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Several neurodegenerative diseases, such as Alzheimer\u2019s (AD) and Parkinson\u2019s (PD) show a characteristic buildup of proteinaceous aggregates in several organs, especially the brain. Despite the enormous upsurge in research articles in this arena, it would not be incorrect to say that we still lack a crystal-clear idea surrounding these notorious aggregates. In this review, we attempt to present a holistic picture on protein aggregation and amyloids in particular. Using a chronological order of discoveries, we present the case of amyloids right from the onset of their discovery, various biophysical techniques, including analysis of the structure, the mechanisms and kinetics of the formation of amyloids. We have discussed important questions on whether aggregation and amyloidosis are restricted to a subset of specific proteins or more broadly influenced by the biophysiochemical and cellular environment. The therapeutic strategies and the significant failure rate of drugs in clinical trials pertaining to these neurodegenerative diseases have been also discussed at length. At a time when the COVID-19 pandemic has hit the globe hard, the review also discusses the plausibility of the far-reaching consequences posed by the virus, such as triggering early onset of amyloidosis. Finally, the application(s) of amyloids as useful biomaterials has also been discussed briefly in this review.<\/jats:p>","DOI":"10.3390\/ijms232213970","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T02:29:32Z","timestamp":1668392972000},"page":"13970","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Amyloidogenesis: What Do We Know So Far?"],"prefix":"10.3390","volume":"23","author":[{"given":"Zeina","family":"Alraawi","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, Fulbright College of Art and Science, University of Arkansas, Fayetteville, AR 72701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4756-6461","authenticated-orcid":false,"given":"Nayan","family":"Banerjee","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences, Indian Association for the Cultivation of Science, 2A & 2B Raja S. 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Mullick Road, Jadavpur, Kolkata 700032, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0108-2795","authenticated-orcid":false,"given":"Srujana","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata 741246, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thallapuranam Krishnaswamy Suresh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Fulbright College of Art and Science, University of Arkansas, Fayetteville, AR 72701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1021\/cr030076o","article-title":"New approaches to nanofabrication: Molding, printing, and other techniques","volume":"105","author":"Gates","year":"2005","journal-title":"Chem. 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