{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:17:51Z","timestamp":1790835471938,"version":"4.1.0"},"reference-count":48,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Background: Alpha-synuclein, abnormally aggregated in Dementia with Lewy Bodies (DLB), could represent a potential biomarker to improve the differentiation between DLB and Alzheimer\u2019s disease (AD). Our main objective was to compare Cerebrospinal Fluid (CSF) alpha-synuclein levels between patients with DLB, AD and Neurological Control (NC) individuals. Methods: In a monocentric retrospective study, we assessed CSF alpha-synuclein concentration with a validated ELISA kit (ADx EUROIMMUN) in patients with DLB, AD and NC from a tertiary memory clinic. Between-group comparisons were performed, and Receiver Operating Characteristic analysis was used to identify the best CSF alpha-synuclein threshold. We examined the associations between CSF alpha-synuclein, other core AD CSF biomarkers and brain MRI characteristics. Results: We included 127 participants (mean age: 69.3 \u00b1 8.1, Men: 41.7%). CSF alpha-synuclein levels were significantly lower in DLB than in AD (1.28 \u00b1 0.52 ng\/mL vs. 2.26 \u00b1 0.91 ng\/mL, respectively, p &lt; 0.001) without differences due to the stage of cognitive impairment. The best alpha-synuclein threshold was characterized by an Area Under the Curve = 0.85, Sensitivity = 82.0% and Specificity = 76.0%. CSF alpha-synuclein was associated with CSF AT(N) biomarkers positivity (p &lt; 0.01) but not with hippocampal atrophy or white matter lesions. Conclusion: CSF Alpha-synuclein evaluation could help to early differentiate patients with DLB and AD in association with existing biomarkers.<\/jats:p>","DOI":"10.3390\/ijms232113488","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T03:28:10Z","timestamp":1667532490000},"page":"13488","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cerebrospinal Fluid Alpha-Synuclein Improves the Differentiation between Dementia with Lewy Bodies and Alzheimer\u2019s Disease in Clinical Practice"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4622-2413","authenticated-orcid":false,"given":"Matthieu","family":"Lilamand","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Inserm UMRS-1144 Optimisation Th\u00e9rapeutique en Neuropsychopharmacologie, 75006 Paris, France"},{"name":"Cognitive Neurology Center, Lariboisi\u00e8re-Fernand Widal Hospital (GHU AP-HP.Nord), 75010 Paris, France"},{"name":"Department of Geriatrics, Lariboisi\u00e8re-Fernand Widal Hospital (GHU AP-HP.Nord), 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josu\u00e9","family":"Clery","sequence":"additional","affiliation":[{"name":"Cognitive Neurology Center, Lariboisi\u00e8re-Fernand Widal Hospital (GHU AP-HP.Nord), 75010 Paris, France"},{"name":"Department of Geriatrics, Lariboisi\u00e8re-Fernand Widal Hospital (GHU AP-HP.Nord), 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0761-7885","authenticated-orcid":false,"given":"Agathe","family":"Vrillon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Inserm UMRS-1144 Optimisation Th\u00e9rapeutique en Neuropsychopharmacologie, 75006 Paris, France"},{"name":"Cognitive Neurology Center, Lariboisi\u00e8re-Fernand Widal Hospital (GHU AP-HP.Nord), 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Mouton-Liger","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Inserm UMRS-1144 Optimisation Th\u00e9rapeutique en Neuropsychopharmacologie, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3521-5832","authenticated-orcid":false,"given":"Emmanuel","family":"Cognat","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Inserm UMRS-1144 Optimisation Th\u00e9rapeutique en Neuropsychopharmacologie, 75006 Paris, France"},{"name":"Cognitive Neurology Center, Lariboisi\u00e8re-Fernand Widal Hospital (GHU AP-HP.Nord), 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9785-0738","authenticated-orcid":false,"given":"Sinead","family":"Gaubert","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Inserm UMRS-1144 Optimisation Th\u00e9rapeutique en Neuropsychopharmacologie, 75006 Paris, France"},{"name":"Cognitive Neurology Center, Lariboisi\u00e8re-Fernand Widal Hospital (GHU AP-HP.Nord), 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Hourregue","sequence":"additional","affiliation":[{"name":"Cognitive Neurology Center, Lariboisi\u00e8re-Fernand Widal Hospital (GHU AP-HP.Nord), 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Martinet","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Lariboisi\u00e8re-Fernand Widal Hospital (GHU AP-HP.Nord), 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2070-9706","authenticated-orcid":false,"given":"Julien","family":"Dumurgier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Inserm UMRS-1144 Optimisation Th\u00e9rapeutique en Neuropsychopharmacologie, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1848-8628","authenticated-orcid":false,"given":"Jacques","family":"Hugon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Inserm UMRS-1144 Optimisation Th\u00e9rapeutique en Neuropsychopharmacologie, 75006 Paris, France"},{"name":"Cognitive Neurology Center, Lariboisi\u00e8re-Fernand Widal Hospital (GHU AP-HP.Nord), 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Bouaziz-Amar","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Inserm UMRS-1144 Optimisation Th\u00e9rapeutique en Neuropsychopharmacologie, 75006 Paris, France"},{"name":"Biochemistery Department, Lariboisi\u00e8re Hospital (GHU AP-HP.Nord), 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Paquet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Inserm UMRS-1144 Optimisation Th\u00e9rapeutique en Neuropsychopharmacologie, 75006 Paris, France"},{"name":"Cognitive Neurology Center, Lariboisi\u00e8re-Fernand Widal Hospital (GHU AP-HP.Nord), 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cger.2018.06.007","article-title":"Lewy Body Dementia","volume":"34","author":"Sanford","year":"2018","journal-title":"Clin. 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