{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T19:25:06Z","timestamp":1779218706555,"version":"3.51.4"},"reference-count":61,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Guangdong Province, China","award":["2022A1515012556"],"award-info":[{"award-number":["2022A1515012556"]}]},{"name":"Natural Science Foundation of Guangdong Province, China","award":["XT202305"],"award-info":[{"award-number":["XT202305"]}]},{"name":"Collaborative Innovation Center of GDAAS","award":["2022A1515012556"],"award-info":[{"award-number":["2022A1515012556"]}]},{"name":"Collaborative Innovation Center of GDAAS","award":["XT202305"],"award-info":[{"award-number":["XT202305"]}]},{"name":"Special Financial Fund of Foshan\u2014Guangdong Agricultural Science and Technology Demonstration City Project in 2021","award":["2022A1515012556"],"award-info":[{"award-number":["2022A1515012556"]}]},{"name":"Special Financial Fund of Foshan\u2014Guangdong Agricultural Science and Technology Demonstration City Project in 2021","award":["XT202305"],"award-info":[{"award-number":["XT202305"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Fc receptors (FcRs) are key players in antibody-dependent cellular phagocytosis (ADCP) with their specific recognition of the Fc portion of an immunoglobulin. Despite reports of Fc\u03b3R-mediated phagocytosis in mammals, little is known about the effects of soluble Fc\u03b3Rs on the immune response. In this study, Fc\u03b3RI\u03b1 was cloned from the largemouth bass (Micropterus salmoides) (MsFc\u03b3RI\u03b1). Without a transmembrane segment or a cytoplasmic tail, MsFc\u03b3RI\u03b1 was identified as a soluble form protein and widely distributed in the spleen, head kidney, and intestine. The native MsFc\u03b3RI\u03b1 was detected in the serum of Nocardia seriolae-infected largemouth bass and the supernatants of transfected HEK293 cells. Additionally, it was verified that the transfected cells\u2019 surface secreted MsFcRI\u03b1 could bind to largemouth bass IgM. Moreover, the expression changes of MsFc\u03b3RI\u03b1, Syk, and Lyn indicated that MsFc\u03b3RI\u03b1 was engaged in the acute phase response to bacteria, and the Fc\u03b3R-mediated phagocytosis pathway was activated by Nocardia seriolae stimulation. Furthermore, recombinant MsFc\u03b3RI\u03b1 could enhance both reactive oxygen species (ROS) and phagocytosis to Nocardia seriolae of leukocytes, presumably through the interaction of MsFc\u03b3RI\u03b1 with a complement receptor. In conclusion, these findings provided a better understanding of the function of soluble Fc\u03b3Rs in the immune response and further shed light on the mechanism of phagocytosis in teleosts.<\/jats:p>","DOI":"10.3390\/ijms232213788","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T01:48:08Z","timestamp":1668044888000},"page":"13788","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Functional Characterization of Largemouth Bass (Micropterus salmoides) Soluble Fc\u03b3R Homolog in Response to Bacterial Infection"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8139-4133","authenticated-orcid":false,"given":"Jing","family":"Wu","sequence":"first","affiliation":[{"name":"Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"},{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"},{"name":"Key Laboratory of Livestock Disease Prevention of Guangdong Province, Guangzhou 510640, China"},{"name":"Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province, Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China"},{"name":"Collaborative Innovation Center of Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Nie","sequence":"additional","affiliation":[{"name":"Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"},{"name":"Key Laboratory of Livestock Disease Prevention of Guangdong Province, Guangzhou 510640, China"},{"name":"Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province, Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China"},{"name":"Collaborative Innovation Center of Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingya","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqing","family":"Feng","sequence":"additional","affiliation":[{"name":"Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"},{"name":"Key Laboratory of Livestock Disease Prevention of Guangdong Province, Guangzhou 510640, China"},{"name":"Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province, Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China"},{"name":"Collaborative Innovation Center of Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Hao","sequence":"additional","affiliation":[{"name":"Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"},{"name":"Key Laboratory of Livestock Disease Prevention of Guangdong Province, Guangzhou 510640, China"},{"name":"Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province, Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China"},{"name":"Collaborative Innovation Center of Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Huang","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"},{"name":"Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5376-7289","authenticated-orcid":false,"given":"Yugu","family":"Li","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenxing","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"},{"name":"Key Laboratory of Livestock Disease Prevention of Guangdong Province, Guangzhou 510640, China"},{"name":"Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province, Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China"},{"name":"Collaborative Innovation Center of Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1146\/annurev.immunol.15.1.203","article-title":"Fc receptor biology","volume":"15","author":"Marc","year":"1997","journal-title":"Annu. 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