{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:23:05Z","timestamp":1773660185313,"version":"3.50.1"},"reference-count":74,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["21-75-10105"],"award-info":[{"award-number":["21-75-10105"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["0245-2021-0009"],"award-info":[{"award-number":["0245-2021-0009"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Russian State","award":["21-75-10105"],"award-info":[{"award-number":["21-75-10105"]}]},{"name":"Russian State","award":["0245-2021-0009"],"award-info":[{"award-number":["0245-2021-0009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Since the onset of the COVID-19 pandemic, numerous publications have appeared describing autoimmune pathologies developing after a coronavirus infection, with several papers reporting autoantibody production during the acute period of the disease. Several viral diseases are known to trigger autoimmune processes, and the appearance of catalytic antibodies with DNase activity is one of the earliest markers of several autoimmune pathologies. Therefore, we analyzed whether IgG antibodies from blood plasma of SARS-CoV-2 patients after recovery could bind and hydrolyze DNA. We analyzed how vaccination of patients with adenovirus Sputnik V vaccine influences the production of abzymes with DNase activity. Four groups were selected for the analysis, each containing 25 patients according to their relative titers of antibodies to S-protein: with high and median titers, vaccinated with Sputnik V with high titers, and a control group of donors with negative titers. The relative titers of antibodies against DNA and the relative DNase activity of IgGs depended very much on the individual patient and the donor, and no significant correlation was found between the relative values of antibodies titers and their DNase activity. Our results indicate that COVID-19 disease and vaccination with adenoviral Sputnik V vaccine do not result in the development or enhancement of strong autoimmune reactions as in the typical autoimmune diseases associated with the production of anti-DNA and DNA hydrolyzing antibodies.<\/jats:p>","DOI":"10.3390\/ijms232213681","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T08:52:56Z","timestamp":1667897576000},"page":"13681","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Natural IgG against S-Protein and RBD of SARS-CoV-2 Do Not Bind and Hydrolyze DNA and Are Not Autoimmune"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1270-7164","authenticated-orcid":false,"given":"Anna M.","family":"Timofeeva","sequence":"first","affiliation":[{"name":"SB RAS Institute of Chemical Biology and Fundamental Medicine, 630090 Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0882-8171","authenticated-orcid":false,"given":"Sergey E.","family":"Sedykh","sequence":"additional","affiliation":[{"name":"SB RAS Institute of Chemical Biology and Fundamental Medicine, 630090 Novosibirsk, Russia"},{"name":"Faculty of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1084-6419","authenticated-orcid":false,"given":"Evgeny A.","family":"Ermakov","sequence":"additional","affiliation":[{"name":"SB RAS Institute of Chemical Biology and Fundamental Medicine, 630090 Novosibirsk, Russia"},{"name":"Faculty of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6884-6104","authenticated-orcid":false,"given":"Andrey L.","family":"Matveev","sequence":"additional","affiliation":[{"name":"SB RAS Institute of Chemical Biology and Fundamental Medicine, 630090 Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva I.","family":"Odegova","sequence":"additional","affiliation":[{"name":"SB RAS Institute of Chemical Biology and Fundamental Medicine, 630090 Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana A.","family":"Sedykh","sequence":"additional","affiliation":[{"name":"SB RAS Institute of Chemical Biology and Fundamental Medicine, 630090 Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8023-4453","authenticated-orcid":false,"given":"Dmitry N.","family":"Shcherbakov","sequence":"additional","affiliation":[{"name":"State Research Center of Virology and Biotechnology Vector, 630559 Koltsovo, Russia"},{"name":"Department of Physical-Chemistry Biology and Biotechnology, Altay State University, 656049 Barnaul, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iuliia A.","family":"Merkuleva","sequence":"additional","affiliation":[{"name":"State Research Center of Virology and Biotechnology Vector, 630559 Koltsovo, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina A.","family":"Volosnikova","sequence":"additional","affiliation":[{"name":"State Research Center of Virology and Biotechnology Vector, 630559 Koltsovo, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina S.","family":"Nesmeyanova","sequence":"additional","affiliation":[{"name":"State Research Center of Virology and Biotechnology Vector, 630559 Koltsovo, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina V.","family":"Tikunova","sequence":"additional","affiliation":[{"name":"SB RAS Institute of Chemical Biology and Fundamental Medicine, 630090 Novosibirsk, Russia"},{"name":"Faculty of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4988-8923","authenticated-orcid":false,"given":"Georgy A.","family":"Nevinsky","sequence":"additional","affiliation":[{"name":"SB RAS Institute of Chemical Biology and Fundamental Medicine, 630090 Novosibirsk, Russia"},{"name":"Faculty of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1136\/jclinpath-2015-203455","article-title":"The Role of Parvovirus B19 in the Pathogenesis of Autoimmunity and Autoimmune Disease","volume":"69","author":"Kerr","year":"2016","journal-title":"J. Clin. Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1600-065X.1999.tb01319.x","article-title":"Viruses, Host Responses, and Autoimmunity","volume":"169","author":"Horwitz","year":"1999","journal-title":"Immunol. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Martirosyan, A., Aminov, R., and Manukyan, G. (2019). Environmental Triggers of Autoreactive Responses: Induction of Antiphospholipid Antibody Formation. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01609"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Gracia-Ramos, A.E., Martin-Nares, E., and Hern\u00e1ndez-Molina, G. (2021). New Onset of Autoimmune Diseases Following COVID-19 Diagnosis. Cells, 10.","DOI":"10.3390\/cells10123592"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1007\/s00277-020-04097-0","article-title":"Autoimmune Thrombotic Thrombocytopenic Purpura (TTP) Associated with COVID-19","volume":"99","author":"Albiol","year":"2020","journal-title":"Ann. Hematol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41584-020-0448-7","article-title":"Autoimmune and Inflammatory Diseases Following COVID-19","volume":"16","author":"Galeotti","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1007\/s00277-020-04137-9","article-title":"COVID-19 Infection Associated with Autoimmune Hemolytic Anemia","volume":"99","author":"Capes","year":"2020","journal-title":"Ann. Hematol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1007\/s00134-020-05991-x","article-title":"Clinical Predictors of Mortality Due to COVID-19 Based on an Analysis of Data of 150 Patients from Wuhan, China","volume":"46","author":"Ruan","year":"2020","journal-title":"Intensive Care Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/path.2067","article-title":"Expression of Elevated Levels of Pro-Inflammatory Cytokines in SARS-CoV-Infected ACE2+ Cells in SARS Patients: Relation to the Acute Lung Injury and Pathogenesis of SARS","volume":"210","author":"He","year":"2006","journal-title":"J. Pathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"eabd3876","DOI":"10.1126\/scitranslmed.abd3876","article-title":"Prothrombotic Autoantibodies in Serum from Patients Hospitalized with COVID-19","volume":"12","author":"Zuo","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1136\/annrheumdis-2020-218009","article-title":"Autoantibodies Related to Systemic Autoimmune Rheumatic Diseases in Severely Ill Patients with COVID-19","volume":"79","author":"Vlachoyiannopoulos","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"584241","DOI":"10.3389\/fimmu.2020.584241","article-title":"Anti-Phospholipid Antibodies in COVID-19 Are Different From Those Detectable in the Anti-Phospholipid Syndrome","volume":"11","author":"Borghi","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41586-021-03631-y","article-title":"Diverse Functional Autoantibodies in Patients with COVID-19","volume":"595","author":"Wang","year":"2021","journal-title":"Nature"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2100918","DOI":"10.1183\/13993003.00918-2021","article-title":"Autoimmunity to Annexin A2 Predicts Mortality among Hospitalised COVID-19 Patients","volume":"58","author":"Zuniga","year":"2021","journal-title":"Eur. Respir. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"210","DOI":"10.11613\/BM.2021.020502","article-title":"Assessment of Antinuclear Antibodies (ANA): National Recommendations on Behalf of the Croatian Society of Medical Biochemistry and Laboratory Medicine","volume":"31","author":"Drvar","year":"2021","journal-title":"Biochem. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1136\/annrheumdis-2013-203863","article-title":"International Recommendations for the Assessment of Autoantibodies to Cellular Antigens Referred to as Anti-Nuclear Antibodies","volume":"73","author":"Damoiseaux","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1111\/cts.12805","article-title":"Clinical and Autoimmune Characteristics of Severe and Critical Cases of COVID-19","volume":"13","author":"Zhou","year":"2020","journal-title":"Clin. Transl. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1100\/tsw.2010.98","article-title":"Natural Catalytic Antibodies in Norm, Autoimmune, Viral, and Bacterial Diseases","volume":"10","author":"Nevinsky","year":"2010","journal-title":"Sci. World J."},{"key":"ref_19","unstructured":"Nevinsky, G.A. (2011). Natural Catalytic Antibodies in Norm and in HIV-Infected Patients. Understanding HIV\/AIDS Management and Care\u2014Pandemic Approaches in the 21st Century, InTech."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Timofeeva, A., Sedykh, S., and Nevinsky, G. (2022). Post-Immune Antibodies in HIV-1 Infection in the Context of Vaccine Development: A Variety of Biological Functions and Catalytic Activities. Vaccines, 10.","DOI":"10.3390\/vaccines10030384"},{"key":"ref_21","first-page":"180","article-title":"Features of Hydrolysis of Specific and Nonspecific Globular Proteins and Oligopeptides by Antibodies against Viral Integrase from Blood of HIV-Infected Patients","volume":"80","author":"Odintsova","year":"2015","journal-title":"Biochemistry"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/jmr.2185","article-title":"IgGs Containing \u03bb- and \u03ba-Type Light Chains and of All Subclasses (IgG1-IgG4) from the Sera of Patients with Autoimmune Diseases and Viral and Bacterial Infections Hydrolyze DNA","volume":"25","author":"Parkhomenko","year":"2012","journal-title":"J. Mol. Recognit."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1582-4934.2009.00738.x","article-title":"Affinity and Catalytic Heterogeneity of Polyclonal Myelin Basic Protein-Hydrolyzing IgGs from Sera of Patients with Multiple Sclerosis","volume":"14","author":"Legostaeva","year":"2010","journal-title":"J. Cell. Mol. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1002\/jmr.1143","article-title":"Affinity and Catalytic Heterogeneity and Metal-Dependence of Polyclonal Myelin Basic Protein-Hydrolyzing IgGs from Sera of Patients with Systemic Lupus Erythematosus","volume":"24","author":"Bezuglova","year":"2011","journal-title":"J. Mol. Recognit."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Timofeeva, A., Sedykh, S., Maksimenko, L., Sedykh, T., Skudarnov, S., Ostapova, T., Yaschenko, S., Gashnikova, N., and Nevinsky, G. (2022). The Blood of the HIV-Infected Patients Contains \u03ba-IgG, \u03bb-IgG, and Bispecific \u039a\u03bb-IgG, Which Possess DNase and Amylolytic Activity. Life, 12.","DOI":"10.3390\/life12020304"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Ermakov, E.A., Nevinsky, G.A., and Buneva, V.N. (2020). Immunoglobulins with Non-Canonical Functions in Inflammatory and Autoimmune Disease States. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21155392"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Parkhomenko, T.A., Doronin, V.B., Castellazzi, M., Padroni, M., Pastore, M., Buneva, V.N., Granieri, E., and Nevinsky, G.A. (2014). Comparison of DNA-Hydrolyzing Antibodies from the Cerebrospinal Fluid and Serum of Patients with Multiple Sclerosis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0093001"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1073\/pnas.0509849103","article-title":"Autoantibodies to Myelin Basic Protein Catalyze Site-Specific Degradation of Their Antigen","volume":"103","author":"Ponomarenko","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Nevinsky, G.A. (2016). Autoimmune Processes in Multiple Sclerosis: Production of Harmful Catalytic Antibodies Associated with Significant Changes in the Hematopoietic Stem Cell Differentiation and Proliferation. Trending Topics in Multiple Sclerosis, InTech.","DOI":"10.5772\/63824"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Nevinsky, G.A. (2017). Catalytic Antibodies in Norm and Systemic Lupus Erythematosus. Lupus, InTech.","DOI":"10.5772\/67790"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.1585181","article-title":"DNA Hydrolyzing Autoantibodies","volume":"256","author":"Shuster","year":"1992","journal-title":"Science"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/intimm\/dxs071","article-title":"IgGs Containing Light Chains of the \u03bb- and \u03ba-Type and of All Subclasses (IgG1-IgG4) from the Sera of Patients with Systemic Lupus Erythematosus Hydrolyze Myelin Basic Protein","volume":"24","author":"Bezuglova","year":"2012","journal-title":"Int. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0165-2478(01)00185-7","article-title":"Catalytic Heterogeneity of Polyclonal DNA-Hydrolyzing Antibodies from the Sera of Patients with Multiple Sclerosis","volume":"76","author":"Baranovskii","year":"2001","journal-title":"Immunol. Lett."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/jmr.1016","article-title":"IgGs Containing Light Chains of the \u03bb and \u03ba Type and of All Subclasses (IgG1-IgG4) from Sera of Patients with Multiple Sclerosis Hydrolyze DNA","volume":"23","author":"Parkhomenko","year":"2010","journal-title":"J. Mol. Recognit."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"150064","DOI":"10.1098\/rsob.150064","article-title":"DNA-Hydrolysing Activity of IgG Antibodies from the Sera of Patients with Schizophrenia","volume":"5","author":"Ermakov","year":"2015","journal-title":"Open Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41537-021-00143-6","article-title":"DNA Hydrolysing IgG Catalytic Antibodies: An Emerging Link between Psychoses and Autoimmunity","volume":"7","author":"Ramesh","year":"2021","journal-title":"Npj Schizophr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s12026-013-8424-9","article-title":"Deoxyribonuclease Activity of Polyclonal IgGs: A Putative Serological Marker in Patients with Spondyloarthritides","volume":"56","author":"Kundzer","year":"2013","journal-title":"Immunol. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1134\/S0026893306050128","article-title":"DNA-Hydrolyzing IgG Antibodies from the Blood of Patients with Acquired Immune Deficiency Syndrome","volume":"40","author":"Odintsova","year":"2006","journal-title":"Mol. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.biochi.2010.01.022","article-title":"DNA-Hydrolyzing Activity of IgG Antibodies from the Sera of Patients with Tick-Borne Encephalitis","volume":"92","author":"Parkhomenko","year":"2010","journal-title":"Biochimie"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1111\/j.1582-4934.2008.00441.x","article-title":"DNA-Hydrolysing Activity of IgG Antibodies from the Sera of Patients with Diseases Caused by Different Bacterial Infections","volume":"13","author":"Parkhomenko","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Gushchin, V.A., Dolzhikova, I.V., Shchetinin, A.M., Odintsova, A.S., Siniavin, A.E., Nikiforova, M.A., Pochtovyi, A.A., Shidlovskaya, E.V., Kuznetsova, N.A., and Burgasova, O.A. (2021). Neutralizing Activity of Sera from Sputnik V-Vaccinated People against Variants of Concern (VOC: B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.3) and Moscow Endemic SARS-CoV-2 Variants. Vaccines, 9.","DOI":"10.3390\/vaccines9070779"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/iub.1712","article-title":"Hydrolysis by Catalytic IgGs of MicroRNA Specific for Patients with Schizophrenia","volume":"70","author":"Ermakov","year":"2018","journal-title":"IUBMB Life"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/jmr.1033","article-title":"Anti-Histone H1 IgGs from Blood Serum of Systemic Lupus Erythematosus Patients Are Capable of Hydrolyzing Histone H1 and Myelin Basic Protein","volume":"23","author":"Magorivska","year":"2010","journal-title":"J. Mol. Recognit."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e2759","DOI":"10.1002\/jmr.2759","article-title":"Autoimmunity and Immune System Dysregulation in Schizophrenia: IgGs from Sera of Patients Hydrolyze Myelin Basic Protein","volume":"32","author":"Parshukova","year":"2019","journal-title":"J. Mol. Recognit."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Kostrikina, I.A., Buneva, V.N., Granieri, E., and Nevinsky, G.A. (2020). Extreme Diversity of IgGs Against Histones, DNA, and Myelin Basic Protein in the Cerebrospinal Fluid and Blood of Patients with Multiple Sclerosis. Biomolecules, 10.","DOI":"10.3390\/biom10040630"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Timofeeva, A.M., Dmitrenok, P.S., Konenkova, L.P., Buneva, V.N., and Nevinsky, G.A. (2013). Multiple Sites of the Cleavage of 21- and 25-Mer Encephalytogenic Oligopeptides Corresponding to Human Myelin Basic Protein (MBP) by Specific Anti-MBP Antibodies from Patients with Systemic Lupus Erythematosus. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0051600"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/biof.1473","article-title":"Autoantibodies in HIV-infected Patients: Cross Site-specific Hydrolysis of H1 Histone and Myelin Basic Protein","volume":"45","author":"Baranova","year":"2019","journal-title":"BioFactors"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/jmr.2534","article-title":"Antibodies from the Sera of HIV-Infected Patients Efficiently Hydrolyze All Human Histones","volume":"29","author":"Baranova","year":"2016","journal-title":"J. Mol. Recognit."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Vidarsson, G., Dekkers, G., and Rispens, T. (2014). IgG Subclasses and Allotypes: From Structure to Effector Functions. Front. Immunol., 5.","DOI":"10.3389\/fimmu.2014.00520"},{"key":"ref_50","first-page":"1305","article-title":"Polyreactivity of Natural Antibodies: Exchange by HL-Fragments","volume":"78","author":"Sedykh","year":"2013","journal-title":"Biochem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1039\/C6MB00479B","article-title":"Half Molecular Exchange of IgGs in the Blood of Healthy Humans: Chimeric Lambda-Kappa-Immunoglobulins Containing HL Fragments of Antibodies of Different Subclasses (IgG1\u2013IgG4)","volume":"12","author":"Sedykh","year":"2016","journal-title":"Mol. Biosyst."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.immuni.2020.07.020","article-title":"Distinct Early Serological Signatures Track with SARS-CoV-2 Survival","volume":"53","author":"Atyeo","year":"2020","journal-title":"Immunity"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Luo, H., Jia, T., Chen, J., Zeng, S., Qiu, Z., Wu, S., Li, X., Lei, Y., Wang, X., and Wu, W. (2021). The Characterization of Disease Severity Associated IgG Subclasses Response in COVID-19 Patients. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.632814"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Bowen, A., Wear, M., and Casadevall, A. (2017). Antibody-Mediated Catalysis in Infection and Immunity. Infect. Immun., 85.","DOI":"10.1128\/IAI.00202-17"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.autrev.2006.01.004","article-title":"Catalytic Autoantibodies in Clinical Autoimmunity and Modern Medicine","volume":"5","author":"Gabibov","year":"2006","journal-title":"Autoimmun. Rev."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Doronin, V.B., Parkhomenko, T.A., Castellazzi, M., Padroni, M., Pastore, M., Buneva, V.N., Granieri, E., and Nevinsky, G.A. (2014). Comparison of Antibodies Hydrolyzing Myelin Basic Protein from the Cerebrospinal Fluid and Serum of Patients with Multiple Sclerosis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0107807"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jaut.2011.05.007","article-title":"Autoantibodies with Enzymatic Properties in Human Autoimmune Diseases","volume":"37","author":"Wootla","year":"2011","journal-title":"J. Autoimmun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1001\/jama.2020.17052","article-title":"Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions","volume":"324","author":"Kox","year":"2020","journal-title":"JAMA"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Bastard, P., Rosen, L.B., Zhang, Q., Michailidis, E., Hoffmann, H.-H., Zhang, Y., Dorgham, K., Philippot, Q., Rosain, J., and B\u00e9ziat, V. (2020). Autoantibodies against Type I IFNs in Patients with Life-Threatening COVID-19. Science, 370.","DOI":"10.1126\/science.abd4585"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1582-4934.2007.00048.x","article-title":"Formation of Different Abzymes in Autoimmune-Prone MRL-Lpr\/Lpr Mice Is Associated with Changes in Colony Formation of Haematopoietic Progenitors","volume":"11","author":"Andryushkova","year":"2007","journal-title":"J. Cell. Mol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Aulova, K.S., Urusov, A.E., Toporkova, L.B., Sedykh, S.E., Shevchenko, J.A., Tereshchenko, V.P., Sennikov, S.V., Orlovskaya, I.A., and Nevinsky, G.A. (2022). Cell Differentiation and Proliferation in the Bone Marrow and Other Organs of 2D2 Mice during Spontaneous Development of EAE Leading to the Production of Abzymes. Molecules, 27.","DOI":"10.3390\/molecules27072195"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Aulova, K.S., Urusov, A.E., Toporkova, L.B., Sedykh, S.E., Shevchenko, Y.A., Tereshchenko, V.P., Sennikov, S.V., Budde, T., Meuth, S.G., and Popova, N.A. (2019). Production of Abzymes in Th, CBA, and C57BL\/6 Mice before and after MOG Treatment: Comparing Changes in Cell Differentiation and Proliferation. Biomolecules, 10.","DOI":"10.3390\/biom10010053"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s11033-020-06117-8","article-title":"Catalytic Antibodies in the Bone Marrow and Other Organs of Th Mice during Spontaneous Development of Experimental Autoimmune Encephalomyelitis Associated with Cell Differentiation","volume":"48","author":"Aulova","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1134\/S0026893317060036","article-title":"Exceptional Diversity of Catalytic Antibodies with Varying Activity in the Blood of Autoimmune and Viral Disease Patients","volume":"51","author":"Buneva","year":"2017","journal-title":"Mol. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/intimm\/dxp004","article-title":"Immunization of Rabbits with DNase II Leads to Formation of Polyclonal Antibodies with DNase and RNase Activities","volume":"21","author":"Krasnorutskii","year":"2009","journal-title":"Int. Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1093\/intimm\/dxn061","article-title":"Antibodies against Pancreatic Ribonuclease A Hydrolyze RNA and DNA","volume":"20","author":"Krasnorutskii","year":"2008","journal-title":"Int. Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4161\/mabs.2.1.10788","article-title":"Neutralizing Epitopes of the SARS-CoV S-Protein Cluster Independent of Repertoire, Antigen Structure or MAb Technology","volume":"2","author":"Berry","year":"2010","journal-title":"MAbs"},{"key":"ref_68","first-page":"507","article-title":"Blood-Derived RNA- and MicroRNA-Hydrolyzing IgG Antibodies in Schizophrenia Patients","volume":"83","author":"Ermakov","year":"2018","journal-title":"Biochem."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Kolosova, E.A., Shaprova, O.N., Shanshin, D.V., Nesmeyanova, V.S., Merkuleva, I.A., Belenkaya, S.V., Isaeva, A.A., Nikitin, A.O., Volosnikova, E.A., and Nikulina, Y.A. (2022). Antibodies to the Spike Protein Receptor-Binding Domain of SARS-CoV-2 at 4\u201313 Months after COVID-19. J. Clin. Med., 11.","DOI":"10.3390\/jcm11144053"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Merkuleva, I.A., Shcherbakov, D.N., Borgoyakova, M.B., Isaeva, A.A., Nesmeyanova, V.S., Volkova, N.V., Aripov, V.S., Shanshin, D.V., Karpenko, L.I., and Belenkaya, S.V. (2022). Are Hamsters a Suitable Model for Evaluating the Immunogenicity of RBD-Based Anti-COVID-19 Subunit Vaccines?. Viruses, 14.","DOI":"10.3390\/v14051060"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Borgoyakova, M.B., Karpenko, L.I., Rudometov, A.P., Volosnikova, E.A., Merkuleva, I.A., Starostina, E.V., Zadorozhny, A.M., Isaeva, A.A., Nesmeyanova, V.S., and Shanshin, D.V. (2022). Self-Assembled Particles Combining SARS-CoV-2 RBD Protein and RBD DNA Vaccine Induce Synergistic Enhancement of the Humoral Response in Mice. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23042188"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Baranova, S.V., Dmitrenok, P.S., Buneva, V.N., Sedykh, S.E., and Nevinsky, G.A. (2021). HIV-Infected Patients: Cross Site-Specific Hydrolysis of H3 and H4 Histones and Myelin Basic Protein with Antibodies against These Three Proteins. Molecules, 26.","DOI":"10.3390\/molecules26020316"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"6431","DOI":"10.3168\/jds.2020-19897","article-title":"Six Catalytic Activities and Cytotoxicity of Immunoglobulin G and Secretory Immunoglobulin A from Human Milk","volume":"104","author":"Nevinsky","year":"2021","journal-title":"J. Dairy Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.placenta.2018.06.007","article-title":"The DNA-Hydrolyzing Activity of IgG Antibodies from Human Placenta","volume":"68","author":"Lekchnov","year":"2018","journal-title":"Placenta"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/22\/13681\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:12:23Z","timestamp":1760145143000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/22\/13681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,8]]},"references-count":74,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["ijms232213681"],"URL":"https:\/\/doi.org\/10.3390\/ijms232213681","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,8]]}}}