{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:15:45Z","timestamp":1783113345292,"version":"3.54.6"},"reference-count":174,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ERA-NET NEURON ANTaRES","award":["ANR-19-NEUR-0005"],"award-info":[{"award-number":["ANR-19-NEUR-0005"]}]},{"name":"ERA-NET NEURON ANTaRES","award":["ANR-19-CE37-0017"],"award-info":[{"award-number":["ANR-19-CE37-0017"]}]},{"DOI":"10.13039\/501100001665","name":"Gebra (Imaging GEne and BRAin networks in stress susceptibility: novel pathways and biomarkers in mice and men)","doi-asserted-by":"publisher","award":["ANR-19-NEUR-0005"],"award-info":[{"award-number":["ANR-19-NEUR-0005"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Gebra (Imaging GEne and BRAin networks in stress susceptibility: novel pathways and biomarkers in mice and men)","doi-asserted-by":"publisher","award":["ANR-19-CE37-0017"],"award-info":[{"award-number":["ANR-19-CE37-0017"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Antidepressants (ADs) are, for now, the best everyday treatment we have for moderate to severe major depressive episodes (MDEs). ADs are among the most prescribed drugs in the Western Hemisphere; however, the trial-and-error prescription strategy and side-effects leave a lot to be desired. More than 60% of patients suffering from major depression fail to respond to the first AD they are prescribed. For those who respond, full response is only observed after several weeks of treatment. In addition, there are no biomarkers that could help with therapeutic decisions; meanwhile, this is already true in cancer and other fields of medicine. For years, many investigators have been working to decipher the underlying mechanisms of AD response. Here, we provide the first systematic review of animal models. We thoroughly searched all the studies involving rodents, profiling transcriptomic alterations consecutive to AD treatment in na\u00efve animals or in animals subjected to stress-induced models of depression. We have been confronted by an important heterogeneity regarding the drugs and the experimental settings. Thus, we perform a meta-analysis of the AD signature of fluoxetine (FLX) in the hippocampus, the most studied target. Among genes and pathways consistently modulated across species, we identify both old players of AD action and novel transcriptional biomarker candidates that warrant further investigation. We discuss the most prominent transcripts (immediate early genes and activity-dependent synaptic plasticity pathways). We also stress the need for systematic studies of AD action in animal models that span across sex, peripheral and central tissues, and pharmacological classes.<\/jats:p>","DOI":"10.3390\/ijms232113543","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T11:56:36Z","timestamp":1667908596000},"page":"13543","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Transcriptomic Studies of Antidepressant Action in Rodent Models of Depression: A First Meta-Analysis"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3973-7862","authenticated-orcid":false,"given":"El Ch\u00e9rif","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Aix-Marseille Univ, CNRS, INT, Inst Neurosci Timone, 13005 Marseille, France"},{"name":"Fondation FondaMental, 94000 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Gorgievski","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, Integrative Neuroscience and Cognition Center, 75006 Paris, France"},{"name":"Sorbonne Universit\u00e9, INSERM, CNRS, Neuroscience Paris Seine, Institut de Biologie Paris Seine, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5441-2228","authenticated-orcid":false,"given":"Pilar","family":"Ortiz-Teba","sequence":"additional","affiliation":[{"name":"Laboratory of Neuropharmacology, Department of Medicine and Life Sciences, Universitat Pompeu Fabra, 08002 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Belzeaux","sequence":"additional","affiliation":[{"name":"Aix-Marseille Univ, CNRS, INT, Inst Neurosci Timone, 13005 Marseille, France"},{"name":"Fondation FondaMental, 94000 Cr\u00e9teil, France"},{"name":"P\u00f4le Universitaire de Psychiatrie, CHU de Montpellier, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4075-2736","authenticated-orcid":false,"given":"Gustavo","family":"Turecki","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute, McGill University, Montreal, QC H4H 1R3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Sibille","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5615-1287","authenticated-orcid":false,"given":"Guillaume","family":"Charbonnier","sequence":"additional","affiliation":[{"name":"Aix-Marseille Univ, INSERM, TAGC, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni T.","family":"Tzavara","sequence":"additional","affiliation":[{"name":"Fondation FondaMental, 94000 Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, Integrative Neuroscience and Cognition Center, 75006 Paris, France"},{"name":"Sorbonne Universit\u00e9, INSERM, CNRS, Neuroscience Paris Seine, Institut de Biologie Paris Seine, 75005 Paris, France"},{"name":"H\u00f4pital Sainte Marguerite AP-HM, P\u00f4le de Psychiatrie, 13274 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"key":"ref_1","first-page":"1517","article-title":"Depression Is the Leading Cause of Disability around the 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