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Although the differences at the intercellular and intracellular signaling level between AD and PS are well described, the resulting differences at the metabolism level have not yet been systematically analyzed. We compared the metabolomic profiles of the lesional skin, non-lesional skin and blood sera of AD and PS. Skin biopsies from 15 patients with AD, 20 patients with PS and 17 controls were collected, and 25 patients with AD, 55 patients with PS and 63 controls were recruited for the blood serum analysis. Serum and skin samples were analyzed using a targeted approach to find the concentrations of 188 metabolites and their ratios. A total of 19 metabolites differed in the comparison of lesional skins, one metabolite in non-lesional skins and 5 metabolites in blood sera. Although we found several metabolomic similarities between PS and AD, clear differences were outlined. Sphingomyelins were elevated in lesional skin of AD, implying a deficient barrier function. Increased levels of phosphatidylcholines, carnitines and asymmetric dimethylarginine in PS lesional skin and carnitines amino acids in the PS serum pointed to elevated cell proliferation. The comparison of the metabolomic profiles of AD and PS skin and sera outlined distinct patterns that were well correlated with the differences in the pathogenetic mechanisms of these two chronic inflammatory dermatoses.<\/jats:p>","DOI":"10.3390\/ijms232113001","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T20:37:58Z","timestamp":1666903078000},"page":"13001","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Metabolomic Differences between the Skin and Blood Sera of Atopic Dermatitis and Psoriasis"],"prefix":"10.3390","volume":"23","author":[{"given":"Liis","family":"Ilves","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, University of Tartu, 50417 Tartu, Estonia"},{"name":"Dermatology Clinic, Tartu University Hospital, 50417 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0829-9337","authenticated-orcid":false,"given":"Aigar","family":"Ottas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411 Tartu, Estonia"},{"name":"Centre of Excellence for Genomics and Translational Medicine, University of Tartu, 50411 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bret","family":"Kaldvee","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, University of Tartu, 50417 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi","family":"Abram","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, University of Tartu, 50417 Tartu, Estonia"},{"name":"Dermatology Clinic, Tartu University Hospital, 50417 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursel","family":"Soomets","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411 Tartu, Estonia"},{"name":"Centre of Excellence for Genomics and Translational Medicine, University of Tartu, 50411 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihkel","family":"Zilmer","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411 Tartu, Estonia"},{"name":"Centre of Excellence for Genomics and Translational Medicine, University of Tartu, 50411 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2221-6262","authenticated-orcid":false,"given":"Viljar","family":"Jaks","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Tartu University Hospital, 50417 Tartu, Estonia"},{"name":"Department of Cell Biology, Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00fclli","family":"Kingo","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, University of Tartu, 50417 Tartu, Estonia"},{"name":"Dermatology Clinic, Tartu University Hospital, 50417 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0140-6736(07)61128-3","article-title":"Pathogenesis and clinical features of psoriasis","volume":"370","author":"Griffiths","year":"2007","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1001\/jama.2020.4006","article-title":"Pathophysiology, Clinical Presentation, and Treatment of Psoriasis: A Review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Puig, L. (2017). Cardiometabolic Comorbidities in Psoriasis and Psoriatic Arthritis. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19010058"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Tokuyama, M., and Mabuchi, T. (2020). New Treatment Addressing the Pathogenesis of Psoriasis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21207488"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1056\/NEJMra0804595","article-title":"Psoriasis","volume":"361","author":"Nestle","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000370220","article-title":"Atopic Dermatitis: Global Epidemiology and Risk Factors","volume":"66","author":"Nutten","year":"2015","journal-title":"Ann. Nutr. 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Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0090-6980(84)90113-8","article-title":"The analysis of arachidonic acid metabolites in normal, uninvolved and lesional psoriatic skin","volume":"28","author":"Barr","year":"1984","journal-title":"Prostaglandins"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/1523-1747.ep12261712","article-title":"The Release of Leukotriene B4-like Material in Biologically Active Amounts from the Lesional Skin of patients with Psoriasis","volume":"83","author":"Brain","year":"1984","journal-title":"J. Investig. Dermatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5130","DOI":"10.1073\/pnas.72.12.5130","article-title":"Increased concentrations of nonesterified arachidonic acid, 12L-hydroxy-5,8,10,14-eicosatetraenoic acid, prostaglandin E2, and prostaglandin F2alpha in epidermis of psoriasis","volume":"72","author":"Hamberg","year":"1975","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.jid.2018.02.003","article-title":"Bioactive Lipid Mediator Profiles in Human Psoriasis Skin and Blood","volume":"138","author":"Sorokin","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Sitter, B., Johnsson, M.K., Halgunset, J., and Bathen, T.F. (2013). Metabolic changes in psoriatic skin under topical corticosteroid treatment. BMC Dermatol., 13.","DOI":"10.1186\/1471-5945-13-8"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"248","DOI":"10.12688\/f1000research.4709.1","article-title":"Metabolomics in psoriatic disease: Pilot study reveals metabolite differences in psoriasis and psoriatic arthritis","volume":"3","author":"Armstrong","year":"2014","journal-title":"F1000Research"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"754","DOI":"10.7150\/thno.51154","article-title":"Metabolomic profiling reveals amino acid and carnitine alterations as metabolic signatures in psoriasis","volume":"11","author":"Chen","year":"2021","journal-title":"Theranostics"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/gigascience\/gix087","article-title":"Lipidomics profiling reveals the role of glycerophospholipid metabolism in psoriasis","volume":"6","author":"Zeng","year":"2017","journal-title":"GigaScience"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e98006","DOI":"10.1172\/jci.insight.98006","article-title":"Lipid abnormalities in atopic skin are driven by type 2 cytokines","volume":"3","author":"Berdyshev","year":"2018","journal-title":"JCI Insight"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5715","DOI":"10.1021\/pr5007069","article-title":"Serum Metabolomics Study and Eicosanoid Analysis of Childhood Atopic Dermatitis Based on Liquid Chromatography-Mass Spectrometry","volume":"13","author":"Huang","year":"2014","journal-title":"J. Proteome Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/j.1365-2133.2011.10711.x","article-title":"An exploratory 1H-nuclear magnetic resonance metabolomics study reveals altered urine spectral profiles in infants with atopic dermatitis","volume":"166","author":"Assfalg","year":"2011","journal-title":"Br. J. Dermatol."},{"key":"ref_23","unstructured":"R Core Team (2021, April 21). R: A Language and Environment for Statistical Computing. Available online: https:\/\/www.R-project.org\/."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"adv00407","DOI":"10.2340\/00015555-3766","article-title":"Metabolomic Analysis of Skin Biopsies from Patients with Atopic Dermatitis Reveals Hallmarks of Inflammation, Disrupted Barrier Function and Oxidative Stress","volume":"101","author":"Ilves","year":"2021","journal-title":"Acta Derm. Venereol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1038\/s41598-020-59996-z","article-title":"Hyperproliferation is the main driver of metabolomic changes in psoriasis lesional skin","volume":"10","author":"Pohla","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2165\/00128071-200506040-00002","article-title":"Role of Ceramides in Barrier Function of Healthy and Diseased Skin","volume":"6","author":"Choi","year":"2005","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1046\/j.1523-1747.2000.00072.x","article-title":"High-Expression of Sphingomyelin Deacylase is an Important Determinant of Ceramide Deficiency Leading to Barrier Disruption in Atopic Dermatitis1","volume":"115","author":"Hara","year":"2000","journal-title":"J. Investig. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/1523-1747.ep12265365","article-title":"A possible function of structural lipids in the water-holding properties of the stratum corneum","volume":"84","author":"Imokawa","year":"1985","journal-title":"J. Investig. Dermatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/1523-1747.ep12470233","article-title":"Decreased level of ceramides in stratum corneum of atopic dermatitis: An etiologic factor in atopic dry skin?","volume":"96","author":"Imokawa","year":"1991","journal-title":"J. Investig. Dermatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000441540","article-title":"Stratum Corneum Lipids: Their Role for the Skin Barrier Function in Healthy Subjects and Atopic Dermatitis Patients","volume":"49","author":"Bouwstra","year":"2016","journal-title":"Curr. Probl. Dermatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature13475","article-title":"Sphingolipid metabolites in inflammatory disease","volume":"510","author":"Maceyka","year":"2014","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/iub.337","article-title":"The Kennedy pathway-De novo synthesis of phosphatidylethanolamine and phosphatidylcholine","volume":"62","author":"Gibellini","year":"2010","journal-title":"IUBMB Life"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4893","DOI":"10.1021\/bi002836k","article-title":"Enzymes of Sphingolipid Metabolism: From Modular to Integrative Signaling","volume":"40","author":"Hannun","year":"2001","journal-title":"Biochemistry"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jdermsci.2009.04.006","article-title":"A possible mechanism underlying the ceramide deficiency in atopic dermatitis: Expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide","volume":"55","author":"Imokawa","year":"2009","journal-title":"J. Dermatol. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1111\/j.0022-202X.2004.22621.x","article-title":"Impaired Sphingomyelinase Activity and Epidermal Differentiation in Atopic Dermatitis","volume":"122","author":"Jensen","year":"2004","journal-title":"J. Investig. Dermatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jdermsci.2012.07.004","article-title":"Th1 cytokines accentuate but Th2 cytokines attenuate ceramide production in the stratum corneum of human epidermal equivalents: An implication for the disrupted barrier mechanism in atopic dermatitis","volume":"68","author":"Sawada","year":"2012","journal-title":"J. Dermatol. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1373\/clinchem.2016.256396","article-title":"Hydrogel Micropatch and Mass Spectrometry\u2014Assisted Screening for Psoriasis-Related Skin Metabolites","volume":"62","author":"Dutkiewicz","year":"2016","journal-title":"Clin. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3109\/09687688.2015.1066894","article-title":"Phosphatidylcholine\u2019s functions beyond that of a membrane brick","volume":"32","author":"Furse","year":"2015","journal-title":"Mol. Membr. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1515\/hsz-2017-0148","article-title":"The sphingomyelin synthase family: Proteins, diseases, and inhibitors","volume":"398","author":"Chen","year":"2017","journal-title":"Biol. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"117443","DOI":"10.1016\/j.lfs.2020.117443","article-title":"The mechanisms of lysophosphatidylcholine in the development of diseases","volume":"247","author":"Liu","year":"2020","journal-title":"Life Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00403-015-1553-3","article-title":"Serum homocysteine, asymmetric dimethyl arginine (ADMA) and other arginine-NO pathway metabolite levels in patients with psoriasis","volume":"307","author":"Bilgic","year":"2015","journal-title":"Arch. Dermatol. Res."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Dowsett, L., Higgins, E., Alanazi, S., Alshuwayer, N.A., Leiper, F.C., and Leiper, J. (2020). ADMA: A Key Player in the Relationship between Vascular Dysfunction and Inflammation in Atherosclerosis. J. Clin. Med., 9.","DOI":"10.3390\/jcm9093026"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.ijcard.2016.06.254","article-title":"Relationship of asymmetric dimethylarginine (ADMA) with extent and functional severity of coronary atherosclerosis","volume":"220","author":"Mangiacapra","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1093\/eurheartj\/ehp567","article-title":"Patients with severe psoriasis are at increased risk of cardiovascular mortality: Cohort study using the General Practice Research Database","volume":"31","author":"Mehta","year":"2010","journal-title":"Eur. Heart J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/BF03261931","article-title":"Carnitine and Acylcarnitines: Pharmacokinetic, Pharmacological and Clinical Aspects","volume":"51","author":"Reuter","year":"2012","journal-title":"Clin. Pharm."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00403-017-1760-1","article-title":"The metabolic analysis of psoriasis identifies the associated metabolites while providing computational models for the monitoring of the disease","volume":"309","author":"Ottas","year":"2017","journal-title":"Arch. Dermatol. Res."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Ottas, A., Fishman, D., Okas, T.-L., P\u00fcssa, T., Toomik, P., Martson, A., Kingo, K., and Soomets, U. (2017). Blood serum metabolome of atopic dermatitis: Altered energy cycle and the markers of systemic inflammation. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0188580"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00726-012-1280-4","article-title":"Glutamate: A truly functional amino acid","volume":"45","author":"Brosnan","year":"2013","journal-title":"Amino Acids"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/hep.29465","article-title":"Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance","volume":"67","author":"Gaggini","year":"2018","journal-title":"Hepatology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jaad.2016.07.065","article-title":"Psoriasis and comorbid diseases: Implications for management","volume":"76","author":"Takeshita","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e982","DOI":"10.1210\/clinem\/dgaa898","article-title":"Elevated Circulating Glutamate Is Associated with Subclinical Atherosclerosis Independently of Established Risk Markers: A Cross-Sectional Study","volume":"106","author":"Peter","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_52","unstructured":"(2021, June 10). KEGG PATHWAY: Arginine and Proline Metabolism\u2014Homo Sapiens. Available online: https:\/\/www.genome.jp\/kegg\/pathway\/map\/hsa00330.html."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/bjd.15008","article-title":"Exploration of candidate biomarkers for human psoriasis based on gas chromatography-mass spectrometry serum metabolomics","volume":"176","author":"Kang","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1021\/pr500782g","article-title":"LC-MS Metabolomics of Psoriasis Patients Reveals Disease Severity-Dependent Increases in Circulating Amino Acids That Are Ameliorated by Anti-TNF\u03b1 Treatment","volume":"14","author":"Kamleh","year":"2014","journal-title":"J. Proteome Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000495992","article-title":"Quantitative Analysis of Free Amino Acids and Urea Derived from Isolated Corneocytes of Healthy Young, Healthy Aged, and Diseased Skin","volume":"32","author":"Hussain","year":"2019","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.immuni.2020.06.004","article-title":"Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis","volume":"53","author":"Lou","year":"2020","journal-title":"Immunity"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.trac.2009.12.003","article-title":"Metabolomics analysis I. Selection of biological samples and practical aspects preceding sample preparation","volume":"29","year":"2010","journal-title":"Trends Anal. Chem."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/21\/13001\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:03:50Z","timestamp":1760144630000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/21\/13001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,27]]},"references-count":57,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["ijms232113001"],"URL":"https:\/\/doi.org\/10.3390\/ijms232113001","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,27]]}}}