{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:12:54Z","timestamp":1769152374943,"version":"3.49.0"},"reference-count":100,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T00:00:00Z","timestamp":1667606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Corona-\u00f4mica-RJ","doi-asserted-by":"publisher","award":["E-26\/210.179\/2020"],"award-info":[{"award-number":["E-26\/210.179\/2020"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Corona-\u00f4mica-RJ","doi-asserted-by":"publisher","award":["E-26\/211.107\/2021"],"award-info":[{"award-number":["E-26\/211.107\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Corona-\u00f4mica-RJ","doi-asserted-by":"publisher","award":["307145\/2021-2"],"award-info":[{"award-number":["307145\/2021-2"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Corona-\u00f4mica-RJ","doi-asserted-by":"publisher","award":["E-26\/201.046\/2022"],"award-info":[{"award-number":["E-26\/201.046\/2022"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Corona-\u00f4mica-RJ","doi-asserted-by":"publisher","award":["E-26\/210.254\/2020"],"award-info":[{"award-number":["E-26\/210.254\/2020"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Corona-\u00f4mica-RJ","doi-asserted-by":"publisher","award":["E-26\/210.657\/2021"],"award-info":[{"award-number":["E-26\/210.657\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Corona-\u00f4mica-RJ","doi-asserted-by":"publisher","award":["E-26\/210.273\/2018"],"award-info":[{"award-number":["E-26\/210.273\/2018"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Corona-\u00f4mica-RJ","doi-asserted-by":"publisher","award":["E-26\/201.040\/2021"],"award-info":[{"award-number":["E-26\/201.040\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Corona-\u00f4mica-RJ","doi-asserted-by":"publisher","award":["E-26\/201.406\/2021"],"award-info":[{"award-number":["E-26\/201.406\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Corona-\u00f4mica-RJ","doi-asserted-by":"publisher","award":["01.20.0029.000462\/20"],"award-info":[{"award-number":["01.20.0029.000462\/20"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Corona-\u00f4mica-RJ","doi-asserted-by":"publisher","award":["404096\/2020-4"],"award-info":[{"award-number":["404096\/2020-4"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["E-26\/210.179\/2020"],"award-info":[{"award-number":["E-26\/210.179\/2020"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["E-26\/211.107\/2021"],"award-info":[{"award-number":["E-26\/211.107\/2021"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["307145\/2021-2"],"award-info":[{"award-number":["307145\/2021-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["E-26\/201.046\/2022"],"award-info":[{"award-number":["E-26\/201.046\/2022"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["E-26\/210.254\/2020"],"award-info":[{"award-number":["E-26\/210.254\/2020"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["E-26\/210.657\/2021"],"award-info":[{"award-number":["E-26\/210.657\/2021"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["E-26\/210.273\/2018"],"award-info":[{"award-number":["E-26\/210.273\/2018"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["E-26\/201.040\/2021"],"award-info":[{"award-number":["E-26\/201.040\/2021"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["E-26\/201.406\/2021"],"award-info":[{"award-number":["E-26\/201.406\/2021"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["01.20.0029.000462\/20"],"award-info":[{"award-number":["01.20.0029.000462\/20"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["404096\/2020-4"],"award-info":[{"award-number":["404096\/2020-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/210.179\/2020"],"award-info":[{"award-number":["E-26\/210.179\/2020"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/211.107\/2021"],"award-info":[{"award-number":["E-26\/211.107\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["307145\/2021-2"],"award-info":[{"award-number":["307145\/2021-2"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/201.046\/2022"],"award-info":[{"award-number":["E-26\/201.046\/2022"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/210.254\/2020"],"award-info":[{"award-number":["E-26\/210.254\/2020"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/210.657\/2021"],"award-info":[{"award-number":["E-26\/210.657\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/210.273\/2018"],"award-info":[{"award-number":["E-26\/210.273\/2018"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/201.040\/2021"],"award-info":[{"award-number":["E-26\/201.040\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/201.406\/2021"],"award-info":[{"award-number":["E-26\/201.406\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["01.20.0029.000462\/20"],"award-info":[{"award-number":["01.20.0029.000462\/20"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["404096\/2020-4"],"award-info":[{"award-number":["404096\/2020-4"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/210.179\/2020"],"award-info":[{"award-number":["E-26\/210.179\/2020"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/211.107\/2021"],"award-info":[{"award-number":["E-26\/211.107\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["307145\/2021-2"],"award-info":[{"award-number":["307145\/2021-2"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/201.046\/2022"],"award-info":[{"award-number":["E-26\/201.046\/2022"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/210.254\/2020"],"award-info":[{"award-number":["E-26\/210.254\/2020"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/210.657\/2021"],"award-info":[{"award-number":["E-26\/210.657\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/210.273\/2018"],"award-info":[{"award-number":["E-26\/210.273\/2018"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/201.040\/2021"],"award-info":[{"award-number":["E-26\/201.040\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/201.406\/2021"],"award-info":[{"award-number":["E-26\/201.406\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["01.20.0029.000462\/20"],"award-info":[{"award-number":["01.20.0029.000462\/20"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["404096\/2020-4"],"award-info":[{"award-number":["404096\/2020-4"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/210.179\/2020"],"award-info":[{"award-number":["E-26\/210.179\/2020"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/211.107\/2021"],"award-info":[{"award-number":["E-26\/211.107\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["307145\/2021-2"],"award-info":[{"award-number":["307145\/2021-2"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/201.046\/2022"],"award-info":[{"award-number":["E-26\/201.046\/2022"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/210.254\/2020"],"award-info":[{"award-number":["E-26\/210.254\/2020"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/210.657\/2021"],"award-info":[{"award-number":["E-26\/210.657\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/210.273\/2018"],"award-info":[{"award-number":["E-26\/210.273\/2018"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/201.040\/2021"],"award-info":[{"award-number":["E-26\/201.040\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/201.406\/2021"],"award-info":[{"award-number":["E-26\/201.406\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["01.20.0029.000462\/20"],"award-info":[{"award-number":["01.20.0029.000462\/20"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["404096\/2020-4"],"award-info":[{"award-number":["404096\/2020-4"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Rede Corona-\u00f4mica BR MCTI\/FINEP affiliated with RedeV\u00edrus\/MCTI","doi-asserted-by":"publisher","award":["E-26\/210.179\/2020"],"award-info":[{"award-number":["E-26\/210.179\/2020"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Rede Corona-\u00f4mica BR MCTI\/FINEP affiliated with RedeV\u00edrus\/MCTI","doi-asserted-by":"publisher","award":["E-26\/211.107\/2021"],"award-info":[{"award-number":["E-26\/211.107\/2021"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Rede Corona-\u00f4mica BR MCTI\/FINEP affiliated with RedeV\u00edrus\/MCTI","doi-asserted-by":"publisher","award":["307145\/2021-2"],"award-info":[{"award-number":["307145\/2021-2"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Rede Corona-\u00f4mica BR MCTI\/FINEP affiliated with RedeV\u00edrus\/MCTI","doi-asserted-by":"publisher","award":["E-26\/201.046\/2022"],"award-info":[{"award-number":["E-26\/201.046\/2022"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Rede Corona-\u00f4mica BR MCTI\/FINEP affiliated with RedeV\u00edrus\/MCTI","doi-asserted-by":"publisher","award":["E-26\/210.254\/2020"],"award-info":[{"award-number":["E-26\/210.254\/2020"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Rede Corona-\u00f4mica BR MCTI\/FINEP affiliated with RedeV\u00edrus\/MCTI","doi-asserted-by":"publisher","award":["E-26\/210.657\/2021"],"award-info":[{"award-number":["E-26\/210.657\/2021"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Rede Corona-\u00f4mica BR MCTI\/FINEP affiliated with RedeV\u00edrus\/MCTI","doi-asserted-by":"publisher","award":["E-26\/210.273\/2018"],"award-info":[{"award-number":["E-26\/210.273\/2018"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Rede Corona-\u00f4mica BR MCTI\/FINEP affiliated with RedeV\u00edrus\/MCTI","doi-asserted-by":"publisher","award":["E-26\/201.040\/2021"],"award-info":[{"award-number":["E-26\/201.040\/2021"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Rede Corona-\u00f4mica BR MCTI\/FINEP affiliated with RedeV\u00edrus\/MCTI","doi-asserted-by":"publisher","award":["E-26\/201.406\/2021"],"award-info":[{"award-number":["E-26\/201.406\/2021"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Rede Corona-\u00f4mica BR MCTI\/FINEP affiliated with RedeV\u00edrus\/MCTI","doi-asserted-by":"publisher","award":["01.20.0029.000462\/20"],"award-info":[{"award-number":["01.20.0029.000462\/20"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Rede Corona-\u00f4mica BR MCTI\/FINEP affiliated with RedeV\u00edrus\/MCTI","doi-asserted-by":"publisher","award":["404096\/2020-4"],"award-info":[{"award-number":["404096\/2020-4"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Transcriptome studies have reported the dysregulation of cell cycle-related genes and the global inhibition of host mRNA translation in COVID-19 cases. However, the key genes and cellular mechanisms that are most affected by the severe outcome of this disease remain unclear. For this work, the RNA-seq approach was used to study the differential expression in buffy coat cells of two groups of people infected with SARS-CoV-2: (a) Mild, with mild symptoms; and (b) SARS (Severe Acute Respiratory Syndrome), who were admitted to the intensive care unit with the severe COVID-19 outcome. Transcriptomic analysis revealed 1009 up-regulated and 501 down-regulated genes in the SARS group, with 10% of both being composed of long non-coding RNA. Ribosome and cell cycle pathways were enriched among down-regulated genes. The most connected proteins among the differentially expressed genes involved transport dysregulation, proteasome degradation, interferon response, cytokinesis failure, and host translation inhibition. Furthermore, interactome analysis showed Fibrillarin to be one of the key genes affected by SARS-CoV-2. This protein interacts directly with the N protein and long non-coding RNAs affecting transcription, translation, and ribosomal processes. This work reveals a group of dysregulated processes, including translation and cell cycle, as key pathways altered in severe COVID-19 outcomes.<\/jats:p>","DOI":"10.3390\/ijms232113588","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T11:56:36Z","timestamp":1667908596000},"page":"13588","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Buffy Coat Transcriptomic Analysis Reveals Alterations in Host Cell Protein Synthesis and Cell Cycle in Severe COVID-19 Patients"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4808-8158","authenticated-orcid":false,"given":"Liliane Tavares de Faria","family":"Cavalcante","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Bioinform\u00e1tica, Laborat\u00f3rio Nacional de Computa\u00e7\u00e3o Cient\u00edfica, Petr\u00f3polis, Rio de Janeiro 25651-076, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0007-9834","authenticated-orcid":false,"given":"Guilherme Cordenonsi","family":"da Fonseca","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Bioinform\u00e1tica, Laborat\u00f3rio Nacional de Computa\u00e7\u00e3o Cient\u00edfica, Petr\u00f3polis, Rio de Janeiro 25651-076, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciane Almeida","family":"Amado Leon","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Desenvolvimento Tecnol\u00f3gico em Virologia, Instituto Oswaldo Cruz\/FIOCRUZ, Rio de Janeiro 21040-360, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreza Lemos","family":"Salvio","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neuroci\u00eancias Translacional, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro 20211-040, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ot\u00e1vio Jos\u00e9","family":"Brustolini","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Bioinform\u00e1tica, Laborat\u00f3rio Nacional de Computa\u00e7\u00e3o Cient\u00edfica, Petr\u00f3polis, Rio de Janeiro 25651-076, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra Lehmkuhl","family":"Gerber","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Bioinform\u00e1tica, Laborat\u00f3rio Nacional de Computa\u00e7\u00e3o Cient\u00edfica, Petr\u00f3polis, Rio de Janeiro 25651-076, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula de Campos","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Bioinform\u00e1tica, Laborat\u00f3rio Nacional de Computa\u00e7\u00e3o Cient\u00edfica, Petr\u00f3polis, Rio de Janeiro 25651-076, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla Augusta Barreto","family":"Marques","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neuroci\u00eancias Translacional, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro 20211-040, Brazil"},{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-617, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2505-039X","authenticated-orcid":false,"given":"Renan Amphilophio","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neuroci\u00eancias Translacional, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro 20211-040, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Henrique Ferreira","family":"Ramos Filho","sequence":"additional","affiliation":[{"name":"Laboratory of Translacional Neurosciences, Biomedical Institute, Universidade Estadual do Rio de Janeiro, Rio de Janeiro 20550-013, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2350-168X","authenticated-orcid":false,"given":"Rafael Lopes","family":"Kader","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-617, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisa","family":"Pimentel Amaro","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-617, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Paulo","family":"da Costa Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neuroci\u00eancias Translacional, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro 20211-040, Brazil"},{"name":"Yale New Haven Hospital, New Haven, CT 06510, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1538-6730","authenticated-orcid":false,"given":"Soniza","family":"Vieira Alves-Leon","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neuroci\u00eancias Translacional, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro 20211-040, Brazil"},{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-617, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4632-2086","authenticated-orcid":false,"given":"Ana Tereza Ribeiro","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Bioinform\u00e1tica, Laborat\u00f3rio Nacional de Computa\u00e7\u00e3o Cient\u00edfica, Petr\u00f3polis, Rio de Janeiro 25651-076, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,5]]},"reference":[{"key":"ref_1","unstructured":"Cascella, M., Rajnik, M., Aleem, A., Dulebohn, S.C., and Di Napoli, R. (2022). Features, Evaluation, and Treatment of Coronavirus (COVID-19), StatPearls Publishing."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/jmv.26424","article-title":"Epidemiology of COVID-19: A systematic review and meta-analysis of clinical characteristics, risk factors, and outcomes","volume":"93","author":"Li","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5235","DOI":"10.1172\/JCI138759","article-title":"Kinetics of viral load and antibody response in relation to COVID-19 severity","volume":"130","author":"Wang","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.1007\/s00415-021-10595-6","article-title":"Blood neurofilament light chain and total tau levels at admission predict death in COVID-19 patients","volume":"268","author":"Finardi","year":"2021","journal-title":"J. Neurol."},{"key":"ref_5","first-page":"421","article-title":"The extent of neuroradiological findings in COVID-19 shows correlation with blood biomarkers, Glasgow coma scale score and days in intensive care","volume":"49","author":"Rostami","year":"2021","journal-title":"J. Neuroradiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"108502","DOI":"10.1016\/j.intimp.2021.108502","article-title":"Oxidative stress and inflammatory markers in patients with COVID-19: Potential role of RAGE, HMGB1, GFAP and COX-2 in disease severity","volume":"104","author":"Passos","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cels.2020.10.003","article-title":"Large-Scale Multi-omic Analysis of COVID-19 Severity","volume":"12","author":"Overmyer","year":"2021","journal-title":"Cell Syst."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1080\/22221751.2020.1747363","article-title":"Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients","volume":"9","author":"Xiong","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s40635-020-00361-9","article-title":"Transcriptional profiling of leukocytes in critically ill COVID19 patients: Implications for interferon response and coagulation","volume":"8","author":"Gill","year":"2020","journal-title":"Intensive Care Med. Exp."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.cell.2020.10.004","article-title":"SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses","volume":"183","author":"Banerjee","year":"2020","journal-title":"Cell"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13578-021-00568-7","article-title":"Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor","volume":"11","author":"Lee","year":"2021","journal-title":"Cell Biosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.bbrc.2006.10.150","article-title":"Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination","volume":"351","author":"Lock","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Roca Suarez, A.A., Van Renne, N., Baumert, T.F., and Lupberger, J. (2018). Viral manipulation of STAT3: Evade, exploit, and injure. PLoS Pathog., 14.","DOI":"10.1371\/journal.ppat.1006839"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.pharmthera.2009.06.012","article-title":"Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: Key regulators of innate immunity","volume":"124","author":"Barral","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature05732","article-title":"TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity","volume":"446","author":"Gack","year":"2007","journal-title":"Nature"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"114316","DOI":"10.1016\/j.bcp.2020.114316","article-title":"Detection of Viral Infections by Innate Immunity","volume":"183","author":"Carty","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.3892\/or.2020.7687","article-title":"Paxillin knockdown suppresses metastasis and epithelial-mesenchymal transition in colorectal cancer via the ERK signalling pathway","volume":"44","author":"Wen","year":"2020","journal-title":"Oncol. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1083\/jcb.200505018","article-title":"Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement","volume":"171","author":"Yoshigi","year":"2005","journal-title":"J. Cell Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3389\/fendo.2018.00338","article-title":"PTEN: Tumor Suppressor and Metabolic Regulator","volume":"9","author":"Chen","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/jcp.25136","article-title":"MDA-9\/Syntenin Control","volume":"231","author":"Philley","year":"2016","journal-title":"J. Cell Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.yexcr.2004.03.016","article-title":"Ribosome biogenesis: Of knobs and RNA processing","volume":"296","author":"Granneman","year":"2004","journal-title":"Exp. Cell Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1101\/gad.1832209","article-title":"RPS25 is essential for translation initiation by the Dicistroviridae and hepatitis C viral IRESs","volume":"23","author":"Landry","year":"2009","journal-title":"Genes Dev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1128\/MCB.26.10.3853-3863.2006","article-title":"RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure","volume":"26","author":"Carleton","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1159\/000438532","article-title":"Inhibition of KIF14 Suppresses Tumor Cell Growth and Promotes Apoptosis in Human Glioblastoma","volume":"37","author":"Huang","year":"2015","journal-title":"Cell Physiol. Biochem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1126\/science.1096896","article-title":"The molecular requirements for cytokinesis","volume":"307","author":"Glotzer","year":"2005","journal-title":"Science"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.5115\/acb.2017.50.2.77","article-title":"The molecular mechanism for nuclear transport and its application","volume":"50","author":"Kim","year":"2017","journal-title":"Anat. Cell Biol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Tabe, Y., Kojima, K., Yamamoto, S., Sekihara, K., Matsushita, H., Davis, R.E., Wang, Z., Ma, W., Ishizawa, J., and Kazuno, S. (2015). Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0137210"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Dimitrova, D.G., Teysset, L., and Carr\u00e9, C. (2019). RNA 2\u2032-O-Methylation (Nm) Modification in Human Diseases. Genes, 10.","DOI":"10.3390\/genes10020117"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-60761-657-3_1","article-title":"RNA modifications: A mechanism that modulates gene expression","volume":"629","author":"Karijolich","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.cell.2015.12.038","article-title":"ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure","volume":"164","author":"Jain","year":"2016","journal-title":"Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41421-021-00275-0","article-title":"SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication","volume":"7","author":"Zheng","year":"2021","journal-title":"Cell Discov."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Prasad, K., Alasmari, A.F., Ali, N., Khan, R., Alghamdi, A., and Kumar, V. (2021). Insights into the SARS-CoV-2-Mediated Alteration in the Stress Granule Protein Regulatory Networks in Humans. Pathogens, 10.","DOI":"10.3390\/pathogens10111459"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"104836","DOI":"10.1016\/j.micpath.2021.104836","article-title":"Contribution of STAT3 to the Pathogenesis of COVID-19","volume":"154","author":"Jafarzadeh","year":"2021","journal-title":"Microb Pathog."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e2112663119","DOI":"10.1073\/pnas.2112663119","article-title":"Impact of ADAR-induced editing of minor viral RNA populations on replication and transmission of SARS-CoV-2","volume":"119","author":"Ringlander","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e61254","DOI":"10.7554\/eLife.61254","article-title":"The final step of 40S ribosomal subunit maturation is controlled by a dual key lock","volume":"10","author":"Plassart","year":"2021","journal-title":"Elife."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1182\/blood-2007-02-075184","article-title":"The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA","volume":"110","author":"Ganapathi","year":"2007","journal-title":"Blood"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"9818","DOI":"10.1073\/pnas.1302934110","article-title":"Translation initiation factor eIF3h targets specific transcripts to polysomes during embryogenesis","volume":"110","author":"Choudhuri","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1128\/MCB.01162-10","article-title":"La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability","volume":"31","author":"Yang","year":"2011","journal-title":"Mol. Cell Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5549","DOI":"10.1074\/jbc.RA118.007018","article-title":"A proteomic approach identifies SAFB-like transcription modulator (SLTM) as a bidirectional regulator of GLI family zinc finger transcription factors","volume":"294","author":"Zhang","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e03142-20","DOI":"10.1128\/mBio.03142-20","article-title":"Cytoplasmic CPSF6 Regulates HIV-1 Capsid Trafficking and Infection in a Cyclophilin A-Dependent Manner","volume":"12","author":"Zhong","year":"2021","journal-title":"MBio"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"102135","DOI":"10.1016\/j.isci.2021.102135","article-title":"Proteomic investigation reveals dominant alterations of neutrophil degranulation and mRNA translation pathways in patients with COVID-19","volume":"24","author":"Bankar","year":"2021","journal-title":"iScience"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2020.05.032","article-title":"Proteomic and Metabolomic Characterization of COVID-19 Patient Sera","volume":"182","author":"Shen","year":"2020","journal-title":"Cell"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Lodge, K.M., Cowburn, A.S., Li, W., and Condliffe, A.M. (2020). The Impact of Hypoxia on Neutrophil Degranulation and Consequences for the Host. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21041183"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"104673","DOI":"10.1016\/j.micpath.2020.104673","article-title":"The interplay between inflammatory pathways and COVID-19: A critical review on pathogenesis and therapeutic options","volume":"150","author":"Choudhary","year":"2021","journal-title":"Microb Pathog."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cytogfr.2020.04.002","article-title":"Cytokine storm intervention in the early stages of COVID-19 pneumonia","volume":"53","author":"Sun","year":"2020","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/JLB.3COVR0520-272R","article-title":"Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts","volume":"108","author":"Wang","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bbrc.2021.03.100","article-title":"SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration","volume":"554","author":"Idrees","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.neuron.2018.10.031","article-title":"Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer\u2019s Disease","volume":"100","author":"Litvinchuk","year":"2018","journal-title":"Neuron"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e3019","DOI":"10.1093\/cid\/ciaa1933","article-title":"Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Encephalitis Is a Cytokine Release Syndrome: Evidences From Cerebrospinal Fluid Analyses","volume":"73","author":"Pilotto","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/jmv.25915","article-title":"Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)","volume":"92","author":"Bryce","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1159\/000468764","article-title":"Translational control in influenza virus-infected cells","volume":"44","author":"Katze","year":"1990","journal-title":"Enzyme"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Li, S. (2019). Regulation of Ribosomal Proteins on Viral Infection. Cells, 8.","DOI":"10.3390\/cells8050508"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.virol.2017.12.033","article-title":"The interactome of EBV LMP1 evaluated by proximity-based BioID approach","volume":"516","author":"Rider","year":"2018","journal-title":"Virology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"32337","DOI":"10.1038\/srep32337","article-title":"The CD63-Syntenin-1 Complex Controls Post-Endocytic Trafficking of Oncogenic Human Papillomaviruses","volume":"6","author":"Fast","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"105115","DOI":"10.1016\/j.antiviral.2021.105115","article-title":"Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo","volume":"192","author":"Kashyap","year":"2021","journal-title":"Antivir. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"6631","DOI":"10.1128\/JVI.00367-09","article-title":"Molecular determinants for subcellular localization of the severe acute respiratory syndrome coronavirus open reading frame 3b protein","volume":"83","author":"Freundt","year":"2009","journal-title":"J. Virol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"108185","DOI":"10.1016\/j.celrep.2020.108185","article-title":"SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant","volume":"32","author":"Konno","year":"2020","journal-title":"Cell Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"198074","DOI":"10.1016\/j.virusres.2020.198074","article-title":"The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway","volume":"286","author":"Li","year":"2020","journal-title":"Virus Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/s41423-020-0514-8","article-title":"SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70","volume":"17","author":"Jiang","year":"2020","journal-title":"Cell Mol. Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.3389\/fmicb.2017.01171","article-title":"CRM1 Inhibitors for Antiviral Therapy","volume":"8","author":"Mathew","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/j.drudis.2020.06.014","article-title":"Exportin 1 inhibition as antiviral therapy","volume":"25","author":"Uddin","year":"2020","journal-title":"Drug Discov. Today"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coviro.2015.09.005","article-title":"Interplay between the virus and the ubiquitin-proteasome system: Molecular mechanism of viral pathogenesis","volume":"17","author":"Luo","year":"2016","journal-title":"Curr. Opin. Virol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0092-8674(93)90384-3","article-title":"The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53","volume":"75","author":"Scheffner","year":"1993","journal-title":"Cell"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1101\/gad.926401","article-title":"Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex","volume":"15","author":"Querido","year":"2001","journal-title":"Genes Dev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/alz.12556","article-title":"Comparison of serum neurodegenerative biomarkers among hospitalized COVID-19 patients versus non-COVID subjects with normal cognition, mild cognitive impairment, or Alzheimer\u2019s dementia","volume":"18","author":"Frontera","year":"2022","journal-title":"Alzheimers Dement."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.bbrc.2017.07.105","article-title":"RPS27a enhances EBV-encoded LMP1-mediated proliferation and invasion by stabilizing of LMP1","volume":"491","author":"Hong","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1099\/vir.0.035691-0","article-title":"The HBx protein of hepatitis B virus regulates the expression, intracellular distribution and functions of ribosomal protein S27a","volume":"93","author":"Fatima","year":"2012","journal-title":"J. Gen. Virol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Jouffe, C., Cretenet, G., Symul, L., Martin, E., Atger, F., Naef, F., and Gachon, F. (2013). The circadian clock coordinates ribosome biogenesis. PLoS Biol., 11.","DOI":"10.1371\/journal.pbio.1001455"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"22730","DOI":"10.1074\/jbc.M111.223651","article-title":"Interplay between ribosomal protein S27a and MDM2 protein in p53 activation in response to ribosomal stress","volume":"286","author":"Sun","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12957-022-02585-3","article-title":"KIF14 affects cell cycle arrest and cell viability in cervical cancer by regulating the p27Kip1 pathway","volume":"20","author":"Zhang","year":"2022","journal-title":"World J. Surg. Oncol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4430","DOI":"10.1128\/JVI.76.9.4430-4440.2002","article-title":"Cell cycle status affects coxsackievirus replication, persistence, and reactivation in vitro","volume":"76","author":"Feuer","year":"2002","journal-title":"J. Virol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.1128\/JVI.76.10.5233-5250.2002","article-title":"Interaction of the coronavirus nucleoprotein with nucleolar antigens and the host cell","volume":"76","author":"Chen","year":"2002","journal-title":"J. Virol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/pro.3978","article-title":"The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions","volume":"30","author":"Oughtred","year":"2021","journal-title":"Protein Sci."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Oh, S.J., and Shin, O.S. (2021). SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response. Cells, 10.","DOI":"10.3390\/cells10030530"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41392-021-00742-w","article-title":"A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response","volume":"6","author":"Zhao","year":"2021","journal-title":"Signal Transduct Target Ther."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41586-020-2286-9","article-title":"A SARS-CoV-2 protein interaction map reveals targets for drug repurposing","volume":"583","author":"Gordon","year":"2020","journal-title":"Nature"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"719037","DOI":"10.3389\/fimmu.2021.719037","article-title":"Structural basis for SARS-CoV-2 Nucleocapsid protein recognition by single-domain antibodies","volume":"12","author":"Ye","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.tins.2019.08.005","article-title":"Physiological, Pathological, and Targetable Membraneless Organelles in Neurons","volume":"42","author":"Ryan","year":"2019","journal-title":"Trends Neurosci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.tim.2012.02.001","article-title":"Regulation of stress granules in virus systems","volume":"20","author":"White","year":"2012","journal-title":"Trends Microbiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1099\/vir.0.033407-0","article-title":"Junin virus infection impairs stress-granule formation in Vero cells treated with arsenite via inhibition of eIF2\u03b1 phosphorylation","volume":"92","author":"Linero","year":"2011","journal-title":"J. Gen. Virol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Bocchetti, M., Scrima, M., Melisi, F., Luce, A., Sperlongano, R., Caraglia, M., Zappavigna, S., and Cossu, A.M. (2021). LncRNAs and Immunity: Coding the Immune System with Noncoding Oligonucleotides. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041741"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"104685","DOI":"10.1016\/j.isci.2022.104685","article-title":"Immunomodulatory LncRNA on antisense strand of ICAM-1 augments SARS-CoV-2 infection-associated airway mucoinflammatory phenotype","volume":"25","author":"Devadoss","year":"2022","journal-title":"iScience"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.bbrc.2018.11.004","article-title":"The positive feedback between lncRNA TNK2-AS1 and STAT3 enhances angiogenesis in non-small cell lung cancer","volume":"507","author":"Wang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"615859","DOI":"10.3389\/fimmu.2021.615859","article-title":"Integrated Transcriptome Profiling Revealed That Elevated Long Non-Coding RNA-AC007278.2 Expression Repressed CCR7 Transcription in Systemic Lupus Erythematosus","volume":"12","author":"You","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1161\/ATVBAHA.119.313430","article-title":"Novel Plaque Enriched Long Noncoding RNA in Atherosclerotic Macrophage Regulation (PELATON)","volume":"40","author":"Hung","year":"2020","journal-title":"Arterioscler Thromb. Vasc. Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"611626","DOI":"10.3389\/fmolb.2020.611626","article-title":"Identification of a Five-Autophagy-Related-lncRNA Signature as a Novel Prognostic Biomarker for Hepatocellular Carcinoma","volume":"7","author":"Deng","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"ref_87","first-page":"3853","article-title":"Integrated bioinformatics analysis reveals role of the LINC01093\/miR-96-5p\/ZFAND5\/NF-\u03baB signaling axis in hepatocellular carcinoma","volume":"18","author":"Zheng","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s12032-021-01478-x","article-title":"Elevated LINC01550 induces the apoptosis and cell cycle arrest of melanoma","volume":"38","author":"Chen","year":"2021","journal-title":"Med. Oncol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Huang, K., Wang, C., Vagts, C., Raguveer, V., Finn, P.W., and Perkins, D.L. (2022). Long non-coding RNAs (lncRNAs) NEAT1 and MALAT1 are differentially expressed in severe COVID-19 patients: An integrated single-cell analysis. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0261242"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1126\/science.aau1646","article-title":"RNA modifications modulate gene expression during development","volume":"361","author":"Frye","year":"2018","journal-title":"Science"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"8080","DOI":"10.1093\/nar\/gkac615","article-title":"Cap-independent translation and a precisely located RNA sequence enable SARS-CoV-2 to control host translation and escape anti-viral response","volume":"50","author":"Slobodin","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41420-020-00358-z","article-title":"RNA 2\u2032-O-methylation modification and its implication in COVID-19 immunity","volume":"6","author":"Paramasivam","year":"2020","journal-title":"Cell Death Discov."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1038\/s41467-020-17495-9","article-title":"Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin","volume":"11","author":"Krafcikova","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: A flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: Ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/bioinformatics\/btl567","article-title":"Using GOstats to test gene lists for GO term association","volume":"23","author":"Falcon","year":"2007","journal-title":"Bioinformatics"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1093\/bioinformatics\/btt285","article-title":"Pathview: An R\/Bioconductor package for pathway-based data integration and visualization","volume":"29","author":"Luo","year":"2013","journal-title":"Bioinformatics"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"ref_100","first-page":"D160","article-title":"NPInter v4.0: An integrated database of ncRNA interactions","volume":"48","author":"Teng","year":"2020","journal-title":"Nucleic Acids Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/21\/13588\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:11:21Z","timestamp":1760145081000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/21\/13588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,5]]},"references-count":100,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["ijms232113588"],"URL":"https:\/\/doi.org\/10.3390\/ijms232113588","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,5]]}}}