{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:47:47Z","timestamp":1784072867788,"version":"3.55.0"},"reference-count":16,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association (AHA) Pre-Doctoral Award","doi-asserted-by":"publisher","award":["2021AHAPRE216237"],"award-info":[{"award-number":["2021AHAPRE216237"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association (AHA) Pre-Doctoral Award","doi-asserted-by":"publisher","award":["19CDA34760185"],"award-info":[{"award-number":["19CDA34760185"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association (AHA) Pre-Doctoral Award","doi-asserted-by":"publisher","award":["1R01HL160966"],"award-info":[{"award-number":["1R01HL160966"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"AHA Career Development Award","doi-asserted-by":"publisher","award":["2021AHAPRE216237"],"award-info":[{"award-number":["2021AHAPRE216237"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"AHA Career Development Award","doi-asserted-by":"publisher","award":["19CDA34760185"],"award-info":[{"award-number":["19CDA34760185"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"AHA Career Development Award","doi-asserted-by":"publisher","award":["1R01HL160966"],"award-info":[{"award-number":["1R01HL160966"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"St. Jude Medical (2015\u20132016 Heart Rhythm Society Cardiac Pacing and Electrophysiology Fellowship Award)","award":["2021AHAPRE216237"],"award-info":[{"award-number":["2021AHAPRE216237"]}]},{"name":"St. Jude Medical (2015\u20132016 Heart Rhythm Society Cardiac Pacing and Electrophysiology Fellowship Award)","award":["19CDA34760185"],"award-info":[{"award-number":["19CDA34760185"]}]},{"name":"St. Jude Medical (2015\u20132016 Heart Rhythm Society Cardiac Pacing and Electrophysiology Fellowship Award)","award":["1R01HL160966"],"award-info":[{"award-number":["1R01HL160966"]}]},{"DOI":"10.13039\/100005859","name":"National Institute of Health","doi-asserted-by":"publisher","award":["2021AHAPRE216237"],"award-info":[{"award-number":["2021AHAPRE216237"]}],"id":[{"id":"10.13039\/100005859","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005859","name":"National Institute of Health","doi-asserted-by":"publisher","award":["19CDA34760185"],"award-info":[{"award-number":["19CDA34760185"]}],"id":[{"id":"10.13039\/100005859","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005859","name":"National Institute of Health","doi-asserted-by":"publisher","award":["1R01HL160966"],"award-info":[{"award-number":["1R01HL160966"]}],"id":[{"id":"10.13039\/100005859","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Arrhythmogenic Cardiomyopathy (ACM) is a familial heart disease, characterized by contractile dysfunction, ventricular arrhythmias (VAs), and the risk of sudden cardiac death. Currently, implantable cardioverter defibrillators and antiarrhythmics are the mainstays in ACM therapeutics. Angiotensin receptor blockers (ARBs) have been highlighted in the treatment of heart diseases, including ACM. Yet, recent research has additionally implicated ARBs in the genesis of VAs and myocardial lipolysis via the peroxisome proliferator-activated receptor gamma (PPAR\u03b3) pathway. The latter is of particular interest, as fibrofatty infiltration is a pathological hallmark in ACM. Here, we tested two ARBs, Valsartan and Telmisartan, and the PPAR agonist, Rosiglitazone, in an animal model of ACM, homozygous Desmoglein-2 mutant mice (Dsg2mut\/mut). Cardiac function, premature ventricular contractions (PVCs), fibrofatty scars, PPAR\u03b1\/\u03b3 protein levels, and PPAR-mediated mRNA transcripts were assessed. Of note, not a single mouse treated with Rosiglitazone made it to the study endpoint (i.e., 100% mortality: n = 5\/5). Telmisartan-treated Dsg2mut\/mut mice displayed the preservation of contractile function (percent ejection fraction [%EF]; 74.8 \u00b1 6.8%EF) compared to Vehicle- (42.5 \u00b1 5.6%EF) and Valsartan-treated (63.1 \u00b1 4.4%EF) mice. However, Telmisartan-treated Dsg2mut\/mut mice showed increased cardiac wall motion abnormalities, augmented %PVCs, electrocardiographic repolarization\/depolarization abnormalities, larger fibrotic lesions, and increased expression of PPARy-regulated gene transcripts compared to their Dsg2mut\/mut counterparts. Alternatively, Valsartan-treated Dsg2mut\/mut mice harbored fewer myocardial scars, reduced %PVC, and increased Wnt-mediated transcripts. Considering our findings, caution should be taken by physicians when prescribing medications that may increase PPARy signaling in patients with ACM.<\/jats:p>","DOI":"10.3390\/ijms232213909","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T02:26:37Z","timestamp":1668392797000},"page":"13909","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy and Safety of Angiotensin Receptor Blockers in a Pre-Clinical Model of Arrhythmogenic Cardiomyopathy"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6696-8888","authenticated-orcid":false,"given":"Maicon","family":"Landim-Vieira","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6319-9614","authenticated-orcid":false,"given":"Aida Rahimi","family":"Kahmini","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Integrative Physiology, Florida State University, Tallahassee, FL 32306, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Engel","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa Nicole","family":"Cannon","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Amat-Alarcon","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Judge","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Renato","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1675-5945","authenticated-orcid":false,"given":"Stephen P.","family":"Chelko","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306, USA"},{"name":"Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Coscarella, I.L., Landim-Vieira, M., Pinto, J.R., and Chelko, S.P. (2022). Arrhythmogenic Cardiomyopathy: Exercise Pitfalls, Role of Connexin-43, and Moving beyond Antiarrhythmics. Int. J. Mol. 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