{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:45:09Z","timestamp":1792799109901,"version":"4.5.0"},"reference-count":182,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005795","name":"Chang Gung Foundation","doi-asserted-by":"publisher","award":["CMRPG3L0801"],"award-info":[{"award-number":["CMRPG3L0801"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Embryo\u2013endometrial communication plays a critical role in embryo implantation and the establishment of a successful pregnancy. Successful pregnancy outcomes involve maternal immune modulation during embryo implantation. The endometrium is usually primed and immunomodulated by steroid hormones and embryo signals for subsequent embryo implantation and the maintenance of pregnancy. The roles of extracellular vesicles (EVs) and microRNAs for the embryo\u2013maternal interactions have been elucidated recently. New evidence shows that endometrial EVs and trophectoderm-originated EV cargo, including microRNAs, proteins, and lipids in the physiological microenvironment, regulate maternal immunomodulation for embryo implantation and subsequent pregnancy. On the other hand, trophoblast-derived EVs also control the cross-communication between the trophoblasts and immune cells. The exploration of EV functions and mechanisms in the processes of embryo implantation and pregnancy will shed light on a practical tool for the diagnostic or therapeutic approaches to reproductive medicine and infertility.<\/jats:p>","DOI":"10.3390\/ijms232113382","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T03:11:21Z","timestamp":1667445081000},"page":"13382","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Immune Tolerance of Embryo Implantation and Pregnancy: The Role of Human Decidual Stromal Cell- and Embryonic-Derived Extracellular Vesicles"],"prefix":"10.3390","volume":"23","author":[{"given":"Hsien-Ming","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Linkou Medical Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5749-6962","authenticated-orcid":false,"given":"Liang-Hsuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Linkou Medical Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le-Tien","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Linkou Medical Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9977-9645","authenticated-orcid":false,"given":"Chyong-Huey","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Linkou Medical Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 333, Taiwan"},{"name":"Gynecologic Cancer Research Center, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1093\/humrep\/dep468","article-title":"Invasiveness of human endometrial stromal cells is promoted by decidualization and by trophoblast-derived signals","volume":"25","author":"Gellersen","year":"2010","journal-title":"Hum. Reprod."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1095\/biolreprod.107.060632","article-title":"Dendritic cells: Key to fetal tolerance?","volume":"77","author":"Blois","year":"2007","journal-title":"Biol. Reprod."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.fertnstert.2019.02.011","article-title":"Clinical approach to recurrent implantation failure: Evidence-based evaluation of the endometrium","volume":"111","author":"Kliman","year":"2019","journal-title":"Fertil. Steril."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nrendo.2016.116","article-title":"Fertile ground: Human endometrial programming and lessons in health and disease","volume":"12","author":"Evans","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1210\/en.2017-03082","article-title":"Embryo Implantation: War in Times of Love","volume":"159","author":"Ashary","year":"2018","journal-title":"Endocrinology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jprot.2016.05.026","article-title":"Modulating the endometrial epithelial proteome and secretome in preparation for pregnancy: The role of ovarian steroid and pregnancy hormones","volume":"144","author":"Greening","year":"2016","journal-title":"J. Proteom."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Wu, H.M., Lo, T.C., Tsai, C.L., Chen, L.H., Huang, H.Y., Wang, H.S., and Yu, J. (2022). Extracellular Vesicle-Associated MicroRNA-138-5p Regulates Embryo Implantation and Early Pregnancy by Adjusting GPR124. Pharmaceutics, 14.","DOI":"10.21203\/rs.3.rs-1467767\/v1"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Doyle, L.M., and Wang, M.Z. (2019). Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis. Cells, 8.","DOI":"10.3390\/cells8070727"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1007\/s00018-016-2413-9","article-title":"Exosomes: Mobile platforms for targeted and synergistic signaling across cell boundaries","volume":"74","author":"Vyas","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Pollet, H., Conrard, L., Cloos, A.S., and Tyteca, D. (2018). Plasma Membrane Lipid Domains as Platforms for Vesicle Biogenesis and Shedding?. Biomolecules, 8.","DOI":"10.3390\/biom8030094"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1210\/er.2017-00229","article-title":"Extracellular Vesicles in Human Reproduction in Health and Disease","volume":"39","author":"Simon","year":"2018","journal-title":"Endocr. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10815-018-1343-x","article-title":"Extracellular vesicle mediated embryo-endometrial cross talk during implantation and in pregnancy","volume":"36","author":"Kurian","year":"2019","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/nm.3012","article-title":"Mechanisms of implantation: Strategies for successful pregnancy","volume":"18","author":"Cha","year":"2012","journal-title":"Nat. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.fertnstert.2016.02.018","article-title":"Local and systemic factors and implantation: What is the evidence?","volume":"105","author":"Fox","year":"2016","journal-title":"Fertil. Steril."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1196\/annals.1429.018","article-title":"The menstrual cycle: Basic biology","volume":"1135","author":"Hawkins","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1067\/mob.2002.127305","article-title":"The myometrial junctional zone spiral arteries in normal and abnormal pregnancies: A review of the literature","volume":"187","author":"Brosens","year":"2002","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/er.2014-1045","article-title":"Cyclic decidualization of the human endometrium in reproductive health and failure","volume":"35","author":"Gellersen","year":"2014","journal-title":"Endocr. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"9596","DOI":"10.1074\/jbc.RA120.012753","article-title":"The transcription factor HAND2 up-regulates transcription of the IL15 gene in human endometrial stromal cells","volume":"295","author":"Murata","year":"2020","journal-title":"J. Biol. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1472-6483(10)61745-2","article-title":"Decidualization of the human endometrial stromal cell: An enigmatic transformation","volume":"7","author":"Dunn","year":"2003","journal-title":"Reprod. Biomed. Online"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1095\/biolreprod.108.074666","article-title":"Manipulating actin dynamics affects human in vitro decidualization","volume":"81","author":"Ihnatovych","year":"2009","journal-title":"Biol. Reprod."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1210\/endo-129-5-2385","article-title":"Sex steroids and growth factors differentially regulate the growth and differentiation of cultured human endometrial stromal cells","volume":"129","author":"Irwin","year":"1991","journal-title":"Endocrinology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0960-0760(92)90137-8","article-title":"In vitro decidualization of human endometrial stromal cells","volume":"42","author":"Tabanelli","year":"1992","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1095\/biolreprod56.5.1274","article-title":"Human decidual cell biosynthesis of leukemia inhibitory factor: Regulation by decidual cytokines and steroid hormones","volume":"56","author":"Sawai","year":"1997","journal-title":"Biol. Reprod."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1002\/j.1460-2075.1990.tb08280.x","article-title":"Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B","volume":"9","author":"Kastner","year":"1990","journal-title":"EMBO J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/1933719110382922","article-title":"Progesterone receptors in the human pregnancy uterus: Do they hold the key to birth timing?","volume":"18","author":"Mesiano","year":"2011","journal-title":"Reprod. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/molehr\/gah161","article-title":"Progesterone receptor expression in human decidua and fetal membranes before and after contractions: Possible mechanism for functional progesterone withdrawal","volume":"11","author":"Goldman","year":"2005","journal-title":"Mol. Hum. Reprod."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0303-7207(02)00111-9","article-title":"Progesterone receptor activates its promoter activity in human endometrial stromal cells","volume":"192","author":"Tang","year":"2002","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/humupd\/dmu056","article-title":"Role of nuclear progesterone receptor isoforms in uterine pathophysiology","volume":"21","author":"Patel","year":"2015","journal-title":"Hum. Reprod. Update"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.placenta.2013.06.305","article-title":"Prolactin stimulates cell migration and invasion by human trophoblast in vitro","volume":"34","author":"Stefanoska","year":"2013","journal-title":"Placenta"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/molehr\/gan038","article-title":"Insulin-like growth factor binding protein-1 induces decidualization of human endometrial stromal cells via alpha5beta1 integrin","volume":"14","author":"Matsumoto","year":"2008","journal-title":"Mol. Hum. Reprod."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1095\/biolreprod.105.043182","article-title":"Role of FOXO1A in the regulation of insulin-like growth factor-binding protein-1 in human endometrial cells: Interaction with progesterone receptor","volume":"73","author":"Kim","year":"2005","journal-title":"Biol. Reprod."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1089\/104454903770238102","article-title":"Progesterone receptor (hPR) upregulates the fibronectin promoter activity in human decidual fibroblasts","volume":"22","author":"Tseng","year":"2003","journal-title":"DNA Cell Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1210\/en.2008-1538","article-title":"Interleukin-11 and leukemia inhibitory factor regulate the adhesion of endometrial epithelial cells: Implications in fertility regulation","volume":"150","author":"Marwood","year":"2009","journal-title":"Endocrinology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.fertnstert.2012.10.004","article-title":"Leukemia inhibitory factor increases the invasiveness of trophoblastic cells through integrated increase in the expression of adhesion molecules and pappalysin 1 with a concomitant decrease in the expression of tissue inhibitor of matrix metalloproteinases","volume":"99","author":"Suman","year":"2013","journal-title":"Fertil. Steril."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1096\/fj.08-124495","article-title":"Prokineticin 1 mediates fetal-maternal dialogue regulating endometrial leukemia inhibitory factor","volume":"23","author":"Evans","year":"2009","journal-title":"FASEB J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2009.07.002","article-title":"Interleukin-11 increases invasiveness of JEG-3 choriocarcinoma cells by modulating STAT3 expression","volume":"82","author":"Suman","year":"2009","journal-title":"J. Reprod. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1600-065X.2011.01002.x","article-title":"Gimme shelter: The immune system during pregnancy","volume":"241","author":"Hamilton","year":"2011","journal-title":"Immunol. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1600-0897.2010.00852.x","article-title":"Th1\/Th2\/Th17 and regulatory T-cell paradigm in pregnancy","volume":"63","author":"Saito","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1093\/humrep\/14.6.1599","article-title":"Human decidual stromal cells express alpha-smooth muscle actin and show ultrastructural similarities with myofibroblasts","volume":"14","author":"Oliver","year":"1999","journal-title":"Hum. Reprod."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"495.e9","DOI":"10.1016\/j.ajog.2010.06.045","article-title":"Isolation and characterization of true mesenchymal stem cells derived from human term decidua capable of multilineage differentiation into all 3 embryonic layers","volume":"203","author":"Macias","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1089\/scd.2013.0079","article-title":"Decidual stromal cells promote regulatory T cells and suppress alloreactivity in a cell contact-dependent manner","volume":"22","author":"Erkers","year":"2013","journal-title":"Stem Cells Dev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1038\/cti.2014.5","article-title":"Human placenta-derived adherent cells induce tolerogenic immune responses","volume":"3","author":"Liu","year":"2014","journal-title":"Clin. Transl. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1097\/BCR.0b013e31818b9e40","article-title":"The role of allogenic amniotic membrane in burn treatment","volume":"29","author":"Kesting","year":"2008","journal-title":"J. Burn Care Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1164\/rccm.201001-0014OC","article-title":"Human amnion epithelial cell transplantation abrogates lung fibrosis and augments repair","volume":"182","author":"Moodley","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3389\/fimmu.2012.00347","article-title":"Natural killer cell distribution and trafficking in human tissues","volume":"3","author":"Carrega","year":"2012","journal-title":"Front. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/nm1452","article-title":"Decidual NK cells regulate key developmental processes at the human fetal-maternal interface","volume":"12","author":"Hanna","year":"2006","journal-title":"Nat. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1182\/blood-2003-02-0517","article-title":"CXCL12 expression by invasive trophoblasts induces the specific migration of CD16\u2212 human natural killer cells","volume":"102","author":"Hanna","year":"2003","journal-title":"Blood"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1073\/pnas.1016257108","article-title":"CD34+ hematopoietic precursors are present in human decidua and differentiate into natural killer cells upon interaction with stromal cells","volume":"108","author":"Vacca","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1093\/humrep\/dey323","article-title":"Differential microRNA expression between decidual and peripheral blood natural killer cells in early pregnancy","volume":"33","author":"Carlino","year":"2018","journal-title":"Hum. Reprod."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.placenta.2017.03.001","article-title":"Uterine NK cells and macrophages in pregnancy","volume":"56","author":"Faas","year":"2017","journal-title":"Placenta"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/cmi.2016.26","article-title":"NK cell education via nonclassical MHC and non-MHC ligands","volume":"14","author":"He","year":"2017","journal-title":"Cell. Mol. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.3389\/fimmu.2019.01397","article-title":"Features of Human Decidual NK Cells in Healthy Pregnancy and During Viral Infection","volume":"10","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/humupd\/dms015","article-title":"Extravillous trophoblast and decidual natural killer cells: A remodelling partnership","volume":"18","author":"Wallace","year":"2012","journal-title":"Hum. Reprod. Update"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41572-020-00228-z","article-title":"Recurrent pregnancy loss","volume":"6","author":"Dimitriadis","year":"2020","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s42003-020-0763-1","article-title":"Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window","volume":"3","author":"Lucas","year":"2020","journal-title":"Commun. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fimmu.2014.00087","article-title":"Human NK cells: From surface receptors to the therapy of leukemias and solid tumors","volume":"5","author":"Moretta","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41586-018-0698-6","article-title":"Single-cell reconstruction of the early maternal-fetal interface in humans","volume":"563","author":"Efremova","year":"2018","journal-title":"Nature"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nri3370","article-title":"Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution","volume":"13","author":"Parham","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/imr.12323","article-title":"Co-evolution of NK receptors and HLA ligands in humans is driven by reproduction","volume":"267","author":"Moffett","year":"2015","journal-title":"Immunol. Rev."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.rbmo.2016.08.019","article-title":"Variation of maternal KIR and fetal HLA-C genes in reproductive failure: Too early for clinical intervention","volume":"33","author":"Moffett","year":"2016","journal-title":"Reprod. Biomed. Online"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1189\/jlb.0511227","article-title":"Maternal KIR and fetal HLA-C: A fine balance","volume":"90","author":"Chazara","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1093\/humrep\/deu251","article-title":"Maternal KIR haplotype influences live birth rate after double embryo transfer in IVF cycles in patients with recurrent miscarriages and implantation failure","volume":"29","author":"Alecsandru","year":"2014","journal-title":"Hum. Reprod."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"8690","DOI":"10.1038\/s41598-017-05947-0","article-title":"Invasive trophoblast promote stromal fibroblast decidualization via Profilin 1 and ALOX5","volume":"7","author":"Menkhorst","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/biolre\/ioab214","article-title":"Impact of growth hormone-releasing hormone antagonist on decidual stromal cell growth and apoptosis in vitrodagger","volume":"106","author":"Wu","year":"2022","journal-title":"Biol. Reprod."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Sternberg, A.K., Buck, V.U., Classen-Linke, I., and Leube, R.E. (2021). How Mechanical Forces Change the Human Endometrium during the Menstrual Cycle in Preparation for Embryo Implantation. Cells, 10.","DOI":"10.3390\/cells10082008"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Ng, S.W., Norwitz, G.A., Pavlicev, M., Tilburgs, T., Simon, C., and Norwitz, E.R. (2020). Endometrial Decidualization: The Primary Driver of Pregnancy Health. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21114092"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.3389\/fimmu.2019.02317","article-title":"Dynamic Function and Composition Changes of Immune Cells During Normal and Pathological Pregnancy at the Maternal-Fetal Interface","volume":"10","author":"Yang","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.1038\/s41467-019-12484-z","article-title":"Human placental trophoblast cells contribute to maternal-fetal tolerance through expressing IL-35 and mediating iTR35 conversion","volume":"10","author":"Liu","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.repbio.2012.10.004","article-title":"Advances in understanding the physiological mechanism of maternal immune tolerance to the embryo","volume":"12","author":"Krzymowski","year":"2012","journal-title":"Reprod. Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/imm.13392","article-title":"Neutrophils in pregnancy: New insights into innate and adaptive immune regulation","volume":"164","author":"Bert","year":"2021","journal-title":"Immunology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/ni.3131","article-title":"Immune mechanisms at the maternal-fetal interface: Perspectives and challenges","volume":"16","author":"PrabhuDas","year":"2015","journal-title":"Nat. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1620\/tjem.250.49","article-title":"Endometrial Immunity for Embryo Implantation and Pregnancy Establishment","volume":"250","author":"Kitazawa","year":"2020","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1387\/ijdb.140054ae","article-title":"T cell behavior at the maternal-fetal interface","volume":"58","author":"Nancy","year":"2014","journal-title":"Int. J. Dev. Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.imlet.2007.09.014","article-title":"Fetal tolerance in human pregnancy\u2014A crucial balance between acceptance and limitation of trophoblast invasion","volume":"115","year":"2008","journal-title":"Immunol. Lett."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"119","DOI":"10.5653\/cerm.2011.38.3.119","article-title":"Role of endometrial immune cells in implantation","volume":"38","author":"Lee","year":"2011","journal-title":"Clin. Exp. Reprod. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00005-019-00552-7","article-title":"Role of Macrophages in Pregnancy and Related Complications","volume":"67","author":"Jena","year":"2019","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40738-018-0052-6","article-title":"ART implantation failure and miscarriage in patients with elevated intracellular cytokine ratios: Response to immune support therapy","volume":"4","author":"Harrity","year":"2018","journal-title":"Fertil. Res. Pract."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.3389\/fimmu.2020.02025","article-title":"T Helper (Th) Cell Profiles in Pregnancy and Recurrent Pregnancy Losses: Th1\/Th2\/Th9\/Th17\/Th22\/Tfh Cells","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1749-6632.2010.05938.x","article-title":"Inflammation and pregnancy: The role of the immune system at the implantation site","volume":"1221","author":"Mor","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.siny.2006.05.001","article-title":"Inflammation in preterm and term labour and delivery","volume":"11","author":"Romero","year":"2006","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_81","first-page":"861920","article-title":"Role of common-gamma chain cytokines in NK cell development and function: Perspectives for immunotherapy","volume":"2011","author":"Meazza","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/molehr\/6.1.75","article-title":"Expression of interleukin-15 in human endometrium and decidua","volume":"6","author":"Okada","year":"2000","journal-title":"Mol. Hum. Reprod."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jri.2003.10.002","article-title":"Interleukin-1 inhibits interleukin-15 production by progesterone during in vitro decidualization in human","volume":"61","author":"Okada","year":"2004","journal-title":"J. Reprod. Immunol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.fertnstert.2010.04.063","article-title":"A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature","volume":"95","author":"Horcajadas","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_85","first-page":"244","article-title":"Innate immune system and preeclampsia","volume":"5","author":"Torres","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"967629","DOI":"10.1155\/2012\/967629","article-title":"The Th1:th2 dichotomy of pregnancy and preterm labour","volume":"2012","author":"Sykes","year":"2012","journal-title":"Mediat. Inflamm."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.placenta.2017.09.003","article-title":"Maternal effector T cells within decidua: The adaptive immune response to pregnancy?","volume":"60","author":"Lissauer","year":"2017","journal-title":"Placenta"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/aji.12185","article-title":"Quantification of the predominant immune cell populations in decidua throughout human pregnancy","volume":"71","author":"Bartmann","year":"2014","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2017.04.007","article-title":"Pregnancy favors the expansion of circulating functional follicular helper T Cells","volume":"121","author":"Monteiro","year":"2017","journal-title":"J. Reprod. Immunol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2016.11.004","article-title":"Pregnancy persistently affects memory T cell populations","volume":"119","author":"Kieffer","year":"2017","journal-title":"J. Reprod. Immunol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature11462","article-title":"Pregnancy imprints regulatory memory that sustains anergy to fetal antigen","volume":"490","author":"Rowe","year":"2012","journal-title":"Nature"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.4049\/jimmunol.1700114","article-title":"Decidual T Cells Exhibit a Highly Differentiated Phenotype and Demonstrate Potential Fetal Specificity and a Strong Transcriptional Response to IFN","volume":"199","author":"Powell","year":"2017","journal-title":"J. Immunol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"937","DOI":"10.3389\/fimmu.2018.00937","article-title":"Deep Surveying of the Transcriptional and Alternative Splicing Signatures for Decidual CD8(+) T Cells at the First Trimester of Human Healthy Pregnancy","volume":"9","author":"Zeng","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/cmi.2013.67","article-title":"Decidual stromal cells recruit Th17 cells into decidua to promote proliferation and invasion of human trophoblast cells by secreting IL-17","volume":"11","author":"Wu","year":"2014","journal-title":"Cell. Mol. Immunol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00281-016-0577-x","article-title":"A new era in reproductive medicine: Consequences of third-party oocyte donation for maternal and fetal health","volume":"38","author":"Saito","year":"2016","journal-title":"Semin. Immunopathol."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Ticconi, C., Pietropolli, A., Di Simone, N., Piccione, E., and Fazleabas, A. (2019). Endometrial Immune Dysfunction in Recurrent Pregnancy Loss. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20215332"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells","volume":"441","author":"Bettelli","year":"2006","journal-title":"Nature"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cell.2012.05.031","article-title":"Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict","volume":"150","author":"Samstein","year":"2012","journal-title":"Cell"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1126\/science.1196509","article-title":"Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans","volume":"330","author":"Mold","year":"2010","journal-title":"Science"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/humupd\/dmp004","article-title":"Regulatory T-cells and immune tolerance in pregnancy: A new target for infertility treatment?","volume":"15","author":"Guerin","year":"2009","journal-title":"Hum. Reprod. Update"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"9145","DOI":"10.4238\/2015.August.7.24","article-title":"Regulation of CD4(+)FOXP3(+) T cells by CCL20\/CCR6 axis in early unexplained recurrent miscarriage patients","volume":"14","author":"Zhang","year":"2015","journal-title":"Genet. Mol. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"157","DOI":"10.5582\/bst.2018.01012","article-title":"Distinct pattern of Th17\/Treg cells in pregnant women with a history of unexplained recurrent spontaneous abortion","volume":"12","author":"Qian","year":"2018","journal-title":"Biosci. Trends"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.3389\/fimmu.2018.01934","article-title":"Clonally Expanded Decidual Effector Regulatory T Cells Increase in Late Gestation of Normal Pregnancy, but Not in Preeclampsia, in Humans","volume":"9","author":"Tsuda","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"E8415","DOI":"10.1073\/pnas.1611944114","article-title":"Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy","volume":"113","author":"Nadkarni","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1073\/pnas.1713957115","article-title":"Mixed signature of activation and dysfunction allows human decidual CD8(+) T cells to provide both tolerance and immunity","volume":"115","author":"Bi","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.3389\/fimmu.2018.02880","article-title":"Cross-Reactivity of Virus-Specific CD8+ T Cells Against Allogeneic HLA-C: Possible Implications for Pregnancy Outcome","volume":"9","author":"Anholts","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.humimm.2008.12.006","article-title":"Decidual CD8+CD28- T cells express CD103 but not perforin","volume":"70","author":"Tilburgs","year":"2009","journal-title":"Hum. Immunol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e1738","DOI":"10.1038\/cddis.2015.112","article-title":"PD-1 and Tim-3 pathways are associated with regulatory CD8+ T-cell function in decidua and maintenance of normal pregnancy","volume":"6","author":"Wang","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1172\/JCI68140","article-title":"Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation","volume":"125","author":"Solano","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1126\/sciimmunol.aat6114","article-title":"Immune responses at the maternal-fetal interface","volume":"4","author":"Ander","year":"2019","journal-title":"Sci. Immunol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Vishnyakova, P., Elchaninov, A., Fatkhudinov, T., and Sukhikh, G. (2019). Role of the Monocyte-Macrophage System in Normal Pregnancy and Preeclampsia. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20153695"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"792","DOI":"10.3389\/fimmu.2019.00792","article-title":"Macrophage Polarization in Physiological and Pathological Pregnancy","volume":"10","author":"Yao","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"103264","DOI":"10.1016\/j.jri.2020.103264","article-title":"Functional regulation of decidual macrophages during pregnancy","volume":"143","author":"Sun","year":"2021","journal-title":"J. Reprod. Immunol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.humimm.2021.02.013","article-title":"Contribution of macrophages to fetomaternal immunological tolerance","volume":"82","author":"Parasar","year":"2021","journal-title":"Hum. Immunol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.3389\/fphys.2018.01659","article-title":"Gene Regulatory Network Modeling of Macrophage Differentiation Corroborates the Continuum Hypothesis of Polarization States","volume":"9","author":"Palma","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00424-017-1963-5","article-title":"Immunophysiology: Macrophages as key regulators of homeostasis in various organs","volume":"469","author":"Jantsch","year":"2017","journal-title":"Pflug. Arch."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.placenta.2018.04.012","article-title":"Innate immune cells in the placental bed in healthy pregnancy and preeclampsia","volume":"69","author":"Faas","year":"2018","journal-title":"Placenta"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/s41423-018-0008-0","article-title":"Three macrophage subsets are identified in the uterus during early human pregnancy","volume":"15","author":"Jiang","year":"2018","journal-title":"Cell. Mol. Immunol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"13","DOI":"10.12703\/P6-13","article-title":"The M1 and M2 paradigm of macrophage activation: Time for reassessment","volume":"6","author":"Martinez","year":"2014","journal-title":"F1000Prime Rep."},{"key":"ref_120","first-page":"120","article-title":"Modulators of the Balance between M1 and M2 Macrophages during Pregnancy","volume":"8","author":"Zhang","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/humrep\/dey347","article-title":"The role of the PD-1\/PD-L1 axis in macrophage differentiation and function during pregnancy","volume":"34","author":"Zhang","year":"2019","journal-title":"Hum. Reprod."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Wheeler, K.C., Jena, M.K., Pradhan, B.S., Nayak, N., Das, S., Hsu, C.D., Wheeler, D.S., Chen, K., and Nayak, N.R. (2018). VEGF may contribute to macrophage recruitment and M2 polarization in the decidua. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0191040"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.molimm.2020.01.021","article-title":"Leukemia inhibitory factor regulates the activation of inflammatory signals in macrophages and trophoblast cells","volume":"120","author":"Dallagi","year":"2020","journal-title":"Mol. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"e13261","DOI":"10.1111\/aji.13261","article-title":"Decidual stromal cells maintain decidual macrophage homeostasis by secreting IL-24 in early pregnancy","volume":"84","author":"Yang","year":"2020","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"106788","DOI":"10.1016\/j.intimp.2020.106788","article-title":"Trophoblast-derived IL-6 serves as an important factor for normal pregnancy by activating Stat3-mediated M2 macrophages polarization","volume":"90","author":"Ding","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.immuni.2018.03.030","article-title":"Trained Memory of Human Uterine NK Cells Enhances Their Function in Subsequent Pregnancies","volume":"48","author":"Gamliel","year":"2018","journal-title":"Immunity"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/imm.12888","article-title":"Human dendritic cell subsets: An update","volume":"154","author":"Collin","year":"2018","journal-title":"Immunology"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e12998","DOI":"10.1111\/aji.12998","article-title":"Downregulation of ILT4(+) dendritic cells in recurrent miscarriage and recurrent implantation failure","volume":"80","author":"Liu","year":"2018","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jri.2018.07.003","article-title":"Human pregnancy is accompanied by modifications in B cell development and immunoglobulin profile","volume":"129","author":"Ziegler","year":"2018","journal-title":"J. Reprod. Immunol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nm.4244","article-title":"Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor","volume":"23","author":"Huang","year":"2017","journal-title":"Nat. Med."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1600-0897.2010.00833.x","article-title":"PIBF: The double edged sword. Pregnancy and tumor","volume":"64","author":"Polgar","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.placenta.2016.12.020","article-title":"Influence of maternal BMI on the exosomal profile during gestation and their role on maternal systemic inflammation","volume":"50","author":"Elfeky","year":"2017","journal-title":"Placenta"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"26913","DOI":"10.3402\/jev.v3.26913","article-title":"Minimal experimental requirements for definition of extracellular vesicles and their functions: A position statement from the International Society for Extracellular Vesicles","volume":"3","author":"Lotvall","year":"2014","journal-title":"J. Extracell. Vesicles"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/humrep\/dew004","article-title":"Proteomic characterization of macro-, micro- and nano-extracellular vesicles derived from the same first trimester placenta: Relevance for feto-maternal communication","volume":"31","author":"Tong","year":"2016","journal-title":"Hum. Reprod."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/1479-5876-12-204","article-title":"Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy","volume":"12","author":"Sarker","year":"2014","journal-title":"J. Transl. Med."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1021\/acs.analchem.8b03619","article-title":"Avoiding Pre-Isolation Step in Exosome Analysis: Direct Isolation and Sensitive Detection of Exosomes Using Gold-Loaded Nanoporous Ferric Oxide Nanozymes","volume":"91","author":"Boriachek","year":"2019","journal-title":"Anal. Chem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12958-016-0207-4","article-title":"Characterization of exosomal release in bovine endometrial intercaruncular stromal cells","volume":"14","author":"Koh","year":"2016","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00441-016-2358-1","article-title":"Exosomes derived from endometriotic stromal cells have enhanced angiogenic effects in vitro","volume":"365","author":"Harp","year":"2016","journal-title":"Cell Tissue Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1530\/REP-18-0616","article-title":"Decidual small extracellular vesicles induce trophoblast invasion by upregulating N-cadherin","volume":"159","author":"Liu","year":"2020","journal-title":"Reproduction"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1056\/NEJMra1704286","article-title":"Circulating Extracellular Vesicles in Human Disease","volume":"379","author":"Shah","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1039\/C7BM00479F","article-title":"Extracellular vesicles, exosomes and shedding vesicles in regenerative medicine\u2014A new paradigm for tissue repair","volume":"6","author":"Bjorge","year":"2017","journal-title":"Biomater. Sci."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.tcb.2016.11.003","article-title":"Extracellular Vesicles: Unique Intercellular Delivery Vehicles","volume":"27","author":"Maas","year":"2017","journal-title":"Trends Cell Biol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1172\/JCI81131","article-title":"Regulation of chronic inflammatory and immune processes by extracellular vesicles","volume":"126","author":"Robbins","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/cmi.2014.45","article-title":"MicroRNAs, immune cells and pregnancy","volume":"11","author":"Bidarimath","year":"2014","journal-title":"Cell. Mol. Immunol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/1933719112453507","article-title":"MicroRNAs miR-30b, miR-30d, and miR-494 regulate human endometrial receptivity","volume":"20","author":"Altmae","year":"2013","journal-title":"Reprod. Sci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/ni.f.209","article-title":"MicroRNAs: New regulators of immune cell development and function","volume":"9","author":"Baltimore","year":"2008","journal-title":"Nat. Immunol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.immuni.2007.02.005","article-title":"MicroRNAs and immunity: Tiny players in a big field","volume":"26","author":"Taganov","year":"2007","journal-title":"Immunity"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jri.2015.03.005","article-title":"First-trimester maternal cell microRNA is a superior pregnancy marker to immunological testing for predicting adverse pregnancy outcome","volume":"110","author":"Winger","year":"2015","journal-title":"J. Reprod. Immunol."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Ng, Y.H., Rome, S., Jalabert, A., Forterre, A., Singh, H., Hincks, C.L., and Salamonsen, L.A. (2013). Endometrial exosomes\/microvesicles in the uterine microenvironment: A new paradigm for embryo-endometrial cross talk at implantation. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0058502"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.1242\/dev.124289","article-title":"Hsa-miR-30d, secreted by the human endometrium, is taken up by the pre-implantation embryo and might modify its transcriptome","volume":"142","author":"Vilella","year":"2015","journal-title":"Development"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Burns, G., Brooks, K., Wildung, M., Navakanitworakul, R., Christenson, L.K., and Spencer, T.E. (2014). Extracellular vesicles in luminal fluid of the ovine uterus. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0090913"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1600-0897.2012.01109.x","article-title":"The myxovirus-resistance protein, MX1, is a component of exosomes secreted by uterine epithelial cells","volume":"67","author":"Racicot","year":"2012","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1095\/biolreprod.115.134890","article-title":"Human Endometrial Exosomes Contain Hormone-Specific Cargo Modulating Trophoblast Adhesive Capacity: Insights into Endometrial-Embryo Interactions","volume":"94","author":"Greening","year":"2016","journal-title":"Biol. Reprod."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"e1800423","DOI":"10.1002\/pmic.201800423","article-title":"Human Endometrial Extracellular Vesicles Functionally Prepare Human Trophectoderm Model for Implantation: Understanding Bidirectional Maternal-Embryo Communication","volume":"19","author":"Evans","year":"2019","journal-title":"Proteomics"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1194\/jlr.E086173","article-title":"Extracellular vesicles: Lipids as key components of their biogenesis and functions","volume":"59","author":"Record","year":"2018","journal-title":"J. Lipid. Res."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1093\/biolre\/ioaa019","article-title":"Characterization and regulation of extracellular vesicles in the lumen of the ovine uterusdagger","volume":"102","author":"Burns","year":"2020","journal-title":"Biol. Reprod."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1177\/107155769700400602","article-title":"Ceramide stimulates prostaglandin production by human amnion and decidual cells","volume":"4","author":"Edwin","year":"1997","journal-title":"J. Soc. Gynecol. Investig."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1007\/s10495-013-0892-9","article-title":"The endocannabinoid anandamide induces apoptosis of rat decidual cells through a mechanism involving ceramide synthesis and p38 MAPK activation","volume":"18","author":"Fonseca","year":"2013","journal-title":"Apoptosis"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1093\/molehr\/gau051","article-title":"Lysophosphatidic acid and sphingosine 1-phosphate metabolic pathways and their receptors are differentially regulated during decidualization of human endometrial stromal cells","volume":"20","author":"Brunnert","year":"2014","journal-title":"Mol. Hum. Reprod."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1095\/biolreprod.109.081604","article-title":"The sphingosine 1-phosphate (S1P) signaling pathway is regulated during pregnancy in sheep","volume":"82","author":"Dunlap","year":"2010","journal-title":"Biol. Reprod."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.fertnstert.2015.09.037","article-title":"Maternal microbiome and pregnancy outcomes","volume":"104","author":"Fox","year":"2015","journal-title":"Fertil. Steril."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"E231","DOI":"10.1073\/pnas.1206322110","article-title":"Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface","volume":"110","author":"Fu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2013.05.003","article-title":"If we know so much about preeclampsia, why haven\u2019t we cured the disease?","volume":"99","author":"Roberts","year":"2013","journal-title":"J. Reprod. Immunol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/172603a0","article-title":"Actively acquired tolerance of foreign cells","volume":"172","author":"Billingham","year":"1953","journal-title":"Nature"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.4049\/jimmunol.1301885","article-title":"Exosomes secreted by human placenta carry functional Fas ligand and TRAIL molecules and convey apoptosis in activated immune cells, suggesting exosome-mediated immune privilege of the fetus","volume":"191","author":"Stenqvist","year":"2013","journal-title":"J. Immunol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"652","DOI":"10.3389\/fimmu.2014.00652","article-title":"HLA Class Ib Molecules and Immune Cells in Pregnancy and Preeclampsia","volume":"5","author":"Djurisic","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/tra.12352","article-title":"Macrophage Exosomes Induce Placental Inflammatory Cytokines: A Novel Mode of Maternal-Placental Messaging","volume":"17","author":"Holder","year":"2016","journal-title":"Traffic"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/cei.13304","article-title":"Embryonic extracellular vesicles as informers to the immune cells at the maternal-fetal interface","volume":"198","author":"Giacomini","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"104063","DOI":"10.1016\/j.cellimm.2020.104063","article-title":"Extracellular vesicles in allograft rejection and tolerance","volume":"349","author":"Benichou","year":"2020","journal-title":"Cell. Immunol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s00441-022-03650-9","article-title":"Small extracellular vesicles derived from PD-L1-modified mesenchymal stem cell promote Tregs differentiation and prolong allograft survival","volume":"389","author":"Ou","year":"2020","journal-title":"Cell Tissue Res."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1795364","DOI":"10.1080\/20013078.2020.1795364","article-title":"Study of immune-tolerized cell lines and extracellular vesicles inductive environment promoting continuous expression and secretion of HLA-G from semi-allograft immune tolerance during pregnancy","volume":"9","author":"Cho","year":"2020","journal-title":"J. Extracell. Vesicles"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.4049\/jimmunol.1401536","article-title":"The human fetal placenta promotes tolerance against the semiallogeneic fetus by inducing regulatory T cells and homeostatic M2 macrophages","volume":"194","author":"Mehta","year":"2015","journal-title":"J. Immunol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/JLB.1A0420-012RR","article-title":"Trophoblast-secreted soluble-PD-L1 modulates macrophage polarization and function","volume":"108","author":"Zhang","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1600-0897.2010.00880.x","article-title":"Trophoblast-derived exosomes mediate monocyte recruitment and differentiation","volume":"65","author":"Atay","year":"2011","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"4662","DOI":"10.1038\/s41598-018-23112-z","article-title":"PIBF+ extracellular vesicles from mouse embryos affect IL-10 production by CD8+ cells","volume":"8","author":"Pallinger","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"11958","DOI":"10.1038\/ncomms11958","article-title":"Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation","volume":"7","author":"Desrochers","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"20330","DOI":"10.1038\/s41598-019-56879-w","article-title":"Effects of miR-98 in intrauterine extracellular vesicles on maternal immune regulation during the peri-implantation period in cattle","volume":"9","author":"Nakamura","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1530\/REP-19-0314","article-title":"IFNT-independent effects of intrauterine extracellular vesicles (EVs) in cattle","volume":"159","author":"Nakamura","year":"2020","journal-title":"Reproduction"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1093\/molehr\/gaaa034","article-title":"Exosomes and soluble secretome from hormone-treated endometrial epithelial cells direct embryo implantation","volume":"26","author":"Gurung","year":"2020","journal-title":"Mol. Hum. Reprod."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/14789450.2017.1260450","article-title":"Proteomic insights into extracellular vesicle biology\u2014Defining exosomes and shed microvesicles","volume":"14","author":"Greening","year":"2017","journal-title":"Expert Rev. Proteom."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Tan, Q., Shi, S., Liang, J., Zhang, X., Cao, D., and Wang, Z. (2020). MicroRNAs in Small Extracellular Vesicles Indicate Successful Embryo Implantation during Early Pregnancy. Cells, 9.","DOI":"10.21203\/rs.2.21948\/v1"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1093\/humrep\/deab123","article-title":"Global transcriptomic changes occur in uterine fluid-derived extracellular vesicles during the endometrial window for embryo implantation","volume":"36","author":"Giacomini","year":"2021","journal-title":"Hum. Reprod."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/21\/13382\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:09:13Z","timestamp":1760144953000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/21\/13382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,2]]},"references-count":182,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["ijms232113382"],"URL":"https:\/\/doi.org\/10.3390\/ijms232113382","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,2]]}}}