{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:58:49Z","timestamp":1790402329222,"version":"4.1.0"},"reference-count":146,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sarcopenia is a disease that becomes more prevalent as the population ages, since it is directly linked to the process of senility, which courses with muscle atrophy and loss of muscle strength. Over time, sarcopenia is linked to obesity, being known as sarcopenic obesity, and leads to other metabolic changes. At the molecular level, organokines act on different tissues and can improve or harm sarcopenia. It all depends on their production process, which is associated with factors such as physical exercise, the aging process, and metabolic diseases. Because of the seriousness of these repercussions, the aim of this literature review is to conduct a review on the relationship between organokines, sarcopenia, diabetes, and other metabolic repercussions, as well the role of physical exercise. To build this review, PubMed-Medline, Embase, and COCHRANE databases were searched, and only studies written in English were included. It was observed that myokines, adipokines, hepatokines, and osteokines had direct impacts on the pathophysiology of sarcopenia and its metabolic repercussions. Therefore, knowing how organokines act is very important to know their impacts on age, disease prevention, and how they can be related to the prevention of muscle loss.<\/jats:p>","DOI":"10.3390\/ijms232113452","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T03:28:10Z","timestamp":1667532490000},"page":"13452","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Organokines, Sarcopenia, and Metabolic Repercussions: The Vicious Cycle and the Interplay with Exercise"],"prefix":"10.3390","volume":"23","author":[{"given":"Giulia","family":"Minniti","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Pharmacology, School of Medicine, University of Mar\u00edlia (UNIMAR), Avenida Hygino Muzzy Filho, 1001, Marilia 17525-902, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia Maria","family":"Pescinini-Salzedas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Santa Casa de Miseric\u00f3rdia de Ara\u00e7atuba, Rua Floriano Peixoto, Ara\u00e7atuba 896, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Almeida dos Santos","family":"Minniti","sequence":"additional","affiliation":[{"name":"School of Medicine, Redentor University Center (UniRedentor), Avenida Presidente Dutra, Cidade Nova, Itaperuna 1155, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3159-0982","authenticated-orcid":false,"given":"Lucas Fornari","family":"Laurindo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, School of Medicine, University of Mar\u00edlia (UNIMAR), Avenida Hygino Muzzy Filho, 1001, Marilia 17525-902, SP, 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University of Mar\u00edlia (UNIMAR), Avenida Hygino Muzzy Filho, 1001, Marilia 17525-902, SP, Brazil"},{"name":"Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Mar\u00edlia (UNIMAR), Marilia 17525-902, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Quesada","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, School of Medicine, University of Mar\u00edlia (UNIMAR), Avenida Hygino Muzzy Filho, 1001, Marilia 17525-902, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesselina F. dos Santos","family":"Haber","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, School of Medicine, University of Mar\u00edlia (UNIMAR), Avenida Hygino Muzzy Filho, 1001, Marilia 17525-902, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo 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diabetes mellitus","volume":"5","author":"Nowotny","year":"2015","journal-title":"Biomolecules"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.diabres.2018.02.023","article-title":"IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045","volume":"138","author":"Cho","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"107843","DOI":"10.1016\/j.diabres.2019.107843","article-title":"Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition","volume":"157","author":"Saeedi","year":"2019","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health Effects of Overweight and Obesity in 195 Countries over 25 Years","volume":"377","author":"Afshin","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3961\/jpmph.19.100","article-title":"The Relationship Between Obesity, Overweight, and the Human Development Index in World Health Organization Eastern Mediterranean Region Countries","volume":"53","author":"Ataey","year":"2020","journal-title":"J. Prev. Med. Public Health"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"101200","DOI":"10.1016\/j.arr.2020.101200","article-title":"Sarcopenia\u2014Molecular mechanisms and open questions","volume":"65","author":"Wiedmer","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41569-021-00541-4","article-title":"Global epidemiology of dyslipidaemias","volume":"18","author":"Pirillo","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1210\/en.2006-0251","article-title":"Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling","volume":"147","author":"Wang","year":"2006","journal-title":"Endocrinology"},{"key":"ref_9","first-page":"720","article-title":"Sarcopenia and chronic illness: From diagnosis to treatment approaches","volume":"112","author":"Petropoulou","year":"2021","journal-title":"Recenti Prog. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"811751","DOI":"10.3389\/fendo.2022.811751","article-title":"Exercise Therapy for People With Sarcopenic Obesity: Myokines and Adipokines as Effective Actors","volume":"13","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/gerona\/glu010","article-title":"The FNIH sarcopenia project: Rationale, study description, conference recommendations, and final estimates","volume":"69","author":"Studenski","year":"2014","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jamda.2013.11.025","article-title":"Sarcopenia in Asia: Consensus report of the Asian Working Group for Sarcopenia","volume":"15","author":"Chen","year":"2014","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jamda.2011.01.003","article-title":"Sarcopenia: An undiagnosed condition in older adults. Current consensus definition: Prevalence, etiology, and consequences. International working group on sarcopenia","volume":"12","author":"Fielding","year":"2011","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People","volume":"39","author":"Baeyens","year":"2010","journal-title":"Age Ageing"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"990s","DOI":"10.1093\/jn\/127.5.990S","article-title":"Sarcopenia: Origins and clinical relevance","volume":"127","author":"Rosenberg","year":"1997","journal-title":"J. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: Revised European consensus on definition and diagnosis","volume":"48","author":"Bahat","year":"2019","journal-title":"Age Ageing"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.arr.2019.02.005","article-title":"Effect of nutritional supplementations on physical performance and muscle strength parameters in older people: A systematic review and meta-analysis","volume":"51","author":"Veronese","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"140","DOI":"10.4093\/dmj.2016.40.2.140","article-title":"Hyperglycemia Is Associated with Impaired Muscle Quality in Older Men with Diabetes: The Korean Longitudinal Study on Health and Aging","volume":"40","author":"Yoon","year":"2016","journal-title":"Diabetes Metab. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/ageing\/afy106","article-title":"The prevalence of sarcopenia in community-dwelling older adults, an exploration of differences between studies and within definitions: A systematic review and meta-analyses","volume":"48","author":"Mayhew","year":"2018","journal-title":"Age Ageing"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40200-017-0302-x","article-title":"Prevalence of sarcopenia in the world: A systematic review and meta- analysis of general population studies","volume":"16","author":"Shafiee","year":"2017","journal-title":"J. Diabetes Metab. Disord."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00223-020-00742-y","article-title":"Type 2 Diabetes Mellitus is Associated with Increased Risk of Sarcopenia: A Systematic Review and Meta-analysis","volume":"107","author":"Anagnostis","year":"2020","journal-title":"Calcif. Tissue Int."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.biocel.2008.07.005","article-title":"The dynamics of the nitric oxide release-transient from stretched muscle cells","volume":"41","author":"Wozniak","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/jcsm.12030","article-title":"Endocrine determinants of incident sarcopenia in middle-aged and elderly European men","volume":"6","author":"Gielen","year":"2015","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s11357-013-9583-2","article-title":"Satellite cells in human skeletal muscle; from birth to old age","volume":"36","author":"Verdijk","year":"2014","journal-title":"Age (Dordr)"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"de Oliveira Dos Santos, A.R., de Oliveira Zanuso, B., Miola, V.F.B., Barbalho, S.M., Santos Bueno, P.C., Flato, U.A.P., Detregiachi, C.R.P., Buchaim, D.V., Buchaim, R.L., and Tofano, R.J. (2021). Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052639"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e1462","DOI":"10.1002\/wsbm.1462","article-title":"Skeletal muscle: A review of molecular structure and function, in health and disease","volume":"12","author":"Mukund","year":"2020","journal-title":"WIREs Syst. Biol. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/mus.20440","article-title":"Molecular architecture of the neuromuscular junction","volume":"33","author":"Hughes","year":"2006","journal-title":"Muscle Nerve"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3389\/fphys.2012.00260","article-title":"Sarcopenia, dynapenia, and the impact of advancing age on human skeletal muscle size and strength; a quantitative review","volume":"3","author":"Mitchell","year":"2012","journal-title":"Front. Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Nishikawa, H., Asai, A., Fukunishi, S., Nishiguchi, S., and Higuchi, K. (2021). Metabolic Syndrome and Sarcopenia. Nutrients, 13.","DOI":"10.3390\/nu13103519"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.2147\/DMSO.S260382","article-title":"Sarcopenia Coexisting with High Adiposity Exacerbates Insulin Resistance and Dyslipidemia in Saudi Adult Men","volume":"13","author":"Habib","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"110715","DOI":"10.1016\/j.exger.2019.110715","article-title":"If my muscle could talk: Myokines as a biomarker of frailty","volume":"127","author":"Picca","year":"2019","journal-title":"Exp. Gerontol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e13367","DOI":"10.1111\/apha.13367","article-title":"Myokines in skeletal muscle physiology and metabolism: Recent advances and future perspectives","volume":"228","author":"Das","year":"2020","journal-title":"Acta Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Barbalho, S.M., Flato, U.A.P., Tofano, R.J., Goulart, R.A., Guiguer, E.L., Detregiachi, C.R.P., Buchaim, D.V., Ara\u00fajo, A.C., Buchaim, R.L., and Reina, F.T.R. (2020). Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103607"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"526.e9","DOI":"10.1016\/j.amjmed.2005.10.049","article-title":"Inflammatory markers and loss of muscle mass (sarcopenia) and strength","volume":"119","author":"Schaap","year":"2006","journal-title":"Am. J. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.coph.2017.05.005","article-title":"Muscle as a paracrine and endocrine organ","volume":"34","author":"Giudice","year":"2017","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1038\/mt.2012.189","article-title":"Proinflammatory macrophages enhance the regenerative capacity of human myoblasts by modifying their kinetics of proliferation and differentiation","volume":"20","author":"Bencze","year":"2012","journal-title":"Mol. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/jcsm.12252","article-title":"Alterations in the in vitro and in vivo regulation of muscle regeneration in healthy ageing and the influence of sarcopenia","volume":"9","author":"Meyer","year":"2018","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1002\/jcsm.12363","article-title":"Cellular and molecular mechanisms of sarcopenia: The S100B perspective","volume":"9","author":"Riuzzi","year":"2018","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"ra80","DOI":"10.1126\/scisignal.2002038","article-title":"G\u03b1i2 signaling promotes skeletal muscle hypertrophy, myoblast differentiation, and muscle regeneration","volume":"4","author":"Minetti","year":"2011","journal-title":"Sci. Signal."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/jcsm.12178","article-title":"Mitochondria and ageing: Role in heart, skeletal muscle and adipose tissue","volume":"8","author":"Boengler","year":"2017","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cell.2010.09.004","article-title":"Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases","volume":"143","author":"Moresi","year":"2010","journal-title":"Cell"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.brainresrev.2007.03.011","article-title":"Aging, plasticity and environmental enrichment: Structural changes and neurotransmitter dynamics in several areas of the brain","volume":"55","author":"Mora","year":"2007","journal-title":"Brain Res. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/s00125-009-1364-1","article-title":"Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase","volume":"52","author":"Matthews","year":"2009","journal-title":"Diabetologia"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1091\/mbc.e10-02-0154","article-title":"Brain-derived neurotrophic factor regulates satellite cell differentiation and skeltal muscle regeneration","volume":"21","author":"Clow","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/bs.pmbts.2015.07.016","article-title":"Endurance Exercise and the Regulation of Skeletal Muscle Metabolism","volume":"135","author":"Booth","year":"2015","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/j.clnu.2016.03.028","article-title":"Sarcopenia, sarcopenic obesity and inflammation: Results from the 1999-2004 National Health and Nutrition Examination Survey","volume":"35","author":"Batsis","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1016\/S0140-6736(18)31132-2","article-title":"Genomic insights into the causes of type 2 diabetes","volume":"391","author":"Langenberg","year":"2018","journal-title":"Lancet"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.diabres.2013.11.002","article-title":"Global estimates of diabetes prevalence for 2013 and projections for 2035","volume":"103","author":"Guariguata","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1016\/S0140-6736(17)30058-2","article-title":"Type 2 diabetes","volume":"389","author":"Chatterjee","year":"2017","journal-title":"Lancet"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"R1210","DOI":"10.1152\/ajpregu.00240.2018","article-title":"The effect of a short-term low-carbohydrate, high-fat diet with or without postmeal walks on glycemic control and inflammation in type 2 diabetes: A randomized trial","volume":"315","author":"Durrer","year":"2018","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12937-019-0518-3","article-title":"Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: A randomized, double blind, and controlled clinical trial","volume":"19","author":"Davari","year":"2020","journal-title":"Nutr. J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.2337\/dc06-2537","article-title":"Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes: The health, aging, and body composition study","volume":"30","author":"Park","year":"2007","journal-title":"Diabetes Care"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"M326","DOI":"10.1093\/gerona\/57.5.M326","article-title":"Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: The Health ABC Study","volume":"57","author":"Visser","year":"2002","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11357-009-9097-0","article-title":"Association of C-reactive protein and muscle strength in the English Longitudinal Study of Ageing","volume":"31","author":"Hamer","year":"2009","journal-title":"Age (Dordr)"},{"key":"ref_55","first-page":"328","article-title":"Correlations between sarcopenia and hypertensive target organ damage in a Turkish cohort","volume":"67","author":"Karadag","year":"2012","journal-title":"Acta Clin. Belg."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.2147\/DMSO.S186600","article-title":"Sarcopenia and type 2 diabetes mellitus: A bidirectional relationship","volume":"12","author":"Mesinovic","year":"2019","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"957","DOI":"10.2174\/1573399816666200109091449","article-title":"Understanding Sarcopenic Obesity in Terms of Definition and Health Consequences: A Clinical Review","volume":"16","author":"Nezameddin","year":"2020","journal-title":"Curr. Diabetes Rev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"111355","DOI":"10.1016\/j.exger.2021.111355","article-title":"Dyslipidemia influences the effect of physical exercise on inflammatory markers on obese women in post-menopause: A randomized clinical trial","volume":"150","author":"Biteli","year":"2021","journal-title":"Exp. Gerontol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Sinatora, R.V., Chagas, E.F.B., Mattera, F.O.P., Mellem, L.J., Santos, A., Pereira, L.P., Aran\u00e3o, A.L.C., Guiguer, E.L., Ara\u00fajo, A.C., and Haber, J. (2022). Relationship of Inflammatory Markers and Metabolic Syndrome in Postmenopausal Women. Metabolites, 12.","DOI":"10.3390\/metabo12010073"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"568","DOI":"10.3389\/fendo.2020.00568","article-title":"Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"535","DOI":"10.2147\/VHRM.S274861","article-title":"Adipokines and Arterial Stiffness in the Elderly","volume":"16","author":"Fantin","year":"2020","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Cobos-Palacios, L., Ruiz-Moreno, M.I., Vilches-Perez, A., Vargas-Candela, A., Mu\u00f1oz-\u00dabeda, M., Ben\u00edtez Porres, J., Navarro-Sanz, A., Lopez-Carmona, M.D., Sanz-Canovas, J., and Perez-Belmonte, L.M. (2022). Metabolically healthy obesity: Inflammatory biomarkers and adipokines in elderly population. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0265362"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.metabol.2018.02.002","article-title":"Effects of canagliflozin versus glimepiride on adipokines and inflammatory biomarkers in type 2 diabetes","volume":"85","author":"Garvey","year":"2018","journal-title":"Metabolism"},{"key":"ref_64","first-page":"546","article-title":"Prevalence of overweight and obesity among adults with diagnosed diabetes\u2014United States, 1988-1994 and 1999-2002 (Reprinted from MMWR, vol 53, pg 1066-1068, 2004)","volume":"293","author":"Eberhardt","year":"2005","journal-title":"JAMA J. Am. Med. Assoc."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Aguilar-Ballester, M., Hurtado-Genov\u00e9s, G., Taberner-Cort\u00e9s, A., Herrero-Cervera, A., Mart\u00ednez-Herv\u00e1s, S., and Gonz\u00e1lez-Navarro, H. (2021). Therapies for the Treatment of Cardiovascular Disease Associated with Type 2 Diabetes and Dyslipidemia. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020660"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Ko, S.H., and Kim, H.S. (2020). Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women. Nutrients, 12.","DOI":"10.3390\/nu12010202"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"701","DOI":"10.2337\/dc06-1400","article-title":"The effect of menopause on the metabolic syndrome among Korean women: The Korean National Health and Nutrition Examination Survey, 2001","volume":"30","author":"Kim","year":"2007","journal-title":"Diabetes Care"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e26529","DOI":"10.1097\/MD.0000000000026529","article-title":"Irisin is a predictor of sarcopenic obesity in type 2 diabetes mellitus: A cross-sectional study","volume":"100","author":"Oguz","year":"2021","journal-title":"Med. (Baltim.)"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Liu, R., Zhang, Q., Peng, N., Xu, S., Zhang, M., Hu, Y., Chen, Z., Tang, K., He, X., and Li, Y. (2021). Inverse correlation between serum irisin and cardiovascular risk factors among Chinese overweight\/obese population. BMC Cardiovasc. Disord., 21.","DOI":"10.1186\/s12872-021-02380-0"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Skrzypczak, D., Skrzypczak-Zieli\u0144ska, M., Ratajczak, A.E., Szymczak-Tomczak, A., Eder, P., S\u0142omski, R., Dobrowolska, A., and Krela-Ka\u017amierczak, I. (2021). Myostatin and Follistatin-New Kids on the Block in the Diagnosis of Sarcopenia in IBD and Possible Therapeutic Implications. Biomedicines, 9.","DOI":"10.3390\/biomedicines9101301"},{"key":"ref_71","first-page":"21","article-title":"The Vicious Cycle of Myostatin Signaling in Sarcopenic Obesity: Myostatin Role in Skeletal Muscle Growth, Insulin Signaling and Implications for Clinical Trials","volume":"7","author":"Consitt","year":"2018","journal-title":"J. Frailty Aging"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"204164","DOI":"10.1155\/2013\/204164","article-title":"Sarcopenic obesity and endocrinal adaptation with age","volume":"2013","author":"Sakuma","year":"2013","journal-title":"Int. J. Endocrinol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3803\/EnM.2022.303","article-title":"Sclerostin as a Putative Myokine in Sarcopenia","volume":"37","author":"Yi","year":"2022","journal-title":"Endocrinol. Metab. (Seoul)"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Saeki, C., and Tsubota, A. (2021). Influencing Factors and Molecular Pathogenesis of Sarcopenia and Osteosarcopenia in Chronic Liver Disease. Life, 11.","DOI":"10.3390\/life11090899"},{"key":"ref_75","first-page":"719","article-title":"Comparison of insulin-like growth factor-1 and sclerostin levels between premenopausal women with and without diabetes mellitus","volume":"16","author":"Sylvawani","year":"2021","journal-title":"J. Taibah Univ. Med. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3803\/EnM.2022.1428","article-title":"Decreased Serum Level of Sclerostin in Older Adults with Sarcopenia","volume":"37","author":"Ahn","year":"2022","journal-title":"Endocrinol. Metab. (Seoul)"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Rozanska, O., Uruska, A., and Zozulinska-Ziolkiewicz, D. (2020). Brain-Derived Neurotrophic Factor and Diabetes. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21030841"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/ggi.14089","article-title":"Brain-derived neurotrophic factor is associated with sarcopenia and frailty in Japanese hemodialysis patients","volume":"21","author":"Miyazaki","year":"2021","journal-title":"Geriatr. Gerontol. Int."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"111022","DOI":"10.1016\/j.exger.2020.111022","article-title":"Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?","volume":"139","author":"Guo","year":"2020","journal-title":"Exp. Gerontol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Bilski, J., Pierzchalski, P., Szczepanik, M., Bonior, J., and Zoladz, J.A. (2022). Multifactorial Mechanism of Sarcopenia and Sarcopenic Obesity. Role of Physical Exercise, Microbiota and Myokines. Cells, 11.","DOI":"10.3390\/cells11010160"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Hong, S.H., and Choi, K.M. (2020). Sarcopenic Obesity, Insulin Resistance, and Their Implications in Cardiovascular and Metabolic Consequences. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21020494"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Oh, K.J., Lee, D.S., Kim, W.K., Han, B.S., Lee, S.C., and Bae, K.H. (2016). Metabolic Adaptation in Obesity and Type II Diabetes: Myokines, Adipokines and Hepatokines. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18010008"},{"key":"ref_83","first-page":"1","article-title":"Role of Interleukin-15 in Sarcopenia: Future New Target Therapy","volume":"2017","author":"Aryana","year":"2018","journal-title":"Int. J. Geriatr. Gerontol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/acel.12341","article-title":"Exercise-stimulated interleukin-15 is controlled by AMPK and regulates skin metabolism and aging","volume":"14","author":"Crane","year":"2015","journal-title":"Aging Cell"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3389\/fendo.2019.00703","article-title":"Cytokines and Abnormal Glucose and Lipid Metabolism","volume":"10","author":"Shi","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.2147\/JIR.S320445","article-title":"Examining the Association Between Serum Leptin and Sarcopenic Obesity","volume":"14","author":"Yang","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Kohara, K., Ochi, M., Tabara, Y., Nagai, T., Igase, M., and Miki, T. (2011). Leptin in sarcopenic visceral obesity: Possible link between adipocytes and myocytes. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0024633"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-nutr-071816-064559","article-title":"Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation","volume":"37","author":"Xiao","year":"2017","journal-title":"Annu. Rev. Nutr."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"112002","DOI":"10.1016\/j.biopha.2021.112002","article-title":"Lipocalin-2: Structure, function, distribution and role in metabolic disorders","volume":"142","author":"Jaberi","year":"2021","journal-title":"Biomed. Pharmacol."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Choi, E.B., Jeong, J.H., Jang, H.M., Ahn, Y.J., Kim, K.H., An, H.S., Lee, J.Y., Jeong, E.A., Lee, J., and Shin, H.J. (2021). Skeletal Lipocalin-2 Is Associated with Iron-Related Oxidative Stress in ob\/ob Mice with Sarcopenia. Antioxidants, 10.","DOI":"10.3390\/antiox10050758"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Foreman, N.A., Hesse, A.S., and Ji, L.L. (2021). Redox Signaling and Sarcopenia: Searching for the Primary Suspect. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22169045"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.cellimm.2012.01.001","article-title":"Aging is associated with circulating cytokine dysregulation","volume":"273","year":"2012","journal-title":"Cell. Immunol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e12750","DOI":"10.1111\/acel.12750","article-title":"Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood","volume":"17","author":"Duggal","year":"2018","journal-title":"Aging Cell"},{"key":"ref_94","unstructured":"Afshounpour, M.T., Habibi, A., and Ranjbar, R. (2016). Impact of combined exercise training on plasma concentration of Apelin, resistin and insulin resistance in patients with type 2 diabetics\u2019 male. Hormozgan Med. J., 20."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e1698","DOI":"10.1210\/clinem\/dgaa972","article-title":"IGF-I\/IGFBP3\/ALS Deficiency in Sarcopenia: Low GHBP Suggests GH Resistance in a Subgroup of Geriatric Patients","volume":"106","author":"Ferrari","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"716533","DOI":"10.3389\/fendo.2021.716533","article-title":"The Impact of Dysmetabolic Sarcopenia Among Insulin Sensitive Tissues: A Narrative Review","volume":"12","author":"Armandi","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1007\/s12603-015-0638-1","article-title":"Sarcopenic Obesity and Metabolic Syndrome in Adult Caucasian Subjects","volume":"20","author":"Poggiogalle","year":"2016","journal-title":"J. Nutr. Health Aging"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s41999-022-00635-3","article-title":"The relationship between sarcopenia detected in newly diagnosed colorectal cancer patients and FGF21, irisin and CRP levels","volume":"13","author":"Oflazoglu","year":"2022","journal-title":"Eur. Geriatr. Med."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Laurindo, L.F., de Maio, M.C., Barbalho, S.M., Guiguer, E.L., Ara\u00fajo, A.C., de Alvares Goulart, R., Flato, U.A.P., J\u00fanior, E.B., Detregiachi, C.R.P., and Dos Santos Haber, J.F. (2022). Organokines in Rheumatoid Arthritis: A Critical Review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23116193"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3803\/EnM.2016.31.1.1","article-title":"The Impact of Organokines on Insulin Resistance, Inflammation, and Atherosclerosis","volume":"31","author":"Choi","year":"2016","journal-title":"Endocrinol. Metab. (Seoul)"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2015.05.014","article-title":"Fetuin A promotes lipotoxicity in \u03b2 cells through the TLR4 signaling pathway and the role of pioglitazone in anti-lipotoxicity","volume":"412","author":"Shen","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"40996","DOI":"10.1038\/srep40996","article-title":"Serum vitamin D, intact parathyroid hormone, and Fetuin A concentrations were associated with geriatric sarcopenia and cardiac hypertrophy","volume":"7","author":"Chang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_103","first-page":"e2011","article-title":"Biomarkers Profile of People With Sarcopenia: A Cross-sectional Analysis From UK Biobank","volume":"21","author":"Gray","year":"2020","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Pereira, S.L., Shoemaker, M.E., Gawel, S., Davis, G.J., Luo, M., Mustad, V.A., and Cramer, J.T. (2022). Biomarker Changes in Response to a 12-Week Supplementation of an Oral Nutritional Supplement Enriched with Protein, Vitamin D and HMB in Malnourished Community Dwelling Older Adults with Sarcopenia. Nutrients, 14.","DOI":"10.3390\/nu14061196"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Yoo, H.J., Hwang, S.Y., Choi, J.H., Lee, H.J., Chung, H.S., Seo, J.A., Kim, S.G., Kim, N.H., Baik, S.H., and Choi, D.S. (2017). Association of leukocyte cell-derived chemotaxin 2 (LECT2) with NAFLD, metabolic syndrome, and atherosclerosis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0174717"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/jcp.30593","article-title":"The molecular structure and role of LECT2 or CHM-II in arthritis, cancer, and other diseases","volume":"237","author":"Zhu","year":"2022","journal-title":"J. Cell. Physiol."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Yoshida, T., and Delafontaine, P. (2020). Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy. Cells, 9.","DOI":"10.3390\/cells9091970"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s11914-020-00599-y","article-title":"Muscle, Bone, and Fat Crosstalk: The Biological Role of Myokines, Osteokines, and Adipokines","volume":"18","author":"Kirk","year":"2020","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Gonzalez-Gil, A.M., and Elizondo-Montemayor, L. (2020). The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review. Nutrients, 12.","DOI":"10.3390\/nu12061899"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"572","DOI":"10.7150\/ijbs.63505","article-title":"Myokine Irisin promotes osteogenesis by activating BMP\/SMAD signaling via \u03b1V integrin and regulates bone mass in mice","volume":"18","author":"Xue","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Santos, J.P.M.d., Maio, M.C.d., Lemes, M.A., Laurindo, L.F., Haber, J.F.d.S., Bechara, M.D., Prado, P.S.d., Rauen, E.C., Costa, F., and Pereira, B.C.d.A. (2022). Non-Alcoholic Steatohepatitis (NASH) and Organokines: What Is Now and What Will Be in the Future. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010498"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s40200-016-0275-1","article-title":"Mechanisms involved in altered bone metabolism in diabetes: A narrative review","volume":"15","author":"Ghodsi","year":"2016","journal-title":"J. Diabetes Metab. Disord."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.13345","article-title":"Irisin and musculoskeletal health","volume":"1402","author":"Colaianni","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/bs.acc.2021.09.006","article-title":"Myostatin: Basic biology to clinical application","volume":"106","author":"Esposito","year":"2022","journal-title":"Adv. Clin. Chem."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/iub.1392","article-title":"Myostatin: Expanding horizons","volume":"67","author":"Sharma","year":"2015","journal-title":"IUBMB Life"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"17353","DOI":"10.1038\/s41598-019-52224-3","article-title":"Elevated glucose acts directly on osteocytes to increase sclerostin expression in diabetes","volume":"9","author":"Pacicca","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_117","first-page":"23","article-title":"Type 2 diabetes and osteoporosis: Current knowledge","volume":"4","author":"Ivanac","year":"2018","journal-title":"Endrocrine Oncol. Metab."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"16111","DOI":"10.1073\/pnas.1900544116","article-title":"BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle","volume":"116","author":"Delezie","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"a029736","DOI":"10.1101\/cshperspect.a029736","article-title":"On the Run for Hippocampal Plasticity","volume":"8","author":"Cooper","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"37950","DOI":"10.1038\/srep37950","article-title":"The correlation between plasma brain-derived neurotrophic factor and cognitive function in bipolar disorder is modulated by the BDNF Val66Met polymorphism","volume":"6","author":"Lee","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"165823","DOI":"10.1016\/j.bbadis.2020.165823","article-title":"Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs","volume":"1866","author":"Scheffer","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Ait Eldjoudi, D., Cordero Barreal, A., Gonzalez-Rodr\u00edguez, M., Ruiz-Fern\u00e1ndez, C., Farrag, Y., Farrag, M., Lago, F., Capuozzo, M., Gonzalez-Gay, M.A., and Mera Varela, A. (2022). Leptin in Osteoarthritis and Rheumatoid Arthritis: Player or Bystander?. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052859"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/endrev\/bnaa027","article-title":"Tissue-Specific Effects of Leptin on Glucose and Lipid Metabolism","volume":"42","author":"Pereira","year":"2021","journal-title":"Endocr. Rev."},{"key":"ref_124","first-page":"37","article-title":"Interleukin-6 and interleukin-10 are expressed in organs of normal young and old mice","volume":"15","author":"Hacham","year":"2004","journal-title":"Eur. Cytokine Netw."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"109076","DOI":"10.1016\/j.clim.2022.109076","article-title":"Effect of IL4 and IL10 on a human in vitro type 1 diabetes model","volume":"241","author":"Pfeiffer","year":"2022","journal-title":"Clin. Immunol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e140644","DOI":"10.1172\/jci.insight.140644","article-title":"Tregs facilitate obesity and insulin resistance via a Blimp-1\/IL-10 axis","volume":"6","author":"Beppu","year":"2021","journal-title":"JCI Insight"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1002\/mus.25596","article-title":"Effects of exercise-induced apelin levels on skeletal muscle and their capillarization in type 2 diabetic rats","volume":"56","author":"Son","year":"2017","journal-title":"Muscle Nerve"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1159\/000479278","article-title":"Regenerative Medicine Approaches for Age-Related Muscle Loss and Sarcopenia: A Mini-Review","volume":"63","author":"Naranjo","year":"2017","journal-title":"Gerontology"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"E7554","DOI":"10.1073\/pnas.1607235113","article-title":"Gut microbiota induce IGF-1 and promote bone formation and growth","volume":"113","author":"Yan","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"504","DOI":"10.3899\/jrheum.200673","article-title":"Circulating Fibroblast Growth Factor-21 Levels in Rheumatoid Arthritis: Associations With Disease Characteristics, Body Composition, and Physical Functioning","volume":"48","author":"Gould","year":"2021","journal-title":"J. Rheumatol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.3389\/fphys.2021.709807","article-title":"The Role of the Skeletal Muscle Secretome in Mediating Endurance and Resistance Training Adaptations","volume":"12","author":"Leuchtmann","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Romanello, V. (2020). The Interplay between Mitochondrial Morphology and Myomitokines in Aging Sarcopenia. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010091"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s42000-020-00245-3","article-title":"Impact of acute exercise on immediate and following early post-exercise FGF-21 concentration in adults: Systematic review and meta-analysis","volume":"20","author":"Khalafi","year":"2021","journal-title":"Horm. (Athens)"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Khoramipour, K., Chamari, K., Hekmatikar, A.A., Ziyaiyan, A., Taherkhani, S., Elguindy, N.M., and Bragazzi, N.L. (2021). Adiponectin: Structure, Physiological Functions, Role in Diseases, and Effects of Nutrition. Nutrients, 13.","DOI":"10.3390\/nu13041180"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/bs.vh.2020.12.021","article-title":"Role of hormones in sarcopenia","volume":"115","author":"Priego","year":"2021","journal-title":"Vitam Horm"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bone.2017.08.005","article-title":"Globular adiponectin reverses osteo-sarcopenia and altered body composition in ovariectomized rats","volume":"105","author":"China","year":"2017","journal-title":"Bone"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jnutbio.2007.05.007","article-title":"Effect of weight loss on some serum cytokines in human obesity: Increase in IL-10 after weight loss","volume":"19","author":"Jung","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Abou-Samra, M., Selvais, C.M., Dubuisson, N., and Brichard, S.M. (2020). Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills \u2026 or Everything Together?. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072620"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"24033","DOI":"10.18632\/aging.104095","article-title":"lncRNA DLEU2 acts as a miR-181a sponge to regulate SEPP1 and inhibit skeletal muscle differentiation and regeneration","volume":"12","author":"Wang","year":"2020","journal-title":"Aging"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1007\/s12325-022-02216-z","article-title":"Prevalence and Determinants of Sarcopenic Obesity in Older Adults: Secondary Data Analysis of the Longitudinal Ageing Study in India (LASI) Wave 1 Survey (2017\u201318)","volume":"39","author":"Verma","year":"2022","journal-title":"Adv. Ther."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13075-020-02202-2","article-title":"Sex hormone-binding globulin and arthritis: A Mendelian randomization study","volume":"22","author":"Qu","year":"2020","journal-title":"Arthritis Res. Ther."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Kornicka-Garbowska, K., Bourebaba, L., R\u00f6cken, M., and Marycz, K. (2021). Sex Hormone Binding Globulin (SHBG) Mitigates ER Stress in Hepatocytes In Vitro and Ex Vivo. Cells, 10.","DOI":"10.3390\/cells10040755"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.tem.2015.05.001","article-title":"Novel insights in SHBG regulation and clinical implications","volume":"26","author":"Selva","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"209","DOI":"10.5114\/ceji.2018.77392","article-title":"Antigenic and immunogenic properties of chondrocytes. Implications for chondrocyte therapeutic transplantation and pathogenesis of inflammatory and degenerative joint diseases","volume":"43","author":"Hyc","year":"2018","journal-title":"Cent. Eur. J. Immunol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"e4884","DOI":"10.7717\/peerj.4884","article-title":"Does bariatric surgery influence plasma levels of fetuin-A and leukocyte cell-derived chemotaxin-2 in patients with type 2 diabetes mellitus?","volume":"6","author":"Huang","year":"2018","journal-title":"PeerJ"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.trsl.2021.08.001","article-title":"Circulating Mir-140 and leptin improve the accuracy of the differential diagnosis between psoriatic arthritis and rheumatoid arthritis: A case-control study","volume":"239","author":"Cheleschi","year":"2022","journal-title":"Transl. 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