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It is unknown, however, whether it plays a role in healing oral mucosal wounds. In this study, we investigate MED1\u2019s functional effects on oral mucosal wound healing and its underlying mechanism. The epithelial-specific MED1 null (Med1epi\u2212\/\u2212) mice were established using the Cre-loxP system with C57\/BL6 background. A 3\u2009mm diameter wound was made in the cheek mucosa of the 8-week-old mice. In vivo experiments were conducted using HE staining and immunostaining with Ki67 and uPAR antibodies. The in vitro study used lentiviral transduction, scratch assays, qRT-PCR, and Western blotting to reveal the underlying mechanisms. The results showed that ablation of MED1 accelerated oral mucosal wound healing in 8-week-old mice. As a result of ablation of MED1, Activin A\/Follistatin expression was altered, resulting in an activation of the JNK\/c-Jun pathway. Similarly, knockdown of MED1 enhanced the proliferation and migration of keratinocytes in vitro, promoting re-epithelialization, which accelerates the healing of oral mucosal wounds. Our study reveals a novel role for MED1 in oral keratinocytes, providing a new molecular therapeutic target for accelerated wound healing.<\/jats:p>","DOI":"10.3390\/ijms232113414","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T03:53:07Z","timestamp":1667447587000},"page":"13414","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["MED1 Ablation Promotes Oral Mucosal Wound Healing via JNK Signaling Pathway"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8977-8446","authenticated-orcid":false,"given":"Zhaosong","family":"Meng","sequence":"first","affiliation":[{"name":"School of Stomatology, Tianjin Medical University, Tianjin 300014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7741-9462","authenticated-orcid":false,"given":"Zhe","family":"Li","sequence":"additional","affiliation":[{"name":"School of Stomatology, Tianjin Medical University, Tianjin 300014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuling","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Stomatology, Tianjin Medical University, Tianjin 300014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danfeng","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Stomatology, Tianjin Medical University, Tianjin 300014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Stomatology, Tianjin Medical University, Tianjin 300014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Stomatology, Tianjin Medical University, Tianjin 300014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhi","family":"Hu","sequence":"additional","affiliation":[{"name":"Immunology Department, Key Laboratory of Immune Microenvironment and Disease, Ministry of Education, Tianjin Medical University, Tianjin 300014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Sui","sequence":"additional","affiliation":[{"name":"School of Stomatology, Tianjin Medical University, Tianjin 300014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1365-2230.2009.03220.x","article-title":"Oral ulcers: Clinical aspects. 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