{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:45:49Z","timestamp":1791812749089,"version":"4.3.4"},"reference-count":132,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"ANR AAPG2020","doi-asserted-by":"publisher","award":["ReproFUN"],"award-info":[{"award-number":["ReproFUN"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CNRS","award":["ReproFUN"],"award-info":[{"award-number":["ReproFUN"]}]},{"name":"Inserm","award":["ReproFUN"],"award-info":[{"award-number":["ReproFUN"]}]},{"name":"Universit\u00e9 Paris Cit\u00e9","award":["ReproFUN"],"award-info":[{"award-number":["ReproFUN"]}]},{"name":"Sorbonne Universit\u00e9","award":["ReproFUN"],"award-info":[{"award-number":["ReproFUN"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Mini-puberty of infancy is a short developmental phase occurring in humans and other mammals after birth. In females, it corresponds to transient and robust activation of the hypothalamo-pituitary-ovarian (HPO) axis revealed by high levels of gonadotropin hormones, follicular growth, and increased estradiol production by the ovary. The roles of estradiol signaling during this intriguing developmental phase are not yet well known, but accumulating data support the idea that it aids in the implementation of reproductive function. This review aims to provide in-depth information on HPO activity during this particular developmental phase in several mammal species, including humans, and to propose emerging hypotheses on the putative effect of estradiol signaling on the development and function of organs involved in female reproduction.<\/jats:p>","DOI":"10.3390\/ijms232213695","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T08:52:56Z","timestamp":1667897576000},"page":"13695","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Deciphering the Roles &amp; Regulation of Estradiol Signaling during Female Mini-Puberty: Insights from Mouse Models"],"prefix":"10.3390","volume":"23","author":[{"given":"Marie M.","family":"Devillers","sequence":"first","affiliation":[{"name":"Sorbonne Paris Cit\u00e9, Universit\u00e9 de Paris Cit\u00e9, CNRS, Inserm, Biologie Fonctionnelle et Adaptative UMR 8251, Physiologie de l\u2019Axe Gonadotrope U1133, CEDEX 13, 75205 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakina","family":"Mhaouty-Kodja","sequence":"additional","affiliation":[{"name":"Neuroscience Paris Seine\u2014Institut de Biologie Paris Seine, Sorbonne Universit\u00e9, CNRS UMR 8246, INSERM U1130, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4489-4304","authenticated-orcid":false,"given":"C\u00e9line J.","family":"Guigon","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Cit\u00e9, Universit\u00e9 de Paris Cit\u00e9, CNRS, Inserm, Biologie Fonctionnelle et Adaptative UMR 8251, Physiologie de l\u2019Axe Gonadotrope U1133, CEDEX 13, 75205 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1097\/01.ju.0000181506.97839.b0","article-title":"The importance of mini-puberty for fertility in cryptorchidism","volume":"174","author":"Hadziselimovic","year":"2005","journal-title":"J. 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