There is currently a growing interest in the use of cannabidiol (CBD) to alleviate the symptoms caused by cancer, including pain, sleep disruption, and anxiety. CBD is often self-administered as an over-the-counter supplement, and patients have reported benefits from its use. However, despite the progress made, the mechanisms underlying CBD\u2019s anti-cancer activity remain divergent and unclear. Herein, we provide a comprehensive review of molecular mechanisms to determine convergent anti-cancer actions of CBD from pre-clinical and clinical studies. In vitro studies have begun to elucidate the molecular targets of CBD and provide evidence of CBD\u2019s anti-tumor properties in cell and mouse models of cancer. Furthermore, several clinical trials have been completed testing CBD\u2019s efficacy in treating cancer-related pain. However, most use a mixture of CBD and the psychoactive, tetrahydrocannabinol (THC), and\/or use variable dosing that is not consistent between individual patients. Despite these limitations, significant reductions in pain and opioid use have been reported in cancer patients using CBD or CBD+THC. Additionally, significant improvements in quality-of-life measures and patients\u2019 overall satisfaction with their treatment have been reported. Thus, there is growing evidence suggesting that CBD might be useful to improve the overall quality of life of cancer patients by both alleviating cancer symptoms and by synergizing with cancer therapies to improve their efficacy. However, many questions remain unanswered regarding the use of CBD in cancer treatment, including the optimal dose, effective combinations with other drugs, and which biomarkers\/clinical presentation of symptoms may guide its use.<\/jats:p>","DOI":"10.3390\/ijms232112956","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T09:59:37Z","timestamp":1666778377000},"page":"12956","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Role of Cannabidiol for Improvement of the Quality of Life in Cancer Patients: Potential and Challenges"],"prefix":"10.3390","volume":"23","author":[{"given":"Ryan","family":"Green","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA"},{"name":"Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA"},{"name":"James A Haley VA Hospital, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roukiah","family":"Khalil","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5838-0681","authenticated-orcid":false,"given":"Shyam S.","family":"Mohapatra","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA"},{"name":"James A Haley VA Hospital, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhra","family":"Mohapatra","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA"},{"name":"James A Haley VA Hospital, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104850","DOI":"10.1016\/j.supflu.2020.104850","article-title":"Extraction of cannabinoids from hemp (Cannabis sativa L.) using high pressure solvents: An overview of different processing options","volume":"161","author":"Moreno","year":"2020","journal-title":"J. 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