{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:58:02Z","timestamp":1790812682667,"version":"4.1.0"},"reference-count":117,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundamental Research Funds for the Central Universities","award":["SWU-KT22013"],"award-info":[{"award-number":["SWU-KT22013"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["2022NSCQ-MSX2392"],"award-info":[{"award-number":["2022NSCQ-MSX2392"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["cstc2020jcyj-msxmX0446"],"award-info":[{"award-number":["cstc2020jcyj-msxmX0446"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["31802215"],"award-info":[{"award-number":["31802215"]}]},{"name":"Natural Science Foundation of Chongqing","award":["SWU-KT22013"],"award-info":[{"award-number":["SWU-KT22013"]}]},{"name":"Natural Science Foundation of Chongqing","award":["2022NSCQ-MSX2392"],"award-info":[{"award-number":["2022NSCQ-MSX2392"]}]},{"name":"Natural Science Foundation of Chongqing","award":["cstc2020jcyj-msxmX0446"],"award-info":[{"award-number":["cstc2020jcyj-msxmX0446"]}]},{"name":"Natural Science Foundation of Chongqing","award":["31802215"],"award-info":[{"award-number":["31802215"]}]},{"name":"National Science Foundation for Young Scientists of China","award":["SWU-KT22013"],"award-info":[{"award-number":["SWU-KT22013"]}]},{"name":"National Science Foundation for Young Scientists of China","award":["2022NSCQ-MSX2392"],"award-info":[{"award-number":["2022NSCQ-MSX2392"]}]},{"name":"National Science Foundation for Young Scientists of China","award":["cstc2020jcyj-msxmX0446"],"award-info":[{"award-number":["cstc2020jcyj-msxmX0446"]}]},{"name":"National Science Foundation for Young Scientists of China","award":["31802215"],"award-info":[{"award-number":["31802215"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Brucellosis is a severe zoonotic infectious disease caused by the infection of the Brucella, which is widespread and causes considerable economic losses in underdeveloped areas. Brucella is a facultative intracellular bacteria whose main target cells for infection are macrophages, placental trophoblast cells and dendritic cells. The main clinical signs of Brucella infection in livestock are reproductive disorders and abortion. At present, the pathogenesis of placentitis or abortion caused by Brucella in livestock is not fully understood, and further research on the effect of Brucella on placental development is still necessary. This review will mainly introduce the research progress of Brucella infection of placental trophoblast cells as well as the inflammatory response caused by it, explaining the molecular regulation mechanism of Brucella leading to reproductive system disorders and abortion, and also to provide the scientific basis for revealing the pathogenesis and infection mechanism of Brucella.<\/jats:p>","DOI":"10.3390\/ijms232113417","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T03:53:07Z","timestamp":1667447587000},"page":"13417","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Inflammatory Mechanism of Brucella Infection in Placental Trophoblast Cells"],"prefix":"10.3390","volume":"23","author":[{"given":"Yu","family":"Xiao","sequence":"first","affiliation":[{"name":"The College of Veterinary Medicine, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjuan","family":"Li","sequence":"additional","affiliation":[{"name":"The College of Veterinary Medicine, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Guo","sequence":"additional","affiliation":[{"name":"The College of Veterinary Medicine, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zeng","sequence":"additional","affiliation":[{"name":"The College of Veterinary Medicine, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehong","family":"Shuai","sequence":"additional","affiliation":[{"name":"The College of Veterinary Medicine, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Guo","sequence":"additional","affiliation":[{"name":"The College of Veterinary Medicine, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingzhou","family":"Huang","sequence":"additional","affiliation":[{"name":"The College of Veterinary Medicine, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefeng","family":"Chu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Yujinxiang Street 573, Changchun 130102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5075-9272","authenticated-orcid":false,"given":"Jake","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Yujinxiang Street 573, Changchun 130102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanwei","family":"Jiao","sequence":"additional","affiliation":[{"name":"The College of Veterinary Medicine, Southwest University, Chongqing 400715, China"},{"name":"The Immunology Research Center, Medical Research Institute, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.3892\/etm.2016.3688","article-title":"Expression and regulation of the ery operon of Brucella melitensis in human trophoblast cells","volume":"12","author":"Zhang","year":"2016","journal-title":"Exp. 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