{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:52:06Z","timestamp":1792727526494,"version":"4.5.0"},"reference-count":119,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Pre-eclampsia is a placenta-related complication occurring in 2\u201310% of all pregnancies. miRNAs are a group of non-coding RNAs regulating gene expression. There is evidence that C19MC miRNAs are involved in the development of the placenta. Deregulation of chromosome 19 microRNA cluster (C19MC) miRNAs expression leads to impaired cell differentiation, abnormal trophoblast invasion and pathological angiogenesis, which can lead to the development of pre-eclampsia. Information was obtained through a review of articles available in PubMed Medline. Articles on the role of the C19MC miRNA in the development of pre-eclampsia published in 2009\u20132022 were analyzed. This review article summarizes the current data on the role of the C19MC miRNA in the development of pre-eclampsia. They indicate a significant increase in the expression of most C19MC miRNAs in placental tissue and a high level of circulating fractions in serum and plasma, both in the first and\/or third trimester in women with PE. Only for miR-525-5p, low levels of plasma expression were noted in the first trimester, and in the placenta in the third trimester. The search for molecular factors indicating the development of pre-eclampsia before the onset of clinical symptoms seems to be a promising diagnostic route. Identifying women at risk of developing pre-eclampsia at the pre-symptomatic stage would avoid serious complications in both mothers and fetuses. We believe that miRNAs belonging to cluster C19MC could be promising biomarkers of pre-eclampsia development.<\/jats:p>","DOI":"10.3390\/ijms232213836","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T19:16:23Z","timestamp":1668107783000},"page":"13836","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Role of Cluster C19MC in Pre-Eclampsia Development"],"prefix":"10.3390","volume":"23","author":[{"given":"Ilona","family":"Jaszczuk","sequence":"first","affiliation":[{"name":"Department of Cancer Genetics with Cytogenetic Laboratory, Medical University of Lublin, Radziwillowska Street 11, 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Winkler","sequence":"additional","affiliation":[{"name":"Second Department of Gynecological Oncology, St. John\u2019s Center of Oncology of the Lublin Region, Jaczewski Street 7, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Koczkodaj","sequence":"additional","affiliation":[{"name":"Department of Cancer Genetics with Cytogenetic Laboratory, Medical University of Lublin, Radziwillowska Street 11, 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Skrzypczak","sequence":"additional","affiliation":[{"name":"Second Department of Gynecology, Lublin Medical University, Jaczewski Street 8, 20-954 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7591-5887","authenticated-orcid":false,"given":"Agata","family":"Filip","sequence":"additional","affiliation":[{"name":"Department of Cancer Genetics with Cytogenetic Laboratory, Medical University of Lublin, Radziwillowska Street 11, 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1089\/dna.2011.1530","article-title":"Extracellular Nucleic Acids in Maternal Circulation as Potential Biomarkers for Placental Insufficiency","volume":"31","author":"Hromadnikova","year":"2012","journal-title":"DNA Cell Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, Biogenesis, Mechanism, and Function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"D155","DOI":"10.1093\/nar\/gky1141","article-title":"miRBase: From microRNA sequences to function","volume":"47","author":"Kozomara","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1101\/gad.1399806","article-title":"Control of translation and mRNA degradation by miRNAs and siRNAs","volume":"20","author":"Liu","year":"2006","journal-title":"Genes Dev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1261\/rna.1804410","article-title":"MicroRNAs, macrocontrol: Regulation of miRNA processing","volume":"16","author":"Durmus","year":"2010","journal-title":"RNA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","article-title":"Metazoan MicroRNAs","volume":"173","author":"Bartel","year":"2018","journal-title":"Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.tcb.2015.07.011","article-title":"The Functions of MicroRNAs: mRNA Decay and Translational Repression","volume":"25","author":"Iwakawa","year":"2015","journal-title":"Trends Cell Biol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Haig, D., and Mainieri, A. 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